SLC17A2
gene geneOn this page
Also known as NPT3
Summary
SLC17A2 (solute carrier family 17 member 2, HGNC:10930) is a protein-coding gene on chromosome 6p22.2, encoding Sodium-dependent phosphate transport protein 3 (O00624). Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions.
Predicted to enable urate transmembrane transporter activity. Predicted to be involved in phosphate-containing compound metabolic process and sodium ion transport. Predicted to be located in plasma membrane. Predicted to be active in apical plasma membrane.
Source: NCBI Gene 10246 — RefSeq curated summary.
At a glance
- Clinical variants (ClinVar): 66 total
- Druggable target: yes
- MANE Select transcript:
NM_001286123
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:10930 |
| Approved symbol | SLC17A2 |
| Name | solute carrier family 17 member 2 |
| Location | 6p22.2 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | NPT3 |
| Ensembl gene | ENSG00000112337 |
| Ensembl biotype | protein_coding |
| OMIM | 611049 |
| Entrez | 10246 |
Gene structure
Transcript identifiers
Ensembl transcripts: 12 — 12 protein_coding
ENST00000265425, ENST00000360488, ENST00000377850, ENST00000882944, ENST00000882945, ENST00000882946, ENST00000882947, ENST00000882948, ENST00000882949, ENST00000882950, ENST00000882951, ENST00000882952
RefSeq mRNA: 3 — MANE Select: NM_001286123
NM_001286123, NM_001286125, NM_005835
CCDS: CCDS4567, CCDS69060
Canonical transcript exons
ENST00000377850 — 12 exons
| Exon | Start | End |
|---|---|---|
| ENSE00000700863 | 25915736 | 25915868 |
| ENSE00000700940 | 25916685 | 25916846 |
| ENSE00000701210 | 25921006 | 25921093 |
| ENSE00000701297 | 25921179 | 25921412 |
| ENSE00000928888 | 25916969 | 25917087 |
| ENSE00000928889 | 25918487 | 25918573 |
| ENSE00001084985 | 25915499 | 25915646 |
| ENSE00001176069 | 25923695 | 25923906 |
| ENSE00001280464 | 25925769 | 25925879 |
| ENSE00002208909 | 25930277 | 25930691 |
| ENSE00003529539 | 25912754 | 25913451 |
| ENSE00003676320 | 25914580 | 25914670 |
Expression profiles
Bgee: expression breadth broad, 22 present calls, max score 94.36.
FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1224 / max 72.4414, expressed in 11 samples.
FANTOM5 promoters (3 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 72288 | 0.1627 | 10 |
| 72286 | 0.0644 | 8 |
| 72287 | 0.0580 | 9 |
Top tissues by expression
280 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| right lobe of liver | UBERON:0001114 | 94.36 | gold quality |
| liver | UBERON:0002107 | 94.13 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 80.69 | gold quality |
| endometrium epithelium | UBERON:0004811 | 70.42 | gold quality |
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 55.79 | gold quality |
| buccal mucosa cell | CL:0002336 | 54.30 | silver quality |
| oocyte | CL:0000023 | 53.14 | gold quality |
| endothelial cell | CL:0000115 | 52.80 | gold quality |
| cranial nerve II | UBERON:0000941 | 50.79 | silver quality |
| frontal pole | UBERON:0002795 | 50.41 | gold quality |
| middle frontal gyrus | UBERON:0002702 | 50.30 | gold quality |
| paraflocculus | UBERON:0005351 | 50.18 | gold quality |
| Brodmann (1909) area 10 | UBERON:0013541 | 50.18 | gold quality |
| quadriceps femoris | UBERON:0001377 | 49.96 | gold quality |
| thymus | UBERON:0002370 | 49.70 | gold quality |
| vastus lateralis | UBERON:0001379 | 49.51 | gold quality |
