SLC22A15

Summary

SLC22A15 (solute carrier family 22 member 15, HGNC:20301) is a protein-coding gene on chromosome 1p13.1, encoding Solute carrier family 22 member 15 (Q8IZD6). Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives.

Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).

Source: NCBI Gene 55356 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 78 total
• MANE Select transcript: NM_018420

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20301
Approved symbol	SLC22A15
Name	solute carrier family 22 member 15
Location	1p13.1
Locus type	gene with protein product
Status	Approved
Aliases	FLIPT1
Ensembl gene	ENSG00000163393
Ensembl biotype	protein_coding
OMIM	608275
Entrez	55356

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000369502, ENST00000369503, ENST00000481127, ENST00000877950, ENST00000920377, ENST00000969657

RefSeq mRNA: 1 — MANE Select: NM_018420 NM_018420

CCDS: CCDS44198

Canonical transcript exons

ENST00000369503 — 12 exons

Exon	Start	End
ENSE00001074085	116064436	116064508
ENSE00001074086	116062762	116062882
ENSE00001074088	116066520	116066708
ENSE00001196521	116037303	116037388
ENSE00001196529	116031366	116031581
ENSE00001196533	116026893	116027022
ENSE00001196537	116020721	116020885
ENSE00001196541	116019582	116019714
ENSE00001196550	115992031	115992243
ENSE00001450193	116067019	116070054
ENSE00001450194	115976513	115976714
ENSE00003496203	116035187	116035327

Expression profiles

Bgee: expression breadth ubiquitous, 213 present calls, max score 94.39.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.8008 / max 217.0966, expressed in 1128 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4799	2.7095	949
4798	0.6990	289
4801	0.2750	133
4800	0.1010	25
4803	0.0163	3

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	94.39	gold quality
monocyte	CL:0000576	90.72	gold quality
leukocyte	CL:0000738	89.64	gold quality
inferior vagus X ganglion	UBERON:0005363	88.03	gold quality
bone marrow	UBERON:0002371	86.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.06	gold quality
subthalamic nucleus	UBERON:0001906	85.95	gold quality
Brodmann (1909) area 46	UBERON:0006483	85.88	gold quality
spinal cord	UBERON:0002240	85.75	gold quality
lower esophagus mucosa	UBERON:0035834	83.99	gold quality
trabecular bone tissue	UBERON:0002483	83.90	gold quality
bone marrow cell	CL:0002092	83.56	gold quality
right lung	UBERON:0002167	83.48	gold quality
blood	UBERON:0000178	83.39	gold quality
dorsal plus ventral thalamus	UBERON:0001897	82.44	gold quality
substantia nigra	UBERON:0002038	82.30	gold quality
substantia nigra pars reticulata	UBERON:0001966	82.19	gold quality
midbrain	UBERON:0001891	82.09	gold quality
skin of leg	UBERON:0001511	82.06	gold quality
medulla oblongata	UBERON:0001896	81.95	gold quality
postcentral gyrus	UBERON:0002581	81.91	gold quality
Ammon’s horn	UBERON:0001954	81.48	gold quality
skin of abdomen	UBERON:0001416	81.14	gold quality
esophagus mucosa	UBERON:0002469	81.10	gold quality
superior vestibular nucleus	UBERON:0007227	80.84	gold quality
upper lobe of left lung	UBERON:0008952	80.15	gold quality
middle temporal gyrus	UBERON:0002771	80.14	gold quality
calcaneal tendon	UBERON:0003701	80.14	gold quality
zone of skin	UBERON:0000014	80.05	gold quality
islet of Langerhans	UBERON:0000006	80.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.85

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

167 targeting SLC22A15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3148	99.97	75.06	6478

Literature-anchored findings (GeneRIF, showing 2)

• Flipts might have a role in carnitine transport, particularly in brain (PMID:12372408)
• Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. (PMID:33124720)

