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SLC25A14

gene
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Also known as BMCP1UCP5

Summary

SLC25A14 (solute carrier family 25 member 14, HGNC:10984) is a protein-coding gene on chromosome Xq26.1, encoding Brain mitochondrial carrier protein 1 (O95258). Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates.

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4.

Source: NCBI Gene 9016 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 101 total
  • MANE Select transcript: NM_001282195

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:10984
Approved symbolSLC25A14
Namesolute carrier family 25 member 14
LocationXq26.1
Locus typegene with protein product
StatusApproved
AliasesBMCP1, UCP5
Ensembl geneENSG00000102078
Ensembl biotypeprotein_coding
OMIM300242
Entrez9016

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 8 protein_coding_CDS_not_defined, 7 protein_coding

ENST00000218197, ENST00000339231, ENST00000361980, ENST00000424447, ENST00000464184, ENST00000464342, ENST00000465988, ENST00000467346, ENST00000467496, ENST00000471795, ENST00000478474, ENST00000495156, ENST00000543953, ENST00000545805, ENST00000612248

RefSeq mRNA: 4 — MANE Select: NM_001282195 NM_001282195, NM_001282196, NM_001282197, NM_001282198

CCDS: CCDS14623, CCDS14624, CCDS76020, CCDS76021

Canonical transcript exons

ENST00000545805 — 11 exons

ExonStartEnd
ENSE00003484613130371564130371644
ENSE00003533313130349251130349345
ENSE00003554954130358640130358735
ENSE00003577591130350646130350731
ENSE00003592341130364628130364752
ENSE00003619948130346544130346691
ENSE00003651437130365541130365676
ENSE00003658911130345182130345275
ENSE00003846602130339919130339976
ENSE00003849862130372909130373357
ENSE00003891622130340107130340353

Expression profiles

Bgee: expression breadth ubiquitous, 277 present calls, max score 97.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.6473 / max 132.9588, expressed in 1730 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
1975504.33991630
1975512.30741180

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
secondary oocyteCL:000065597.99gold quality
oocyteCL:000002395.91gold quality
middle temporal gyrusUBERON:000277194.63gold quality
endothelial cellCL:000011594.41gold quality
Brodmann (1909) area 23UBERON:001355494.35gold quality
spermCL:000001993.90gold quality
male germ cellCL:000001593.67gold quality
right uterine tubeUBERON:000130293.23gold quality
pituitary glandUBERON:000000792.91gold quality
adenohypophysisUBERON:000219692.69gold quality
tongue squamous epitheliumUBERON:000691991.03silver quality
epithelium of nasopharynxUBERON:000195190.72gold quality
Brodmann (1909) area 9UBERON:001354090.71gold quality
nasopharynxUBERON:000172890.70gold quality
nucleus accumbensUBERON:000188290.44gold quality
cerebellar hemisphereUBERON:000224590.27gold quality
bronchial epithelial cellCL:000232890.23gold quality
cerebellar cortexUBERON:000212990.22gold quality
epithelium of bronchusUBERON:000203190.01gold quality
primary visual cortexUBERON:000243690.01gold quality
right hemisphere of cerebellumUBERON:001489089.97gold quality
germinal epithelium of ovaryUBERON:000130489.88gold quality
type B pancreatic cellCL:000016989.82gold quality
bronchusUBERON:000218589.60gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099189.51gold quality
gingival epitheliumUBERON:000194989.37silver quality
hair follicleUBERON:000207389.36gold quality
olfactory bulbUBERON:000226489.21gold quality
cerebellumUBERON:000203789.01gold quality
occipital lobeUBERON:000202188.88gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-MTAB-6379no299.29
E-ANND-3no0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F4

Literature-anchored findings (GeneRIF, showing 9)