| Brodmann (1909) area 46 | UBERON:0006483 | 49.30 | gold quality |
| blood vessel layer | UBERON:0004797 | 49.29 | gold quality |
| cerebellar vermis | UBERON:0004720 | 49.25 | gold quality |
| cervix squamous epithelium | UBERON:0006922 | 49.20 | gold quality |
| hair follicle | UBERON:0002073 | 49.18 | gold quality |
| olfactory bulb | UBERON:0002264 | 48.92 | gold quality |
| choroid plexus epithelium | UBERON:0003911 | 48.89 | gold quality |
| adult mammalian kidney | UBERON:0000082 | 48.87 | gold quality |
| myocardium | UBERON:0002349 | 48.87 | gold quality |
| type B pancreatic cell | CL:0000169 | 48.83 | gold quality |
| oviduct epithelium | UBERON:0004804 | 48.82 | gold quality |
| cardiac muscle of right atrium | UBERON:0003379 | 48.55 | gold quality |
| CA1 field of hippocampus | UBERON:0003881 | 48.50 | gold quality |
| nephron tubule | UBERON:0001231 | 48.37 | silver quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | yes | 3.27 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
39 targeting SLC17A2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-5692A | 100.00 | 74.40 | 6850 |
| HSA-MIR-568 | 99.98 | 69.86 | 2084 |
| HSA-MIR-23B-5P | 99.98 | 66.07 | 587 |
| HSA-MIR-12136 | 99.98 | 72.81 | 5713 |
| HSA-MIR-548AJ-3P | 99.96 | 73.38 | 5345 |
| HSA-MIR-548X-3P | 99.96 | 73.38 | 5345 |
| HSA-MIR-1250-3P | 99.96 | 70.04 | 4038 |
| HSA-MIR-590-3P | 99.96 | 74.34 | 6478 |
| HSA-MIR-548J-3P | 99.94 | 72.61 | 4881 |
| HSA-MIR-23A-5P | 99.94 | 65.39 | 468 |
| HSA-MIR-548AE-3P | 99.93 | 72.66 | 4867 |
| HSA-MIR-548AH-3P | 99.93 | 72.54 | 4872 |
| HSA-MIR-548AM-3P | 99.93 | 72.54 | 4872 |
| HSA-MIR-548AQ-3P | 99.93 | 72.66 | 4867 |
| HSA-MIR-5582-3P | 99.86 | 72.48 | 4221 |
| HSA-MIR-4307 | 99.82 | 70.45 | 3374 |
| HSA-MIR-4306 | 99.72 | 70.50 | 3630 |
| HSA-MIR-33A-3P | 99.70 | 70.27 | 3362 |
| HSA-MIR-6733-3P | 99.54 | 67.80 | 1281 |
| HSA-MIR-942-5P | 99.41 | 68.40 | 1977 |
| HSA-MIR-185-5P | 99.35 | 68.60 | 2497 |
| HSA-MIR-4644 | 99.35 | 69.12 | 2514 |
| HSA-MIR-3191-5P | 99.24 | 66.52 | 1722 |
| HSA-MIR-664A-3P | 99.22 | 71.08 | 2696 |
| HSA-MIR-8077 | 99.17 | 66.67 | 862 |
| HSA-MIR-4758-3P | 99.12 | 63.96 | 869 |
| HSA-MIR-4711-3P | 98.97 | 66.87 | 1020 |
| HSA-MIR-374A-3P | 98.87 | 67.82 | 1531 |
| HSA-MIR-3145-3P | 98.85 | 69.07 | 2031 |
| HSA-MIR-5094 | 98.63 | 67.11 | 1062 |
Literature-anchored findings (GeneRIF, showing 2)
- Association was detected in premenopausal women of European descent between percent iron saturation and variants in the chromosome 6 region containing both HFE and SLC17A2 genes. (PMID:26852655)
- a novel gout-associated gene, SLC17A2, was identified (OR = 0.83, PFDR = 0.017).The common variant rs2071299 is an expression associated SNP and SLC17A2 mRNA expression is modified by different genotypes of this variant. the mRNA expression and protein levels of SLC17A2 between healthy individuals and hyperuricemia patients were significantly different (PMID:29497127)
Cross-species orthologs
56 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | slc17a5 | ENSDARG00000055190 |
| danio_rerio | slc37a4b | ENSDARG00000077180 |
| danio_rerio | si:ch1073-513e17.1 | ENSDARG00000086739 |
| danio_rerio | slc37a4bl | ENSDARG00000093531 |
| mus_musculus | Slc17a2 | ENSMUSG00000036110 |
| rattus_norvegicus | Slc17a2 | ENSRNOG00000017180 |
| drosophila_melanogaster | dmGlut | FBGN0010497 |
