SLC22A10

Summary

SLC22A10 (solute carrier family 22 member 10 (gene/pseudogene), HGNC:18057) is a protein-coding gene on chromosome 11q12.3, encoding Solute carrier family 22 member 10 (Q63ZE4).

Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in membrane.

Source: NCBI Gene 387775 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 91 total
• MANE Select transcript: NM_001039752

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18057
Approved symbol	SLC22A10
Name	solute carrier family 22 member 10 (gene/pseudogene)
Location	11q12.3
Locus type	gene with protein product
Status	Approved
Aliases	OAT5, hOAT5
Ensembl gene	ENSG00000184999
Ensembl biotype	protein_coding
OMIM	607580
Entrez	387775

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 11 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000332793, ENST00000525620, ENST00000526800, ENST00000532724, ENST00000533483, ENST00000682643, ENST00000861889, ENST00000861890, ENST00000861891, ENST00000861892, ENST00000861893, ENST00000861894, ENST00000861895, ENST00000861896

RefSeq mRNA: 1 — MANE Select: NM_001039752 NM_001039752

CCDS: CCDS41661

Canonical transcript exons

ENST00000332793 — 10 exons

Exon	Start	End
ENSE00001326877	63302329	63302543
ENSE00002149469	63289903	63290567
ENSE00002167060	63311007	63311783
ENSE00003461553	63299514	63299629
ENSE00003472647	63298920	63299043
ENSE00003480177	63297559	63297727
ENSE00003512279	63291540	63291643
ENSE00003538690	63297303	63297457
ENSE00003627189	63304108	63304216
ENSE00003684597	63304686	63304889

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 87.72.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1324 / max 66.2833, expressed in 9 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
114788	0.0535	6
114787	0.0405	7
114786	0.0271	6
114789	0.0113	5

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	87.72	gold quality
right lobe of liver	UBERON:0001114	85.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.82	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.45	silver quality
quadriceps femoris	UBERON:0001377	70.35	gold quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
superior frontal gyrus	UBERON:0002661	63.77	gold quality
thymus	UBERON:0002370	63.06	silver quality
primary visual cortex	UBERON:0002436	60.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.75	gold quality
right frontal lobe	UBERON:0002810	58.51	gold quality
anterior cingulate cortex	UBERON:0009835	49.98	gold quality
cerebral cortex	UBERON:0000956	49.06	gold quality
temporal lobe	UBERON:0001871	46.83	gold quality
amygdala	UBERON:0001876	46.59	gold quality
frontal cortex	UBERON:0001870	45.77	gold quality
lung	UBERON:0002048	45.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	44.20	gold quality
lower esophagus	UBERON:0013473	44.19	gold quality
upper lobe of left lung	UBERON:0008952	43.92	gold quality
sural nerve	UBERON:0015488	43.82	gold quality
corpus callosum	UBERON:0002336	43.53	silver quality
putamen	UBERON:0001874	43.52	gold quality
nucleus accumbens	UBERON:0001882	43.31	gold quality
cortex of kidney	UBERON:0001225	41.16	gold quality
placenta	UBERON:0001987	40.81	gold quality
brain	UBERON:0000955	40.44	gold quality
kidney	UBERON:0002113	39.97	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	39.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.39

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HNF1A

miRNA regulators (miRDB)

61 targeting SLC22A10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514

Literature-anchored findings (GeneRIF, showing 1)

• Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. (PMID:38782905)