  • expressed in skeletal muscle as three different isoforms; expression level of UCP5SI positively correlated with resting metabolic rate and lipid oxidation rate during a euglycemic clamp with infusion of insulin at a physiologic concentration (PMID:12051969)
  • UCP5 might be physiologically important in the pathology of oxidative stress-induced neurodegeneration (PMID:16941493)
  • These findings suggest that UCP2 and UCP4 have a modest but important involvement in the genetic etiology of schizophrenia. (PMID:17066476)
  • The brain may respond to neuroprotection through the increased expression of UCP5 under ischemic conditions. (PMID:18018477)
  • The enhanced level of UCP5 is associated to mitochondrial dysfunction in colonic cells. (PMID:19910678)
  • observed significant associations between genetic variants in the SIRT6 and UCP5 genes and atherosclerotic plaque (PMID:22087257)
  • Neuronal UCP5 exhibits transmembrane chloride transport activity. (PMID:22524567)
  • Compares and contrasts all the known human SLC25A* genes and includes functional information. (PMID:23266187)
  • Increased expression of cerebral UCP5 and UCP4 is observed in a model of high altitude hypoxia and mitochondrial oxidative phosphorylation deficiency. (PMID:23266757)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusSlc25a14ENSMUSG00000031105
rattus_norvegicusSlc25a14ENSRNOG00000006871

Paralogs (49): SLC25A13 (ENSG00000004864), SLC25A5 (ENSG00000005022), SLC25A39 (ENSG00000013306), SLC25A40 (ENSG00000075303), SLC25A3 (ENSG00000075415), SLC25A43 (ENSG00000077713), SLC25A24 (ENSG00000085491), SLC25A1 (ENSG00000100075), SLC25A17 (ENSG00000100372), SLC25A15 (ENSG00000102743), SLC25A11 (ENSG00000108528), UCP1 (ENSG00000109424), SLC25A36 (ENSG00000114120), SLC25A12 (ENSG00000115840), SLC25A2 (ENSG00000120329), SLC25A51 (ENSG00000122696), SLC25A16 (ENSG00000122912), SLC25A35 (ENSG00000125434), SLC25A19 (ENSG00000125454), SLC25A23 (ENSG00000125648), SLC25A47 (ENSG00000140107), SLC25A52 (ENSG00000141437), SLC25A38 (ENSG00000144659), SLC25A26 (ENSG00000144741), SLC25A48 (ENSG00000145832), SLC25A37 (ENSG00000147454), SLC25A25 (ENSG00000148339), SLC25A31 (ENSG00000151475), SLC25A4 (ENSG00000151729), SLC25A27 (ENSG00000153291), SLC25A28 (ENSG00000155287), SLC25A44 (ENSG00000160785), SLC25A45 (ENSG00000162241), SLC25A34 (ENSG00000162461), SLC25A32 (ENSG00000164933), SLC25A6 (ENSG00000169100), SLC25A33 (ENSG00000171612), SLC25A30 (ENSG00000174032), UCP3 (ENSG00000175564), UCP2 (ENSG00000175567)

Protein

Protein identifiers

Brain mitochondrial carrier protein 1 — O95258 (reviewed: O95258)

Alternative names: Mitochondrial uncoupling protein 5, Solute carrier family 25 member 14

All UniProt accessions (3): O95258, F6SL11, Q5JY88

UniProt curated annotations — full annotation on UniProt →

Function. Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide. Also can mediate a very low unidirectional transport of anions including sulfate, phosphate, (S)-malate, citrate, L-aspartate and L-glutamate. Maintains oxidative balance (through uncoupling activities) and ATP production (by modifying mitochondrial membrane potential). Is able to transport protons across lipid membranes. Also exhibits transmembrane chloride transport activity to a lesser extent. May modify mitochondrial respiratory efficiency and mitochondrial oxidant production.

Subunit / interactions. Homotetramer.

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Mainly expressed in brain. Some expression in testis and pituitary.

Activity regulation. Increased activity at pH lower than 8.0. sulfate/sulfate exchange activity is inhibited strongly by pyridoxal 5’-phosphate, bathophenanthroline and the organic mercurials mersalyl, p-chloromercuribenzoate and HgCl2. Proton conductance is activated by cardiolipin and long-chain free fatty acids and inhibited by purine nucleotides ATP and ADP. Chloride ion transporter activity is inhibited by long-chain free fatty acids.

Similarity. Belongs to the mitochondrial carrier (TC 2.A.29) family.