| drosophila_melanogaster | MFS14 | FBGN0010651 |
| drosophila_melanogaster | Picot | FBGN0024315 |
| drosophila_melanogaster | CG9254 | FBGN0028513 |
| drosophila_melanogaster | CG6978 | FBGN0029727 |
| drosophila_melanogaster | VGlut | FBGN0031424 |
| drosophila_melanogaster | CG7881 | FBGN0033048 |
| drosophila_melanogaster | MFS12 | FBGN0033234 |
| drosophila_melanogaster | MFS15 | FBGN0034392 |
| drosophila_melanogaster | CG15096 | FBGN0034394 |
| drosophila_melanogaster | MFS16 | FBGN0034611 |
| drosophila_melanogaster | CG12490 | FBGN0034782 |
| drosophila_melanogaster | CG9825 | FBGN0034783 |
| drosophila_melanogaster | CG9826 | FBGN0034784 |
| drosophila_melanogaster | CG3649 | FBGN0034785 |
| drosophila_melanogaster | CG2003 | FBGN0039886 |
| drosophila_melanogaster | CG30265 | FBGN0050265 |
| drosophila_melanogaster | MFS1 | FBGN0050272 |
| caenorhabditis_elegans | WBGENE00001135 | |
| caenorhabditis_elegans | WBGENE00007669 | |
| caenorhabditis_elegans | WBGENE00008000 | |
| caenorhabditis_elegans | WBGENE00008677 | |
| caenorhabditis_elegans | WBGENE00010755 | |
| caenorhabditis_elegans | WBGENE00010931 | |
| caenorhabditis_elegans | WBGENE00011185 | |
| caenorhabditis_elegans | WBGENE00011349 | |
| caenorhabditis_elegans | WBGENE00011556 | |
| caenorhabditis_elegans | WBGENE00011688 | |
| caenorhabditis_elegans | WBGENE00012443 | |
| caenorhabditis_elegans | WBGENE00015271 | |
| caenorhabditis_elegans | WBGENE00015272 | |
| caenorhabditis_elegans | WBGENE00016003 | |
| caenorhabditis_elegans | WBGENE00018429 | |
| caenorhabditis_elegans | WBGENE00018918 | |
| caenorhabditis_elegans | WBGENE00018920 | |
| caenorhabditis_elegans | WBGENE00019187 | |
| caenorhabditis_elegans | WBGENE00019655 | |
| caenorhabditis_elegans | WBGENE00020583 | |
| caenorhabditis_elegans | WBGENE00020584 | |
| caenorhabditis_elegans | WBGENE00020697 | |
| caenorhabditis_elegans | WBGENE00020698 | |
| caenorhabditis_elegans | WBGENE00020699 | |
| caenorhabditis_elegans | WBGENE00020700 | |
| caenorhabditis_elegans | WBGENE00021157 | |
| caenorhabditis_elegans | WBGENE00021158 | |
| caenorhabditis_elegans | WBGENE00021219 | |
| caenorhabditis_elegans | WBGENE00021220 | |
| caenorhabditis_elegans | WBGENE00021223 | |
| caenorhabditis_elegans | WBGENE00021226 | |
| caenorhabditis_elegans | WBGENE00302978 |
Paralogs (12): SLC17A6 (ENSG00000091664), SLC17A9 (ENSG00000101194), SLC17A7 (ENSG00000104888), SLC17A5 (ENSG00000119899), SLC17A3 (ENSG00000124564), SLC17A1 (ENSG00000124568), SLC37A2 (ENSG00000134955), SLC37A4 (ENSG00000137700), SLC17A4 (ENSG00000146039), SLC37A3 (ENSG00000157800), SLC37A1 (ENSG00000160190), SLC17A8 (ENSG00000179520)
Protein
Protein identifiers
Sodium-dependent phosphate transport protein 3 — O00624 (reviewed: O00624)
Alternative names: Na(+)/PI cotransporter 3, Sodium/phosphate cotransporter 3, Solute carrier family 17 member 2
All UniProt accessions (1): O00624
UniProt curated annotations — full annotation on UniProt →
Function. Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. Mediates chloride-dependent transport of urate. Can actively transport inorganic phosphate into cells via Na(+) cotransport.
Subcellular location. Apical cell membrane.
Tissue specificity. Expressed in the small intestine, kidney, spleen and testis. Not detected in fetal brain, bone marrow, and mammary gland.
Similarity. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
Isoforms (3)
| UniProt ID | Names | Canonical? |
|---|---|---|
| O00624-1 | 1 | yes |
| O00624-2 | 2 | |
| O00624-3 | 3 |
RefSeq proteins (3): NP_001273052, NP_001273054, NP_005826 (=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR011701 | MFS | Family |
| IPR020846 | MFS_dom | Domain |
| IPR036259 | MFS_trans_sf | Homologous_superfamily |
| IPR050382 | MFS_Na/Anion_cotransporter | Family |
Pfam: PF07690
Catalyzed reactions (Rhea), 2 shown:
- 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in) (RHEA:71255)
- urate(out) + n chloride(in) = urate(in) + n chloride(out) (RHEA:72319)
UniProt features (16 total): transmembrane region 9, glycosylation site 4, splice variant 2, chain 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-O00624-F1 | 83.34 | 0.50 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Glycosylation sites (4): 47, 56, 68, 69
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 97 (showing top):
MODULE_162, GOBP_SODIUM_ION_TRANSMEMBRANE_TRANSPORT, GOBP_MONOATOMIC_CATION_TRANSPORT, TCF4_Q5, MODULE_368, RGTTAMWNATT_HNF1_01, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4, GOBP_ORGANIC_ANION_TRANSPORT, GOCC_APICAL_PLASMA_MEMBRANE, GCM_TEC, HNF1_C, USF_02, LEF1_Q6, GCM_CDH5, GOBP_TRANSMEMBRANE_TRANSPORT
GO Biological Process (7): phosphate-containing compound metabolic process (GO:0006796), sodium ion transport (GO:0006814), monoatomic ion transport (GO:0006811), inorganic anion transport (GO:0015698), urate transport (GO:0015747), sodium ion transmembrane transport (GO:0035725), transmembrane transport (GO:0055085)
GO Molecular Function (4): sodium:phosphate symporter activity (GO:0005436), urate transmembrane transporter activity (GO:0015143), transmembrane transporter activity (GO:0022857), symporter activity (GO:0015293)
GO Cellular Component (3): plasma membrane (GO:0005886), membrane (GO:0016020), apical plasma membrane (GO:0016324)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| transport | 3 |
| metabolic process | 1 |
| metal ion transport | 1 |
| nitrogen compound transport | 1 |
| sodium ion transport | 1 |
| monoatomic cation transmembrane transport | 1 |
| cellular process | 1 |
| phosphate transmembrane transporter activity | 1 |
| solute:sodium symporter activity | 1 |
| urate transport | 1 |
| salt transmembrane transporter activity | 1 |
| transporter activity | 1 |
| transmembrane transport | 1 |
| secondary active transmembrane transporter activity | 1 |
| membrane | 1 |
| cell periphery | 1 |
| cellular anatomical structure | 1 |
| apical part of cell | 1 |
| plasma membrane region | 1 |
Protein interactions and networks
STRING
604 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| SLC17A2 | SLC34A1 | Q06495 | 742 |
| SLC17A2 | SLC20A1 | Q8WUM9 | 637 |
| SLC17A2 | SLC20A2 | Q08357 | 585 |
| SLC17A2 | HFE | Q30201 | 544 |
| SLC17A2 | SLC34A3 | Q8N130 | 430 |
| SLC17A2 | SLC18B1 | Q6NT16 | 389 |
| SLC17A2 | SLC2A9 | Q9NRM0 | 335 |
| SLC17A2 | ITPK1 | Q13572 | 327 |
| SLC17A2 | KRT38 | O76015 | 320 |
| SLC17A2 | LGI4 | Q8N135 | 307 |
| SLC17A2 | SASH1 | O94885 | 296 |
| SLC17A2 | PPCDC | Q96CD2 | 290 |
| SLC17A2 | SLC22A11 | Q9NSA0 | 288 |
| SLC17A2 | SLC18A3 | Q16572 | 282 |
| SLC17A2 | SLC22A9 | Q8IVM8 | 271 |
IntAct
2 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| SLC17A2 | ABCD4 | psi-mi:“MI:0914”(association) | 0.350 |
