SLC25A16

Summary

SLC25A16 (solute carrier family 25 member 16, HGNC:10986) is a protein-coding gene on chromosome 10q21.3, encoding Mitochondrial coenzyme A transporter SLC25A16 (P16260). Mitochondrial inner membrane transporter that regulates coenzyme A homeostasis between cytosol and mitochondria.

This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. This gene has a possible role in Graves’ disease.

Source: NCBI Gene 8034 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 108 total — 1 likely-pathogenic
• MANE Select transcript: NM_152707

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10986
Approved symbol	SLC25A16
Name	solute carrier family 25 member 16
Location	10q21.3
Locus type	gene with protein product
Status	Approved
Aliases	GDA, D10S105E, HGT.1, ML7
Ensembl gene	ENSG00000122912
Ensembl biotype	protein_coding
OMIM	139080
Entrez	8034

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 8 protein_coding, 3 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined

ENST00000265870, ENST00000439904, ENST00000474927, ENST00000491102, ENST00000493963, ENST00000608053, ENST00000609923, ENST00000873655, ENST00000873656, ENST00000873657, ENST00000966724, ENST00000966725, ENST00000966726

RefSeq mRNA: 6 — MANE Select: NM_152707 NM_001324312, NM_001324313, NM_001324314, NM_001324315, NM_001324317, NM_152707

CCDS: CCDS7280

Canonical transcript exons

ENST00000609923 — 9 exons

Exon	Start	End
ENSE00001373143	68527246	68527523
ENSE00003505522	68493449	68493570
ENSE00003703220	68503632	68503695
ENSE00003706742	68477998	68483588
ENSE00003707755	68487144	68487212
ENSE00003708077	68493132	68493198
ENSE00003708406	68516751	68516843
ENSE00003709873	68488467	68488629
ENSE00003710535	68506585	68506718

Expression profiles

Bgee: expression breadth ubiquitous, 273 present calls, max score 89.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.2197 / max 203.0742, expressed in 1810 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109764	9.1394	1786
109763	4.9029	1713
109762	0.6479	375
109761	0.5104	255
109760	0.0191	6

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	89.33	gold quality
right lobe of liver	UBERON:0001114	88.06	gold quality
metanephros cortex	UBERON:0010533	87.36	gold quality
liver	UBERON:0002107	86.83	gold quality
adipose tissue	UBERON:0001013	86.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.45	gold quality
mammary gland	UBERON:0001911	86.32	gold quality
thoracic mammary gland	UBERON:0005200	86.31	gold quality
colonic epithelium	UBERON:0000397	86.20	gold quality
mammary duct	UBERON:0001765	86.20	gold quality
connective tissue	UBERON:0002384	85.95	gold quality
corpus epididymis	UBERON:0004359	85.94	gold quality
duodenum	UBERON:0002114	85.86	gold quality
pigmented layer of retina	UBERON:0001782	85.77	gold quality
tibia	UBERON:0000979	85.74	gold quality
cauda epididymis	UBERON:0004360	85.47	gold quality
caput epididymis	UBERON:0004358	85.11	gold quality
body of pancreas	UBERON:0001150	84.91	gold quality
postcentral gyrus	UBERON:0002581	84.83	gold quality
apex of heart	UBERON:0002098	84.55	gold quality
upper lobe of left lung	UBERON:0008952	84.34	gold quality
epithelium of mammary gland	UBERON:0003244	84.24	gold quality
upper lobe of lung	UBERON:0008948	84.06	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.99	gold quality
endothelial cell	CL:0000115	83.97	silver quality
subcutaneous adipose tissue	UBERON:0002190	83.93	gold quality
parietal lobe	UBERON:0001872	83.82	gold quality
mucosa of sigmoid colon	UBERON:0004993	83.81	gold quality
prostate gland	UBERON:0002367	83.75	gold quality
substantia nigra pars compacta	UBERON:0001965	83.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

106 targeting SLC25A16, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-96-5P	99.95	72.80	2140

Literature-anchored findings (GeneRIF, showing 2)

• Compares and contrasts all the known human SLC25A* genes and includes functional information. (PMID:23266187)
• The authors findings report an extreme rare missense mutation in SLC25A1 which supports the causality of this variant for autosomal recessive form of isolated fingernail dysplasia. (PMID:28504827)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc25a16	ENSDARG00000057287
mus_musculus	Slc25a16	ENSMUSG00000071253
rattus_norvegicus	Slc25a16	ENSRNOG00000000387

Paralogs (49): SLC25A13 (ENSG00000004864), SLC25A5 (ENSG00000005022), SLC25A39 (ENSG00000013306), SLC25A40 (ENSG00000075303), SLC25A3 (ENSG00000075415), SLC25A43 (ENSG00000077713), SLC25A24 (ENSG00000085491), SLC25A1 (ENSG00000100075), SLC25A17 (ENSG00000100372), SLC25A14 (ENSG00000102078), SLC25A15 (ENSG00000102743), SLC25A11 (ENSG00000108528), UCP1 (ENSG00000109424), SLC25A36 (ENSG00000114120), SLC25A12 (ENSG00000115840), SLC25A2 (ENSG00000120329), SLC25A51 (ENSG00000122696), SLC25A35 (ENSG00000125434), SLC25A19 (ENSG00000125454), SLC25A23 (ENSG00000125648), SLC25A47 (ENSG00000140107), SLC25A52 (ENSG00000141437), SLC25A38 (ENSG00000144659), SLC25A26 (ENSG00000144741), SLC25A48 (ENSG00000145832), SLC25A37 (ENSG00000147454), SLC25A25 (ENSG00000148339), SLC25A31 (ENSG00000151475), SLC25A4 (ENSG00000151729), SLC25A27 (ENSG00000153291), SLC25A28 (ENSG00000155287), SLC25A44 (ENSG00000160785), SLC25A45 (ENSG00000162241), SLC25A34 (ENSG00000162461), SLC25A32 (ENSG00000164933), SLC25A6 (ENSG00000169100), SLC25A33 (ENSG00000171612), SLC25A30 (ENSG00000174032), UCP3 (ENSG00000175564), UCP2 (ENSG00000175567)

Protein

Protein identifiers

Mitochondrial coenzyme A transporter SLC25A16 — P16260 (reviewed: P16260)

Alternative names: Graves disease autoantigen, Graves disease carrier protein, Graves’ didease protein, Mitochondrial solute carrier protein homolog, Solute carrier family 25 member 16

All UniProt accessions (5): P16260, V9GY06, V9GYA5, V9GYB8, V9GZ24

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial inner membrane transporter that regulates coenzyme A homeostasis between cytosol and mitochondria. Could mediate the import of coenzyme A from the cytosol into the mitochondrial matrix. Alternatively, it could function in the export of 3’-dephospho-CoA from the mitochondrial matrix to the cytosol.

Subcellular location. Mitochondrion inner membrane.

Similarity. Belongs to the mitochondrial carrier (TC 2.A.29) family.

RefSeq proteins (6): NP_001311241, NP_001311242, NP_001311243, NP_001311244, NP_001311246, NP_689920* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002067	MCP	Family
IPR002167	GDC-like	Family
IPR018108	MCP_transmembrane	Repeat
IPR023395	MCP_dom_sf	Homologous_superfamily

Pfam: PF00153

Catalyzed reactions (Rhea), 2 shown:

• ADP(out) + CoA(in) = ADP(in) + CoA(out) (RHEA:72839)
• 3’-dephospho-CoA(in) + ADP(out) = 3’-dephospho-CoA(out) + ADP(in) (RHEA:72843)

UniProt features (17 total): sequence conflict 7, transmembrane region 6, repeat 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P16260-F1	85.09	0.53

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-199220	Vitamin B5 (pantothenate) metabolism

MSigDB gene sets: 335 (showing top): GAANYNYGACNY_UNKNOWN, TGCACTT_MIR519C_MIR519B_MIR519A, MODULE_418, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, GOBP_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, chr10q21, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, MODULE_503, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, RODRIGUES_NTN1_TARGETS_DN, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, MODULE_195

GO Biological Process (4): mitochondrial transport (GO:0006839), pantothenate metabolic process (GO:0015939), mitochondrial coenzyme A transmembrane transport (GO:1990559), transmembrane transport (GO:0055085)

GO Molecular Function (2): coenzyme A transmembrane transporter activity (GO:0015228), antiporter activity (GO:0015297)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of water-soluble vitamins and cofactors	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
coenzyme A transmembrane transport	2
intracellular transport	1
modified amino acid metabolic process	1
monocarboxylic acid metabolic process	1
transport	1
cellular process	1
organophosphate ester transmembrane transporter activity	1
nucleobase-containing compound transmembrane transporter activity	1
sulfur compound transmembrane transporter activity	1
secondary active transmembrane transporter activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1718 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC25A16	CS	O75390	819
SLC25A16	TRIM13	O60858	790
SLC25A16	MTCH2	Q9Y6C9	782
SLC25A16	MTCH1	Q9NZJ7	781
SLC25A16	CD274	Q9NZQ7	576
SLC25A16	PAEP	P09466	576
SLC25A16	TP53	P04637	541
SLC25A16	CD8A	P01732	528
SLC25A16	CTLA4	P16410	507
SLC25A16	GAPDH	P00354	500
SLC25A16	CD4	P01730	477
SLC25A16	MTUS1	Q9ULD2	473
SLC25A16	MTUS2	Q5JR59	473
SLC25A16	PDCD1	Q15116	472
SLC25A16	TBL1X	O60907	468

IntAct

56 interactions, top by confidence:

A	B	Type	Score
TOR1AIP2	TMEM223	psi-mi:“MI:0914”(association)	0.530
CNDP1	POTEF	psi-mi:“MI:0914”(association)	0.530
DKK3	NME4	psi-mi:“MI:0914”(association)	0.530
FAM131B	AURKA	psi-mi:“MI:0914”(association)	0.530
HLA-DPA1	TYW5	psi-mi:“MI:0914”(association)	0.530
PDCD1	RTL8C	psi-mi:“MI:0914”(association)	0.530
SYP	APBB1	psi-mi:“MI:0914”(association)	0.530
GALNS	CLGN	psi-mi:“MI:0914”(association)	0.530
PDCD1	TMEM223	psi-mi:“MI:0914”(association)	0.350
HLA-DPA1	GXYLT2	psi-mi:“MI:0914”(association)	0.350
NRG1	HS6ST1	psi-mi:“MI:0914”(association)	0.350
EDEM2	HACD1	psi-mi:“MI:0914”(association)	0.350
SYP	APBB1	psi-mi:“MI:0914”(association)	0.350
PPP6R2	POLRMT	psi-mi:“MI:0914”(association)	0.350
CD79B	GOLIM4	psi-mi:“MI:0914”(association)	0.350
TPP1	NME4	psi-mi:“MI:0914”(association)	0.350
RNF126	CAPN15	psi-mi:“MI:0914”(association)	0.350
MGARP	BTAF1	psi-mi:“MI:0914”(association)	0.350
HLA-DRA	TMEM223	psi-mi:“MI:0914”(association)	0.350
LRRC55	TMEM120B	psi-mi:“MI:0914”(association)	0.350
DNAJA2	DENND11	psi-mi:“MI:0914”(association)	0.350
GPR182	METTL15	psi-mi:“MI:0914”(association)	0.350
DGCR2	CCDC85C	psi-mi:“MI:0914”(association)	0.350
DKK3	MYO9A	psi-mi:“MI:0914”(association)	0.350
RAMP3	GOLIM4	psi-mi:“MI:0914”(association)	0.350
GPR12	TLCD2	psi-mi:“MI:0914”(association)	0.350

BioGRID (82): SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS), SLC25A16 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D6N272, A1DI57, A2R5A0, A4RF23, A6RF73, A6SL61, A7ER02, B4FIJ0, G3XP90, G3YAF3, G3YD89, O04619, O13844, O65023, P0C546, P16260, Q01888, Q05AQ3, Q0CEN9, Q0P483, Q0UUH1, Q1E7P0, Q1LZB3, Q29RM1, Q2UCW8, Q3TZX3, Q4X022, Q5AVW1, Q5IS35, Q5NVC1, Q5PQ27, Q6AYL0, Q6P036, Q7K566, Q7S2H8, Q86VD7, Q8BZ09, Q8C0K5, Q8R0Y8, Q8RWA5

Diamond homologs: A0JN87, A2A3V2, A4RPU0, F1LZW6, G3YAF3, G3YFS7, O04200, O43772, O77792, O95258, O97649, P16260, P33303, P39953, P97521, Q03028, Q08DK7, Q12482, Q3ZBJ8, Q54FE6, Q54RB9, Q54S10, Q55GE2, Q5HZE0, Q5RFB7, Q68F18, Q6GLJ0, Q6PGY3, Q75AH6, Q7DNC3, Q86AV5, Q86I81, Q8BL03, Q8BZ09, Q8HXW2, Q8HXY2, Q8WUT9, Q93XM7, Q99297, Q99JD3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

108 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	81
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
224813	NM_152707.4(SLC25A16):c.793C>T (p.Arg265Cys)	Likely pathogenic

SpliceAI

4728 predictions. Top by Δscore:

Variant	Effect	Δscore
10:68487138:ACTT:A	donor_loss	1.0000
10:68487139:CTTA:C	donor_loss	1.0000
10:68487140:TTA:T	donor_loss	1.0000
10:68487141:TA:T	donor_loss	1.0000
10:68487142:A:AC	donor_gain	1.0000
10:68487142:A:C	donor_loss	1.0000
10:68487142:ACAGG:A	donor_gain	1.0000
10:68487143:C:CA	donor_gain	1.0000
10:68487143:CA:C	donor_gain	1.0000
10:68487143:CAGG:C	donor_gain	1.0000
10:68487143:CAGGC:C	donor_gain	1.0000
10:68487208:GGTAG:G	acceptor_gain	1.0000
10:68487209:GTAG:G	acceptor_gain	1.0000
10:68487210:TAG:T	acceptor_gain	1.0000
10:68487210:TAGC:T	acceptor_loss	1.0000
10:68487211:AG:A	acceptor_gain	1.0000
10:68487211:AGCT:A	acceptor_loss	1.0000
10:68487212:GCTA:G	acceptor_loss	1.0000
10:68487213:C:CC	acceptor_gain	1.0000
10:68487213:CT:C	acceptor_loss	1.0000
10:68488465:A:AC	donor_gain	1.0000
10:68488466:C:CC	donor_gain	1.0000
10:68488627:CAC:C	acceptor_gain	1.0000
10:68493482:T:TA	donor_gain	1.0000
10:68503620:AACT:A	donor_gain	1.0000
10:68503621:A:C	donor_gain	1.0000
10:68503691:ATTAA:A	acceptor_gain	1.0000
10:68503692:TTAA:T	acceptor_gain	1.0000
10:68503693:TAA:T	acceptor_gain	1.0000
10:68503694:AA:A	acceptor_gain	1.0000

AlphaMissense

2132 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:68483474:A:C	F319L	0.999
10:68483474:A:T	F319L	0.999
10:68483476:A:G	F319L	0.999
10:68483485:C:G	A316P	0.999
10:68483524:C:G	G303R	0.999
10:68487207:G:T	P260Q	0.999
10:68488497:C:T	G248D	0.999
10:68488500:C:T	G247D	0.999
10:68488610:A:C	F210L	0.999
10:68488610:A:T	F210L	0.999
10:68488612:A:G	F210L	0.999
10:68488629:C:T	G204D	0.999
10:68493171:C:G	G191R	0.999
10:68493538:C:G	D152H	0.999
10:68493540:A:T	L151H	0.999
10:68493561:G:T	A144E	0.999
10:68503643:C:T	G137E	0.999
10:68506619:G:T	A108E	0.999
10:68506658:C:T	G95E	0.999
10:68506659:C:G	G95R	0.999
10:68506659:C:T	G95R	0.999
10:68516791:C:A	K61N	0.999
10:68516791:C:G	K61N	0.999
10:68516798:C:G	R59P	0.999
10:68516843:C:T	G44D	0.999
10:68527246:C:G	G44R	0.999
10:68527248:C:T	G43E	0.999
10:68483475:A:G	F319S	0.998
10:68483484:G:T	A316E	0.998
10:68483510:A:C	N307K	0.998

dbSNP variants (sampled 300 via entrez): RS1000052110 (10:68498416 G>A), RS1000100847 (10:68522862 C>G), RS1000114981 (10:68483909 C>A), RS1000223135 (10:68517694 C>T), RS1000239573 (10:68517448 T>C), RS1000285636 (10:68495955 G>A,C), RS1000306760 (10:68478472 T>C), RS1000396662 (10:68505732 C>T), RS1000437303 (10:68490140 C>A), RS1000468110 (10:68478209 T>C), RS1000536418 (10:68522614 G>A,T), RS1000627814 (10:68511222 C>T), RS1000760165 (10:68493455 A>G), RS1000775572 (10:68491486 A>T), RS1000802498 (10:68525480 GTCTC>G,GTC)

Disease associations

OMIM: gene MIM:139080 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000816_1	Suicidal ideation	7.000000e-06
GCST000816_2	Suicidal ideation	8.000000e-07
GCST90020028_78	Hip circumference adjusted for BMI	9.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004320	suicidal ideation
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Mitochondrial nucleotide transporter subfamily

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	7
Acetaminophen	increases expression, decreases expression	3
Panobinostat	affects cotreatment, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
urushiol	decreases expression	1
testosterone enanthate	affects expression	1
bisphenol A	decreases expression	1
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	affects expression, affects response to substance	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	increases expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	decreases methylation	1
Sunitinib	increases expression	1
Vorinostat	affects cotreatment, increases expression	1
Benzo(a)pyrene	decreases expression	1
Formaldehyde	increases expression	1
Hydrogen Peroxide	increases expression	1
Methyl Methanesulfonate	increases expression	1
Progesterone	increases expression	1
Quercetin	decreases expression	1
Selenium	affects cotreatment, decreases expression	1
Testosterone	decreases expression	1
Vitamin E	decreases expression, affects cotreatment	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	affects expression	1
Zidovudine	increases expression	1
Isotretinoin	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4CQ	HCT116-SLC25A16-KO-c4	Cancer cell line	Male
CVCL_D4CR	HCT116-SLC25A16-KO-c7	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.