Cross-species orthologs

50 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc22a4	ENSDARG00000005335
danio_rerio	oatx	ENSDARG00000019713
danio_rerio	si:dkey-166k12.1	ENSDARG00000054690
danio_rerio	slc22a15	ENSDARG00000055445
danio_rerio	si:dkey-119m7.4	ENSDARG00000071049
danio_rerio	si:dkey-119m7.8	ENSDARG00000096654
drosophila_melanogaster	Orct	FBGN0019952
drosophila_melanogaster	CG15221	FBGN0030331
drosophila_melanogaster	Balat	FBGN0033778
drosophila_melanogaster	CG4630	FBGN0033809
drosophila_melanogaster	CG5592	FBGN0035645
drosophila_melanogaster	CG10486	FBGN0035647
drosophila_melanogaster	SLC22A	FBGN0037140
drosophila_melanogaster	CG7458	FBGN0037144
drosophila_melanogaster	CG14691	FBGN0037829
drosophila_melanogaster	CG14855	FBGN0038260
drosophila_melanogaster	CG14856	FBGN0038261
drosophila_melanogaster	CG14857	FBGN0038262
drosophila_melanogaster	CG12783	FBGN0038448
drosophila_melanogaster	CG7333	FBGN0038715
drosophila_melanogaster	CG7342	FBGN0038716
drosophila_melanogaster	CG17751	FBGN0038717
drosophila_melanogaster	CG17752	FBGN0038718
drosophila_melanogaster	CG16727	FBGN0038719
drosophila_melanogaster	CG6231	FBGN0038720
drosophila_melanogaster	CG4465	FBGN0038750
drosophila_melanogaster	CG4462	FBGN0038752
drosophila_melanogaster	CG4459	FBGN0038753
drosophila_melanogaster	CG6356	FBGN0039178
drosophila_melanogaster	CG3690	FBGN0040350
drosophila_melanogaster	CG31103	FBGN0051103
drosophila_melanogaster	CG31106	FBGN0051106
drosophila_melanogaster	CG31272	FBGN0051272
drosophila_melanogaster	CG33233	FBGN0053233
drosophila_melanogaster	CG33234	FBGN0053234
drosophila_melanogaster	Orct2	FBGN0086365
drosophila_melanogaster	CG42269	FBGN0259164
drosophila_melanogaster	CG44098	FBGN0264907
caenorhabditis_elegans		WBGENE00003837
caenorhabditis_elegans	oct-1	WBGENE00003842
caenorhabditis_elegans		WBGENE00003843
caenorhabditis_elegans		WBGENE00006220
caenorhabditis_elegans		WBGENE00008110
caenorhabditis_elegans		WBGENE00011456
caenorhabditis_elegans		WBGENE00014127
caenorhabditis_elegans		WBGENE00015088
caenorhabditis_elegans		WBGENE00017751
caenorhabditis_elegans		WBGENE00019408
caenorhabditis_elegans		WBGENE00020701
caenorhabditis_elegans		WBGENE00044455

Paralogs (22): SLC22A16 (ENSG00000004809), SLC22A17 (ENSG00000092096), SLC22A2 (ENSG00000112499), SLC22A7 (ENSG00000137204), SLC22A23 (ENSG00000137266), SLC22A14 (ENSG00000144671), SLC22A3 (ENSG00000146477), SLC22A8 (ENSG00000149452), SLC22A9 (ENSG00000149742), SVOPL (ENSG00000157703), SLC22A15 (ENSG00000163393), SVOP (ENSG00000166111), SLC22A11 (ENSG00000168065), SLC22A13 (ENSG00000172940), SLC22A1 (ENSG00000175003), SLC22A25 (ENSG00000196600), SLC22A4 (ENSG00000197208), SLC22A5 (ENSG00000197375), SLC22A24 (ENSG00000197658), SLC22A12 (ENSG00000197891), SLC22A6 (ENSG00000197901), SLC22A31 (ENSG00000259803)

Protein

Protein identifiers

Solute carrier family 22 member 10 — Q63ZE4 (reviewed: Q63ZE4)

Alternative names: Organic anion transporter 5

All UniProt accessions (4): Q63ZE4, A0A804HHY1, E9PIT2, E9PMM0

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Detected in fetal and adult liver, and in adult kidney.

Similarity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q63ZE4-1	1	yes
Q63ZE4-2	2

RefSeq proteins (1): NP_001034841* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005828	MFS_sugar_transport-like	Family
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF00083

UniProt features (29 total): topological domain 12, transmembrane region 11, splice variant 3, glycosylation site 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q63ZE4-F1	87.53	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 56, 102

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 25 (showing top): GOBP_ORGANIC_ANION_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, GOMF_TRANSPORTER_ACTIVITY, SRSF9_TARGET_GENES, MIR520D_5P, MIR524_5P, MIR374A_5P, MIR1185_1_3P_MIR1185_2_3P, LET_7F_2_3P, MIR374B_5P, MIR7152_5P, MIR4666B, MIR96_3P, MIR6886_3P, MIR3923

GO Biological Process (2): obsolete organic anion transport (GO:0015711), transmembrane transport (GO:0055085)

