SLC25A18

Summary

SLC25A18 (solute carrier family 25 member 18, HGNC:10988) is a protein-coding gene on chromosome 22q11.21, encoding Mitochondrial glutamate carrier 2 (Q9H1K4). Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).

Enables amino acid:proton symporter activity. Involved in L-glutamate transmembrane transport. Located in mitochondrion.

Source: NCBI Gene 83733 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 16 total
• MANE Select transcript: NM_031481

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10988
Approved symbol	SLC25A18
Name	solute carrier family 25 member 18
Location	22q11.21
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000182902
Ensembl biotype	protein_coding
OMIM	609303
Entrez	83733

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 31 protein_coding, 3 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000327451, ENST00000399813, ENST00000467228, ENST00000469889, ENST00000496051, ENST00000497401, ENST00000907596, ENST00000907597, ENST00000907598, ENST00000907599, ENST00000907600, ENST00000907601, ENST00000907602, ENST00000907603, ENST00000907604, ENST00000907605, ENST00000907606, ENST00000907607, ENST00000907608, ENST00000907609, ENST00000907610, ENST00000907611, ENST00000907612, ENST00000907613, ENST00000907614, ENST00000907615, ENST00000907616, ENST00000907617, ENST00000907618, ENST00000907619, ENST00000925887, ENST00000943247, ENST00000943248, ENST00000943249, ENST00000943250

RefSeq mRNA: 2 — MANE Select: NM_031481 NM_001303484, NM_031481

CCDS: CCDS13744

Canonical transcript exons

ENST00000327451 — 11 exons

Exon	Start	End
ENSE00001298916	17587136	17587301
ENSE00001311106	17587925	17588079
ENSE00001312572	17583416	17583534
ENSE00001321506	17589590	17589665
ENSE00001433126	17569924	17569986
ENSE00001955974	17563498	17563713
ENSE00003475345	17581358	17581413
ENSE00003532916	17581037	17581159
ENSE00003558498	17582563	17582653
ENSE00003663381	17579745	17579964
ENSE00003708716	17590095	17590995

Expression profiles

Bgee: expression breadth ubiquitous, 186 present calls, max score 97.61.

FANTOM5 (CAGE): breadth broad, TPM avg 3.9110 / max 213.2844, expressed in 210 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190981	1.8839	126
190978	0.9005	138
190979	0.4277	99
190983	0.4100	102
190980	0.1533	75
190982	0.1356	61

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
medial globus pallidus	UBERON:0002477	97.61	gold quality
amygdala	UBERON:0001876	97.36	gold quality
putamen	UBERON:0001874	96.89	gold quality
globus pallidus	UBERON:0001875	96.86	gold quality
caudate nucleus	UBERON:0001873	96.68	gold quality
right lobe of liver	UBERON:0001114	96.67	gold quality
nucleus accumbens	UBERON:0001882	96.37	gold quality
temporal lobe	UBERON:0001871	96.16	gold quality
substantia nigra	UBERON:0002038	95.91	gold quality
entorhinal cortex	UBERON:0002728	95.60	gold quality
right frontal lobe	UBERON:0002810	95.56	gold quality
anterior cingulate cortex	UBERON:0009835	95.41	gold quality
lateral globus pallidus	UBERON:0002476	95.27	gold quality
Ammon’s horn	UBERON:0001954	95.24	gold quality
midbrain	UBERON:0001891	95.16	gold quality
hypothalamus	UBERON:0001898	95.06	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.36	gold quality
endothelial cell	CL:0000115	94.20	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	93.71	gold quality
liver	UBERON:0002107	93.69	gold quality
superior frontal gyrus	UBERON:0002661	93.63	gold quality
postcentral gyrus	UBERON:0002581	93.50	gold quality
primary visual cortex	UBERON:0002436	93.09	gold quality
frontal cortex	UBERON:0001870	92.91	gold quality
substantia nigra pars reticulata	UBERON:0001966	92.82	gold quality
cerebral cortex	UBERON:0000956	92.75	gold quality
neocortex	UBERON:0001950	92.46	gold quality
parietal lobe	UBERON:0001872	92.32	gold quality
prefrontal cortex	UBERON:0000451	92.31	gold quality
middle temporal gyrus	UBERON:0002771	91.97	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	23.56
E-GEOD-84465	yes	12.64
E-ANND-3	no	2.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

40 targeting SLC25A18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4500	99.99	72.72	2367
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-6848-3P	99.64	66.49	885
HSA-MIR-653-5P	99.46	67.35	1300
HSA-MIR-6843-3P	99.26	66.42	915
HSA-MIR-371A-5P	99.08	66.51	1914
HSA-MIR-670-3P	99.03	68.88	2404
HSA-MIR-5088-3P	98.29	66.63	1310
HSA-MIR-637	97.91	64.05	1517
HSA-MIR-4446-3P	97.91	64.29	991
HSA-MIR-7113-5P	97.88	67.33	1735
HSA-MIR-4294	97.86	65.72	1110
HSA-MIR-943	97.81	64.42	694

Literature-anchored findings (GeneRIF, showing 3)

• The genes CECR2, SLC25A18 and ATP6V1E1, mapping within the critical region for cat eye syndrome (CES), may be responsible for anorectal, renal and preauricular anomalies in patients with CES. (PMID:22395867)
• Compares and contrasts all the known human SLC25A* genes and includes functional information. (PMID:23266187)
• Increased expression of SLC25A18 is associated with Alzheimer’s disease and is involved in Abeta42-induced mitochondrial dysfunction and apoptosis in neuronal cells. (PMID:38871013)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc25a18	ENSMUSG00000004902
rattus_norvegicus	Slc25a18	ENSRNOG00000042731

Paralogs (49): SLC25A13 (ENSG00000004864), SLC25A5 (ENSG00000005022), SLC25A39 (ENSG00000013306), SLC25A40 (ENSG00000075303), SLC25A3 (ENSG00000075415), SLC25A43 (ENSG00000077713), SLC25A24 (ENSG00000085491), SLC25A1 (ENSG00000100075), SLC25A17 (ENSG00000100372), SLC25A14 (ENSG00000102078), SLC25A15 (ENSG00000102743), SLC25A11 (ENSG00000108528), UCP1 (ENSG00000109424), SLC25A36 (ENSG00000114120), SLC25A12 (ENSG00000115840), SLC25A2 (ENSG00000120329), SLC25A51 (ENSG00000122696), SLC25A16 (ENSG00000122912), SLC25A35 (ENSG00000125434), SLC25A19 (ENSG00000125454), SLC25A23 (ENSG00000125648), SLC25A47 (ENSG00000140107), SLC25A52 (ENSG00000141437), SLC25A38 (ENSG00000144659), SLC25A26 (ENSG00000144741), SLC25A48 (ENSG00000145832), SLC25A37 (ENSG00000147454), SLC25A25 (ENSG00000148339), SLC25A31 (ENSG00000151475), SLC25A4 (ENSG00000151729), SLC25A27 (ENSG00000153291), SLC25A28 (ENSG00000155287), SLC25A44 (ENSG00000160785), SLC25A45 (ENSG00000162241), SLC25A34 (ENSG00000162461), SLC25A32 (ENSG00000164933), SLC25A6 (ENSG00000169100), SLC25A33 (ENSG00000171612), SLC25A30 (ENSG00000174032), UCP3 (ENSG00000175564)

Protein

Protein identifiers

Mitochondrial glutamate carrier 2 — Q9H1K4 (reviewed: Q9H1K4)

Alternative names: Glutamate/H(+) symporter 2, Solute carrier family 25 member 18

All UniProt accessions (1): Q9H1K4

UniProt curated annotations — full annotation on UniProt →

Function. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Expressed in brain, to a lesser extent in testis, and poorly in all the other tissues.

Similarity. Belongs to the mitochondrial carrier (TC 2.A.29) family.

RefSeq proteins (2): NP_001290413, NP_113669* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002067	MCP	Family
IPR018108	MCP_transmembrane	Repeat
IPR023395	MCP_dom_sf	Homologous_superfamily
IPR051028	Mito_Solute_Carrier	Family

Pfam: PF00153

Catalyzed reactions (Rhea), 1 shown:

• L-glutamate(in) + H(+)(in) = L-glutamate(out) + H(+)(out) (RHEA:70955)

UniProt features (13 total): transmembrane region 6, repeat 3, chain 1, region of interest 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H1K4-F1	73.24	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 145

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-442660	SLC-mediated transport of neurotransmitters
R-HSA-9856872	Malate-aspartate shuttle
R-HSA-428643	Organic anion transport by SLC5/17/25 transporters

MSigDB gene sets: 108 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_AMINO_ACID_TRANSMEMBRANE_TRANSPORT, GOBP_NADPLUS_METABOLIC_PROCESS, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_AMINO_ACID_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, GGGNNTTTCC_NFKB_Q6_01, GOCC_MITOCHONDRIAL_ENVELOPE, GOBP_DICARBOXYLIC_ACID_TRANSPORT, GOMF_PROTON_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOBP_ACIDIC_AMINO_ACID_TRANSPORT, GFI1_01

GO Biological Process (7): monoatomic ion transport (GO:0006811), aspartate transmembrane transport (GO:0015810), L-glutamate transmembrane transport (GO:0015813), malate-aspartate shuttle (GO:0043490), transmembrane transport (GO:0055085), L-aspartate transmembrane transport (GO:0070778), proton transmembrane transport (GO:1902600)

GO Molecular Function (5): amino acid:proton symporter activity (GO:0005280), L-glutamate transmembrane transporter activity (GO:0005313), L-aspartate transmembrane transporter activity (GO:0015183), protein binding (GO:0005515), symporter activity (GO:0015293)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
SLC-mediated transmembrane transport	1
Respiratory electron transport	1
SLC-mediated transport of organic anions	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
L-alpha-amino acid transmembrane transport	2
acidic amino acid transmembrane transporter activity	2
L-amino acid transmembrane transporter activity	2
amino acid transmembrane transport	1
C4-dicarboxylate transport	1
acidic amino acid transport	1
nitrogen compound transport	1
carboxylic acid transmembrane transport	1
L-glutamate import	1
L-aspartate:2-oxoglutarate transaminase activity	1
NAD+ metabolic process	1
L-malate dehydrogenase (NAD+) activity	1
mitochondrial transmembrane transport	1
cellular process	1
aspartate transmembrane transport	1
monoatomic cation transmembrane transport	1
amino acid:monoatomic cation symporter activity	1
solute:proton symporter activity	1
dicarboxylic acid transmembrane transporter activity	1
L-glutamate transmembrane transport	1
C4-dicarboxylate transmembrane transporter activity	1
L-aspartate transmembrane transport	1
binding	1
secondary active transmembrane transporter activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

872 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC25A18	GC	P02774	907
SLC25A18	ST6GALNAC1	Q9NSC7	795
SLC25A18	GUCA1C	O95843	760
SLC25A18	GUCA1B	Q9UMX6	696
SLC25A18	NDRG1	Q92597	646
SLC25A18	MTCH1	Q9NZJ7	571
SLC25A18	C3	P01024	551
SLC25A18	SCIN	Q9Y6U3	548
SLC25A18	MTCH2	Q9Y6C9	530
SLC25A18	GSN	P06396	506
SLC25A18	ALB	P02768	500
SLC25A18	A6NFB4	A6NFB4	485
SLC25A18	AFP	P02771	475
SLC25A18	CECR2	Q9BXF3	462
SLC25A18	CYP2R1	Q6VVX0	447

IntAct

33 interactions, top by confidence:

A	B	Type	Score
HSPD1	NUDT19	psi-mi:“MI:0914”(association)	0.710
SLC25A18	GOPC	psi-mi:“MI:0915”(physical association)	0.560
GOPC	SLC25A18	psi-mi:“MI:0915”(physical association)	0.560
KRTAP9-3	SLC25A18	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	SLC25A18	psi-mi:“MI:0915”(physical association)	0.560
KRTAP13-2	SLC25A18	psi-mi:“MI:0915”(physical association)	0.560
KRTAP19-6	SLC25A18	psi-mi:“MI:0915”(physical association)	0.560
SLC25A22	DNLZ	psi-mi:“MI:0914”(association)	0.530
PJA1	SMC5	psi-mi:“MI:0914”(association)	0.530
FLT4	ILVBL	psi-mi:“MI:0914”(association)	0.420
SLC25A18	GAPDHS	psi-mi:“MI:0915”(physical association)	0.400
FGR	HNRNPCL1	psi-mi:“MI:0914”(association)	0.350
MAP2K5	DNAJA2	psi-mi:“MI:0914”(association)	0.350
LCK	CDK1	psi-mi:“MI:0914”(association)	0.350
MAP2K5	MAGEB2	psi-mi:“MI:0914”(association)	0.350
LCK	UQCRQ	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
SLC16A11	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC25A18	HSPA8	psi-mi:“MI:0914”(association)	0.350
SLC25A18	FAM83B	psi-mi:“MI:0914”(association)	0.350
P/V	ESYT2	psi-mi:“MI:0914”(association)	0.350
MRPL58		psi-mi:“MI:0914”(association)	0.350
SLC25A18	KRTAP9-3	psi-mi:“MI:0915”(physical association)	0.000
SLC25A18	CYSRT1	psi-mi:“MI:0915”(physical association)	0.000
SLC25A18	KRTAP13-2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (46): SLC25A18 (Two-hybrid), SLC25A18 (Affinity Capture-MS), SLC25A18 (Affinity Capture-MS), SLC25A18 (Affinity Capture-MS), SLC25A18 (Affinity Capture-MS), SLC25A18 (Two-hybrid), KRTAP19-6 (Two-hybrid), CYSRT1 (Two-hybrid), KRTAP9-3 (Two-hybrid), SLC25A18 (Affinity Capture-MS), SLC25A18 (Affinity Capture-MS), SLC25A18 (Affinity Capture-MS), SLC25A18 (Affinity Capture-MS), SLC25A18 (Affinity Capture-MS), SLC25A18 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2K309, A0A1D6N272, A3KPP4, G3XP90, G3YD89, O13844, P04575, P04633, P12234, P12242, P16036, P33303, Q08DK7, Q0VCH6, Q1LZB3, Q27257, Q29RM1, Q3KQZ1, Q3TZX3, Q505J6, Q58DS3, Q5HZE0, Q5IS35, Q5NVC1, Q5R7W2, Q5SWT3, Q6AYL0, Q6DFK2, Q6P036, Q6P316, Q7K566, Q8BGP6, Q8BL03, Q8BZ09, Q8N8R3, Q8TBP6, Q8VEM8, Q93XM7, Q99JD3, Q9BSK2

Diamond homologs: A0A0G2K5L2, A2ADF7, A4QNX2, B0G143, F1LX07, F1LZW6, F1RFX9, O13844, O43772, O75746, P16261, P39953, Q02978, Q08DK4, Q0II44, Q12482, Q1DRJ3, Q21153, Q26365, Q3KQZ1, Q3TZX3, Q4V8K4, Q505J6, Q54QN2, Q54RB9, Q552L9, Q58DS3, Q5B717, Q5RBC8, Q5RD81, Q5SWT3, Q5XIF9, Q5ZKP7, Q66L49, Q68F18, Q6ZT89, Q75AH6, Q7PQV7, Q86AV5, Q8BH59

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

16 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	11
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2173 predictions. Top by Δscore:

Variant	Effect	Δscore
22:17563714:G:GG	donor_gain	1.0000
22:17581035:A:AG	acceptor_gain	1.0000
22:17581036:G:GA	acceptor_gain	1.0000
22:17581036:GC:G	acceptor_gain	1.0000
22:17581140:A:T	donor_gain	1.0000
22:17581155:GGAAT:G	donor_gain	1.0000
22:17581156:GAAT:G	donor_gain	1.0000
22:17581156:GAATG:G	donor_gain	1.0000
22:17581157:A:T	donor_gain	1.0000
22:17581158:AT:A	donor_gain	1.0000
22:17581160:G:GG	donor_gain	1.0000
22:17582556:C:G	acceptor_gain	1.0000
22:17582559:CCA:C	acceptor_loss	1.0000
22:17582561:A:AG	acceptor_gain	1.0000
22:17582561:A:C	acceptor_loss	1.0000
22:17582561:AG:A	acceptor_gain	1.0000
22:17582561:AGG:A	acceptor_gain	1.0000
22:17582561:AGGG:A	acceptor_gain	1.0000
22:17582562:G:A	acceptor_gain	1.0000
22:17582562:G:GA	acceptor_gain	1.0000
22:17582562:GGG:G	acceptor_gain	1.0000
22:17582562:GGGG:G	acceptor_gain	1.0000
22:17582562:GGGGC:G	acceptor_gain	1.0000
22:17582646:G:T	donor_gain	1.0000
22:17582646:GAAGA:G	donor_gain	1.0000
22:17582649:GATGG:G	donor_gain	1.0000
22:17582650:A:G	donor_gain	1.0000
22:17582650:ATGG:A	donor_loss	1.0000
22:17582652:GG:G	donor_gain	1.0000
22:17582652:GGGTA:G	donor_loss	1.0000

AlphaMissense

2042 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:17590171:T:C	F295L	0.996
22:17590173:T:A	F295L	0.996
22:17590173:T:G	F295L	0.996
22:17581089:T:C	C25R	0.995
22:17581095:T:C	F27L	0.994
22:17581097:C:A	F27L	0.994
22:17581097:C:G	F27L	0.994
22:17581115:G:C	K33N	0.994
22:17581115:G:T	K33N	0.994
22:17587935:T:C	F196L	0.994
22:17587937:C:A	F196L	0.994
22:17587937:C:G	F196L	0.994
22:17590163:C:A	A292E	0.994
22:17587950:T:C	F201L	0.993
22:17587952:C:A	F201L	0.993
22:17587952:C:G	F201L	0.993
22:17587951:T:G	F201C	0.992
22:17589597:A:C	K246N	0.992
22:17589597:A:T	K246N	0.992
22:17590166:C:A	P293H	0.992
22:17590175:G:A	G296E	0.992
22:17581080:G:A	G22R	0.991
22:17581080:G:C	G22R	0.991
22:17583506:G:C	K127N	0.991
22:17583506:G:T	K127N	0.991
22:17588032:G:A	G228D	0.991
22:17588053:C:A	A235D	0.991
22:17588076:G:C	D243H	0.991
22:17589602:G:C	R248P	0.991
22:17581069:C:A	A18E	0.990

dbSNP variants (sampled 300 via entrez): RS1000136944 (22:17574974 T>C), RS1000187943 (22:17567423 T>C,G), RS1000208610 (22:17584178 G>C), RS1000222450 (22:17589484 A>C,G), RS1000307803 (22:17589207 G>A), RS1000308988 (22:17565089 GTTTTGTTTTT>G), RS1000333019 (22:17565360 C>T), RS1000437762 (22:17564977 G>A,C), RS1000558609 (22:17590744 G>A), RS1000668007 (22:17568405 G>C), RS1000809240 (22:17580033 A>C), RS1000861491 (22:17580389 A>G,T), RS1000891834 (22:17565205 C>T), RS1000893323 (22:17584403 G>A,T), RS1001131960 (22:17590949 T>C)

Disease associations

OMIM: gene MIM:609303 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Mitochondrial amino acid transporter subfamily

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation, affects cotreatment, increases expression	2
Acetaminophen	increases expression, decreases expression	2
Nickel	decreases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	increases expression	1
sodium arsenite	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
bisphenol S	decreases expression, affects cotreatment	1
jinfukang	affects cotreatment, decreases expression	1
Amiodarone	increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Cisplatin	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	affects cotreatment, increases expression, decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Indomethacin	increases expression, decreases expression, affects cotreatment	1
Tetrachlorodibenzodioxin	decreases expression	1
Thiram	decreases expression	1
Valproic Acid	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression, decreases expression	1
Aflatoxin B1	decreases expression	1
Palmitic Acid	decreases expression	1
Okadaic Acid	decreases expression	1
Acrylamide	increases expression	1

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4SI	HuH7-SLC25A18-KO-c10	Cancer cell line	Male
CVCL_D4SJ	HuH7-SLC25A18-KO-c3	Cancer cell line	Male
CVCL_D4SK	HuH7-SLC25A18-KO-c9	Cancer cell line	Male
CVCL_TM19	HAP1 SLC25A18 (-) 1	Cancer cell line	Male
CVCL_TM20	HAP1 SLC25A18 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.