SLC25A21-AS1

Summary

SLC25A21-AS1 (SLC25A21 antisense RNA 1, HGNC:44298) is a long non-coding RNA gene on chromosome 14q13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44298
Approved symbol	SLC25A21-AS1
Name	SLC25A21 antisense RNA 1
Location	14q13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258708
Ensembl biotype	lncRNA
Entrez	100129794
RNAcentral	URS0000759D83 — lncRNA, 1819 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000556667

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000556667 — 1 exons

Exon	Start	End
ENSE00002535305	37171888	37173811

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 80.40.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6420 / max 34.0718, expressed in 856 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
139303	1.6253	855
139302	0.0167	1

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.40	gold quality
pigmented layer of retina	UBERON:0001782	76.08	gold quality
body of pancreas	UBERON:0001150	74.84	gold quality
left ovary	UBERON:0002119	74.60	gold quality
right uterine tube	UBERON:0001302	73.44	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.42	gold quality
pancreas	UBERON:0001264	72.63	gold quality
tibial nerve	UBERON:0001323	72.42	gold quality
ovary	UBERON:0000992	72.08	gold quality
germinal epithelium of ovary	UBERON:0001304	71.95	gold quality
popliteal artery	UBERON:0002250	71.81	gold quality
tibial artery	UBERON:0007610	71.80	gold quality
body of stomach	UBERON:0001161	71.52	gold quality
islet of Langerhans	UBERON:0000006	71.46	gold quality
mucosa of stomach	UBERON:0001199	71.32	gold quality
body of uterus	UBERON:0009853	71.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.05	gold quality
right ovary	UBERON:0002118	71.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.71	gold quality
lower esophagus	UBERON:0013473	70.68	gold quality
right lobe of thyroid gland	UBERON:0001119	70.50	gold quality
spinal cord	UBERON:0002240	70.44	gold quality
bronchial epithelial cell	CL:0002328	70.15	gold quality
left coronary artery	UBERON:0001626	70.10	gold quality
left lobe of thyroid gland	UBERON:0001120	69.87	gold quality
endocervix	UBERON:0000458	69.80	gold quality
thyroid gland	UBERON:0002046	69.76	gold quality
aorta	UBERON:0000947	69.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.47	gold quality
adenohypophysis	UBERON:0002196	69.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Gliomas with Downregulation of lncRNA SLC25A21-AS1 Carry a Dismal Prognosis and an Accelerated Progression in Cell Proliferation, Migration and Invasion. (PMID:35266110)
• Long Noncoding RNA Solute Carrier Family 25 Member 21 Antisense RNA 1 Inhibits Cell Malignant Behaviors and Enhances Radiosensitivity of Gastric Cancer Cells by Upregulating Synuclein Gamma Expression. (PMID:35444105)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.