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Atlas / Gene / SLC25A36

SLC25A36

gene
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Also known as FLJ10618PNC2

Summary

SLC25A36 (solute carrier family 25 member 36, HGNC:25554) is a protein-coding gene on chromosome 3q23, encoding Solute carrier family 25 member 36 (Q96CQ1). Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria.

Enables pyrimidine nucleotide transmembrane transporter activity. Involved in mitochondrial genome maintenance; pyrimidine nucleotide transport; and regulation of mitochondrial membrane potential. Located in mitochondrion. Implicated in familial hyperinsulinemic hypoglycemia 8.

Source: NCBI Gene 55186 — RefSeq curated summary.

At a glance

  • Gene–disease (curated): hyperinsulinemic hypoglycemia, familial, 8 (Strong, GenCC)
  • GWAS associations: 2
  • Clinical variants (ClinVar): 43 total — 2 pathogenic
  • Phenotypes (HPO): 18
  • MANE Select transcript: NM_001104647

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:25554
Approved symbolSLC25A36
Namesolute carrier family 25 member 36
Location3q23
Locus typegene with protein product
StatusApproved
AliasesFLJ10618, PNC2
Ensembl geneENSG00000114120
Ensembl biotypeprotein_coding
OMIM616149
Entrez55186

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 13 protein_coding, 5 nonsense_mediated_decay, 5 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000324194, ENST00000393015, ENST00000446041, ENST00000453248, ENST00000502594, ENST00000502756, ENST00000502866, ENST00000507429, ENST00000511757, ENST00000512023, ENST00000512506, ENST00000513887, ENST00000514629, ENST00000515813, ENST00000631654, ENST00000648615, ENST00000874794, ENST00000874795, ENST00000874796, ENST00000874797, ENST00000947563, ENST00000947564, ENST00000947565, ENST00000947566

RefSeq mRNA: 2 — MANE Select: NM_001104647 NM_001104647, NM_018155

CCDS: CCDS3114, CCDS46927

Canonical transcript exons

ENST00000324194 — 7 exons

ExonStartEnd
ENSE00002051736140976260140980995
ENSE00003566910140973716140974005
ENSE00003587233140970927140970993
ENSE00003610321140956527140956691
ENSE00003628135140959463140959540
ENSE00003644986140963127140963227
ENSE00003890869140941836140942095

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 36.2880 / max 339.1804, expressed in 1822 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
3886035.61161822
388610.6764426

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
caput epididymisUBERON:000435899.20gold quality
corpus epididymisUBERON:000435998.90gold quality
right uterine tubeUBERON:000130298.33gold quality
cauda epididymisUBERON:000436098.22gold quality
mucosa of stomachUBERON:000119997.60gold quality
tibiaUBERON:000097997.53gold quality
body of pancreasUBERON:000115097.31gold quality
cardia of stomachUBERON:000116297.15gold quality
pylorusUBERON:000116697.02gold quality
nippleUBERON:000203096.97gold quality
visceral pleuraUBERON:000240196.87gold quality
adrenal tissueUBERON:001830396.75gold quality
calcaneal tendonUBERON:000370196.55gold quality
mucosa of paranasal sinusUBERON:000503096.48gold quality
cartilage tissueUBERON:000241896.37gold quality
left ovaryUBERON:000211996.32gold quality
cranial nerve IIUBERON:000094196.31gold quality
bronchial epithelial cellCL:000232896.09gold quality
right ovaryUBERON:000211896.08gold quality
duodenumUBERON:000211496.06gold quality
renal medullaUBERON:000036295.98gold quality
tibial nerveUBERON:000132395.92gold quality
jejunumUBERON:000211595.88gold quality
fundus of stomachUBERON:000116095.84gold quality
ganglionic eminenceUBERON:000402395.70gold quality
jejunal mucosaUBERON:000039995.69gold quality
pleuraUBERON:000097795.67gold quality
ovaryUBERON:000099295.67gold quality
pigmented layer of retinaUBERON:000178295.63gold quality
body of uterusUBERON:000985395.44gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes14.03

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

219 targeting SLC25A36, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-5692A100.0074.406850
HSA-MIR-190A-3P100.0080.355520
HSA-MIR-200B-3P100.0073.312693
HSA-MIR-200C-3P100.0073.352685
HSA-MIR-429100.0073.442698
HSA-MIR-4262100.0073.263931
HSA-MIR-3924100.0072.092394
HSA-MIR-30A-5P100.0076.313233
HSA-MIR-30B-5P100.0076.293248
HSA-MIR-30C-5P100.0076.293248
HSA-MIR-30D-5P100.0076.323233
HSA-MIR-30E-5P100.0076.323242
HSA-MIR-5011-5P100.0083.465820
HSA-MIR-9-5P100.0072.282361
HSA-MIR-3120-5P100.0065.56965
HSA-MIR-548C-3P99.9974.017587
HSA-MIR-428299.9975.366408
HSA-MIR-453499.9966.581907
HSA-MIR-181A-5P99.9972.962995
HSA-MIR-181B-5P99.9972.972996
HSA-MIR-181C-5P99.9972.952996
HSA-MIR-181D-5P99.9973.042997
HSA-MIR-196A-1-3P99.9972.152772
HSA-MIR-480399.9871.993117
HSA-MIR-477599.9875.006394
HSA-MIR-363-3P99.9874.721821
HSA-MIR-367-3P99.9874.831819
HSA-MIR-32-5P99.9875.211964
HSA-MIR-92A-3P99.9875.211960
HSA-MIR-92B-3P99.9875.251955

Literature-anchored findings (GeneRIF, showing 3)

  • Compares and contrasts all the known human SLC25A* genes and includes functional information. (PMID:23266187)
  • The main physiological role of SLC25A33 and SLC25A36 is to import/export pyrimidine nucleotides into and from mitochondria (PMID:25320081)
  • Hyperinsulinism/hyperammonemia syndrome caused by biallelic SLC25A36 mutation. (PMID:36695547)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_rerioslc25a36aENSDARG00000038731
mus_musculusSlc25a36ENSMUSG00000032449
rattus_norvegicusSlc25a36l1ENSRNOG00000054284
rattus_norvegicusENSRNOG00000078852

Paralogs (49): SLC25A13 (ENSG00000004864), SLC25A5 (ENSG00000005022), SLC25A39 (ENSG00000013306), SLC25A40 (ENSG00000075303), SLC25A3 (ENSG00000075415), SLC25A43 (ENSG00000077713), SLC25A24 (ENSG00000085491), SLC25A1 (ENSG00000100075), SLC25A17 (ENSG00000100372), SLC25A14 (ENSG00000102078), SLC25A15 (ENSG00000102743), SLC25A11 (ENSG00000108528), UCP1 (ENSG00000109424), SLC25A12 (ENSG00000115840), SLC25A2 (ENSG00000120329), SLC25A51 (ENSG00000122696), SLC25A16 (ENSG00000122912), SLC25A35 (ENSG00000125434), SLC25A19 (ENSG00000125454), SLC25A23 (ENSG00000125648), SLC25A47 (ENSG00000140107), SLC25A52 (ENSG00000141437), SLC25A38 (ENSG00000144659), SLC25A26 (ENSG00000144741), SLC25A48 (ENSG00000145832), SLC25A37 (ENSG00000147454), SLC25A25 (ENSG00000148339), SLC25A31 (ENSG00000151475), SLC25A4 (ENSG00000151729), SLC25A27 (ENSG00000153291), SLC25A28 (ENSG00000155287), SLC25A44 (ENSG00000160785), SLC25A45 (ENSG00000162241), SLC25A34 (ENSG00000162461), SLC25A32 (ENSG00000164933), SLC25A6 (ENSG00000169100), SLC25A33 (ENSG00000171612), SLC25A30 (ENSG00000174032), UCP3 (ENSG00000175564), UCP2 (ENSG00000175567)

Protein

Protein identifiers

Solute carrier family 25 member 36 — Q96CQ1 (reviewed: Q96CQ1)

All UniProt accessions (8): A0A384MEA9, A0A3B3ISS3, D6R8Y3, D6RB26, D6RCF5, Q96CQ1, F6SDC8, J3KQA4

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports cytosine, guanosine, inosine and uridine (deoxy)nucleoside mono-, di-, and triphosphates by antiport mechanism. Catalyzes uniport at much lower rate. May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside mono- and diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism. Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Widely expressed at moderate level. Expressed most strongly in pancreas.

Disease relevance. Hyperinsulinemic hypoglycemia, familial, 8 (HHF8) [MIM:620211] A form of hyperinsulinemic hypoglycemia, a clinically and genetically heterogeneous disorder characterized by inappropriate insulin secretion from the pancreatic beta-cells in the presence of low blood glucose levels. HHF8 is an autosomal recessive form characterized by episodes of symptomatic hypoglycemia provoked by protein feeding, and persistent mild hyperammonemia. Affected children tend to have recurrent generalized seizures. The disease is caused by variants affecting the gene represented in this entry.

Activity regulation. Inhibited by pyridoxal 5’-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate).

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the mitochondrial carrier (TC 2.A.29) family.

Isoforms (4)

UniProt IDNamesCanonical?
Q96CQ1-11yes
Q96CQ1-22
Q96CQ1-33
Q96CQ1-44

RefSeq proteins (2): NP_001098117, NP_060625 (=MANE)

Domains & families (InterPro)

IDNameType
IPR002067MCPFamily
IPR018108MCP_transmembraneRepeat
IPR023395MCP_dom_sfHomologous_superfamily
IPR049562SLC25A33/36-likeFamily

Pfam: PF00153

Catalyzed reactions (Rhea), 12 shown:

  • UTP(in) + CTP(out) = UTP(out) + CTP(in) (RHEA:73531)
  • CTP(out) + UDP(in) = CTP(in) + UDP(out) (RHEA:73583)
  • UMP(in) + CTP(out) = UMP(out) + CTP(in) (RHEA:73587)
  • dUTP(in) + CTP(out) = dUTP(out) + CTP(in) (RHEA:73591)
  • dUMP(in) + CTP(out) = dUMP(out) + CTP(in) (RHEA:73595)
  • CDP(in) + CTP(out) = CDP(out) + CTP(in) (RHEA:73599)
  • CTP(out) + CMP(in) = CTP(in) + CMP(out) (RHEA:73603)
  • dCTP(in) + CTP(out) = dCTP(out) + CTP(in) (RHEA:73607)
  • dCDP(in) + CTP(out) = dCDP(out) + CTP(in) (RHEA:73611)
  • dCMP(in) + CTP(out) = dCMP(out) + CTP(in) (RHEA:73615)
  • GTP(in) + CTP(out) = GTP(out) + CTP(in) (RHEA:73619)
  • CTP(out) + GDP(in) = CTP(in) + GDP(out) (RHEA:73623)

UniProt features (15 total): transmembrane region 6, splice variant 4, repeat 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q96CQ1-F187.020.62

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 300 (showing top): GOBP_NUCLEOTIDE_TRANSPORT, RODWELL_AGING_KIDNEY_NO_BLOOD_DN, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, MORF_RAF1, GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOBP_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, GOCC_MITOCHONDRIAL_ENVELOPE, LIAO_METASTASIS, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, CAIRO_HEPATOBLASTOMA_UP, GOBP_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT, FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN

GO Biological Process (7): pyrimidine nucleotide import into mitochondrion (GO:1990519), obsolete mitochondrial genome maintenance (GO:0000002), nucleotide transport (GO:0006862), pyrimidine nucleotide transport (GO:0006864), mitochondrion organization (GO:0007005), regulation of mitochondrial membrane potential (GO:0051881), transmembrane transport (GO:0055085)

GO Molecular Function (1): pyrimidine nucleotide transmembrane transporter activity (GO:0015218)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
pyrimidine nucleotide transport2
intercellular transport1
pyrimidine-containing compound transmembrane transport1
nucleotide transmembrane transport1
organophosphate ester transport1
nucleobase-containing compound transport1
nucleotide transport1
organelle organization1
regulation of membrane potential1
transport1
cellular process1
nucleotide transmembrane transporter activity1
cytoplasm1
intracellular membrane-bounded organelle1
organelle inner membrane1
mitochondrial membrane1
cellular anatomical structure1

Protein interactions and networks

STRING

1086 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
SLC25A36SLC25A53Q5H9E4567
SLC25A36TTC16Q8NEE8497
SLC25A36MDH1BQ5I0G3432
SLC25A36SLC25A26Q70HW3425
SLC25A36RIMS2Q9UQ26402
SLC25A36KCNC4Q03721391
SLC25A36KLHL8Q9P2G9375
SLC25A36YME1L1Q96TA2373
SLC25A36B3GNT9Q6UX72367
SLC25A36MRPL1Q9BYD6365
SLC25A36SLC37A1P57057353
SLC25A36QRICH1Q2TAL8346
SLC25A36SLC25A52Q3SY17344
SLC25A36SLC25A51Q9H1U9333
SLC25A36NMNAT1Q9HAN9326

IntAct

6 interactions, top by confidence:

ABTypeScore
STAT3BANF1psi-mi:“MI:0914”(association)0.530
SLC25A36NME2P1psi-mi:“MI:0915”(physical association)0.400
SLC25A36SLC25A35psi-mi:“MI:0915”(physical association)0.400
Mpsi-mi:“MI:0914”(association)0.350
SLC25A36PTNpsi-mi:“MI:0915”(physical association)0.000

BioGRID (13): NME2P1 (Affinity Capture-MS), NME2P1 (Affinity Capture-MS), SLC25A36 (Affinity Capture-RNA), SLC25A36 (Affinity Capture-RNA), PTN (Two-hybrid), SLC25A36 (Positive Genetic), NME2P1 (Affinity Capture-MS), SLC25A36 (Affinity Capture-MS), SLC25A36 (Affinity Capture-MS), SLC25A36 (Protein-peptide), SLC25A35 (Affinity Capture-MS), SLC25A36 (Affinity Capture-RNA), SLC25A36 (Affinity Capture-RNA)

ESM2 similar proteins: A0A0G2K5L2, A0JN87, G3XP90, G3YAF3, O04619, O77792, O95847, O97562, P55851, P55916, P56499, P56500, P56501, P70406, Q08DK4, Q1LZB3, Q29RM1, Q2YDD9, Q3SZI5, Q3TZX3, Q3V132, Q4V9P0, Q505J6, Q5IS35, Q5NVC1, Q5R5A8, Q5RD81, Q5RFB7, Q5ZKP7, Q6DG32, Q6P036, Q6PGY3, Q7K566, Q8BZ09, Q922G0, Q96CQ1, Q99JD3, Q9BQT8, Q9BSK2, Q9C5M0

Diamond homologs: A0A0G2K5L2, A2ADF7, A4QNX2, B0G143, F1LX07, F1LZW6, F1RFX9, O13844, O43772, O75746, P16261, P39953, Q02978, Q08DK4, Q0II44, Q12482, Q1DRJ3, Q21153, Q26365, Q3KQZ1, Q3TZX3, Q4V8K4, Q505J6, Q54QN2, Q54RB9, Q552L9, Q58DS3, Q5B717, Q5RBC8, Q5RD81, Q5SWT3, Q5XIF9, Q5ZKP7, Q66L49, Q68F18, Q6ZT89, Q75AH6, Q7PQV7, Q86AV5, Q8BH59

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic2
Likely pathogenic0
Uncertain significance27
Likely benign0
Benign1

Top pathogenic / likely-pathogenic (2)

Variant IDHGVSClassification
2443806NM_001104647.3(SLC25A36):c.803dup (p.Ser269fs)Pathogenic
2443807NM_001104647.3(SLC25A36):c.284+3A>TPathogenic

SpliceAI

980 predictions. Top by Δscore:

VariantEffectΔscore
3:140942091:GGAGG:Gdonor_gain1.0000
3:140942092:GAGGG:Gdonor_gain1.0000
3:140942094:GG:Gdonor_gain1.0000
3:140942095:GG:Gdonor_gain1.0000
3:140956523:TTAG:Tacceptor_loss1.0000
3:140956524:TA:Tacceptor_loss1.0000
3:140956525:A:AGacceptor_gain1.0000
3:140956525:A:Tacceptor_loss1.0000
3:140956526:G:GGacceptor_gain1.0000
3:140956526:GA:Gacceptor_gain1.0000
3:140956526:GAT:Gacceptor_gain1.0000
3:140956526:GATGT:Gacceptor_gain1.0000
3:140956692:G:GGdonor_gain1.0000
3:140956695:A:Tdonor_gain1.0000
3:140956698:GCATA:Gdonor_gain1.0000
3:140956711:G:GTdonor_gain1.0000
3:140956712:A:Tdonor_gain1.0000
3:140970990:CAAGG:Cdonor_loss1.0000
3:140970991:AAG:Adonor_loss1.0000
3:140970994:GTAT:Gdonor_loss1.0000
3:140970995:T:Adonor_loss1.0000
3:140973710:TTTCA:Tacceptor_loss1.0000
3:140973711:TTCA:Tacceptor_loss1.0000
3:140973712:TCA:Tacceptor_loss1.0000
3:140973713:CAG:Cacceptor_loss1.0000
3:140973714:A:AGacceptor_gain1.0000
3:140973714:AG:Aacceptor_gain1.0000
3:140973715:G:GAacceptor_gain1.0000
3:140973715:GG:Gacceptor_gain1.0000
3:140974002:CATGG:Cdonor_loss1.0000

AlphaMissense

1985 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
3:140976404:C:AA296D1.000
3:140942089:C:AA12D0.999
3:140942092:G:AG13E0.999
3:140956532:G:AG16D0.999
3:140956543:G:AG20R0.999
3:140956543:G:CG20R0.999
3:140956544:G:AG20E0.999
3:140956567:G:AE28K0.999
3:140956577:A:TK31I0.999
3:140956578:A:CK31N0.999
3:140956578:A:TK31N0.999
3:140956586:T:CL34P0.999
3:140956590:G:CQ35H0.999
3:140956590:G:TQ35H0.999
3:140959503:G:AG83R0.999
3:140959503:G:CG83R0.999
3:140959504:G:AG83E0.999
3:140959524:G:AG90R0.999
3:140959524:G:CG90R0.999
3:140959525:G:AG90E0.999
3:140959531:C:AA92D0.999
3:140959534:C:AP93H0.999
3:140963129:C:AA96E0.999
3:140963132:T:AI97K0.999
3:140963137:T:CF99L0.999
3:140963138:T:CF99S0.999
3:140963138:T:GF99C0.999
3:140963139:T:AF99L0.999
3:140963139:T:GF99L0.999
3:140963160:G:CK106N0.999

dbSNP variants (sampled 300 via entrez): RS1000019563 (3:140949917 C>G), RS1000065758 (3:140949647 A>G), RS1000126689 (3:140955536 A>C), RS1000216906 (3:140974810 G>A), RS1000232211 (3:140955247 A>G), RS1000278350 (3:140946250 T>C), RS1000337408 (3:140961450 T>C), RS1000378870 (3:140952085 C>G,T), RS1000505642 (3:140940924 T>C), RS1000608620 (3:140945002 C>A,T), RS1000706905 (3:140964245 G>A,T), RS1000806601 (3:140971236 A>C), RS1000954157 (3:140951131 T>C), RS1000986793 (3:140963015 T>C), RS1001595079 (3:140952730 A>G)

Disease associations

OMIM: gene MIM:616149 | disease phenotypes: MIM:620211

GenCC curated gene-disease

DiseaseClassificationInheritance
hyperinsulinemic hypoglycemia, familial, 8StrongAutosomal recessive

Mondo (1): hyperinsulinemic hypoglycemia, familial, 8 (MONDO:0859362)

Orphanet (0):

HPO phenotypes

18 total (18 of 18 shown, HPO-id order):

HPOTerm
HP:0000007Autosomal recessive inheritance
HP:0000821Hypothyroidism
HP:0000842Hyperinsulinemia
HP:0001256Mild intellectual disability
HP:0001263Global developmental delay
HP:0001510Growth delay
HP:0001631Atrial septal defect
HP:0001943Hypoglycemia
HP:0001987Hyperammonemia
HP:0002173Hypoglycemic seizures
HP:0002474Expressive language delay
HP:0002925Elevated circulating thyroid-stimulating hormone concentration
HP:0003124Hypercholesterolemia
HP:0003593Infantile onset
HP:0004322Short stature
HP:0007018Attention deficit hyperactivity disorder
HP:0012450Chronic constipation
HP:0030796Increased C-peptide level

GWAS associations

2 associations (top):

StudyTraitp-value
GCST000269_2Multiple sclerosis3.000000e-06
GCST001572_6Erectile dysfunction in type 1 diabetes5.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Mitochondrial nucleotide transporter subfamily

CTD chemical–gene interactions

60 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects expression, decreases expression, increases expression6
bisphenol Aaffects expression, increases expression3
sodium arsenitedecreases expression, increases abundance, increases expression3
Benzo(a)pyrenedecreases expression3
trichostatin Aaffects cotreatment, decreases expression2
Leflunomideincreases expression2
Arsenicaffects methylation, increases abundance, increases expression2
Dexamethasoneaffects cotreatment, increases expression2
1-Methyl-3-isobutylxanthineincreases expression, affects cotreatment2
aristolochic acid Idecreases expression1
GSK-J4increases expression1
bisphenol Fincreases expression, affects cotreatment1
dicrotophosdecreases expression1
methylmercuric chloridedecreases expression1
triphenyl phosphateaffects expression1
alpha-pineneincreases abundance, affects cotreatment, increases oxidation1
tris(1,3-dichloro-2-propyl)phosphateincreases expression1
cobaltous chlorideincreases expression1
manganese chlorideincreases abundance, increases expression1
potassium chromate(VI)affects cotreatment, increases expression1
methacrylaldehydeaffects cotreatment, increases oxidation, increases abundance1
diallyl trisulfideincreases expression1
epigallocatechin gallateaffects cotreatment, increases expression1
di-n-butylphosphoric acidaffects expression1
perfluorooctane sulfonic aciddecreases expression1
K 7174increases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
ICG 001increases expression1
dorsomorphinaffects cotreatment, decreases expression1
jinfukangdecreases expression1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_D4JZHCT116-SLC25A36-KO-c10Cancer cell lineMale
CVCL_D4K0HCT116-SLC25A36-KO-c8Cancer cell lineMale
CVCL_TM37HAP1 SLC25A36 (-)Cancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgtopdb_interactiongwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot