SLC24A3

Summary

SLC24A3 (solute carrier family 24 member 3, HGNC:10977) is a protein-coding gene on chromosome 20p11.23, encoding Sodium/potassium/calcium exchanger 3 (Q9HC58). Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).

Source: NCBI Gene 57419 — RefSeq curated summary.

At a glance

• GWAS associations: 56
• Clinical variants (ClinVar): 98 total
• MANE Select transcript: NM_020689

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10977
Approved symbol	SLC24A3
Name	solute carrier family 24 member 3
Location	20p11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000185052
Ensembl biotype	protein_coding
OMIM	609839
Entrez	57419

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000328041, ENST00000962751

RefSeq mRNA: 1 — MANE Select: NM_020689 NM_020689

CCDS: CCDS13140

Canonical transcript exons

ENST00000328041 — 17 exons

Exon	Start	End
ENSE00001294995	19717528	19717593
ENSE00001299918	19693259	19693425
ENSE00001300255	19280959	19281087
ENSE00001304840	19681858	19681991
ENSE00001305231	19685100	19685361
ENSE00001306774	19515488	19515564
ENSE00001308601	19665864	19665889
ENSE00001311193	19654062	19654136
ENSE00001311618	19698568	19698680
ENSE00001314541	19673601	19673654
ENSE00001319993	19720991	19722926
ENSE00001320557	19684176	19684336
ENSE00001328703	19584971	19585055
ENSE00001594215	19585441	19585544
ENSE00001669029	19696797	19696911
ENSE00001704017	19212642	19212984
ENSE00001747414	19580000	19580074

Expression profiles

Bgee: expression breadth ubiquitous, 272 present calls, max score 97.87.

FANTOM5 (CAGE): breadth broad, TPM avg 4.1154 / max 339.1804, expressed in 624 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
183706	2.0174	412
183703	1.1265	421
183705	0.5792	255
183704	0.3923	198

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lateral nuclear group of thalamus	UBERON:0002736	97.87	gold quality
tongue squamous epithelium	UBERON:0006919	95.06	gold quality
saphenous vein	UBERON:0007318	93.51	gold quality
cervix squamous epithelium	UBERON:0006922	93.27	gold quality
epithelium of esophagus	UBERON:0001976	93.20	gold quality
esophagus squamous epithelium	UBERON:0006920	93.11	gold quality
squamous epithelium	UBERON:0006914	92.89	gold quality
triceps brachii	UBERON:0001509	92.45	gold quality
gingiva	UBERON:0001828	92.32	gold quality
quadriceps femoris	UBERON:0001377	92.25	gold quality
vastus lateralis	UBERON:0001379	92.24	gold quality
gingival epithelium	UBERON:0001949	92.16	gold quality
myometrium	UBERON:0001296	91.44	gold quality
decidua	UBERON:0002450	91.24	gold quality
CA1 field of hippocampus	UBERON:0003881	90.95	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	90.91	gold quality
left uterine tube	UBERON:0001303	90.87	gold quality
body of uterus	UBERON:0009853	90.71	gold quality
gluteal muscle	UBERON:0002000	90.67	gold quality
urethra	UBERON:0000057	90.66	gold quality
cervix epithelium	UBERON:0004801	89.95	gold quality
Ammon’s horn	UBERON:0001954	89.91	gold quality
right coronary artery	UBERON:0001625	89.36	gold quality
lower esophagus mucosa	UBERON:0035834	89.24	gold quality
skeletal muscle tissue	UBERON:0001134	89.12	gold quality
cerebellar vermis	UBERON:0004720	88.34	gold quality
uterus	UBERON:0000995	88.17	gold quality
deltoid	UBERON:0001476	88.04	gold quality
popliteal artery	UBERON:0002250	87.94	gold quality
tibial artery	UBERON:0007610	87.93	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-ANND-2	yes	4909.78
E-HCAD-30	yes	356.11
E-HCAD-35	yes	63.39
E-ANND-3	yes	16.48
E-GEOD-81383	no	15.18

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

6 targets.

Target	Regulation
CALB1	Repression
NR3C1	Repression
PTH1R	Activation
S100G	Activation
TRPV5	Repression
TRPV6	Activation

Upstream regulators (CollecTRI, top): GATA3

miRNA regulators (miRDB)

142 targeting SLC24A3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502

Literature-anchored findings (GeneRIF, showing 2)

• Plasma membrane ion transporter.Displayed K(+)-dependent Na(+)/Ca(2+) exchanger activity when assayed in heterologous expression systems, using digital imaging of fura-2 fluorescence, electrophysiology, or radioactive (45)Ca(2+) uptake. (PMID:11294880)
• NCKX3 is abundantly expressed within the human endometrium at the transcriptional and translational levels, and its level is regulated by steroid hormones (particularly estradiol) during the human menstrual cycle. (PMID:21321244)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc24a3	ENSDARG00000006760
mus_musculus	Slc24a3	ENSMUSG00000063873
rattus_norvegicus	Slc24a3	ENSRNOG00000060687
drosophila_melanogaster	CG17167	FBGN0039941
drosophila_melanogaster	CG12061	FBGN0040031
drosophila_melanogaster	zyd	FBGN0265767

Paralogs (4): SLC24A1 (ENSG00000074621), SLC24A4 (ENSG00000140090), SLC24A2 (ENSG00000155886), SLC24A5 (ENSG00000188467)

Protein

Protein identifiers

Sodium/potassium/calcium exchanger 3 — Q9HC58 (reviewed: Q9HC58)

Alternative names: Na(+)/K(+)/Ca(2+)-exchange protein 3, Solute carrier family 24 member 3

All UniProt accessions (1): Q9HC58

UniProt curated annotations — full annotation on UniProt →

Function. Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Subcellular location. Cell membrane.

Tissue specificity. Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine.

Similarity. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.

RefSeq proteins (1): NP_065740* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004481	K/Na/Ca-exchanger	Family
IPR004837	NaCa_Exmemb	Domain
IPR044880	NCX_ion-bd_dom_sf	Homologous_superfamily

Pfam: PF01699

Catalyzed reactions (Rhea), 1 shown:

• Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out) (RHEA:69967)

UniProt features (34 total): topological domain 11, transmembrane region 10, sequence variant 4, repeat 2, glycosylation site 2, signal peptide 1, chain 1, region of interest 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HC58-F1	70.31	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 308

Glycosylation sites (2): 71, 86

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-425561	Sodium/Calcium exchangers
R-HSA-382551	Transport of small molecules
R-HSA-425393
R-HSA-425407	SLC-mediated transmembrane transport

MSigDB gene sets: 223 (showing top): GOBP_POTASSIUM_ION_TRANSPORT, RNGTGGGC_UNKNOWN, CLAUS_PGR_POSITIVE_MENINGIOMA_UP, ELVIDGE_HYPOXIA_DN, RRAGTTGT_UNKNOWN, AAGCAAT_MIR137, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_SODIUM_ION_TRANSMEMBRANE_TRANSPORT, GCANCTGNY_MYOD_Q6, AREB6_03, GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, CAGCTG_AP4_Q5, GOBP_MONOATOMIC_CATION_TRANSPORT

GO Biological Process (13): monoatomic ion transport (GO:0006811), intracellular calcium ion homeostasis (GO:0006874), positive regulation of gene expression (GO:0010628), negative regulation of gene expression (GO:0010629), bone mineralization (GO:0030282), sodium ion transmembrane transport (GO:0035725), calcium ion transmembrane transport (GO:0070588), potassium ion transmembrane transport (GO:0071805), transport across blood-brain barrier (GO:0150104), potassium ion transport (GO:0006813), sodium ion transport (GO:0006814), calcium ion transport (GO:0006816), transmembrane transport (GO:0055085)

GO Molecular Function (4): calcium channel activity (GO:0005262), calcium, potassium:sodium antiporter activity (GO:0008273), symporter activity (GO:0015293), antiporter activity (GO:0015297)

GO Cellular Component (3): plasma membrane (GO:0005886), cell periphery (GO:0071944), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Metal ion SLC transporters	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
monoatomic cation transmembrane transport	3
metal ion transport	3
transport	2
gene expression	2
regulation of gene expression	2
secondary active transmembrane transporter activity	2
cellular anatomical structure	2
intracellular monoatomic cation homeostasis	1
calcium ion homeostasis	1
positive regulation of macromolecule biosynthetic process	1
negative regulation of macromolecule biosynthetic process	1
ossification	1
biomineral tissue development	1
sodium ion transport	1
calcium ion transport	1
potassium ion transport	1
vascular transport	1
cellular process	1
monoatomic cation channel activity	1
calcium ion transmembrane transporter activity	1
calcium:sodium antiporter activity	1
solute:potassium antiporter activity	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

1301 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC24A3	OR8G5	Q8NG78	514
SLC24A3	ZNF133	P52736	494
SLC24A3	RBBP9	O75884	488
SLC24A3	DENND5B	Q6ZUT9	443
SLC24A3	ITFG1	Q8TB96	433
SLC24A3	TMEM212	A6NML5	428
SLC24A3	KCNK18	Q7Z418	421
SLC24A3	KAT14	Q9H8E8	418
SLC24A3	KCNK5	O95279	417
SLC24A3	CDC42EP1	Q00587	401
SLC24A3	KCNK10	P57789	395
SLC24A3	CCDC15	Q0P6D6	390
SLC24A3	CFAP61	Q8NHU2	389
SLC24A3	SPATC1	Q76KD6	380
SLC24A3	AKT3	Q9Y243	371

IntAct

3 interactions, top by confidence:

A	B	Type	Score
SLC24A3	GPR89A	psi-mi:“MI:0914”(association)	0.350
SLC24A3	SNRPGP15	psi-mi:“MI:0914”(association)	0.350

BioGRID (48): FADS1 (Affinity Capture-MS), SLC30A5 (Affinity Capture-MS), UBXN8 (Affinity Capture-MS), NAT14 (Affinity Capture-MS), GPR89A (Affinity Capture-MS), ELOVL4 (Affinity Capture-MS), SLC35B2 (Affinity Capture-MS), LDHC (Affinity Capture-MS), MTX3 (Affinity Capture-MS), PXMP2 (Affinity Capture-MS), LPCAT3 (Affinity Capture-MS), HMGCR (Affinity Capture-MS), SYVN1 (Affinity Capture-MS), DPY19L1 (Affinity Capture-MS), SLC30A6 (Affinity Capture-MS)

ESM2 similar proteins: A2WR31, A2X5B4, A2XGM7, A2YQB8, A2ZIM4, A8XI14, B8A833, B8AYH1, B8BKP4, F4IJ08, O45102, O82587, P0DI37, P0DKJ4, P0DKJ5, P93332, Q0D2K0, Q0DJY3, Q10LI8, Q10LN5, Q19VE6, Q2QR07, Q2QWX8, Q2R3P9, Q5JJY5, Q5N8J1, Q5NAZ9, Q60EC2, Q6K602, Q6L8F9, Q6NQN5, Q6YZF3, Q6Z1Y7, Q7RTP0, Q84WN3, Q8BZF2, Q8LBF7, Q8LFH5, Q8RZQ8, Q99PD7

Diamond homologs: B8K1V7, O22252, O54701, P23685, P32418, P48765, P48766, P48767, P48768, P57103, P70414, P70549, Q01728, Q2R041, Q6H641, Q8BUN9, Q8CGQ8, Q8K596, Q8NFF2, Q99PD7, Q9EPQ0, Q9HC58, Q9UI40, Q9UPR5, Q9VDG5, Q9VN12, S4R2P9, F1NXU8, O04034, O16242, P87122, Q49SH1, Q6AXS0, Q71RS6, Q925Q3, Q9FKP1, Q9FKP2, Q9U6A0, P34315, P34322

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
SLC24A3	“down-regulates quantity”	calcium(2+)	relocalization
SLC24A3	“down-regulates quantity”	potassium(1+)	relocalization
SLC24A3	“up-regulates quantity”	sodium(1+)	relocalization

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	83
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

5086 predictions. Top by Δscore:

Variant	Effect	Δscore
20:19212980:GAAGG:G	donor_gain	1.0000
20:19212983:GG:G	donor_gain	1.0000
20:19212984:GG:G	donor_gain	1.0000
20:19212985:G:GA	donor_loss	1.0000
20:19212986:T:A	donor_loss	1.0000
20:19280954:CCCA:C	acceptor_loss	1.0000
20:19280956:CAGA:C	acceptor_loss	1.0000
20:19280957:A:AG	acceptor_gain	1.0000
20:19280958:G:GA	acceptor_gain	1.0000
20:19280958:GA:G	acceptor_gain	1.0000
20:19280958:GAGC:G	acceptor_gain	1.0000
20:19280958:GAGCT:G	acceptor_gain	1.0000
20:19281083:ACCAG:A	donor_loss	1.0000
20:19281084:CCAG:C	donor_loss	1.0000
20:19281085:CAG:C	donor_loss	1.0000
20:19281086:AG:A	donor_loss	1.0000
20:19281087:GG:G	donor_loss	1.0000
20:19281088:GTAAC:G	donor_loss	1.0000
20:19281089:T:A	donor_loss	1.0000
20:19515486:A:AG	acceptor_gain	1.0000
20:19515487:G:GG	acceptor_gain	1.0000
20:19579994:TTCCA:T	acceptor_loss	1.0000
20:19579995:TCCAG:T	acceptor_loss	1.0000
20:19579996:CCA:C	acceptor_loss	1.0000
20:19579997:CAG:C	acceptor_loss	1.0000
20:19579998:A:AG	acceptor_gain	1.0000
20:19579998:AG:A	acceptor_gain	1.0000
20:19579998:AGGC:A	acceptor_loss	1.0000
20:19579999:G:A	acceptor_loss	1.0000
20:19579999:G:GA	acceptor_gain	1.0000

AlphaMissense

4263 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:19515500:T:G	F95C	1.000
20:19580022:T:C	L124P	1.000
20:19580034:G:A	C128Y	1.000
20:19580035:T:G	C128W	1.000
20:19584996:C:A	A150D	1.000
20:19584998:G:A	G151R	1.000
20:19584998:G:C	G151R	1.000
20:19584998:G:T	G151W	1.000
20:19584999:G:A	G151E	1.000
20:19585005:C:A	T153K	1.000
20:19585012:G:A	M155I	1.000
20:19585012:G:C	M155I	1.000
20:19585012:G:T	M155I	1.000
20:19585019:G:A	G158R	1.000
20:19585019:G:C	G158R	1.000
20:19585020:G:A	G158E	1.000
20:19585022:A:C	S159R	1.000
20:19585024:T:A	S159R	1.000
20:19585024:T:G	S159R	1.000
20:19585029:C:A	A161D	1.000
20:19585032:C:A	P162Q	1.000
20:19585038:T:C	L164P	1.000
20:19585485:G:C	G185R	1.000
20:19585486:G:A	G185D	1.000
20:19585497:T:C	F189L	1.000
20:19585499:C:A	F189L	1.000
20:19585499:C:G	F189L	1.000
20:19585502:C:A	N190K	1.000
20:19585502:C:G	N190K	1.000
20:19585519:G:A	G196D	1.000

dbSNP variants (sampled 300 via entrez): RS1000005342 (20:19507318 G>C), RS1000007644 (20:19513753 C>G,T), RS1000017187 (20:19305864 C>T), RS1000023847 (20:19696596 T>C), RS1000026385 (20:19475863 T>G), RS1000028680 (20:19583449 G>A), RS1000029248 (20:19360333 C>G), RS1000033106 (20:19661661 A>G), RS1000034434 (20:19267673 C>A,G,T), RS1000037094 (20:19340218 C>T), RS1000037433 (20:19644026 A>G), RS1000037931 (20:19347699 T>C), RS1000048307 (20:19306108 C>A), RS1000049637 (20:19260435 C>G), RS1000061549 (20:19715190 G>A)

Disease associations

OMIM: gene MIM:609839 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

56 associations (top):

Study	Trait	p-value
GCST000450_3	Matrix metalloproteinase levels	3.000000e-07
GCST001113_9	Age at smoking initiation in chronic obstructive pulmonary disease	3.000000e-06
GCST001444_18	Pulmonary function decline	3.000000e-06
GCST002211_5	Psychosis (atypical)	1.000000e-06
GCST003720_27	Migraine	2.000000e-19
GCST003811_3	Response to citalopram or escitalopram and depression	7.000000e-07
GCST003986_6	Migraine	2.000000e-15
GCST004031_7	QT interval (sulfonylurea treatment interaction)	1.000000e-07
GCST004141_1	Body fat mass	2.000000e-09
GCST004278_10	Pulse pressure	2.000000e-13
GCST004599_209	Mean platelet volume	4.000000e-11
GCST006009_11	Pulse pressure	1.000000e-08
GCST006035_18	Breast cancer and/or colorectal cancer	9.000000e-06
GCST006431_13	Plasma parathyroid hormone levels	7.000000e-07
GCST006631_27	Nicotine dependence and major depression (severity of comorbidity)	9.000000e-06
GCST007096_246	Pulse pressure	3.000000e-15
GCST007097_86	Pulse pressure	6.000000e-06
GCST007268_68	Diastolic blood pressure	9.000000e-11
GCST007269_140	Pulse pressure	9.000000e-24
GCST007637_5	Diffusing capacity of carbon monoxide	9.000000e-06
GCST007705_4	Pulse pressure	3.000000e-06
GCST007705_6	Pulse pressure	1.000000e-06
GCST007705_60	Pulse pressure	6.000000e-08
GCST008141_7	HDL cholesterol	4.000000e-06
GCST008512_39	Multisite chronic pain	4.000000e-10
GCST009391_451	Metabolite levels	2.000000e-06
GCST009963_20	Cataracts (operation)	7.000000e-40
GCST010105_204	Nicotine dependence symptom count	3.000000e-06
GCST010105_50	Nicotine dependence symptom count	3.000000e-06
GCST012013_18	Cataracts	2.000000e-51

EFO canonical traits (15, from GWAS)

EFO ID	Trait name
EFO:0004744	matrix metalloproteinase measurement
EFO:0005670	smoking initiation
EFO:0004713	FEV/FVC ratio
EFO:0004682	QT interval
EFO:0007922	response to sulfonylurea
EFO:0005763	pulse pressure measurement
EFO:0007006	depressive symptom measurement
EFO:0009262	nicotine dependence symptom count
EFO:0006336	diastolic blood pressure
EFO:0009369	diffusing capacity of the lung for carbon monoxide
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0010100	multisite chronic pain
EFO:0010521	phosphocreatine measurement
EFO:0004309	platelet count
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC24 family of sodium/potassium/calcium exchangers

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects expression, affects methylation, decreases expression	3
Valproic Acid	increases expression, affects expression, affects cotreatment	3
entinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Estradiol	decreases expression, affects cotreatment	2
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression, increases expression	2
fluorene-9-bisphenol	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases methylation	1
sodium arsenite	affects methylation	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	increases methylation	1
Decitabine	decreases expression, decreases reaction	1
Sunitinib	increases expression	1
Arsenic Trioxide	increases expression	1
Allergens	increases expression	1
Lead	affects expression	1
Lipopolysaccharides	decreases expression, affects cotreatment	1
Smoke	decreases expression, decreases reaction	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Triclosan	increases expression	1
1-Methyl-4-phenylpyridinium	decreases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	increases expression	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.