Cross-species orthologs

42 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc22a15	ENSMUSG00000033147
rattus_norvegicus	Slc22a15	ENSRNOG00000033051
drosophila_melanogaster	Orct	FBGN0019952
drosophila_melanogaster	CG15221	FBGN0030331
drosophila_melanogaster	Balat	FBGN0033778
drosophila_melanogaster	CG5592	FBGN0035645
drosophila_melanogaster	CG10486	FBGN0035647
drosophila_melanogaster	CG14691	FBGN0037829
drosophila_melanogaster	CG14855	FBGN0038260
drosophila_melanogaster	CG14856	FBGN0038261
drosophila_melanogaster	CG14857	FBGN0038262
drosophila_melanogaster	CG12783	FBGN0038448
drosophila_melanogaster	CG7333	FBGN0038715
drosophila_melanogaster	CG7342	FBGN0038716
drosophila_melanogaster	CG17751	FBGN0038717
drosophila_melanogaster	CG17752	FBGN0038718
drosophila_melanogaster	CG16727	FBGN0038719
drosophila_melanogaster	CG6231	FBGN0038720
drosophila_melanogaster	CG4465	FBGN0038750
drosophila_melanogaster	CG4462	FBGN0038752
drosophila_melanogaster	CG4459	FBGN0038753
drosophila_melanogaster	CG6356	FBGN0039178
drosophila_melanogaster	CG3690	FBGN0040350
drosophila_melanogaster	CG31103	FBGN0051103
drosophila_melanogaster	CG31106	FBGN0051106
drosophila_melanogaster	CG31272	FBGN0051272
drosophila_melanogaster	CG33233	FBGN0053233
drosophila_melanogaster	CG33234	FBGN0053234
drosophila_melanogaster	Orct2	FBGN0086365
drosophila_melanogaster	CG42269	FBGN0259164
drosophila_melanogaster	CG44098	FBGN0264907
caenorhabditis_elegans		WBGENE00003837
caenorhabditis_elegans	oct-1	WBGENE00003842
caenorhabditis_elegans		WBGENE00003843
caenorhabditis_elegans		WBGENE00006220
caenorhabditis_elegans		WBGENE00008110
caenorhabditis_elegans		WBGENE00011456
caenorhabditis_elegans		WBGENE00014127
caenorhabditis_elegans		WBGENE00017751
caenorhabditis_elegans		WBGENE00019408
caenorhabditis_elegans		WBGENE00020701
caenorhabditis_elegans		WBGENE00044455

Paralogs (22): SLC22A16 (ENSG00000004809), SLC22A17 (ENSG00000092096), SLC22A2 (ENSG00000112499), SLC22A7 (ENSG00000137204), SLC22A23 (ENSG00000137266), SLC22A14 (ENSG00000144671), SLC22A3 (ENSG00000146477), SLC22A8 (ENSG00000149452), SLC22A9 (ENSG00000149742), SVOPL (ENSG00000157703), SVOP (ENSG00000166111), SLC22A11 (ENSG00000168065), SLC22A13 (ENSG00000172940), SLC22A1 (ENSG00000175003), SLC22A10 (ENSG00000184999), SLC22A25 (ENSG00000196600), SLC22A4 (ENSG00000197208), SLC22A5 (ENSG00000197375), SLC22A24 (ENSG00000197658), SLC22A12 (ENSG00000197891), SLC22A6 (ENSG00000197901), SLC22A31 (ENSG00000259803)

Protein

Protein identifiers

Solute carrier family 22 member 15 — Q8IZD6 (reviewed: Q8IZD6)

Alternative names: Fly-like putative transporter 1

All UniProt accessions (1): Q8IZD6

UniProt curated annotations — full annotation on UniProt →

Function. Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Has low affinity for its substrates and may regulate their flux across the plasma membrane at high substrate concentrations. Bidirectionally transports carnitine and acetylcarnitine, possibly regulating their cytosolic abundance and further fatty acid catabolism via beta oxidation. Displays high transport activity toward zwitterionic substrates such as glycine betaine and diet-derived ergothioneine and carnosine. Can transport cations having an indole skeleton such as thiamine with lower efficiency. Does not transport agmatine. The transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remains to be elucidated.

Subcellular location. Cell membrane.

Tissue specificity. Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.

Post-translational modifications. N-glycosylated.

Activity regulation. Inhibited by gamma-aminobutyric acid and drugs including quinidine and levofloxacin.

Similarity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8IZD6-1	1	yes
Q8IZD6-2	2

RefSeq proteins (1): NP_060890* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005828	MFS_sugar_transport-like	Family
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF00083

Catalyzed reactions (Rhea), 8 shown:

• glycine betaine(in) = glycine betaine(out) (RHEA:28943)
• thiamine(in) = thiamine(out) (RHEA:34919)
• (R)-carnitine(in) = (R)-carnitine(out) (RHEA:34959)
• creatine(in) = creatine(out) (RHEA:73043)
• O-acetyl-(R)-carnitine(in) = O-acetyl-(R)-carnitine(out) (RHEA:74319)
• ergothioneine(in) = ergothioneine(out) (RHEA:76263)
• carnosine(in) = carnosine(out) (RHEA:76267)
• N,N-dimethylglycine(in) = N,N-dimethylglycine(out) (RHEA:76271)

UniProt features (22 total): transmembrane region 12, glycosylation site 4, splice variant 2, chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IZD6-F1	82.96	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (4): 58, 63, 80, 106

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-549127	SLC-mediated transport of organic cations
R-HSA-382551	Transport of small molecules
R-HSA-425366
R-HSA-425407	SLC-mediated transmembrane transport
R-HSA-549132

MSigDB gene sets: 119 (showing top): GOBP_MODIFIED_AMINO_ACID_TRANSPORT, GOBP_AMINO_ACID_BETAINE_TRANSPORT, CADWELL_ATG16L1_TARGETS_DN, GOBP_QUATERNARY_AMMONIUM_GROUP_TRANSPORT, GOBP_AMINO_ACID_TRANSPORT, LIAO_METASTASIS, LIAO_HAVE_SOX4_BINDING_SITES, GOBP_TRANSMEMBRANE_TRANSPORT, GAVIN_FOXP3_TARGETS_CLUSTER_P4, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP, GOMF_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_TRANSPORTER_ACTIVITY, BRUINS_UVC_RESPONSE_LATE, FORTSCHEGGER_PHF8_TARGETS_DN

GO Biological Process (4): monoatomic ion transport (GO:0006811), amino acid transport (GO:0006865), amino-acid betaine transport (GO:0015838), transmembrane transport (GO:0055085)

GO Molecular Function (2): amino-acid betaine transmembrane transporter activity (GO:0015199), transmembrane transporter activity (GO:0022857)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
SLC-mediated transmembrane transport	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	3
quaternary ammonium group transport	1
modified amino acid transport	1
cellular process	1
quaternary ammonium group transmembrane transporter activity	1
amino-acid betaine transport	1
modified amino acid transmembrane transporter activity	1
transporter activity	1
transmembrane transport	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

750 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC22A15	SLC67A1	Q96BI1	627
SLC22A15	SLC15A1	P46059	518
SLC22A15	SLC22A23	A1A5C7	498
SLC22A15	SLC22A17	Q8WUG5	476
SLC22A15	SLC35F5	Q8WV83	472
SLC22A15	SLC25A34	Q6PIV7	471
SLC22A15	SLC22A25	Q6T423	469
SLC22A15	MAB21L3	Q8N8X9	438
SLC22A15	SLC4A8	Q2Y0W8	417
SLC22A15	SLC22A10	Q63ZE4	411
SLC22A15	SLC22A14	Q9Y267	404
SLC22A15	SLC28A1	O00337	402
SLC22A15	FAM149A	A5PLN7	399
SLC22A15	SLC10A7	Q0GE19	393
SLC22A15	AKAIN1	P0CW23	391

IntAct

5 interactions, top by confidence:

A	B	Type	Score
SLC22A15	VAPB	psi-mi:“MI:0914”(association)	0.640
SLC22A15	ZFPL1	psi-mi:“MI:0914”(association)	0.530
KCNE3	TMEM131L	psi-mi:“MI:0914”(association)	0.350
SLC22A15	C2CD2L	psi-mi:“MI:0914”(association)	0.350

BioGRID (43): DPY19L4 (Affinity Capture-MS), GHDC (Affinity Capture-MS), SYVN1 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), ANKRD13C (Affinity Capture-MS), ATP12A (Affinity Capture-MS), SELT (Affinity Capture-MS), CNNM1 (Affinity Capture-MS), LMBRD2 (Affinity Capture-MS), GUF1 (Affinity Capture-MS), ERGIC3 (Affinity Capture-MS), ERGIC2 (Affinity Capture-MS), PRKDC (Affinity Capture-MS), UFD1L (Affinity Capture-MS)

ESM2 similar proteins: A6NFX1, A6QQL0, D2HKB0, D3ZG27, F1NCD6, F1NJ67, O09014, O70496, O82390, P51798, P51799, Q17QZ3, Q1JQC1, Q32LQ6, Q3T9M1, Q3T9X0, Q3TIT8, Q4PKH3, Q504N2, Q58CV5, Q5F3N0, Q5R8G5, Q5RB09, Q5T4D3, Q5ZIT9, Q5ZKS8, Q66H95, Q68F72, Q69YG0, Q6AY78, Q6PDE8, Q7SY29, Q8BFQ6, Q8BG19, Q8GX78, Q8IVW8, Q8IZD6, Q8N697, Q8NCC5, Q8NEB5

Diamond homologs: A0A1D8PCL1, B8MYS7, K0E3U9, O42922, O74713, P0AEP1, P0AEP2, P10870, P13181, P13865, P18631, P23585, P32465, P32466, P38695, P39003, P39004, P39924, P40441, P40885, P40886, P43581, P47185, P49374, P53387, P53631, P54854, P54862, P58351, Q06222, Q09039, Q12300, Q46909, Q4WC50, Q504N2, Q7XA64, Q8IZD6, Q9FRL3, Q9LNV3, A0A3Q2IDB4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

78 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2456 predictions. Top by Δscore:

Variant	Effect	Δscore
1:115976711:GCAG:G	donor_gain	1.0000
1:115976712:CAGGT:C	donor_loss	1.0000
1:115976714:GGT:G	donor_loss	1.0000
1:115976715:G:C	donor_loss	1.0000
1:115976715:G:GG	donor_gain	1.0000
1:115976716:T:A	donor_loss	1.0000
1:115992028:CAG:C	acceptor_loss	1.0000
1:115992029:A:AG	acceptor_gain	1.0000
1:115992029:AGC:A	acceptor_loss	1.0000
1:115992030:G:GG	acceptor_gain	1.0000
1:115992030:GCTC:G	acceptor_gain	1.0000
1:115992030:GCTCT:G	acceptor_gain	1.0000
1:115992239:CGGAG:C	donor_loss	1.0000
1:115992240:GGAGG:G	donor_loss	1.0000
1:115992241:G:GT	donor_gain	1.0000
1:115992242:AGGT:A	donor_loss	1.0000
1:115992243:GG:G	donor_loss	1.0000
1:115992244:GTAA:G	donor_loss	1.0000
1:115992245:T:G	donor_loss	1.0000
1:116019580:A:AG	acceptor_gain	1.0000
1:116019580:AGT:A	acceptor_gain	1.0000
1:116019581:G:GA	acceptor_gain	1.0000
1:116019581:GT:G	acceptor_gain	1.0000
1:116019581:GTG:G	acceptor_gain	1.0000
1:116019581:GTGGT:G	acceptor_gain	1.0000
1:116027005:G:GA	donor_gain	1.0000
1:116031515:G:GT	donor_gain	1.0000
1:116066503:A:AG	acceptor_gain	1.0000
1:116066504:C:G	acceptor_gain	1.0000
1:116066519:GAA:G	acceptor_gain	1.0000

AlphaMissense

3530 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:116035197:A:C	S319R	0.999
1:116035199:C:A	S319R	0.999
1:116035199:C:G	S319R	0.999
1:116062882:G:T	R431M	0.999
1:116019643:G:A	G121D	0.998
1:116019655:G:A	G125E	0.998
1:116019694:G:C	R138T	0.998
1:116019694:G:T	R138M	0.998
1:116019695:G:C	R138S	0.998
1:116019695:G:T	R138S	0.998
1:116020804:G:C	G173R	0.998
1:116020805:G:A	G173D	0.998
1:116062824:A:C	S412R	0.998
1:116062826:T:A	S412R	0.998
1:116062826:T:G	S412R	0.998
1:116062882:G:C	R431T	0.998
1:116019654:G:A	G125R	0.997
1:116019654:G:C	G125R	0.997
1:116020793:G:C	R169P	0.997
1:116020837:T:C	F184L	0.997
1:116020839:T:A	F184L	0.997
1:116020839:T:G	F184L	0.997
1:116020853:A:T	E189V	0.997
1:116031388:T:A	W251R	0.997
1:116031388:T:C	W251R	0.997
1:116031418:G:C	A261P	0.997
1:116062833:T:C	F415L	0.997
1:116062835:T:A	F415L	0.997
1:116062835:T:G	F415L	0.997
1:116064457:T:G	C438W	0.997

dbSNP variants (sampled 300 via entrez): RS1000025649 (1:116046421 G>C), RS1000058073 (1:116046233 AG>A), RS1000074365 (1:116033512 G>A,C,T), RS1000082460 (1:115993415 G>T), RS1000122115 (1:116019110 A>G), RS1000159940 (1:116036149 A>G), RS1000193071 (1:116069654 C>T), RS1000261904 (1:116018438 C>T), RS1000293059 (1:116018230 C>G), RS1000299795 (1:116032156 CT>C), RS1000328776 (1:116031821 C>T), RS1000382069 (1:115986984 T>A,C), RS1000387738 (1:115980599 A>T), RS1000407794 (1:116040227 A>C,G), RS1000430088 (1:116018753 T>C)

Disease associations

OMIM: gene MIM:608275 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004735_19	Epstein-Barr virus copy number in lymphoblastoid cell lines	1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Orphan or poorly characterized SLC22 family members

CTD chemical–gene interactions

56 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	5
Valproic Acid	affects cotreatment, increases expression, affects expression	4
trichostatin A	affects cotreatment, increases expression	3
sodium arsenite	decreases expression, increases expression	3
Air Pollutants	increases expression, decreases expression, affects expression, increases abundance	3
Tetrachlorodibenzodioxin	decreases expression	3
mercuric bromide	increases expression, affects cotreatment	2
Nickel	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
2,5,2’,5’-tetrachlorobiphenyl	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
manganese chloride	decreases expression	1
didecyldimethylammonium	increases expression	1
di-n-butylphosphoric acid	affects expression	1
pentabromodiphenyl ether	increases expression	1
tebuconazole	increases expression	1
perfluoro-n-nonanoic acid	increases expression	1
monomethylarsonous acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
quinocetone	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	decreases expression	1
NSC 689534	affects binding, increases expression	1
Temozolomide	decreases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4S8	HuH7-SLC22A15-KO-c7	Cancer cell line	Male
CVCL_D4S9	HuH7-SLC22A15-KO-c8	Cancer cell line	Male
CVCL_TL96	HAP1 SLC22A15 (-) 1	Cancer cell line	Male
CVCL_XS96	HAP1 SLC22A15 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.