GO Molecular Function (1): transmembrane transporter activity (GO:0022857)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	1
cellular process	1
transporter activity	1
transmembrane transport	1
cellular anatomical structure	1

Protein interactions and networks

STRING

628 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC22A10	SLC67A1	Q96BI1	594
SLC22A10	OR2L8	Q8NGY9	519
SLC22A10	MAGEB16	A2A368	512
SLC22A10	SLCO4C1	Q6ZQN7	508
SLC22A10	SLCO1A2	P46721	490
SLC22A10	SLC28A1	O00337	474
SLC22A10	UROC1	Q96N76	474
SLC22A10	SLCO3A1	Q9UIG8	472
SLC22A10	SLC22A23	A1A5C7	459
SLC22A10	SLCO4A1	Q96BD0	455
SLC22A10	SLC2A9	Q9NRM0	452
SLC22A10	FAM187B	Q17R55	439
SLC22A10	SLC22A9	Q8IVM8	436
SLC22A10	SLC7A13	Q8TCU3	429
SLC22A10	SLC22A17	Q8WUG5	427

IntAct

2 interactions, top by confidence:

A	B	Type	Score
SLC22A10	PGRMC1	psi-mi:“MI:0914”(association)	0.350

BioGRID (22): SLC22A10 (Positive Genetic), ATP13A1 (Affinity Capture-MS), CANX (Affinity Capture-MS), CLGN (Affinity Capture-MS), CLPTM1 (Affinity Capture-MS), DNAJC16 (Affinity Capture-MS), ERLEC1 (Affinity Capture-MS), ERLIN1 (Affinity Capture-MS), ERLIN2 (Affinity Capture-MS), FADS2 (Affinity Capture-MS), FAM8A1 (Affinity Capture-MS), NGLY1 (Affinity Capture-MS), OS9 (Affinity Capture-MS), PGRMC1 (Affinity Capture-MS), PLD3 (Affinity Capture-MS)

ESM2 similar proteins: A0A3Q2IDB4, A0A8B7HA97, A4ZYQ5, A6NK97, G1SZD9, O35956, O57379, O88909, P22732, P23945, P43427, Q0IHM1, Q2KIV1, Q3ZAV1, Q4U2R8, Q4W8A2, Q4W8A3, Q5R9C4, Q5RC45, Q5RCH6, Q5RET7, Q63ZE4, Q66J52, Q6DFR1, Q6NUB3, Q6NYN7, Q6PXP3, Q6T423, Q70BM6, Q76M72, Q76M99, Q80UJ1, Q863Y9, Q864Z3, Q8CFZ5, Q8HY24, Q8IVM8, Q8MK48, Q8N4F4, Q8R0S9

Diamond homologs: A0A3Q2IDB4, A0A8B7HA97, A6NK97, A6QLW8, B2GV36, G1SZD9, O34691, O35956, O57379, O75751, O88446, O88909, Q1RPP5, Q28ES4, Q2KIV1, Q3YAW7, Q3ZAV1, Q4U2R8, Q4W8A2, Q4W8A3, Q5R540, Q5R9C4, Q5RC45, Q5RCH6, Q5RLM2, Q63ZE4, Q66J52, Q66J54, Q6A4L0, Q6NYN7, Q6T423, Q70BM6, Q76M72, Q76M99, Q80UJ1, Q864Z3, Q8CFZ5, Q8HY24, Q8IVM8, Q8MK48

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
HNF1A	“up-regulates quantity by expression”	SLC22A10	“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

91 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	82
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1462 predictions. Top by Δscore:

