SLC22A17

Summary

SLC22A17 (solute carrier family 22 member 17, HGNC:23095) is a protein-coding gene on chromosome 14q11.2, encoding Solute carrier family 22 member 17 (Q8WUG5). Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport.

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in siderophore transport. Located in organelle membrane and plasma membrane.

Source: NCBI Gene 51310 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 98 total
• MANE Select transcript: NM_016609

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23095
Approved symbol	SLC22A17
Name	solute carrier family 22 member 17
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	BOCT, BOIT, NGALR
Ensembl gene	ENSG00000092096
Ensembl biotype	protein_coding
OMIM	611461
Entrez	51310

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 4 retained_intron, 4 nonsense_mediated_decay, 2 protein_coding

ENST00000206544, ENST00000354772, ENST00000397260, ENST00000397267, ENST00000473917, ENST00000474057, ENST00000474774, ENST00000556803, ENST00000557699, ENST00000636431

RefSeq mRNA: 3 — MANE Select: NM_016609 NM_001289050, NM_016609, NM_020372

CCDS: CCDS9593, CCDS9594

Canonical transcript exons

ENST00000354772 — 10 exons

Exon	Start	End
ENSE00001856963	23346318	23346936
ENSE00003536059	23351948	23352451
ENSE00003797123	23352646	23352887
ENSE00003802859	23348161	23348306
ENSE00003803339	23347514	23347731
ENSE00003803458	23347101	23347212
ENSE00003804026	23351752	23351855
ENSE00003805957	23347891	23347996
ENSE00003806276	23348506	23348671
ENSE00003806342	23349272	23349426

Expression profiles

Bgee: expression breadth ubiquitous, 212 present calls, max score 99.45.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.5707 / max 741.0036, expressed in 1366 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142355	29.7706	1357
142354	2.0871	459
142353	0.4027	180
142351	0.2270	130
142352	0.0832	41

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	99.45	gold quality
cerebellar hemisphere	UBERON:0002245	99.36	gold quality
cerebellar cortex	UBERON:0002129	99.32	gold quality
right frontal lobe	UBERON:0002810	99.25	gold quality
adenohypophysis	UBERON:0002196	99.18	gold quality
pituitary gland	UBERON:0000007	98.91	gold quality
nucleus accumbens	UBERON:0001882	98.88	gold quality
prefrontal cortex	UBERON:0000451	98.66	gold quality
cingulate cortex	UBERON:0003027	98.66	gold quality
anterior cingulate cortex	UBERON:0009835	98.66	gold quality
cerebellum	UBERON:0002037	98.64	gold quality
caudate nucleus	UBERON:0001873	98.57	gold quality
hypothalamus	UBERON:0001898	98.54	gold quality
amygdala	UBERON:0001876	98.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	98.26	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	98.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.98	gold quality
frontal cortex	UBERON:0001870	97.92	gold quality
frontal lobe	UBERON:0016525	97.92	gold quality
neocortex	UBERON:0001950	97.82	gold quality
putamen	UBERON:0001874	97.76	gold quality
forebrain	UBERON:0001890	97.50	gold quality
brain	UBERON:0000955	97.39	gold quality
telencephalon	UBERON:0001893	97.38	gold quality
cerebral cortex	UBERON:0000956	97.29	gold quality
cortical plate	UBERON:0005343	97.24	gold quality
spinal cord	UBERON:0002240	97.16	gold quality
ganglionic eminence	UBERON:0004023	97.10	gold quality
Ammon’s horn	UBERON:0001954	96.85	gold quality
temporal lobe	UBERON:0001871	96.57	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-MTAB-5061	yes	839.42
E-GEOD-81608	yes	139.68
E-GEOD-81547	yes	27.29
E-GEOD-84465	yes	26.77
E-GEOD-83139	yes	9.72
E-ANND-3	yes	6.91
E-ENAD-17	no	26.52

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): LCN2, RUNX1, RUNX3

miRNA regulators (miRDB)

12 targeting SLC22A17, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-451B	99.55	68.28	1380
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-511-5P	98.97	70.94	2268
HSA-MIR-3190-5P	98.87	64.89	1345
HSA-MIR-4297	98.77	66.95	2013
HSA-MIR-6830-3P	98.62	68.07	1760
HSA-MIR-6776-5P	98.54	67.43	1304
HSA-MIR-5581-5P	97.91	66.50	965
HSA-MIR-3921	97.81	67.45	1431
HSA-MIR-4653-5P	97.22	67.72	1429

Literature-anchored findings (GeneRIF, showing 13)

• NGALR hypomethylation contributes to its expression in esophageal carcinomas and that this overexpression may play a role in the pathogenesis of esophageal carcinomas. (PMID:19047093)
• This study suggested that NGAL and NGALR expression are frequently up-regulated in gliomas, and are closely associated with poor clinical outcome. (PMID:21184133)
• Neutrophil gelatinase-associated lipocalin receptor (NGALR) is differentially expressed in human glomerular disease and is significantly up-regulated by Il-1beta in HMC via MAPK/ERK activation. (PMID:21305251)
• These results suggested that SLC22A17, in cooperation with LCN2, to be involved in the acquisition of aggressive behavior among endometrial carcinoma cells. (PMID:21763306)
• NGAL and NGALR expression might be served as novel prognostic factors and potential therapeutic targets in Hepatocellular carcinoma. (PMID:22728279)
• No significant difference was found in the expressions of NGALR mRNA in placenta among moderate preeclampsia group, severe preeclampsia group and control group. (PMID:22932106)
• Lipocalin 2 might restore the health and regeneration potential of MSCs by decreasing senescence (PMID:24452457)
• Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity. (PMID:26230641)
• Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17. (PMID:26635366)
• Results showed the expression levels of NGAL and NGALR significantly downregulated in clear cell renal cell carcinoma samples. (PMID:30138675)
• Identification of immune cells and mRNA associated with prognosis of gastric cancer. (PMID:32164594)
• The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients. (PMID:38391165)
• SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia. (PMID:38738428)

Cross-species orthologs

42 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc22a17	ENSMUSG00000022199
rattus_norvegicus	Slc22a17	ENSRNOG00000016414
drosophila_melanogaster	Orct	FBGN0019952
drosophila_melanogaster	CG15221	FBGN0030331
drosophila_melanogaster	Balat	FBGN0033778
drosophila_melanogaster	CG5592	FBGN0035645
drosophila_melanogaster	CG10486	FBGN0035647
drosophila_melanogaster	CG14691	FBGN0037829
drosophila_melanogaster	CG14855	FBGN0038260
drosophila_melanogaster	CG14856	FBGN0038261
drosophila_melanogaster	CG14857	FBGN0038262
drosophila_melanogaster	CG12783	FBGN0038448
drosophila_melanogaster	CG7333	FBGN0038715
drosophila_melanogaster	CG7342	FBGN0038716
drosophila_melanogaster	CG17751	FBGN0038717
drosophila_melanogaster	CG17752	FBGN0038718
drosophila_melanogaster	CG16727	FBGN0038719
drosophila_melanogaster	CG6231	FBGN0038720
drosophila_melanogaster	CG4465	FBGN0038750
drosophila_melanogaster	CG4462	FBGN0038752
drosophila_melanogaster	CG4459	FBGN0038753
drosophila_melanogaster	CG6356	FBGN0039178
drosophila_melanogaster	CG3690	FBGN0040350
drosophila_melanogaster	CG31103	FBGN0051103
drosophila_melanogaster	CG31106	FBGN0051106
drosophila_melanogaster	CG31272	FBGN0051272
drosophila_melanogaster	CG33233	FBGN0053233
drosophila_melanogaster	CG33234	FBGN0053234
drosophila_melanogaster	Orct2	FBGN0086365
drosophila_melanogaster	CG42269	FBGN0259164
drosophila_melanogaster	CG44098	FBGN0264907
caenorhabditis_elegans		WBGENE00003837
caenorhabditis_elegans	oct-1	WBGENE00003842
caenorhabditis_elegans		WBGENE00003843
caenorhabditis_elegans		WBGENE00006220
caenorhabditis_elegans		WBGENE00008110
caenorhabditis_elegans		WBGENE00011456
caenorhabditis_elegans		WBGENE00014127
caenorhabditis_elegans		WBGENE00017751
caenorhabditis_elegans		WBGENE00019408
caenorhabditis_elegans		WBGENE00020701
caenorhabditis_elegans		WBGENE00044455

Paralogs (22): SLC22A16 (ENSG00000004809), SLC22A2 (ENSG00000112499), SLC22A7 (ENSG00000137204), SLC22A23 (ENSG00000137266), SLC22A14 (ENSG00000144671), SLC22A3 (ENSG00000146477), SLC22A8 (ENSG00000149452), SLC22A9 (ENSG00000149742), SVOPL (ENSG00000157703), SLC22A15 (ENSG00000163393), SVOP (ENSG00000166111), SLC22A11 (ENSG00000168065), SLC22A13 (ENSG00000172940), SLC22A1 (ENSG00000175003), SLC22A10 (ENSG00000184999), SLC22A25 (ENSG00000196600), SLC22A4 (ENSG00000197208), SLC22A5 (ENSG00000197375), SLC22A24 (ENSG00000197658), SLC22A12 (ENSG00000197891), SLC22A6 (ENSG00000197901), SLC22A31 (ENSG00000259803)

Protein

Protein identifiers

Solute carrier family 22 member 17 — Q8WUG5 (reviewed: Q8WUG5)

Alternative names: 24p3 receptor, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor

All UniProt accessions (5): Q8WUG5, A0A1B0GUC0, A0A1B0GUP4, A0A1B0GVR9, H9KVA1

UniProt curated annotations — full annotation on UniProt →

Function. Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.

Subcellular location. Cell membrane. Vacuole membrane.

Tissue specificity. Expressed in brain.

Induction. Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway.

Similarity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8WUG5-1	1, NgalR-1	yes
Q8WUG5-2	2, NgalR-2
Q8WUG5-3	3, NgalR-3

RefSeq proteins (3): NP_001275979, NP_057693, NP_065105 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005828	MFS_sugar_transport-like	Family
IPR005829	Sugar_transporter_CS	Conserved_site
IPR020846	MFS_dom	Domain

Pfam: PF00083

UniProt features (23 total): transmembrane region 11, splice variant 3, sequence conflict 3, compositionally biased region 2, glycosylation site 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WUG5-F1	71.34	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 134, 143

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-917937	Iron uptake and transport
R-HSA-382551	Transport of small molecules

MSigDB gene sets: 116 (showing top): CCAWYNNGAAR_UNKNOWN, GOBP_IRON_COORDINATION_ENTITY_TRANSPORT, GOCC_VACUOLAR_MEMBRANE, GOBP_TRANSITION_METAL_ION_TRANSPORT, GCANCTGNY_MYOD_Q6, GOBP_INTRACELLULAR_IRON_ION_HOMEOSTASIS, GOBP_IRON_ION_TRANSPORT, CHANDRAN_METASTASIS_DN, CAGCTG_AP4_Q5, GOBP_MONOATOMIC_CATION_TRANSPORT, TGCTGAY_UNKNOWN, AAAGACA_MIR511, TGGNNNNNNKCCAR_UNKNOWN, GOBP_MONOATOMIC_ION_HOMEOSTASIS, POU3F2_02

GO Biological Process (5): intracellular iron ion homeostasis (GO:0006879), siderophore transport (GO:0015891), monoatomic ion transport (GO:0006811), iron ion transport (GO:0006826), transmembrane transport (GO:0055085)

GO Molecular Function (3): transmembrane signaling receptor activity (GO:0004888), transmembrane transporter activity (GO:0022857), protein binding (GO:0005515)

GO Cellular Component (5): vacuolar membrane (GO:0005774), plasma membrane (GO:0005886), organelle membrane (GO:0031090), vacuole (GO:0005773), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
membrane	2
intracellular monoatomic cation homeostasis	1
inorganic ion homeostasis	1
iron coordination entity transport	1
transition metal ion transport	1
cellular process	1
signaling receptor activity	1
transporter activity	1
transmembrane transport	1
binding	1
vacuole	1
bounding membrane of organelle	1
cell periphery	1
membrane-bounded organelle	1
cytoplasm	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1120 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC22A17	LCN2	P30150	994
SLC22A17	STXBP6	Q8NFX7	845
SLC22A17	COCH	O43405	830
SLC22A17	LRP2	P98164	708
SLC22A17	SLC67A1	Q96BI1	573
SLC22A17	ABL1	P00519	544
SLC22A17	LTF	P02788	527
SLC22A17	ALB	P02768	495
SLC22A17	BCL2L11	O43521	490
SLC22A17	SLC22A14	Q9Y267	477
SLC22A17	SLC22A15	Q8IZD6	476
SLC22A17	SLC22A25	Q6T423	462
SLC22A17	SLC22A10	Q63ZE4	427
SLC22A17	IL3	P08700	423
SLC22A17	BDH2	Q9BUT1	420
SLC22A17	SLC22A11	Q9NSA0	420

IntAct

11 interactions, top by confidence:

A	B	Type	Score
P4HB	SLC22A17	psi-mi:“MI:0915”(physical association)	0.560
SLC22A17	DRD2	psi-mi:“MI:0915”(physical association)	0.370
SLC22A17	CREB3	psi-mi:“MI:0915”(physical association)	0.370
SLC22A17	NUFIP2	psi-mi:“MI:0915”(physical association)	0.370
ECE1	SLC22A17	psi-mi:“MI:0915”(physical association)	0.370
	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC1A4	MGST3	psi-mi:“MI:0914”(association)	0.350
SLC22A17	EMC8	psi-mi:“MI:0914”(association)	0.350

BioGRID (46): SLC22A17 (Affinity Capture-MS), SLC22A17 (Two-hybrid), SLC22A17 (Affinity Capture-MS), SLC22A17 (Two-hybrid), SLC22A17 (Co-fractionation), SLC22A17 (Co-fractionation), SLC22A17 (Affinity Capture-MS), ACADVL (Affinity Capture-MS), ARL6IP6 (Affinity Capture-MS), ATP13A1 (Affinity Capture-MS), C1GALT1C1 (Affinity Capture-MS), CCDC47 (Affinity Capture-MS), CLPTM1L (Affinity Capture-MS), CYB5D2 (Affinity Capture-MS), DNAJC16 (Affinity Capture-MS)

ESM2 similar proteins: A4FV98, A5D7B1, A5PK51, A6QLN9, A8MUP2, D3ZVU9, O15527, O35595, O75078, O95848, P57775, Q05B60, Q06643, Q14728, Q14CX5, Q1LZB9, Q27HK4, Q2T9T5, Q2TBS1, Q3UGX3, Q4R3I0, Q4V892, Q58CT4, Q5E9H2, Q5RCI5, Q5SUV1, Q5TM22, Q642A6, Q6IA17, Q6PCB0, Q6XQN6, Q862Z7, Q8N8L6, Q8R2R5, Q8R2Z5, Q8R366, Q8WUG5, Q95JH0, Q95JH2, Q969P0

Diamond homologs: A1A5C7, A6NKX4, Q3SZQ2, Q3UHH2, Q8WUG5, Q9D9E0, Q9P290, Q9QZG1, A7MBE0, C0SPB2, Q0WUU6, Q3YAW7, Q46909, Q5RC45, Q5RLM2, Q96S37, Q9Y226, O02713, O75751, O77504, O88446, Q9VCA2, Q9WTW5, A0A3Q2IDB4, A0A8B7HA97, A6NK97, A6QLW8, B2GV36, G1SZD9, O08966, O15244, O15245, O35956, O57379, O70577, O70594, O76082, O88909, Q1RPP5, Q28ES4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1386 predictions. Top by Δscore:

Variant	Effect	Δscore
14:23346932:GGCCC:G	acceptor_gain	1.0000
14:23346933:GCCC:G	acceptor_gain	1.0000
14:23346934:CCC:C	acceptor_gain	1.0000
14:23346934:CCCC:C	acceptor_gain	1.0000
14:23346935:CC:C	acceptor_gain	1.0000
14:23346935:CCC:C	acceptor_gain	1.0000
14:23346936:CC:C	acceptor_gain	1.0000
14:23346937:C:CC	acceptor_gain	1.0000
14:23346937:C:T	acceptor_gain	1.0000
14:23346938:T:C	acceptor_loss	1.0000
14:23347096:CTCAC:C	donor_loss	1.0000
14:23347097:TCA:T	donor_loss	1.0000
14:23347098:CA:C	donor_loss	1.0000
14:23347099:A:AC	donor_gain	1.0000
14:23347099:ACCGG:A	donor_loss	1.0000
14:23347100:C:CC	donor_gain	1.0000
14:23347100:CCGGA:C	donor_gain	1.0000
14:23347208:CAGAT:C	acceptor_gain	1.0000
14:23347211:ATCT:A	acceptor_loss	1.0000
14:23347212:TCTG:T	acceptor_loss	1.0000
14:23347213:C:CC	acceptor_gain	1.0000
14:23347213:C:CG	acceptor_loss	1.0000
14:23347214:T:A	acceptor_loss	1.0000
14:23347889:A:AC	donor_gain	1.0000
14:23347890:C:CC	donor_gain	1.0000
14:23347997:C:CC	acceptor_gain	1.0000
14:23347998:T:C	acceptor_gain	1.0000
14:23348156:CTTA:C	donor_loss	1.0000
14:23348158:TA:T	donor_loss	1.0000
14:23348159:A:AC	donor_gain	1.0000

AlphaMissense

3996 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:23346798:G:C	S489R	0.997
14:23346798:G:T	S489R	0.997
14:23346800:T:G	S489R	0.997
14:23347113:G:T	P439H	0.997
14:23347901:C:G	G312R	0.997
14:23348559:C:A	W213C	0.997
14:23348559:C:G	W213C	0.997
14:23347113:G:C	P439R	0.996
14:23347139:G:C	S430R	0.996
14:23347139:G:T	S430R	0.996
14:23347141:T:G	S430R	0.996
14:23348271:A:G	L243P	0.996
14:23348561:A:G	W213R	0.996
14:23348561:A:T	W213R	0.996
14:23346787:A:G	L493P	0.995
14:23347174:C:G	G419R	0.995
14:23347174:C:T	G419R	0.995
14:23348275:A:G	W242R	0.995
14:23348275:A:T	W242R	0.995
14:23348283:G:A	S239F	0.995
14:23348666:C:T	E178K	0.995
14:23351782:C:T	G114D	0.995
14:23346821:A:G	C482R	0.994
14:23347122:T:A	E436V	0.994
14:23347173:C:T	G419E	0.994
14:23347900:C:T	G312D	0.994
14:23351853:C:A	W90C	0.994
14:23351853:C:G	W90C	0.994
14:23347586:G:T	R364S	0.993
14:23347588:C:A	G363V	0.993

dbSNP variants (sampled 300 via entrez): RS1001307541 (14:23350539 C>G,T), RS1002719400 (14:23351676 T>A), RS1002837165 (14:23354497 C>T), RS1003585770 (14:23353370 C>A), RS1003601681 (14:23353359 C>G), RS1003870019 (14:23349673 A>G), RS1004373633 (14:23346239 G>A,C), RS1005229035 (14:23349129 A>C,G), RS1005778883 (14:23352759 C>G,T), RS1005959543 (14:23345872 T>G), RS1006037139 (14:23346855 A>G), RS1006075028 (14:23351383 T>C), RS1006767828 (14:23347790 A>G), RS1006778255 (14:23353975 T>C), RS1006919176 (14:23353670 G>A)

Disease associations

OMIM: gene MIM:611461 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003248_4	Body mass index	3.000000e-06
GCST90020028_1236	Hip circumference adjusted for BMI	4.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs4982753	SLC22A17		0.00	0

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Orphan or poorly characterized SLC22 family members

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	5
sodium arsenite	decreases expression, decreases reaction, affects expression, affects methylation	3
bisphenol A	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
entinostat	increases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
(+)-JQ1 compound	increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Acetylcysteine	decreases expression, decreases reaction	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Caffeine	decreases phosphorylation	1
Cisplatin	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, increases expression	1
Hydralazine	affects cotreatment, increases expression	1
Lead	affects expression	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tunicamycin	increases expression	1
Zidovudine	increases expression	1
Cyclosporine	decreases expression	1
Copper Sulfate	decreases expression	1
Genistein	increases expression	1
Phytochelatins	increases uptake	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4IW	HCT116-SLC22A17-KO-c2	Cancer cell line	Male
CVCL_D4IX	HCT116-SLC22A17-KO-c3	Cancer cell line	Male
CVCL_D4IY	HCT116-SLC22A17-KO-c7	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.