Isoforms (3)

UniProt IDNamesCanonical?
O95258-11, UCP5Lyes
O95258-22, UCP5S
O95258-33, UCP5SI

RefSeq proteins (4): NP_001269124, NP_001269125, NP_001269126, NP_001269127 (=MANE)

Domains & families (InterPro)

IDNameType
IPR002067MCPFamily
IPR018108MCP_transmembraneRepeat
IPR023395MCP_dom_sfHomologous_superfamily
IPR050391Mito_Metabolite_TransporterFamily

Pfam: PF00153

Catalyzed reactions (Rhea), 12 shown:

  • chloride(in) = chloride(out) (RHEA:29823)
  • phosphate(in) = phosphate(out) (RHEA:32823)
  • citrate(in) = citrate(out) (RHEA:33183)
  • H(+)(in) = H(+)(out) (RHEA:34979)
  • sulfate(in) = sulfate(out) (RHEA:34983)
  • L-aspartate(out) = L-aspartate(in) (RHEA:66332)
  • L-glutamate(out) = L-glutamate(in) (RHEA:66336)
  • (S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in) (RHEA:71615)
  • sulfate(out) + phosphate(in) = sulfate(in) + phosphate(out) (RHEA:71631)
  • oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in) (RHEA:72275)
  • malonate(in) + sulfate(out) = malonate(out) + sulfate(in) (RHEA:73195)
  • maleate(in) + sulfate(out) = maleate(out) + sulfate(in) (RHEA:73199)

UniProt features (13 total): transmembrane region 6, repeat 3, splice variant 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-O95258-F178.820.25

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-167826The fatty acid cycling model

MSigDB gene sets: 155 (showing top): E2F4DP1_01, ENK_UV_RESPONSE_KERATINOCYTE_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN, MODULE_493, GOBP_INORGANIC_ANION_TRANSPORT, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, E2F_Q3, GOBP_CHLORIDE_TRANSPORT, DOANE_RESPONSE_TO_ANDROGEN_DN, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOCC_MITOCHONDRIAL_ENVELOPE, GOMF_PROTON_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GATA1_03, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P

GO Biological Process (6): aerobic respiration (GO:0009060), inorganic anion transport (GO:0015698), regulation of cellular response to oxidative stress (GO:1900407), transmembrane transport (GO:0055085), chloride transmembrane transport (GO:1902476), proton transmembrane transport (GO:1902600)

GO Molecular Function (5): solute:inorganic anion antiporter activity (GO:0005452), proton transmembrane transporter activity (GO:0015078), chloride transmembrane transporter activity (GO:0015108), transmembrane transporter activity (GO:0022857), protein homodimerization activity (GO:0042803)

GO Cellular Component (4): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Mitochondrial Uncoupling1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
transport2
cellular respiration1
cellular response to oxidative stress1
regulation of cellular response to stress1
regulation of response to oxidative stress1
cellular process1
chloride transport1
monoatomic anion transmembrane transport1
monoatomic cation transmembrane transport1
antiporter activity1
monoatomic cation transmembrane transporter activity1
proton transmembrane transport1
monoatomic anion transmembrane transporter activity1
chloride transmembrane transport1
transporter activity1
transmembrane transport1
identical protein binding1
protein dimerization activity1
cytoplasm1
intracellular membrane-bounded organelle1
organelle inner membrane1
mitochondrial membrane1
membrane1
cell periphery1
cellular anatomical structure1

Protein interactions and networks

STRING

740 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
SLC25A14OPN1LWP04000668
SLC25A14PARK7Q99497648
SLC25A14NYXQ9GZU5636
SLC25A14GPX7Q96SL4569
SLC25A14GPX8Q8TED1569
SLC25A14GPX6P59796567
SLC25A14GPX5O75715567
SLC25A14GPX2P18283566
SLC25A14GPX3P22352561
SLC25A14ACO2Q99798539
SLC25A14PPIFP30405500
SLC25A14PXDNLA1KZ92475
SLC25A14PXDNQ92626474
SLC25A14FRMD7Q6ZUT3468
SLC25A14SOX3P35714468

IntAct

34 interactions, top by confidence:

