SLC22A25

Summary

SLC22A25 (solute carrier family 22 member 25, HGNC:32935) is a protein-coding gene on chromosome 11q12.3, encoding Solute carrier family 22 member 25 (Q6T423).

Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in membrane.

Source: NCBI Gene 387601 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 109 total
• MANE Select transcript: NM_199352

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32935
Approved symbol	SLC22A25
Name	solute carrier family 22 member 25
Location	11q12.3
Locus type	gene with protein product
Status	Approved
Aliases	UST6, HIMTP, MGC120420
Ensembl gene	ENSG00000196600
Ensembl biotype	protein_coding
OMIM	610792
Entrez	387601

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 nonsense_mediated_decay, 1 protein_coding

ENST00000306494, ENST00000525295, ENST00000527057, ENST00000528239

RefSeq mRNA: 3 — MANE Select: NM_199352 NM_001394058, NM_001394059, NM_199352

CCDS: CCDS31592

Canonical transcript exons

ENST00000306494 — 12 exons

Exon	Start	End
ENSE00002189703	63158437	63164073
ENSE00002216674	63238717	63239135
ENSE00002288052	63237881	63238012
ENSE00002481946	63228461	63228564
ENSE00003481244	63166044	63166258
ENSE00003553710	63180660	63180775
ENSE00003558871	63183694	63183817
ENSE00003564133	63164526	63164634
ENSE00003575894	63217581	63217735
ENSE00003654881	63217314	63217482
ENSE00003922688	63229251	63230096
ENSE00003928423	63243434	63243599

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 89.46.

Top tissues by expression

212 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	89.46	gold quality
buccal mucosa cell	CL:0002336	85.39	gold quality
liver	UBERON:0002107	84.80	gold quality
upper leg skin	UBERON:0004262	67.51	silver quality
skin of hip	UBERON:0001554	63.81	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.06	gold quality
lower lobe of lung	UBERON:0008949	54.89	silver quality
oviduct epithelium	UBERON:0004804	52.27	gold quality
lower esophagus mucosa	UBERON:0035834	49.44	gold quality
gall bladder	UBERON:0002110	46.86	gold quality
sural nerve	UBERON:0015488	43.50	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
nucleus accumbens	UBERON:0001882	42.80	gold quality
adrenal tissue	UBERON:0018303	42.62	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
vastus lateralis	UBERON:0001379	41.91	gold quality
quadriceps femoris	UBERON:0001377	41.86	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
bone marrow	UBERON:0002371	41.33	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
primary visual cortex	UBERON:0002436	41.02	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
occipital lobe	UBERON:0002021	40.70	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
prefrontal cortex	UBERON:0000451	40.42	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-75688	yes	725.18
E-ANND-3	yes	3.42
E-GEOD-130473	no	141.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• cloning of a novel human slc22 family member, UST6, expressed exclusively in liver in both embryo and adult, is reported [UST6] (PMID:15054140)
• Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier family (SLC) member 25. (PMID:18466105)
• TNFSF13, SPATC1L, SLC22A25 and SALL4 may thus be novel susceptibility loci for atrial fibrillation in the Japanese population (PMID:28849223)

Cross-species orthologs

52 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc22a4	ENSDARG00000005335
danio_rerio	oatx	ENSDARG00000019713
danio_rerio	si:dkey-166k12.1	ENSDARG00000054690
danio_rerio	slc22a15	ENSDARG00000055445
danio_rerio	si:dkey-119m7.4	ENSDARG00000071049
danio_rerio	slc22a21	ENSDARG00000094112
danio_rerio	si:dkey-119m7.8	ENSDARG00000096654
danio_rerio	slc22a5	ENSDARG00000101021
drosophila_melanogaster	Orct	FBGN0019952
drosophila_melanogaster	CG15221	FBGN0030331
drosophila_melanogaster	Balat	FBGN0033778
drosophila_melanogaster	CG4630	FBGN0033809
drosophila_melanogaster	CG5592	FBGN0035645
drosophila_melanogaster	CG10486	FBGN0035647
drosophila_melanogaster	SLC22A	FBGN0037140
drosophila_melanogaster	CG7458	FBGN0037144
drosophila_melanogaster	CG14691	FBGN0037829
drosophila_melanogaster	CG14855	FBGN0038260
drosophila_melanogaster	CG14856	FBGN0038261
drosophila_melanogaster	CG14857	FBGN0038262
drosophila_melanogaster	CG12783	FBGN0038448
drosophila_melanogaster	CG7333	FBGN0038715
drosophila_melanogaster	CG7342	FBGN0038716
drosophila_melanogaster	CG17751	FBGN0038717
drosophila_melanogaster	CG17752	FBGN0038718
drosophila_melanogaster	CG16727	FBGN0038719
drosophila_melanogaster	CG6231	FBGN0038720
drosophila_melanogaster	CG4465	FBGN0038750
drosophila_melanogaster	CG4462	FBGN0038752
drosophila_melanogaster	CG4459	FBGN0038753
drosophila_melanogaster	CG6356	FBGN0039178
drosophila_melanogaster	CG3690	FBGN0040350
drosophila_melanogaster	CG31103	FBGN0051103
drosophila_melanogaster	CG31106	FBGN0051106
drosophila_melanogaster	CG31272	FBGN0051272
drosophila_melanogaster	CG33233	FBGN0053233
drosophila_melanogaster	CG33234	FBGN0053234
drosophila_melanogaster	Orct2	FBGN0086365
drosophila_melanogaster	CG42269	FBGN0259164
drosophila_melanogaster	CG44098	FBGN0264907
caenorhabditis_elegans		WBGENE00003837
caenorhabditis_elegans	oct-1	WBGENE00003842
caenorhabditis_elegans		WBGENE00003843
caenorhabditis_elegans		WBGENE00006220
caenorhabditis_elegans		WBGENE00008110
caenorhabditis_elegans		WBGENE00011456
caenorhabditis_elegans		WBGENE00014127
caenorhabditis_elegans		WBGENE00015088
caenorhabditis_elegans		WBGENE00017751
caenorhabditis_elegans		WBGENE00019408
caenorhabditis_elegans		WBGENE00020701
caenorhabditis_elegans		WBGENE00044455

Paralogs (22): SLC22A16 (ENSG00000004809), SLC22A17 (ENSG00000092096), SLC22A2 (ENSG00000112499), SLC22A7 (ENSG00000137204), SLC22A23 (ENSG00000137266), SLC22A14 (ENSG00000144671), SLC22A3 (ENSG00000146477), SLC22A8 (ENSG00000149452), SLC22A9 (ENSG00000149742), SVOPL (ENSG00000157703), SLC22A15 (ENSG00000163393), SVOP (ENSG00000166111), SLC22A11 (ENSG00000168065), SLC22A13 (ENSG00000172940), SLC22A1 (ENSG00000175003), SLC22A10 (ENSG00000184999), SLC22A4 (ENSG00000197208), SLC22A5 (ENSG00000197375), SLC22A24 (ENSG00000197658), SLC22A12 (ENSG00000197891), SLC22A6 (ENSG00000197901), SLC22A31 (ENSG00000259803)

Protein

Protein identifiers

Solute carrier family 22 member 25 — Q6T423 (reviewed: Q6T423)

Alternative names: Organic anion transporter UST6

All UniProt accessions (4): Q6T423, E9PJ86, H0YCA2, H0YCS4

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Expressed exclusively in liver in both embryo and adult.

Similarity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

RefSeq proteins (3): NP_001380987, NP_001380988, NP_955384* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011701	MFS	Family
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF07690

UniProt features (33 total): topological domain 13, transmembrane region 12, sequence variant 5, glycosylation site 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6T423-F1	87.88	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 56, 102

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 36 (showing top): SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4, ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, MATSUDA_NATURAL_KILLER_DIFFERENTIATION, GOMF_TRANSPORTER_ACTIVITY, OHGUCHI_LIVER_HNF4A_TARGETS_DN, SERVITJA_LIVER_HNF1A_TARGETS_DN, RAO_BOUND_BY_SALL4_ISOFORM_A, IRF1_01, GSE13485_DAY1_VS_DAY3_YF17D_VACCINE_PBMC_UP, GSE17721_LPS_VS_PAM3CSK4_1H_BMDC_DN, DESCARTES_MAIN_FETAL_HEPATOBLASTS, DESCARTES_FETAL_LIVER_HEPATOBLASTS, DESCARTES_FETAL_LUNG_VASCULAR_ENDOTHELIAL_CELLS

GO Biological Process (2): obsolete organic anion transport (GO:0015711), transmembrane transport (GO:0055085)

GO Molecular Function (1): transmembrane transporter activity (GO:0022857)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	1
cellular process	1
transporter activity	1
transmembrane transport	1
cellular anatomical structure	1

Protein interactions and networks

STRING

580 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC22A25	SLC22A31	A6NKX4	624
SLC22A25	SLC67A1	Q96BI1	617
SLC22A25	SLC22A23	A1A5C7	502
SLC22A25	SLC22A15	Q8IZD6	469
SLC22A25	SLC22A17	Q8WUG5	462
SLC22A25	SLC35G4	P0C7Q5	449
SLC22A25	SLC35F6	Q8N357	446
SLC22A25	SLC35E2B	P0CK96	429
SLC22A25	SPATC1L	Q9H0A9	417
SLC22A25	SLC16A9	Q7RTY1	412
SLC22A25	SLC35G3	Q8N808	400
SLC22A25	KRTAP5-10	Q6L8G5	358
SLC22A25	SLC25A52	Q3SY17	355
SLC22A25	NEB	P20929	349
SLC22A25	SLC7A13	Q8TCU3	340

IntAct

2 interactions, top by confidence:

A	B	Type	Score
SLC22A25	PLSCR1	psi-mi:“MI:0914”(association)	0.350

BioGRID (13): SLC22A25 (Synthetic Lethality), SLC22A25 (Affinity Capture-MS), SLC22A25 (Affinity Capture-MS), CANX (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), GHITM (Affinity Capture-MS), PLSCR1 (Affinity Capture-MS), RAN (Affinity Capture-MS), REEP5 (Affinity Capture-MS), RNF5 (Affinity Capture-MS), SEL1L (Affinity Capture-MS), SYVN1 (Affinity Capture-MS), WLS (Affinity Capture-MS)

ESM2 similar proteins: A0A3Q2IDB4, A0A8B7HA97, A4ZYQ5, A6NK97, G1SZD9, O35956, O57379, O88909, P22732, P23945, P43427, Q0IHM1, Q2KIV1, Q3ZAV1, Q4U2R8, Q4W8A2, Q4W8A3, Q5R9C4, Q5RC45, Q5RCH6, Q5RET7, Q63ZE4, Q66J52, Q6DFR1, Q6NUB3, Q6NYN7, Q6PXP3, Q6T423, Q70BM6, Q76M72, Q76M99, Q80UJ1, Q863Y9, Q864Z3, Q8CFZ5, Q8HY24, Q8IVM8, Q8MK48, Q8N4F4, Q8R0S9

Diamond homologs: A0A3Q2IDB4, A0A8B7HA97, A6NK97, A6QLW8, B2GV36, G1SZD9, O34691, O35956, O57379, O75751, O88446, O88909, Q1RPP5, Q28ES4, Q2KIV1, Q3YAW7, Q3ZAV1, Q4U2R8, Q4W8A2, Q4W8A3, Q5R540, Q5R9C4, Q5RC45, Q5RCH6, Q5RLM2, Q63ZE4, Q66J52, Q66J54, Q6A4L0, Q6NYN7, Q6T423, Q70BM6, Q76M72, Q76M99, Q80UJ1, Q864Z3, Q8CFZ5, Q8HY24, Q8IVM8, Q8MK48

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

109 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	80
Likely benign	22
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1386 predictions. Top by Δscore:

Variant	Effect	Δscore
11:63183689:CTTA:C	donor_loss	1.0000
11:63183690:TTACC:T	donor_loss	1.0000
11:63183691:TA:T	donor_loss	1.0000
11:63183692:ACCT:A	donor_gain	1.0000
11:63183693:C:G	donor_loss	1.0000
11:63183693:CCT:C	donor_gain	1.0000
11:63183693:CCTC:C	donor_gain	1.0000
11:63229247:TTACC:T	donor_loss	1.0000
11:63229248:TA:T	donor_loss	1.0000
11:63229249:ACCTT:A	donor_loss	1.0000
11:63164072:CCCT:C	acceptor_gain	0.9900
11:63164073:CCT:C	acceptor_gain	0.9900
11:63164075:T:C	acceptor_gain	0.9900
11:63164088:A:T	acceptor_gain	0.9900
11:63166038:TCTCA:T	donor_loss	0.9900
11:63166039:CTCAC:C	donor_loss	0.9900
11:63166040:TCACC:T	donor_loss	0.9900
11:63166041:CA:C	donor_loss	0.9900
11:63166042:A:AG	donor_loss	0.9900
11:63166043:C:T	donor_loss	0.9900
11:63181412:T:TA	donor_gain	0.9900
11:63183692:A:AC	donor_gain	0.9900
11:63183692:ACCTC:A	donor_gain	0.9900
11:63183693:C:CC	donor_gain	0.9900
11:63183693:CCTCC:C	donor_gain	0.9900
11:63183814:CCAC:C	acceptor_gain	0.9900
11:63183815:CAC:C	acceptor_gain	0.9900
11:63183815:CACC:C	acceptor_gain	0.9900
11:63183816:ACCTG:A	acceptor_loss	0.9900
11:63183817:CCTGA:C	acceptor_loss	0.9900

AlphaMissense

3597 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:63229644:A:C	F3L	0.945
11:63229644:A:T	F3L	0.945
11:63229646:A:G	F3L	0.945
11:63229605:G:C	F16L	0.936
11:63229605:G:T	F16L	0.936
11:63229607:A:G	F16L	0.936
11:63229380:A:C	F91L	0.927
11:63229380:A:T	F91L	0.927
11:63229382:A:G	F91L	0.927
11:63229533:G:C	F40L	0.891
11:63229533:G:T	F40L	0.891
11:63229535:A:G	F40L	0.891
11:63217418:A:C	S242R	0.859
11:63217418:A:T	S242R	0.859
11:63217420:T:G	S242R	0.859
11:63166105:G:C	S408R	0.838
11:63166105:G:T	S408R	0.838
11:63166107:T:G	S408R	0.838
11:63166192:G:C	F379L	0.833
11:63166192:G:T	F379L	0.833
11:63166194:A:G	F379L	0.833
11:63217726:T:A	R172S	0.833
11:63217726:T:G	R172S	0.833
11:63217474:A:G	W224R	0.832
11:63217474:A:T	W224R	0.832
11:63183741:C:G	A303P	0.821
11:63183795:A:G	W285R	0.820
11:63183795:A:T	W285R	0.820
11:63183752:A:G	L299P	0.816
11:63217730:C:A	G171V	0.812

dbSNP variants (sampled 300 via entrez): RS1000040877 (11:63195278 C>T), RS1000064689 (11:63231599 C>T), RS1000092681 (11:63210849 G>A,C), RS1000097175 (11:63232334 G>A), RS1000132225 (11:63185109 C>T), RS1000177485 (11:63231523 G>T), RS1000177652 (11:63217011 G>A,C), RS1000225457 (11:63222036 G>A), RS1000232083 (11:63205832 C>T), RS1000310195 (11:63174495 G>C), RS1000319390 (11:63226328 T>A), RS1000319722 (11:63210543 T>G), RS1000321997 (11:63163488 G>A,T), RS1000335051 (11:63199103 C>G), RS1000368458 (11:63168819 C>T)

Disease associations

OMIM: gene MIM:610792 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010512_8	Serum uric acid levels	4.000000e-12

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004761	uric acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Orphan or poorly characterized SLC22 family members

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
perfluorooctane sulfonic acid	decreases expression	2
Benzo(a)pyrene	decreases expression, increases methylation	2
lasiocarpine	decreases expression	1
methyleugenol	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment	1
perfluoro-n-nonanoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Copper	affects cotreatment, decreases expression	1
Lipopolysaccharides	affects response to substance, increases expression, affects cotreatment	1
N-Nitrosopyrrolidine	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.