SLC25A30

Summary

SLC25A30 (solute carrier family 25 member 30, HGNC:27371) is a protein-coding gene on chromosome 13q14.13, encoding Kidney mitochondrial carrier protein 1 (Q5SVS4). Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate.

Although the outer mitochondrial membrane is permeable to many small metabolites, transport of solutes across the inner mitochondrial membrane is achieved by members of the mitochondrial carrier protein family, such as SLC25A30 (Haguenauer et al., 2005 [PubMed 15809292]).

Source: NCBI Gene 253512 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_001010875

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27371
Approved symbol	SLC25A30
Name	solute carrier family 25 member 30
Location	13q14.13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000174032
Ensembl biotype	protein_coding
OMIM	610793
Entrez	253512

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 13 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000310862, ENST00000463262, ENST00000519547, ENST00000519676, ENST00000522438, ENST00000523988, ENST00000539591, ENST00000618165, ENST00000857529, ENST00000857530, ENST00000857531, ENST00000857532, ENST00000857533, ENST00000857534, ENST00000857535, ENST00000954031

RefSeq mRNA: 3 — MANE Select: NM_001010875 NM_001010875, NM_001286806, NM_001286807

CCDS: CCDS31967, CCDS66539

Canonical transcript exons

ENST00000519676 — 10 exons

Exon	Start	End
ENSE00002096074	45393316	45396015
ENSE00002692420	45411362	45411480
ENSE00003460024	45401083	45401207
ENSE00003468564	45402275	45402370
ENSE00003471425	45398940	45399078
ENSE00003498427	45408927	45409074
ENSE00003520583	45404327	45404412
ENSE00003611955	45397258	45397338
ENSE00003631537	45405883	45405977
ENSE00003845739	45418300	45418373

Expression profiles

Bgee: expression breadth ubiquitous, 247 present calls, max score 96.21.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.7344 / max 88.6392, expressed in 1692 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137093	6.7344	1692

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
biceps brachii	UBERON:0001507	96.21	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	95.23	gold quality
heart right ventricle	UBERON:0002080	93.07	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.01	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	92.90	gold quality
renal medulla	UBERON:0000362	92.33	gold quality
cardiac ventricle	UBERON:0002082	91.70	gold quality
heart left ventricle	UBERON:0002084	91.63	gold quality
apex of heart	UBERON:0002098	90.70	gold quality
muscle of leg	UBERON:0001383	89.05	gold quality
heart	UBERON:0000948	88.63	gold quality
gastrocnemius	UBERON:0001388	88.48	gold quality
right lobe of liver	UBERON:0001114	87.37	gold quality
calcaneal tendon	UBERON:0003701	87.09	gold quality
secondary oocyte	CL:0000655	87.05	gold quality
right atrium auricular region	UBERON:0006631	86.83	gold quality
skeletal muscle organ	UBERON:0014892	86.36	gold quality
adrenal tissue	UBERON:0018303	86.35	gold quality
muscle organ	UBERON:0001630	86.34	gold quality
metanephros cortex	UBERON:0010533	86.32	gold quality
liver	UBERON:0002107	86.27	gold quality
stromal cell of endometrium	CL:0002255	85.95	gold quality
cardiac atrium	UBERON:0002081	85.22	gold quality
adult mammalian kidney	UBERON:0000082	84.79	gold quality
pigmented layer of retina	UBERON:0001782	84.48	gold quality
colonic epithelium	UBERON:0000397	84.02	gold quality
cortex of kidney	UBERON:0001225	83.40	gold quality
right coronary artery	UBERON:0001625	83.01	gold quality
oocyte	CL:0000023	83.00	gold quality
descending thoracic aorta	UBERON:0002345	82.96	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6386	no	28.97
E-ANND-3	no	5.30

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

140 targeting SLC25A30, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502

Literature-anchored findings (GeneRIF, showing 1)

• Compares and contrasts all the known human SLC25A* genes and includes functional information. (PMID:23266187)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc25a30	ENSMUSG00000022003
rattus_norvegicus	Slc25a30	ENSRNOG00000001052

Paralogs (49): SLC25A13 (ENSG00000004864), SLC25A5 (ENSG00000005022), SLC25A39 (ENSG00000013306), SLC25A40 (ENSG00000075303), SLC25A3 (ENSG00000075415), SLC25A43 (ENSG00000077713), SLC25A24 (ENSG00000085491), SLC25A1 (ENSG00000100075), SLC25A17 (ENSG00000100372), SLC25A14 (ENSG00000102078), SLC25A15 (ENSG00000102743), SLC25A11 (ENSG00000108528), UCP1 (ENSG00000109424), SLC25A36 (ENSG00000114120), SLC25A12 (ENSG00000115840), SLC25A2 (ENSG00000120329), SLC25A51 (ENSG00000122696), SLC25A16 (ENSG00000122912), SLC25A35 (ENSG00000125434), SLC25A19 (ENSG00000125454), SLC25A23 (ENSG00000125648), SLC25A47 (ENSG00000140107), SLC25A52 (ENSG00000141437), SLC25A38 (ENSG00000144659), SLC25A26 (ENSG00000144741), SLC25A48 (ENSG00000145832), SLC25A37 (ENSG00000147454), SLC25A25 (ENSG00000148339), SLC25A31 (ENSG00000151475), SLC25A4 (ENSG00000151729), SLC25A27 (ENSG00000153291), SLC25A28 (ENSG00000155287), SLC25A44 (ENSG00000160785), SLC25A45 (ENSG00000162241), SLC25A34 (ENSG00000162461), SLC25A32 (ENSG00000164933), SLC25A6 (ENSG00000169100), SLC25A33 (ENSG00000171612), UCP3 (ENSG00000175564), UCP2 (ENSG00000175567)

Protein

Protein identifiers

Kidney mitochondrial carrier protein 1 — Q5SVS4 (reviewed: Q5SVS4)

Alternative names: Solute carrier family 25 member 30, Uncoupling protein 6

All UniProt accessions (5): Q5SVS4, A0A087WWR9, D6RJI0, E5RIS9, E5RIW6

UniProt curated annotations — full annotation on UniProt →

Function. Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate. The sulfate/sulfate exchange is much higher than the phosphate/phosphate and malate/malate exchanges. The transport affinities is higher for sulfate and thiosulfate than for any other substrate. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide. Also may mediate a very low unidirectional transport of sulfate, phosphate and (S)-malate.

Subunit / interactions. Interacts with VDAC1.

Subcellular location. Mitochondrion inner membrane.

Activity regulation. Increased activity at pH 6.0. sulfate/sulfate exchange activity is inhibited strongly by pyridoxal 5’-phosphate, bathophenanthroline and the organic mercurials mersalyl, p-chloromercuribenzoate and HgCl2.

Similarity. Belongs to the mitochondrial carrier (TC 2.A.29) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5SVS4-1	1	yes
Q5SVS4-2	2

RefSeq proteins (3): NP_001010875, NP_001273735, NP_001273736 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002067	MCP	Family
IPR018108	MCP_transmembrane	Repeat
IPR023395	MCP_dom_sf	Homologous_superfamily
IPR050391	Mito_Metabolite_Transporter	Family

Pfam: PF00153

Catalyzed reactions (Rhea), 12 shown:

• phosphate(in) = phosphate(out) (RHEA:32823)
• sulfate(in) = sulfate(out) (RHEA:34983)
• (S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in) (RHEA:71615)
• sulfate(out) + phosphate(in) = sulfate(in) + phosphate(out) (RHEA:71631)
• oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in) (RHEA:72275)
• malonate(in) + sulfate(out) = malonate(out) + sulfate(in) (RHEA:73195)
• maleate(in) + sulfate(out) = maleate(out) + sulfate(in) (RHEA:73199)
• sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in) (RHEA:73207)
• thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in) (RHEA:73215)
• (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in) (RHEA:73223)
• (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in) (RHEA:73227)
• L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in) (RHEA:73395)

UniProt features (14 total): transmembrane region 6, repeat 3, initiator methionine 1, chain 1, modified residue 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5SVS4-F1	80.38	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 113 (showing top): GOZGIT_ESR1_TARGETS_DN, GOBP_INORGANIC_ANION_TRANSPORT, MARTINEZ_RB1_TARGETS_UP, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP, GOCC_MITOCHONDRIAL_ENVELOPE, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, MARTINEZ_RB1_AND_TP53_TARGETS_UP, GOBP_TRANSMEMBRANE_TRANSPORT, CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP, chr13q14, GOCC_ORGANELLE_INNER_MEMBRANE, ZHENG_IL22_SIGNALING_UP, GEORGES_TARGETS_OF_MIR192_AND_MIR215, GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

GO Biological Process (2): inorganic anion transport (GO:0015698), transmembrane transport (GO:0055085)

GO Molecular Function (3): solute:inorganic anion antiporter activity (GO:0005452), transmembrane transporter activity (GO:0022857), protein binding (GO:0005515)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
cellular process	1
antiporter activity	1
transporter activity	1
transmembrane transport	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

626 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC25A30	MTCH1	Q9NZJ7	662
SLC25A30	MTCH2	Q9Y6C9	599
SLC25A30	SLC25A53	Q5H9E4	451
SLC25A30	LGALS2	P05162	423
SLC25A30	TMEM217	Q8N7C4	406
SLC25A30	C2CD2L	O14523	396
SLC25A30	CRELD2	Q6UXH1	381
SLC25A30	ERICH6B	Q5W0A0	372
SLC25A30	ZNF836	Q6ZNA1	367
SLC25A30	TIMM8B	Q9Y5J9	349
SLC25A30	SLC25A51	Q9H1U9	348
SLC25A30	SLC12A4	Q9UP95	342
SLC25A30	CARD19	Q96LW7	339
SLC25A30	ZNF285	Q96NJ3	336
SLC25A30	SLC16A13	Q7RTY0	329

IntAct

49 interactions, top by confidence:

A	B	Type	Score
DNAJB11	HSPA5	psi-mi:“MI:0914”(association)	0.830
TOR1AIP2	TMEM223	psi-mi:“MI:0914”(association)	0.530
BTN2A1	POTEF	psi-mi:“MI:0914”(association)	0.530
CD79A	METTL15	psi-mi:“MI:0914”(association)	0.530
LRP1	NME4	psi-mi:“MI:0914”(association)	0.530
SDF4	GTPBP6	psi-mi:“MI:0914”(association)	0.530
SLC22A15	ZFPL1	psi-mi:“MI:0914”(association)	0.530
SLC22A16	APBA3	psi-mi:“MI:0914”(association)	0.530
ECE1	SLC25A30	psi-mi:“MI:0915”(physical association)	0.370
CD79B	GOLIM4	psi-mi:“MI:0914”(association)	0.350
SLC22A16	AGPAT2	psi-mi:“MI:0914”(association)	0.350
NAXD	KDELR3	psi-mi:“MI:0914”(association)	0.350
SLC37A3	CYB5R3	psi-mi:“MI:0914”(association)	0.350
HLA-DRA	TMEM223	psi-mi:“MI:0914”(association)	0.350
RAMP2	GXYLT2	psi-mi:“MI:0914”(association)	0.350
OSTM1	ILVBL	psi-mi:“MI:0914”(association)	0.350
SV2A	ILVBL	psi-mi:“MI:0914”(association)	0.350
DNAJA2	DENND11	psi-mi:“MI:0914”(association)	0.350
LRRC25	POTEF	psi-mi:“MI:0914”(association)	0.350
CD80	POTEF	psi-mi:“MI:0914”(association)	0.350
MAGEA8	METTL15	psi-mi:“MI:0914”(association)	0.350
OPRL1	METTL15	psi-mi:“MI:0914”(association)	0.350
MGARP	RTL8C	psi-mi:“MI:0914”(association)	0.350
SCGB2A2	RTL8C	psi-mi:“MI:0914”(association)	0.350

BioGRID (56): SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS)

ESM2 similar proteins: A6QR09, F1R4U0, F1RFX9, O43772, O46373, O77792, O95258, O97562, O97649, P02722, P05141, P12235, P12236, P22292, P32007, P32089, P48962, P51881, P53007, P55851, P70406, P79110, P97700, Q000K2, Q02978, Q05962, Q08DK4, Q09073, Q3SZI5, Q5PQM9, Q5R5A1, Q5R5A8, Q5SVS4, Q5U680, Q5XGI1, Q6GQ22, Q6QRN9, Q70HW3, Q8HXE3, Q8HXY2

Diamond homologs: A0PC02, A6SL61, A6ZXL1, A7ER02, A7TIQ0, B0G143, B3LH09, F1RFX9, G3Y1Q5, G5EE96, K3VFR5, O74439, O77792, O81845, O89035, O95258, O95847, O97562, O97649, P04575, P04633, P10861, P12242, P14271, P22292, P25874, P32332, P55851, P55916, P56499, P56500, P56501, P70406, P90992, P97700, Q02978, Q06143, Q07534, Q08DK7, Q18P97

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 66 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Adaptive Immune System	9	6.0×	4e-03

GO biological processes:

GO term	Partners	Fold	FDR
adaptive immune response	7	9.8×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1604 predictions. Top by Δscore:

Variant	Effect	Δscore
13:45397917:CGGT:C	donor_gain	1.0000
13:45398934:TCTTA:T	donor_loss	1.0000
13:45398935:CTTAC:C	donor_loss	1.0000
13:45398936:TTAC:T	donor_loss	1.0000
13:45398937:TAC:T	donor_loss	1.0000
13:45398938:ACCTG:A	donor_loss	1.0000
13:45398939:C:CA	donor_loss	1.0000
13:45399074:TTGAG:T	acceptor_gain	1.0000
13:45399075:TGAG:T	acceptor_gain	1.0000
13:45399076:GAG:G	acceptor_gain	1.0000
13:45399077:AG:A	acceptor_gain	1.0000
13:45399078:GC:G	acceptor_loss	1.0000
13:45399079:C:CA	acceptor_loss	1.0000
13:45399079:C:CC	acceptor_gain	1.0000
13:45399081:A:C	acceptor_gain	1.0000
13:45399090:CCAT:C	acceptor_gain	1.0000
13:45399091:C:T	acceptor_gain	1.0000
13:45399091:CA:C	acceptor_gain	1.0000
13:45399092:A:C	acceptor_gain	1.0000
13:45399092:A:T	acceptor_gain	1.0000
13:45399093:T:C	acceptor_gain	1.0000
13:45399093:T:TC	acceptor_gain	1.0000
13:45401081:A:AC	donor_gain	1.0000
13:45401082:C:CC	donor_gain	1.0000
13:45402269:GCTTA:G	donor_loss	1.0000
13:45402270:CTTA:C	donor_loss	1.0000
13:45402271:TTACC:T	donor_loss	1.0000
13:45402272:TA:T	donor_loss	1.0000
13:45402273:A:C	donor_loss	1.0000
13:45402274:C:CG	donor_loss	1.0000

AlphaMissense

1879 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:45397280:C:G	R271T	0.999
13:45399072:G:C	S207R	0.999
13:45399072:G:T	S207R	0.999
13:45399074:T:G	S207R	0.999
13:45401136:C:A	K187N	0.999
13:45401136:C:G	K187N	0.999
13:45409041:A:G	L33P	0.999
13:45409049:C:A	K30N	0.999
13:45409049:C:G	K30N	0.999
13:45411370:G:T	A19D	0.999
13:45411382:G:T	A15D	0.999
13:45397302:C:G	G264R	0.998
13:45399013:C:G	R227P	0.998
13:45399029:C:G	D222H	0.998
13:45401179:G:T	A173D	0.998
13:45402366:C:G	R133P	0.998
13:45404338:C:G	D128H	0.998
13:45404349:G:T	A124D	0.998
13:45404370:C:T	G117E	0.998
13:45404382:C:T	G113E	0.998
13:45405958:G:T	R78S	0.998
13:45408927:C:T	G71E	0.998
13:45408928:C:A	G71W	0.998
13:45409044:C:G	R32P	0.998
13:45409051:T:C	K30E	0.998
13:45411371:C:G	A19P	0.998
13:45397269:A:G	W275R	0.997
13:45397269:A:T	W275R	0.997
13:45397274:C:T	G273D	0.997
13:45397279:T:A	R271S	0.997

dbSNP variants (sampled 300 via entrez): RS1000000806 (13:45421104 C>T), RS1000006353 (13:45398110 C>A,T), RS1000032064 (13:45421360 C>A,G,T), RS1000062164 (13:45412613 G>T), RS1000123052 (13:45419958 G>A), RS1000206421 (13:45393562 AC>A), RS1000259672 (13:45427931 G>A,C), RS1000319582 (13:45393132 G>A,C,T), RS1000343687 (13:45434841 C>A), RS1000419132 (13:45435215 C>T), RS1000465884 (13:45416109 A>C), RS1000496876 (13:45416301 G>A), RS1000765027 (13:45432721 AC>A), RS1000788686 (13:45401933 G>A), RS1000837091 (13:45405432 C>T)

Disease associations

OMIM: gene MIM:610793 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Mitochondrial uncoupling proteins

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	8
methylmercuric chloride	decreases expression	2
trichostatin A	affects expression, increases expression	2
Acetaminophen	decreases expression, increases expression	2
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	2
Tetrachlorodibenzodioxin	increases expression	2
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression, affects cotreatment, increases abundance	1
perfluorooctanoic acid	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
nickel sulfate	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	increases expression	1
Rosiglitazone	increases expression	1
Sunitinib	increases expression	1
Vorinostat	increases expression	1
Amiodarone	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Cisplatin	increases expression	1
Estradiol	decreases expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Quercetin	increases expression	1
Vanadates	increases expression	1
Cyclosporine	decreases expression	1
Sodium Selenite	increases expression	1
Lactic Acid	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4JT	HCT116-SLC25A30-KO-c10	Cancer cell line	Male
CVCL_D4JU	HCT116-SLC25A30-KO-c9	Cancer cell line	Male
CVCL_TM32	HAP1 SLC25A30 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.