ABTypeScore
POLR3EPOLR3Apsi-mi:“MI:0914”(association)0.730
TOR1AIP2TMEM223psi-mi:“MI:0914”(association)0.530
BTN2A1POTEFpsi-mi:“MI:0914”(association)0.530
VSIG4TCAF2psi-mi:“MI:0914”(association)0.530
LAMP3METTL15psi-mi:“MI:0914”(association)0.530
PDCD1RTL8Cpsi-mi:“MI:0914”(association)0.530
IMPDH1BCAT2psi-mi:“MI:0914”(association)0.530
SDF4GTPBP6psi-mi:“MI:0914”(association)0.530
SPACA1ESYT2psi-mi:“MI:0914”(association)0.350
SV2AILVBLpsi-mi:“MI:0914”(association)0.350
LRRC25POTEFpsi-mi:“MI:0914”(association)0.350
MAGEA8METTL15psi-mi:“MI:0914”(association)0.350
OPRL1METTL15psi-mi:“MI:0914”(association)0.350
MGARPRTL8Cpsi-mi:“MI:0914”(association)0.350
GLMPRTL8Cpsi-mi:“MI:0914”(association)0.350
EDEM2HACD1psi-mi:“MI:0914”(association)0.350
CD79BGOLIM4psi-mi:“MI:0914”(association)0.350
GPR12TLCD2psi-mi:“MI:0914”(association)0.350
FAM131BUQCRQpsi-mi:“MI:0914”(association)0.350
CD3DCLGNpsi-mi:“MI:0914”(association)0.350
MUC20RAD51Bpsi-mi:“MI:0914”(association)0.350
UPK2NRP2psi-mi:“MI:0914”(association)0.350
PMELMAN1A2psi-mi:“MI:0914”(association)0.350
CACNG6TSPAN3psi-mi:“MI:0914”(association)0.350
WFDC11PLXNA2psi-mi:“MI:0914”(association)0.350
SPOCK2VPS4Bpsi-mi:“MI:0914”(association)0.350
HS3ST4IPO13psi-mi:“MI:0914”(association)0.350
TMPRSS5SLC25A14psi-mi:“MI:0914”(association)0.350
TOR1AIP2XPO1psi-mi:“MI:0914”(association)0.350

BioGRID (74): SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS), SLC25A14 (Affinity Capture-MS)

ESM2 similar proteins: A0JN87, A6QR09, F1R4U0, F1RFX9, O22261, O43772, O43808, O70579, O77792, O95258, O97562, O97649, P55851, P55916, P56499, P56501, P70406, P97521, Q08DK4, Q287T7, Q3SZI5, Q4V9P0, Q5R5A8, Q5RD81, Q5RFB7, Q5U680, Q5ZKP7, Q641C8, Q66H23, Q6DG32, Q6GLA2, Q6IZB5, Q70HW3, Q8BMG8, Q8HXY2, Q8R0Z5, Q920G8, Q922G0, Q95J75, Q96A46

Diamond homologs: A0JN87, A2A3V2, A4RPU0, F1LZW6, G3YAF3, G3YFS7, O04200, O43772, O77792, O95258, O97649, P16260, P33303, P39953, P97521, Q03028, Q08DK7, Q12482, Q3ZBJ8, Q54FE6, Q54RB9, Q54S10, Q55GE2, Q5HZE0, Q5RFB7, Q68F18, Q6GLJ0, Q6PGY3, Q75AH6, Q7DNC3, Q86AV5, Q86I81, Q8BL03, Q8BZ09, Q8HXW2, Q8HXY2, Q8WUT9, Q93XM7, Q99297, Q99JD3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

101 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance1
Likely benign2
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1515 predictions. Top by Δscore:

VariantEffectΔscore
X:130346538:TTATA:Tacceptor_loss1.0000
X:130346539:TATA:Tacceptor_loss1.0000
X:130346541:TA:Tacceptor_loss1.0000
X:130346542:A:ACacceptor_loss1.0000
X:130346542:A:AGacceptor_gain1.0000
X:130346542:AG:Aacceptor_gain1.0000
X:130346543:G:Cacceptor_loss1.0000
X:130346543:G:GGacceptor_gain1.0000
X:130346543:GG:Gacceptor_gain1.0000
X:130346632:G:Tdonor_gain1.0000
X:130346666:G:GTdonor_gain1.0000
X:130346667:A:Tdonor_gain1.0000
X:130346690:GG:Gdonor_gain1.0000
X:130346691:GG:Gdonor_gain1.0000
X:130349248:CAG:Cacceptor_loss1.0000
X:130349249:A:AGacceptor_gain1.0000
X:130349249:AG:Aacceptor_loss1.0000
X:130349250:G:GAacceptor_gain1.0000
X:130349250:GA:Gacceptor_gain1.0000
X:130349250:GAA:Gacceptor_gain1.0000
X:130349250:GAAT:Gacceptor_gain1.0000
X:130349250:GAATT:Gacceptor_gain1.0000
X:130349342:GAAG:Gdonor_gain1.0000
X:130349347:T:Gdonor_loss1.0000
X:130358633:A:AGacceptor_gain1.0000
X:130358638:A:AGacceptor_gain1.0000
X:130358639:G:GAacceptor_gain1.0000
X:130358639:GA:Gacceptor_gain1.0000
X:130358639:GATT:Gacceptor_gain1.0000
X:130358639:GATTC:Gacceptor_gain1.0000

AlphaMissense

2125 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
X:130346569:A:CK65N1.000
X:130346569:A:TK65N1.000
X:130346577:T:CL68P1.000
X:130364628:G:CG199R1.000
X:130364644:C:AA204D1.000
X:130364649:C:AR206S1.000
X:130364650:G:CR206P1.000
X:130364656:C:AA208D1.000
X:130364699:G:CK222N1.000
X:130364699:G:TK222N1.000
X:130345248:G:CG48R0.999
X:130345255:C:AA50D0.999
X:130345267:C:AA54D0.999
X:130346558:G:CD62H0.999
X:130346559:A:GD62G0.999
X:130346562:T:CL63P0.999
X:130346567:A:GK65E0.999
X:130346568:A:TK65I0.999
X:130346574:G:CR67P0.999
X:130346691:G:AG106E0.999
X:130349271:G:CR113T0.999
X:130349271:G:TR113I0.999
X:130349272:A:CR113S0.999
X:130349272:A:TR113S0.999
X:130349285:G:CG118R0.999
X:130350675:G:AG148R0.999
X:130350675:G:CG148R0.999
X:130350675:G:TG148W0.999
X:130350676:G:AG148E0.999
X:130350687:G:AG152R0.999

dbSNP variants (sampled 300 via entrez): RS1000082474 (X:130359528 T>C), RS1000198001 (X:130354654 A>G), RS1000220450 (X:130360989 A>G), RS1000275855 (X:130343481 A>C,G), RS1000352631 (X:130365443 G>T), RS1000700043 (X:130373569 A>C), RS1000812304 (X:130373391 C>T), RS1000821118 (X:130363279 A>G,T), RS1000873456 (X:130347648 G>A), RS1000891638 (X:130366119 T>C), RS1000979601 (X:130349212 A>G), RS1001015283 (X:130340988 T>C), RS1001017785 (X:130362217 A>C,G), RS1001208225 (X:130357928 AAC>A), RS1001220194 (X:130356824 A>C)

Disease associations

OMIM: gene MIM:300242 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

4 variants.

VariantGenesLevelScore#Clin annotsDrugs
rs1010978SLC25A140.000
rs2235800SLC25A140.000
rs2239483SLC25A140.000
rs5977250SLC25A140.000

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Mitochondrial uncoupling proteins

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

ChemicalActions (top 5)PubMed papers
1-Methyl-4-phenylpyridiniumincreases expression, decreases reaction, increases reaction, increases abundance, decreases response to substance3
Leflunomidedecreases expression2
triphenyl phosphateaffects expression1
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphateaffects expression, affects response to substance1
di-n-butylphosphoric acidaffects expression1
Acetaminophenincreases expression1
Adenosine Triphosphatedecreases chemical synthesis1
Air Pollutantsincreases abundance, increases expression1
Atrazinedecreases expression1
Benzo(a)pyreneaffects methylation, decreases methylation1
Cisplatinincreases expression1
Dactinomycindecreases reaction, increases expression1
Dopaminedecreases reaction, increases expression, increases abundance, decreases response to substance1
Doxorubicindecreases expression1
Methyl Methanesulfonateincreases expression1
Smokeincreases expression, increases abundance1
Superoxidesincreases abundance, decreases reaction1
Tobacco Smoke Pollutiondecreases expression1
Tunicamycinincreases expression1
Valproic Acidaffects expression1
Cyclosporinedecreases expression1
Fenretinideincreases expression1
Okadaic Acidincreases expression1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_D4CLHCT116-SLC25A14-KO-c10Cancer cell lineMale
CVCL_D4CMHCT116-SLC25A14-KO-c11Cancer cell lineMale
CVCL_TM13HAP1 SLC25A14 (-) 1Cancer cell lineMale
CVCL_TM14HAP1 SLC25A14 (-) 2Cancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 76

This page pulls from 76 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgtopdb_interactiongwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot