SLC22A23

Summary

SLC22A23 (solute carrier family 22 member 23, HGNC:21106) is a protein-coding gene on chromosome 6p25.2, encoding Solute carrier family 22 member 23 (A1A5C7).

SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).

Source: NCBI Gene 63027 — RefSeq curated summary.

At a glance

• GWAS associations: 59
• Clinical variants (ClinVar): 89 total
• MANE Select transcript: NM_015482

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21106
Approved symbol	SLC22A23
Name	solute carrier family 22 member 23
Location	6p25.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ22174
Ensembl gene	ENSG00000137266
Ensembl biotype	protein_coding
OMIM	611697
Entrez	63027

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 7 protein_coding, 3 protein_coding_CDS_not_defined, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000380298, ENST00000380302, ENST00000406686, ENST00000433689, ENST00000436008, ENST00000467144, ENST00000467177, ENST00000482874, ENST00000485307, ENST00000490273, ENST00000496753, ENST00000497691

RefSeq mRNA: 8 — MANE Select: NM_015482 NM_001286455, NM_001286456, NM_001382317, NM_001382318, NM_001382319, NM_001382321, NM_015482, NM_021945

CCDS: CCDS34331, CCDS47363, CCDS75389

Canonical transcript exons

ENST00000406686 — 10 exons

Exon	Start	End
ENSE00001949115	3268973	3273412
ENSE00003475640	3289764	3289866
ENSE00003483185	3298091	3298218
ENSE00003498751	3410188	3410342
ENSE00003525367	3415752	3415855
ENSE00003541282	3323834	3324002
ENSE00003600910	3285079	3285111
ENSE00003634468	3286859	3287091
ENSE00003686626	3283852	3283975
ENSE00003907731	3455906	3457050

Expression profiles

Bgee: expression breadth ubiquitous, 247 present calls, max score 99.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.4819 / max 57.4924, expressed in 1232 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
71475	2.1543	932
71476	1.2880	702
71469	0.2212	103
71472	0.1902	90
71474	0.1810	77
71473	0.1541	76
71465	0.0991	35
71471	0.0845	23
71470	0.0830	39
71464	0.0223	7

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	99.32	gold quality
ileal mucosa	UBERON:0000331	98.21	gold quality
ganglionic eminence	UBERON:0004023	96.01	gold quality
secondary oocyte	CL:0000655	94.75	gold quality
gingival epithelium	UBERON:0001949	94.69	gold quality
bronchial epithelial cell	CL:0002328	94.55	gold quality
esophagus squamous epithelium	UBERON:0006920	94.45	gold quality
bronchus	UBERON:0002185	93.47	gold quality
gingiva	UBERON:0001828	93.39	gold quality
cortical plate	UBERON:0005343	92.60	gold quality
amniotic fluid	UBERON:0000173	90.84	gold quality
lower esophagus mucosa	UBERON:0035834	90.11	gold quality
jejunal mucosa	UBERON:0000399	89.99	gold quality
mucosa of transverse colon	UBERON:0004991	89.25	gold quality
colonic mucosa	UBERON:0000317	89.23	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	89.09	gold quality
middle temporal gyrus	UBERON:0002771	88.72	gold quality
esophagus mucosa	UBERON:0002469	88.48	gold quality
Brodmann (1909) area 23	UBERON:0013554	88.40	gold quality
duodenum	UBERON:0002114	88.33	gold quality
mucosa of sigmoid colon	UBERON:0004993	88.08	gold quality
spinal cord	UBERON:0002240	88.00	gold quality
primary visual cortex	UBERON:0002436	87.97	gold quality
corpus callosum	UBERON:0002336	87.39	gold quality
Brodmann (1909) area 46	UBERON:0006483	87.26	gold quality
stromal cell of endometrium	CL:0002255	87.19	gold quality
right uterine tube	UBERON:0001302	87.17	gold quality
tendon of biceps brachii	UBERON:0008188	86.98	gold quality
sperm	CL:0000019	86.87	gold quality
transverse colon	UBERON:0001157	86.87	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-7381	yes	438.79
E-CURD-119	yes	31.77
E-ANND-3	yes	8.28

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

194 targeting SLC22A23, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-10401-5P	99.99	65.79	948
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4775	99.98	75.00	6394
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-302E	99.96	70.74	2669

Literature-anchored findings (GeneRIF, showing 2)

• Genetic variations in the SLC22A23 locus contribute to the susceptibility to inflammatory bowel disease in a small fraction of white patients. (PMID:24740203)
• Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression. (PMID:38400886)

Cross-species orthologs

43 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc22a23	ENSDARG00000078856
mus_musculus	Slc22a23	ENSMUSG00000038267
rattus_norvegicus	Slc22a23	ENSRNOG00000017210
drosophila_melanogaster	Orct	FBGN0019952
drosophila_melanogaster	CG15221	FBGN0030331
drosophila_melanogaster	Balat	FBGN0033778
drosophila_melanogaster	CG5592	FBGN0035645
drosophila_melanogaster	CG10486	FBGN0035647
drosophila_melanogaster	CG14691	FBGN0037829
drosophila_melanogaster	CG14855	FBGN0038260
drosophila_melanogaster	CG14856	FBGN0038261
drosophila_melanogaster	CG14857	FBGN0038262
drosophila_melanogaster	CG12783	FBGN0038448
drosophila_melanogaster	CG7333	FBGN0038715
drosophila_melanogaster	CG7342	FBGN0038716
drosophila_melanogaster	CG17751	FBGN0038717
drosophila_melanogaster	CG17752	FBGN0038718
drosophila_melanogaster	CG16727	FBGN0038719
drosophila_melanogaster	CG6231	FBGN0038720
drosophila_melanogaster	CG4465	FBGN0038750
drosophila_melanogaster	CG4462	FBGN0038752
drosophila_melanogaster	CG4459	FBGN0038753
drosophila_melanogaster	CG6356	FBGN0039178
drosophila_melanogaster	CG3690	FBGN0040350
drosophila_melanogaster	CG31103	FBGN0051103
drosophila_melanogaster	CG31106	FBGN0051106
drosophila_melanogaster	CG31272	FBGN0051272
drosophila_melanogaster	CG33233	FBGN0053233
drosophila_melanogaster	CG33234	FBGN0053234
drosophila_melanogaster	Orct2	FBGN0086365
drosophila_melanogaster	CG42269	FBGN0259164
drosophila_melanogaster	CG44098	FBGN0264907
caenorhabditis_elegans		WBGENE00003837
caenorhabditis_elegans	oct-1	WBGENE00003842
caenorhabditis_elegans		WBGENE00003843
caenorhabditis_elegans		WBGENE00006220
caenorhabditis_elegans		WBGENE00008110
caenorhabditis_elegans		WBGENE00011456
caenorhabditis_elegans		WBGENE00014127
caenorhabditis_elegans		WBGENE00017751
caenorhabditis_elegans		WBGENE00019408
caenorhabditis_elegans		WBGENE00020701
caenorhabditis_elegans		WBGENE00044455

Paralogs (22): SLC22A16 (ENSG00000004809), SLC22A17 (ENSG00000092096), SLC22A2 (ENSG00000112499), SLC22A7 (ENSG00000137204), SLC22A14 (ENSG00000144671), SLC22A3 (ENSG00000146477), SLC22A8 (ENSG00000149452), SLC22A9 (ENSG00000149742), SVOPL (ENSG00000157703), SLC22A15 (ENSG00000163393), SVOP (ENSG00000166111), SLC22A11 (ENSG00000168065), SLC22A13 (ENSG00000172940), SLC22A1 (ENSG00000175003), SLC22A10 (ENSG00000184999), SLC22A25 (ENSG00000196600), SLC22A4 (ENSG00000197208), SLC22A5 (ENSG00000197375), SLC22A24 (ENSG00000197658), SLC22A12 (ENSG00000197891), SLC22A6 (ENSG00000197901), SLC22A31 (ENSG00000259803)

Protein

Protein identifiers

Solute carrier family 22 member 23 — A1A5C7 (reviewed: A1A5C7)

All UniProt accessions (5): A1A5C7, C9IZW5, C9J4Z0, F8WBC7, H7C4T9

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Isoforms (4)

UniProt ID	Names	Canonical?
A1A5C7-1	1	yes
A1A5C7-2	2
A1A5C7-3	3
A1A5C7-4	4

RefSeq proteins (7): NP_001273384, NP_001273385, NP_001369246, NP_001369247, NP_001369248, NP_056297, NP_068764 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005828	MFS_sugar_transport-like	Family
IPR005829	Sugar_transporter_CS	Conserved_site
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF00083

UniProt features (19 total): transmembrane region 10, splice variant 3, region of interest 2, glycosylation site 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A1A5C7-F1	73.39	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 24, 279

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 200 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, GGTGTGT_MIR329, IVANOVA_HEMATOPOIESIS_MATURE_CELL, RODWELL_AGING_KIDNEY_NO_BLOOD_DN, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, chr6p25, LE_EGR2_TARGETS_UP, CORRE_MULTIPLE_MYELOMA_UP, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, HOOI_ST7_TARGETS_DN, ACTTTAT_MIR1425P, GOBP_TRANSMEMBRANE_TRANSPORT, XU_GH1_AUTOCRINE_TARGETS_DN, ATGTACA_MIR493, MODULE_534

GO Biological Process (2): monoatomic ion transport (GO:0006811), transmembrane transport (GO:0055085)

GO Molecular Function (2): transmembrane transporter activity (GO:0022857), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
cellular process	1
transporter activity	1
transmembrane transport	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

826 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC22A23	SLC67A1	Q96BI1	649
SLC22A23	SLC22A25	Q6T423	502
SLC22A23	SLC22A15	Q8IZD6	498
SLC22A23	SLC22A14	Q9Y267	487
SLC22A23	NUBPL	Q8TB37	487
SLC22A23	SLC22A10	Q63ZE4	459
SLC22A23	CHLSN	Q9BRJ6	449
SLC22A23	SLC18B1	Q6NT16	448
SLC22A23	PXDC1	Q5TGL8	445
SLC22A23	SLCO3A1	Q9UIG8	441
SLC22A23	CFAP74	Q9C0B2	435
SLC22A23	SLC22A11	Q9NSA0	431
SLC22A23	RPAP3	Q9H6T3	423
SLC22A23	SLC16A9	Q7RTY1	418
SLC22A23	SLC22A2	O15244	408

IntAct

19 interactions, top by confidence:

A	B	Type	Score
SLC22A23	NOTCH2NLA	psi-mi:“MI:0915”(physical association)	0.670
NOTCH2NLA	SLC22A23	psi-mi:“MI:0915”(physical association)	0.670
SLC22A23	KRTAP5-9	psi-mi:“MI:0915”(physical association)	0.560
SLC22A23	KRTAP10-8	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	SLC22A23	psi-mi:“MI:0915”(physical association)	0.560
CLEC2D	TMEM120B	psi-mi:“MI:0914”(association)	0.350
LRRC55	TMEM120B	psi-mi:“MI:0914”(association)	0.350
TNFRSF10C	SLC22A23	psi-mi:“MI:0914”(association)	0.350
LGALS8	SLC22A23	psi-mi:“MI:0914”(association)	0.350
KRTCAP3	SLC22A23	psi-mi:“MI:0914”(association)	0.350
SLC22A23	BMP4	psi-mi:“MI:0914”(association)	0.350
SLC22A23	MVK	psi-mi:“MI:0914”(association)	0.350
SLC22A23	NRP1	psi-mi:“MI:0914”(association)	0.350

BioGRID (73): SLC22A23 (Two-hybrid), SLC22A23 (Two-hybrid), KRTAP10-8 (Two-hybrid), NOTCH2NL (Two-hybrid), SLC22A23 (Affinity Capture-MS), SLC22A23 (Affinity Capture-MS), SLC22A23 (Affinity Capture-MS), SLC22A23 (Affinity Capture-MS), BMP4 (Affinity Capture-MS), SLC22A23 (Affinity Capture-MS), SIRT2 (Affinity Capture-MS), PAXBP1 (Affinity Capture-MS), KPRP (Affinity Capture-MS), TAX1BP1 (Affinity Capture-MS), DSCC1 (Affinity Capture-MS)

ESM2 similar proteins: A1A5C7, A6H7A0, B0BMW8, B0CM95, B0KWE9, B1MTH4, B2KI79, O43688, O62772, O75147, P0CK96, P35438, P35439, P52875, P57791, Q05586, Q28D01, Q2KJ29, Q3KNV8, Q3SZQ2, Q3UHH2, Q4L208, Q4V899, Q5R1P0, Q5R890, Q5SP67, Q5ZJ75, Q7TPB4, Q86YN1, Q8BTQ0, Q8C6G8, Q8C811, Q8R4D1, Q8VDI9, Q8VE98, Q90812, Q9BWV1, Q9D9E0, Q9H6U8, Q9H7D7

Diamond homologs: A1A5C7, A6NKX4, Q3SZQ2, Q3UHH2, Q8WUG5, Q9D9E0, Q9P290, Q9QZG1, A7MBE0, C0SPB2, Q0WUU6, Q3YAW7, Q46909, Q5RC45, Q5RLM2, Q96S37, Q9Y226, A9R4E0, C5BC70, D0CCT2, D0JKF6, D0JUX5, D0ZHC6, D5B5U5, E0T2N0, P0AEY8, P0AEY9, P0AEZ0, P39386, Q28ES4, Q323U7, Q51955, Q7CP73, Q8XB84, Q8XFG0, A0A161CLJ6, A1AHP3, A7ZTR5, A8A6H2, A8ACM0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

89 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	65
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2904 predictions. Top by Δscore:

Variant	Effect	Δscore
6:3283971:CATCC:C	acceptor_gain	1.0000
6:3283973:TCC:T	acceptor_gain	1.0000
6:3283974:CCC:C	acceptor_gain	1.0000
6:3283975:CCT:C	acceptor_loss	1.0000
6:3283976:C:CC	acceptor_gain	1.0000
6:3283976:CT:C	acceptor_loss	1.0000
6:3285152:C:CT	acceptor_gain	1.0000
6:3285152:C:T	acceptor_gain	1.0000
6:3285153:A:T	acceptor_gain	1.0000
6:3285156:C:CT	acceptor_gain	1.0000
6:3285157:A:T	acceptor_gain	1.0000
6:3285160:C:CT	acceptor_gain	1.0000
6:3285161:G:T	acceptor_gain	1.0000
6:3286857:A:AC	donor_gain	1.0000
6:3286858:C:CC	donor_gain	1.0000
6:3289762:A:AC	donor_gain	1.0000
6:3289763:C:CC	donor_gain	1.0000
6:3289763:CG:C	donor_gain	1.0000
6:3289862:CAGCT:C	acceptor_gain	1.0000
6:3289865:CT:C	acceptor_gain	1.0000
6:3289867:C:CC	acceptor_gain	1.0000
6:3298086:CTCA:C	donor_loss	1.0000
6:3298087:TCA:T	donor_loss	1.0000
6:3298088:CACCT:C	donor_loss	1.0000
6:3298090:C:CT	donor_loss	1.0000
6:3298217:TC:T	acceptor_gain	1.0000
6:3298218:CCT:C	acceptor_gain	1.0000
6:3323833:CGA:C	donor_gain	1.0000
6:3410186:A:AC	donor_gain	1.0000
6:3410187:C:CC	donor_gain	1.0000

AlphaMissense

4453 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:3273276:A:G	C614R	0.999
6:3273371:C:T	G582D	0.999
6:3273382:G:C	S578R	0.999
6:3273382:G:T	S578R	0.999
6:3273384:T:G	S578R	0.999
6:3273399:C:G	G573R	0.999
6:3273399:C:T	G573R	0.999
6:3283852:C:A	R568M	0.999
6:3283864:G:T	P564Q	0.999
6:3283890:G:C	S555R	0.999
6:3283890:G:T	S555R	0.999
6:3283892:T:G	S555R	0.999
6:3283924:C:T	G544D	0.999
6:3283925:C:G	G544R	0.999
6:3287061:A:C	F448L	0.999
6:3287061:A:T	F448L	0.999
6:3287063:A:G	F448L	0.999
6:3298196:A:G	W369R	0.999
6:3298196:A:T	W369R	0.999
6:3323890:C:A	W342C	0.999
6:3323890:C:G	W342C	0.999
6:3415767:C:T	G248E	0.999
6:3415768:C:G	G248R	0.999
6:3415768:C:T	G248R	0.999
6:3415782:C:T	G243D	0.999
6:3415794:C:T	G239E	0.999
6:3415795:C:G	G239R	0.999
6:3415795:C:T	G239R	0.999
6:3273263:A:G	L618P	0.998
6:3273285:A:G	C611R	0.998

dbSNP variants (sampled 300 via entrez): RS1000017346 (6:3405481 C>A,T), RS1000058134 (6:3283963 C>G,T), RS1000087012 (6:3399056 G>A), RS1000138111 (6:3359440 C>T), RS1000138193 (6:3360524 C>T), RS1000159598 (6:3320469 C>G), RS1000166190 (6:3331022 G>A), RS1000171880 (6:3387578 G>A,T), RS1000197511 (6:3333475 G>A), RS1000202796 (6:3397753 C>G,T), RS1000203096 (6:3387873 G>A), RS1000205752 (6:3359081 C>G,T), RS1000235083 (6:3348692 C>T), RS1000249117 (6:3311083 G>T), RS1000253004 (6:3412116 A>G)

Disease associations

OMIM: gene MIM:611697 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

59 associations (top):

Study	Trait	p-value
GCST000822_1	Antipsychotic drug-induced QTc interval prolongation	2.000000e-07
GCST000942_1	Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN)	9.000000e-06
GCST001762_909	Obesity-related traits	1.000000e-06
GCST002248_8	Fasting insulin (dietary factor interaction)	2.000000e-06
GCST002253_10	Homeostasis model assessment of insulin resistance (dietary factor interaction)	2.000000e-06
GCST002821_13	Survival in rectal cancer	5.000000e-06
GCST004294_7	Nicotine dependence	4.000000e-06
GCST004302_12	Primary biliary cholangitis	2.000000e-07
GCST004599_40	Mean platelet volume	8.000000e-13
GCST004621_91	Red cell distribution width	5.000000e-10
GCST005141_55	Cognitive ability (MTAG)	2.000000e-09
GCST005142_6	Cognitive ability	3.000000e-06
GCST005316_633	Intelligence (MTAG)	1.000000e-11
GCST005784_1	Bone mineral density (femoral neck) in inflammatory bowel disease	1.000000e-07
GCST006269_1160	General cognitive ability	3.000000e-08
GCST006804_179	Red cell distribution width	2.000000e-08
GCST009524_105	Household income (MTAG)	3.000000e-08
GCST009524_255	Household income (MTAG)	3.000000e-11
GCST010002_46	Refractive error	2.000000e-20
GCST010796_1142	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-08
GCST010796_4376	Electrocardiogram morphology (amplitude at temporal datapoints)	6.000000e-10
GCST010796_4377	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-10
GCST010796_4378	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-09
GCST010796_4379	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-08
GCST010796_4380	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-08
GCST010796_4423	Electrocardiogram morphology (amplitude at temporal datapoints)	7.000000e-13
GCST010796_4424	Electrocardiogram morphology (amplitude at temporal datapoints)	7.000000e-11
GCST010796_4425	Electrocardiogram morphology (amplitude at temporal datapoints)	7.000000e-10
GCST010796_4451	Electrocardiogram morphology (amplitude at temporal datapoints)	5.000000e-09
GCST010796_4452	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-08

EFO canonical traits (10, from GWAS)

EFO ID	Trait name
EFO:0004520	ICAM-1 measurement
EFO:0008111	diet measurement
EFO:0004501	HOMA-IR
EFO:0000409	disease free survival
EFO:0009188	Red cell distribution width
EFO:0004337	intelligence
EFO:0004784	self reported educational attainment
EFO:0007785	femoral neck bone mineral density
EFO:0009695	household income
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Orphan or poorly characterized SLC22 family members

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	4
Valproic Acid	decreases methylation, increases expression	3
Particulate Matter	affects cotreatment, increases abundance, increases expression	3
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Aflatoxin B1	affects methylation, decreases methylation	2
aristolochic acid I	increases expression	1
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	decreases expression	1
sulforaphane	increases expression	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	affects methylation	1
nickel sulfate	increases expression	1
S-(1,2-dichlorovinyl)cysteine	decreases reaction, increases expression	1
di-n-butylphosphoric acid	affects expression	1
pseudoisocyanine	decreases reaction, increases uptake	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects methylation	1
Vehicle Emissions	increases abundance, increases expression	1
Calcitriol	increases expression	1
Cisplatin	decreases expression	1
Coumestrol	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4IZ	HCT116-SLC22A23-KO-c10	Cancer cell line	Male
CVCL_D4J0	HCT116-SLC22A23-KO-c7	Cancer cell line	Male
CVCL_TL99	HAP1 SLC22A23 (-) 1	Cancer cell line	Male
CVCL_XS97	HAP1 SLC22A23 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.