BioGRID (94): LRRC8D (Affinity Capture-MS), KCNT2 (Affinity Capture-MS), UBB (Affinity Capture-MS), ABCD4 (Affinity Capture-MS), ANO10 (Affinity Capture-MS), ABCB9 (Affinity Capture-MS), TAP2 (Affinity Capture-MS), SARAF (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), SLC16A13 (Affinity Capture-MS), ATP8A1 (Affinity Capture-MS), SLC12A6 (Affinity Capture-MS), KIAA0195 (Affinity Capture-MS), KCNJ11 (Affinity Capture-MS), RHBDD3 (Affinity Capture-MS)
ESM2 similar proteins: A4FV52, A6QLI1, O00476, O00624, O61369, O62786, P34272, P34644, P38142, Q03567, Q05B21, Q10046, Q14916, Q1L8X9, Q21455, Q28722, Q2QWW7, Q32LF0, Q3TXX4, Q3UHK1, Q5NCM1, Q5SZA1, Q5W8I7, Q5W8I8, Q61983, Q62634, Q62795, Q66KG0, Q6INC8, Q7TSF2, Q7ZX53, Q8BFU8, Q8BLE7, Q8NDX2, Q921A2, Q95R48, Q961J5, Q96QE2, Q9C757, Q9FKV1
Diamond homologs: A4FV52, A6QLI1, O00476, O00624, O61369, O82390, P34644, Q03567, Q05B21, Q0IZQ3, Q10046, Q14916, Q1L8X9, Q28722, Q2QWW7, Q32LF0, Q3E9A0, Q3TXX4, Q53P54, Q5NCM1, Q5Q0U0, Q5SZA1, Q5W8I7, Q5W8I8, Q61983, Q62634, Q62795, Q652N5, Q66GI9, Q6INC8, Q7TSF2, Q8BFU8, Q8BLE7, Q8BN82, Q8GX78, Q8NDX2, Q9FKV1, Q9JI12, Q9MZD1, Q9NRA2
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
66 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 58 |
| Likely benign | 3 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
1328 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 6:25918482:CTCA:C | donor_loss | 1.0000 |
| 6:25918483:TCA:T | donor_loss | 1.0000 |
| 6:25918484:CACCA:C | donor_loss | 1.0000 |
| 6:25918485:A:AC | donor_gain | 1.0000 |
| 6:25918486:C:CC | donor_gain | 1.0000 |
| 6:25918570:GACCC:G | acceptor_gain | 1.0000 |
| 6:25918571:ACCC:A | acceptor_loss | 1.0000 |
| 6:25918571:ACCCT:A | acceptor_gain | 1.0000 |
| 6:25918572:CC:C | acceptor_gain | 1.0000 |
| 6:25918573:CC:C | acceptor_gain | 1.0000 |
| 6:25918574:C:A | acceptor_loss | 1.0000 |
| 6:25918574:C:CC | acceptor_gain | 1.0000 |
| 6:25918575:T:A | acceptor_loss | 1.0000 |
| 6:25921092:CC:C | acceptor_gain | 1.0000 |
| 6:25921093:CC:C | acceptor_gain | 1.0000 |
| 6:25923692:TAC:T | donor_loss | 1.0000 |
| 6:25923693:A:AC | donor_gain | 1.0000 |
| 6:25923693:AC:A | donor_gain | 1.0000 |
| 6:25923693:ACCTT:A | donor_loss | 1.0000 |
| 6:25923694:C:CG | donor_gain | 1.0000 |
| 6:25923694:CC:C | donor_gain | 1.0000 |
| 6:25923694:CCT:C | donor_gain | 1.0000 |
| 6:25923694:CCTT:C | donor_gain | 1.0000 |
| 6:25923694:CCTTT:C | donor_gain | 1.0000 |
| 6:25923905:ACC:A | acceptor_loss | 1.0000 |
| 6:25923907:C:CC | acceptor_gain | 1.0000 |
| 6:25913449:ATCCT:A | acceptor_loss | 0.9900 |
| 6:25913450:TCC:T | acceptor_loss | 0.9900 |
| 6:25913451:CCT:C | acceptor_loss | 0.9900 |
| 6:25913452:CTA:C | acceptor_loss | 0.9900 |
AlphaMissense
3107 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 6:25921054:A:G | W172R | 0.996 |
| 6:25921054:A:T | W172R | 0.996 |
| 6:25921052:C:A | W172C | 0.994 |
| 6:25921052:C:G | W172C | 0.994 |
| 6:25915532:C:T | G393E | 0.991 |
| 6:25915533:C:A | G393W | 0.990 |
| 6:25915736:C:G | G355R | 0.987 |
| 6:25915736:C:T | G355R | 0.987 |
| 6:25921063:A:G | W169R | 0.987 |
| 6:25921063:A:T | W169R | 0.987 |
| 6:25915519:G:C | N397K | 0.986 |
| 6:25915519:G:T | N397K | 0.986 |
| 6:25915756:C:G | R348P | 0.986 |
| 6:25916763:G:C | S284R | 0.984 |
| 6:25916763:G:T | S284R | 0.984 |
| 6:25916765:T:G | S284R | 0.984 |
| 6:25917058:A:G | W227R | 0.984 |
| 6:25917058:A:T | W227R | 0.984 |
| 6:25921395:C:A | W86C | 0.984 |
| 6:25921395:C:G | W86C | 0.984 |
| 6:25921397:A:G | W86R | 0.984 |
| 6:25921397:A:T | W86R | 0.984 |
| 6:25915533:C:G | G393R | 0.983 |
| 6:25915533:C:T | G393R | 0.983 |
| 6:25918497:G:C | F213L | 0.983 |
| 6:25918497:G:T | F213L | 0.983 |
| 6:25918499:A:G | F213L | 0.983 |
| 6:25921031:G:C | S179R | 0.983 |
| 6:25921031:G:T | S179R | 0.983 |
| 6:25921033:T:G | S179R | 0.983 |
dbSNP variants (sampled 300 via entrez): RS1000080460 (6:25913069 G>A,T), RS1000144806 (6:25930520 A>G), RS1000327892 (6:25925861 T>C), RS1000443996 (6:25926247 G>A), RS1000603671 (6:25932495 A>T), RS1000946174 (6:25922444 A>G), RS1000996792 (6:25922123 G>A,C), RS1001121629 (6:25928712 T>G), RS1001437905 (6:25927750 G>A), RS1001574218 (6:25920886 A>G), RS1001794292 (6:25931975 G>A), RS1001968200 (6:25916103 C>A,T), RS1002082816 (6:25916332 C>T), RS1002223713 (6:25932277 G>A), RS1002973031 (6:25917958 G>C)
Disease associations
OMIM: gene MIM:611049 | disease phenotypes:
GenCC curated gene-disease
Mondo (0):
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
0 associations (top):
Drugs & pharmacology
Drug and pharmacology data
Is drug target: yes
ChEMBL targets (1): CHEMBL3769300 (SINGLE PROTEIN)
PharmGKB: 1 entry (VIP=true, CPIC=false)
GtoPdb / IUPHAR curated pharmacology
(IUPHAR/BPS Guide to Pharmacology — expert-curated)
Target class: transporter — Type I sodium-phosphate co-transporters
CTD chemical–gene interactions
29 total (human), top 29 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Benzo(a)pyrene | affects methylation, decreases expression | 4 |
| Cyclosporine | affects expression, increases expression | 4 |
| Aflatoxin B1 | affects expression, decreases expression, increases methylation | 4 |
| Acetaminophen | decreases expression | 2 |
| Tetrachlorodibenzodioxin | decreases expression | 2 |
| OTX015 | decreases expression | 1 |
| mivebresib | decreases expression | 1 |
| uranyl acetate | affects expression | 1 |
| bisphenol A | affects cotreatment, increases methylation, decreases methylation | 1 |
| kojic acid | decreases expression | 1 |
| 3,4,3’,4’-tetrachlorobiphenyl | affects expression | 1 |
| resorcinol | decreases expression | 1 |
| CGP 52608 | affects binding, increases reaction | 1 |
| (+)-JQ1 compound | decreases expression | 1 |
| Resveratrol | affects cotreatment, decreases expression | 1 |
| Fulvestrant | affects cotreatment, increases methylation | 1 |
| Estradiol | decreases expression | 1 |
| Hydrogen Peroxide | affects expression | 1 |
| Plant Extracts | affects cotreatment, decreases expression | 1 |
| Quercetin | decreases expression | 1 |
| Smoke | increases expression | 1 |
| Uranium | affects expression | 1 |
| Urethane | decreases expression | 1 |
| Valproic Acid | decreases expression, decreases methylation | 1 |
| 2,4-Dichlorophenoxyacetic Acid | decreases expression | 1 |
| Zidovudine | decreases expression | 1 |
| Copper Sulfate | increases expression | 1 |
| tert-Butylhydroperoxide | affects expression | 1 |
| Vitamin K 3 | affects expression | 1 |
ChEMBL screening assays
1 unique, capped per target: 1 binding
Representative assays (with source publication via chembl_document):
| Assay ID | Type | Description | Source paper |
|---|---|---|---|
| CHEMBL3773489 | Binding | Inhibition of NaPiA3 (unknown origin) | Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. — J Med Chem |
Cellosaurus cell lines
2 cell lines: 2 cancer cell line
First 10 cell lines (id-ordered, not curated):
| Cellosaurus | Name | Category | Sex |
|---|---|---|---|
| CVCL_D4RY | HuH7-SLC17A2-KO-c2 | Cancer cell line | Male |
| CVCL_D4RZ | HuH7-SLC17A2-KO-c3 | Cancer cell line | Male |
Clinical trials (associated diseases)
0 trials via MONDO — disease-level, not drug-specific.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.