Variant	Effect	Δscore
11:63299040:AGAGG:A	donor_loss	1.0000
11:63299041:GAG:G	donor_gain	1.0000
11:63299041:GAGGT:G	donor_loss	1.0000
11:63299042:AGG:A	donor_loss	1.0000
11:63299043:GGT:G	donor_loss	1.0000
11:63299044:G:GG	donor_gain	1.0000
11:63299044:GTG:G	donor_loss	1.0000
11:63299045:TGA:T	donor_loss	1.0000
11:63299046:GAG:G	donor_loss	1.0000
11:63304890:G:GG	donor_gain	1.0000
11:63297413:C:T	donor_gain	0.9900
11:63297453:GCCCA:G	donor_gain	0.9900
11:63297458:G:GG	donor_gain	0.9900
11:63298914:TATCA:T	acceptor_loss	0.9900
11:63298915:ATCAG:A	acceptor_gain	0.9900
11:63298916:T:G	acceptor_gain	0.9900
11:63298916:TCAGG:T	acceptor_loss	0.9900
11:63298917:CAG:C	acceptor_loss	0.9900
11:63298918:A:T	acceptor_loss	0.9900
11:63298918:AGGT:A	acceptor_gain	0.9900
11:63298919:G:GC	acceptor_loss	0.9900
11:63298919:GGTG:G	acceptor_gain	0.9900
11:63299039:TAGAG:T	donor_gain	0.9900
11:63299593:G:GG	donor_gain	0.9900
11:63299606:GA:G	donor_gain	0.9900
11:63304876:G:GT	donor_gain	0.9900
11:63304886:ATCA:A	donor_gain	0.9900
11:63304887:TCA:T	donor_gain	0.9900
11:63297557:A:AG	acceptor_gain	0.9800
11:63297558:G:GG	acceptor_gain	0.9800

AlphaMissense

3521 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:63290310:T:A	C49S	0.979
11:63290311:G:C	C49S	0.979
11:63290283:T:C	F40L	0.971
11:63290285:T:A	F40L	0.971
11:63290285:T:G	F40L	0.971
11:63290436:T:C	F91L	0.971
11:63290438:T:A	F91L	0.971
11:63290438:T:G	F91L	0.971
11:63290172:T:C	F3L	0.970
11:63290174:T:A	F3L	0.970
11:63290174:T:G	F3L	0.970
11:63302480:A:C	S408R	0.966
11:63302482:C:A	S408R	0.966
11:63302482:C:G	S408R	0.966
11:63290511:T:A	C116S	0.965
11:63290512:G:C	C116S	0.965
11:63290211:T:C	F16L	0.958
11:63290213:T:A	F16L	0.958
11:63290213:T:G	F16L	0.958
11:63290310:T:C	C49R	0.958
11:63290525:G:C	W120C	0.957
11:63290525:G:T	W120C	0.957
11:63304204:C:A	P461H	0.957
11:63291552:T:A	C139S	0.956
11:63291553:G:C	C139S	0.956
11:63290427:T:A	C88S	0.954
11:63290428:G:C	C88S	0.954
11:63304198:T:C	L459P	0.954
11:63297621:A:C	S242R	0.953
11:63297623:T:A	S242R	0.953

dbSNP variants (sampled 300 via entrez): RS1000017286 (11:63308558 A>C,G), RS1000057603 (11:63321539 C>A), RS1000118883 (11:63341247 C>T), RS1000123727 (11:63303215 T>A), RS1000136072 (11:63333791 C>A,T), RS1000159001 (11:63330362 G>A,C), RS1000162178 (11:63355314 C>T), RS1000209039 (11:63361049 G>T), RS1000237909 (11:63297024 A>G), RS1000269391 (11:63288775 T>A), RS1000337791 (11:63338494 A>C,G), RS1000352987 (11:63351260 A>G), RS1000369402 (11:63308245 T>C), RS1000405428 (11:63318320 G>C), RS1000439069 (11:63343210 G>A)

Disease associations

OMIM: gene MIM:607580 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST009733_211	Urinary metabolite levels in chronic kidney disease	3.000000e-43
GCST009733_240	Urinary metabolite levels in chronic kidney disease	4.000000e-53
GCST009733_97	Urinary metabolite levels in chronic kidney disease	2.000000e-11
GCST010512_8	Serum uric acid levels	4.000000e-12

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005116	urinary metabolite measurement
EFO:0004761	uric acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Orphan or poorly characterized SLC22 family members

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
perfluorooctane sulfonic acid	decreases expression	2
Benzo(a)pyrene	increases expression, decreases expression	2
methyleugenol	decreases expression	1
bisphenol A	affects cotreatment, increases methylation	1
2-amino-9H-pyrido(2,3-b)indole	decreases expression	1
sodium arsenite	increases expression	1
perfluorooctanoic acid	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
Rosiglitazone	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Troglitazone	decreases expression	1
Endosulfan	affects cotreatment, decreases expression	1
Folic Acid	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Silicon Dioxide	increases expression	1
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4S6	HuH7-SLC22A10-KO-c10	Cancer cell line	Male
CVCL_D4S7	HuH7-SLC22A10-KO-c15	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.