SLC17A4

Summary

SLC17A4 (solute carrier family 17 member 4, HGNC:10932) is a protein-coding gene on chromosome 6p22.2, encoding Probable small intestine urate exporter (Q9Y2C5). Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions.

Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).

Source: NCBI Gene 10050 — RefSeq curated summary.

At a glance

• GWAS associations: 73
• MANE Select transcript: NM_005495

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10932
Approved symbol	SLC17A4
Name	solute carrier family 17 member 4
Location	6p22.2
Locus type	gene with protein product
Status	Approved
Aliases	KIAA2138
Ensembl gene	ENSG00000146039
Ensembl biotype	protein_coding
OMIM	604216
Entrez	10050

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 protein_coding

ENST00000377905, ENST00000397076, ENST00000439485, ENST00000867587, ENST00000867588, ENST00000867589, ENST00000867590, ENST00000867591, ENST00000867592, ENST00000867593, ENST00000867594, ENST00000867595, ENST00000867596, ENST00000867597, ENST00000867598, ENST00000867599, ENST00000867600, ENST00000957018

RefSeq mRNA: 2 — MANE Select: NM_005495 NM_001286121, NM_005495

CCDS: CCDS4564, CCDS75411

Canonical transcript exons

ENST00000377905 — 12 exons

Exon	Start	End
ENSE00000973604	25770067	25770300
ENSE00000973605	25770384	25770471
ENSE00000973606	25770926	25771012
ENSE00000973607	25773275	25773393
ENSE00000973608	25773513	25773674
ENSE00000973609	25776595	25776727
ENSE00000973610	25776812	25776959
ENSE00001825243	25779054	25781199
ENSE00003619809	25777926	25778016
ENSE00003665322	25768985	25769190
ENSE00003739453	25761927	25762053
ENSE00003890267	25754742	25754781

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 90.87.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1252 / max 30.2651, expressed in 23 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66451	0.1252	23

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	90.87	gold quality
jejunal mucosa	UBERON:0000399	90.42	gold quality
rectum	UBERON:0001052	90.38	gold quality
right lobe of liver	UBERON:0001114	90.36	gold quality
body of pancreas	UBERON:0001150	88.74	gold quality
colonic mucosa	UBERON:0000317	86.44	gold quality
gall bladder	UBERON:0002110	85.99	gold quality
liver	UBERON:0002107	85.40	gold quality
duodenum	UBERON:0002114	85.30	gold quality
mucosa of sigmoid colon	UBERON:0004993	84.64	gold quality
diaphragm	UBERON:0001103	84.60	gold quality
small intestine Peyer’s patch	UBERON:0003454	79.99	gold quality
ileal mucosa	UBERON:0000331	79.28	gold quality
pancreatic ductal cell	CL:0002079	79.02	silver quality
small intestine	UBERON:0002108	78.96	gold quality
pancreas	UBERON:0001264	78.57	gold quality
transverse colon	UBERON:0001157	77.88	gold quality
hair follicle	UBERON:0002073	74.57	gold quality
jejunum	UBERON:0002115	73.80	gold quality
mucosa of paranasal sinus	UBERON:0005030	72.66	gold quality
intestine	UBERON:0000160	69.59	gold quality
olfactory bulb	UBERON:0002264	68.95	gold quality
type B pancreatic cell	CL:0000169	68.86	gold quality
epithelial cell of pancreas	CL:0000083	68.79	silver quality
CA1 field of hippocampus	UBERON:0003881	68.01	gold quality
large intestine	UBERON:0000059	66.32	gold quality
adult mammalian kidney	UBERON:0000082	65.93	gold quality
colon	UBERON:0001155	65.67	gold quality
left ventricle myocardium	UBERON:0006566	64.93	gold quality
cardiac muscle of right atrium	UBERON:0003379	64.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.26

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

66 targeting SLC17A4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-3618	99.69	68.57	1012
HSA-MIR-4690-5P	99.65	66.24	813
HSA-MIR-3177-5P	99.65	70.38	1174
HSA-MIR-892A	99.54	68.16	1141
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-122B-5P	99.46	70.81	1457
HSA-MIR-516A-3P	99.46	67.96	1378
HSA-MIR-516B-3P	99.46	67.96	1378
HSA-MIR-7162-5P	99.46	68.08	1368
HSA-MIR-4273	99.45	67.93	1206
HSA-MIR-135A-5P	99.36	71.85	1601
HSA-MIR-135B-5P	99.36	71.63	1613
HSA-MIR-520A-5P	99.35	66.72	1632

Literature-anchored findings (GeneRIF, showing 4)

• SLC17A4 is an intestinal organic anion exporter that acts in delta-psi and Chloride dependent manners (PMID:22460716)
• Thyroid hormone transporter (SLC17A4) single nucleotide polymorphism is associated with replicated free thyroxine (FT4) susceptibility loci in genome wide association study. Genetic variant SLC17A4-rs9356988 is associated with the 3,3’,5-triiodothyronine (T3)/T4 ratio. (PMID:30367059)
• Functional Characterization of the Novel and Specific Thyroid Hormone Transporter SLC17A4. (PMID:34937426)
• A prognostic signature consisting of metabolism-related genes and SLC17A4 serves as a potential biomarker of immunotherapeutic prediction in prostate cancer. (PMID:36325340)

Cross-species orthologs

55 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc17a5	ENSDARG00000055190
danio_rerio	slc37a4b	ENSDARG00000077180
danio_rerio	si:ch1073-513e17.1	ENSDARG00000086739
danio_rerio	slc37a4bl	ENSDARG00000093531
mus_musculus	Slc17a4	ENSMUSG00000021336
rattus_norvegicus	Slc17a4	ENSRNOG00000022505
drosophila_melanogaster	dmGlut	FBGN0010497
drosophila_melanogaster	MFS14	FBGN0010651
drosophila_melanogaster	Picot	FBGN0024315
drosophila_melanogaster	CG9254	FBGN0028513
drosophila_melanogaster	CG6978	FBGN0029727
drosophila_melanogaster	VGlut	FBGN0031424
drosophila_melanogaster	CG7881	FBGN0033048
drosophila_melanogaster	MFS12	FBGN0033234
drosophila_melanogaster	MFS15	FBGN0034392
drosophila_melanogaster	CG15096	FBGN0034394
drosophila_melanogaster	MFS16	FBGN0034611
drosophila_melanogaster	CG12490	FBGN0034782
drosophila_melanogaster	CG9825	FBGN0034783
drosophila_melanogaster	CG9826	FBGN0034784
drosophila_melanogaster	CG3649	FBGN0034785
drosophila_melanogaster	CG2003	FBGN0039886
drosophila_melanogaster	CG30265	FBGN0050265
drosophila_melanogaster	MFS1	FBGN0050272
caenorhabditis_elegans		WBGENE00001135
caenorhabditis_elegans		WBGENE00007669
caenorhabditis_elegans		WBGENE00008000
caenorhabditis_elegans		WBGENE00008677
caenorhabditis_elegans		WBGENE00010755
caenorhabditis_elegans		WBGENE00010931
caenorhabditis_elegans		WBGENE00011185
caenorhabditis_elegans		WBGENE00011349
caenorhabditis_elegans		WBGENE00011556
caenorhabditis_elegans		WBGENE00012443
caenorhabditis_elegans		WBGENE00015271
caenorhabditis_elegans		WBGENE00015272
caenorhabditis_elegans		WBGENE00016003
caenorhabditis_elegans		WBGENE00018429
caenorhabditis_elegans		WBGENE00018918
caenorhabditis_elegans		WBGENE00018920
caenorhabditis_elegans		WBGENE00019187
caenorhabditis_elegans		WBGENE00019655
caenorhabditis_elegans		WBGENE00020583
caenorhabditis_elegans		WBGENE00020584
caenorhabditis_elegans		WBGENE00020697
caenorhabditis_elegans		WBGENE00020698
caenorhabditis_elegans		WBGENE00020699
caenorhabditis_elegans		WBGENE00020700
caenorhabditis_elegans		WBGENE00021157
caenorhabditis_elegans		WBGENE00021158
caenorhabditis_elegans		WBGENE00021219
caenorhabditis_elegans		WBGENE00021220
caenorhabditis_elegans		WBGENE00021223
caenorhabditis_elegans		WBGENE00021226
caenorhabditis_elegans		WBGENE00302978

Paralogs (12): SLC17A6 (ENSG00000091664), SLC17A9 (ENSG00000101194), SLC17A7 (ENSG00000104888), SLC17A2 (ENSG00000112337), SLC17A5 (ENSG00000119899), SLC17A3 (ENSG00000124564), SLC17A1 (ENSG00000124568), SLC37A2 (ENSG00000134955), SLC37A4 (ENSG00000137700), SLC37A3 (ENSG00000157800), SLC37A1 (ENSG00000160190), SLC17A8 (ENSG00000179520)

Protein

Protein identifiers

Probable small intestine urate exporter — Q9Y2C5 (reviewed: Q9Y2C5)

Alternative names: Solute carrier family 17 member 4

All UniProt accessions (1): Q9Y2C5

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. Mediates chloride-dependent transport of urate. Mediates sodium-independent high affinity transport of thyroid hormones including L-thyroxine (T4) and 3,3’,5-triiodo-L-thyronine (T3). Can actively transport inorganic phosphate into cells via Na(+) cotransport.

Subcellular location. Apical cell membrane.

Tissue specificity. Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs.

Similarity. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9Y2C5-1	1	yes
Q9Y2C5-2	2
Q9Y2C5-3	3
Q9Y2C5-4	4

RefSeq proteins (2): NP_001273050, NP_005486* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011701	MFS	Family
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily
IPR050382	MFS_Na/Anion_cotransporter	Family

Pfam: PF07690

Catalyzed reactions (Rhea), 4 shown:

• 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in) (RHEA:71255)
• 3,3’,5-triiodo-L-thyronine(out) = 3,3’,5-triiodo-L-thyronine(in) (RHEA:71811)
• L-thyroxine(out) = L-thyroxine(in) (RHEA:71819)
• urate(out) + n chloride(in) = urate(in) + n chloride(out) (RHEA:72319)

UniProt features (26 total): transmembrane region 10, glycosylation site 5, splice variant 5, mutagenesis site 3, chain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2C5-F1	83.87	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (5): 47, 56, 66, 75, 90

Mutagenesis-validated functional residues (3):

Position	Phenotype
66	loss of glycosylation and significant reduction in the transport of thyroid hormones t3 and t4; when associated with a-7
75	loss of glycosylation and significant reduction in the transport of thyroid hormones t3 and t4; when associated with a-6
90	loss of glycosylation and significant reduction in the transport of thyroid hormones t3 and t4; when associated with a-7

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 80 (showing top): WANG_CLIM2_TARGETS_UP, GOBP_SODIUM_ION_TRANSMEMBRANE_TRANSPORT, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_HORMONE_TRANSPORT, GOBP_INORGANIC_ANION_TRANSPORT, GOBP_MONOATOMIC_CATION_TRANSPORT, RGTTAMWNATT_HNF1_01, GOBP_PHOSPHATE_ION_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOCC_APICAL_PLASMA_MEMBRANE, AACTTT_UNKNOWN, SABATES_COLORECTAL_ADENOMA_DN, ACEVEDO_LIVER_CANCER_UP, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_SODIUM_ION_TRANSPORT

GO Biological Process (8): phosphate-containing compound metabolic process (GO:0006796), sodium ion transport (GO:0006814), sodium-dependent phosphate transport (GO:0044341), monoatomic ion transport (GO:0006811), urate transport (GO:0015747), sodium ion transmembrane transport (GO:0035725), transmembrane transport (GO:0055085), thyroid hormone transport (GO:0070327)

GO Molecular Function (5): sodium:phosphate symporter activity (GO:0005436), urate transmembrane transporter activity (GO:0015143), thyroid hormone transmembrane transporter activity (GO:0015349), transmembrane transporter activity (GO:0022857), symporter activity (GO:0015293)

GO Cellular Component (4): plasma membrane (GO:0005886), membrane (GO:0016020), apical plasma membrane (GO:0016324), brush border membrane (GO:0031526)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
secondary active transmembrane transporter activity	2
metabolic process	1
metal ion transport	1
phosphate ion transport	1
nitrogen compound transport	1
sodium ion transport	1
monoatomic cation transmembrane transport	1
cellular process	1
hormone transport	1
phosphate transmembrane transporter activity	1
solute:sodium symporter activity	1
urate transport	1
salt transmembrane transporter activity	1
thyroid hormone transport	1
transporter activity	1
transmembrane transport	1
membrane	1
cell periphery	1
cellular anatomical structure	1
apical part of cell	1
plasma membrane region	1
brush border	1
apical plasma membrane	1
cell projection membrane	1

Protein interactions and networks

STRING

546 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC17A4	SLC34A1	Q06495	816
SLC17A4	SLC16A9	Q7RTY1	657
SLC17A4	SLC2A9	Q9NRM0	602
SLC17A4	SLC22A11	Q9NSA0	573
SLC17A4	PDZK1	Q5T2W1	527
SLC17A4	SLC22A12	Q96S37	506
SLC17A4	TMEM170A	Q8WVE7	506
SLC17A4	ZHX2	Q9Y6X8	471
SLC17A4	CARMIL1	Q5VZK9	446
SLC17A4	ITPK1	Q13572	438
SLC17A4	ABCA8	O94911	436
SLC17A4	SLC23A3	Q6PIS1	419
SLC17A4	SLC39A5	Q6ZMH5	416
SLC17A4	SLCO1B1	Q9Y6L6	413
SLC17A4	ALDH16A1	Q8IZ83	410

IntAct

0 interactions, top by confidence:

BioGRID (1): SLC17A4 (Affinity Capture-MS)

ESM2 similar proteins: A4FV52, A6QLI1, O00476, O00624, O61369, O62786, P34272, P34644, P38142, Q03567, Q05B21, Q10046, Q14916, Q1L8X9, Q21455, Q28722, Q2QWW7, Q32LF0, Q3TXX4, Q3UHK1, Q5NCM1, Q5SZA1, Q5W8I7, Q5W8I8, Q61983, Q62634, Q62795, Q66KG0, Q6INC8, Q7TSF2, Q7ZX53, Q8BFU8, Q8BLE7, Q8NDX2, Q921A2, Q95R48, Q961J5, Q96QE2, Q9C757, Q9FKV1

Diamond homologs: A4FV52, A6QLI1, O00476, O00624, O61369, O82390, P34644, Q03567, Q05B21, Q0IZQ3, Q10046, Q14916, Q1L8X9, Q28722, Q2QWW7, Q32LF0, Q3E9A0, Q3TXX4, Q53P54, Q5NCM1, Q5Q0U0, Q5SZA1, Q5W8I7, Q5W8I8, Q61983, Q62634, Q62795, Q652N5, Q66GI9, Q6INC8, Q7TSF2, Q8BFU8, Q8BLE7, Q8BN82, Q8GX78, Q8NDX2, Q9FKV1, Q9JI12, Q9MZD1, Q9NRA2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1974 predictions. Top by Δscore:

Variant	Effect	Δscore
6:25762050:A:T	donor_gain	1.0000
6:25761925:A:AG	acceptor_gain	0.9900
6:25761926:G:GC	acceptor_gain	0.9900
6:25761926:GTAA:G	acceptor_gain	0.9900
6:25769187:AATGG:A	donor_loss	0.9900
6:25769189:TGGT:T	donor_loss	0.9900
6:25769190:GGT:G	donor_loss	0.9900
6:25769191:GTAAG:G	donor_loss	0.9900
6:25769192:T:TC	donor_loss	0.9900
6:25770183:G:GG	donor_gain	0.9900
6:25776594:GA:G	acceptor_gain	0.9900
6:25754777:CTCAG:C	donor_loss	0.9800
6:25754779:CAG:C	donor_loss	0.9800
6:25754780:AG:A	donor_loss	0.9800
6:25754781:GGT:G	donor_loss	0.9800
6:25754782:G:GA	donor_loss	0.9800
6:25754783:T:A	donor_loss	0.9800
6:25761923:TCAGT:T	acceptor_loss	0.9800
6:25761924:CAGT:C	acceptor_loss	0.9800
6:25761924:CAGTA:C	acceptor_gain	0.9800
6:25761925:A:AC	acceptor_loss	0.9800
6:25761925:AGTAA:A	acceptor_gain	0.9800
6:25761926:GT:G	acceptor_gain	0.9800
6:25761926:GTAAG:G	acceptor_gain	0.9800
6:25762050:AAAGG:A	donor_loss	0.9800
6:25762051:AAGGT:A	donor_loss	0.9800
6:25762052:AGGTA:A	donor_loss	0.9800
6:25762053:G:GA	donor_loss	0.9800
6:25762054:G:A	donor_loss	0.9800
6:25762055:T:A	donor_loss	0.9800

AlphaMissense

3214 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:25770423:T:A	W191R	0.992
6:25770423:T:C	W191R	0.992
6:25770425:G:C	W191C	0.988
6:25770425:G:T	W191C	0.988
6:25770988:T:A	W228R	0.988
6:25770988:T:C	W228R	0.988
6:25770990:G:C	W228C	0.986
6:25770990:G:T	W228C	0.986
6:25771000:T:C	F232L	0.985
6:25771002:C:A	F232L	0.985
6:25771002:C:G	F232L	0.985
6:25773304:T:A	W246R	0.983
6:25773304:T:C	W246R	0.983
6:25770112:A:C	S115R	0.980
6:25770114:C:A	S115R	0.980
6:25770114:C:G	S115R	0.980
6:25776708:G:C	R367S	0.977
6:25776708:G:T	R367S	0.977
6:25779071:G:C	W459C	0.976
6:25779071:G:T	W459C	0.976
6:25779158:G:C	W488C	0.976
6:25779158:G:T	W488C	0.976
6:25770414:T:A	W188R	0.975
6:25770414:T:C	W188R	0.975
6:25779069:T:A	W459R	0.974
6:25779069:T:C	W459R	0.974
6:25779156:T:A	W488R	0.974
6:25779156:T:C	W488R	0.974
6:25770084:G:C	W105C	0.973
6:25770084:G:T	W105C	0.973

dbSNP variants (sampled 300 via entrez): RS1000140139 (6:25777073 C>T), RS1000200195 (6:25763697 T>C), RS1000213434 (6:25756870 T>C), RS1000273680 (6:25763441 T>C), RS1000748670 (6:25758245 G>A), RS1000781618 (6:25757378 G>A,C,T), RS1000835024 (6:25776448 TTG>T), RS1000855214 (6:25764861 A>G), RS1000888718 (6:25776158 T>A,C), RS1000981729 (6:25775898 T>C), RS1001033950 (6:25771573 C>A,T), RS1001213940 (6:25757143 T>C), RS1001227913 (6:25777966 C>T), RS1001307383 (6:25765105 C>A), RS1001553235 (6:25778243 C>T)

Disease associations

OMIM: gene MIM:604216 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

73 associations (top):

Study	Trait	p-value
GCST001231_8	Carotid intima media thickness	8.000000e-08
GCST001247_16	Cardiovascular disease risk factors	4.000000e-09
GCST002594_28	Neurofibrillary tangles	8.000000e-06
GCST002829_11	Urate levels in overweight individuals	1.000000e-07
GCST002829_32	Urate levels in overweight individuals	4.000000e-15
GCST002829_42	Urate levels in overweight individuals	1.000000e-09
GCST002830_1	Urate levels in lean individuals	9.000000e-06
GCST002830_26	Urate levels in lean individuals	3.000000e-13
GCST002830_8	Urate levels in lean individuals	1.000000e-11
GCST004521_113	Autism spectrum disorder or schizophrenia	3.000000e-19
GCST004521_169	Autism spectrum disorder or schizophrenia	4.000000e-14
GCST004521_69	Autism spectrum disorder or schizophrenia	8.000000e-24
GCST004521_83	Autism spectrum disorder or schizophrenia	1.000000e-13
GCST004748_54	Lung cancer	2.000000e-08
GCST005316_415	Intelligence (MTAG)	4.000000e-09
GCST006896_14	Free thyroxine concentration	6.000000e-14
GCST006945_7	Feeling guilty	1.000000e-08
GCST007201_418	Schizophrenia	7.000000e-13
GCST007400_17	Systemic lupus erythematosus	1.000000e-24
GCST008970_1	Gout	8.000000e-32
GCST008972_164	Urate levels	4.000000e-11
GCST009733_101	Urinary metabolite levels in chronic kidney disease	4.000000e-11
GCST009733_116	Urinary metabolite levels in chronic kidney disease	1.000000e-39
GCST009733_133	Urinary metabolite levels in chronic kidney disease	1.000000e-32
GCST009733_136	Urinary metabolite levels in chronic kidney disease	4.000000e-14
GCST009733_18	Urinary metabolite levels in chronic kidney disease	2.000000e-20
GCST009733_187	Urinary metabolite levels in chronic kidney disease	1.000000e-13
GCST009733_194	Urinary metabolite levels in chronic kidney disease	6.000000e-13
GCST009733_196	Urinary metabolite levels in chronic kidney disease	2.000000e-11
GCST009733_199	Urinary metabolite levels in chronic kidney disease	3.000000e-13

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0004761	uric acid measurement
EFO:0006797	neurofibrillary tangles measurement
EFO:0004531	urate measurement
EFO:0004337	intelligence
EFO:0009595	guilt measurement
EFO:0005116	urinary metabolite measurement
EFO:0004509	hemoglobin measurement
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs11754288	SLC17A1, SLC17A4		0.00	0

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Type I sodium-phosphate co-transporters

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	affects expression, decreases expression, decreases methylation	3
Acetaminophen	decreases expression	2
Benzo(a)pyrene	affects methylation, increases mutagenesis	2
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression	2
Cyclosporine	decreases expression	2
bisphenol A	increases methylation, affects cotreatment	1
sodium arsenite	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
bisphenol S	affects methylation	1
Fulvestrant	affects cotreatment, increases methylation	1
Troglitazone	decreases expression	1
Ethanol	decreases expression	1
Cadmium	decreases expression, increases response to substance	1
Endosulfan	decreases expression, affects cotreatment	1
Estradiol	decreases expression	1
Silicon Dioxide	decreases expression	1
Valproic Acid	decreases expression, decreases methylation	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.