SLC25A37

Summary

SLC25A37 (solute carrier family 25 member 37, HGNC:29786) is a protein-coding gene on chromosome 8p21.2, encoding Mitoferrin-1 (Q9NYZ2). Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.

SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).

Source: NCBI Gene 51312 — RefSeq curated summary.

At a glance

• GWAS associations: 38
• Clinical variants (ClinVar): 43 total
• MANE Select transcript: NM_016612

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29786
Approved symbol	SLC25A37
Name	solute carrier family 25 member 37
Location	8p21.2
Locus type	gene with protein product
Status	Approved
Aliases	MSCP, MFRN, MFRN1, HT015
Ensembl gene	ENSG00000147454
Ensembl biotype	protein_coding
OMIM	610387
Entrez	51312

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 5 protein_coding_CDS_not_defined, 3 retained_intron, 2 nonsense_mediated_decay, 2 protein_coding

ENST00000290075, ENST00000417331, ENST00000517923, ENST00000518881, ENST00000519192, ENST00000519973, ENST00000520654, ENST00000520949, ENST00000521637, ENST00000522164, ENST00000523883, ENST00000523930

RefSeq mRNA: 4 — MANE Select: NM_016612 NM_001317812, NM_001317813, NM_001317814, NM_016612

CCDS: CCDS47828

Canonical transcript exons

ENST00000519973 — 4 exons

Exon	Start	End
ENSE00001109011	23566108	23566336
ENSE00002099106	23528956	23529212
ENSE00002106908	23571335	23575463
ENSE00003527106	23568322	23568378

Expression profiles

Bgee: expression breadth ubiquitous, 280 present calls, max score 99.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 164.1648 / max 29079.7212, expressed in 1823 samples.

FANTOM5 promoters (23 alternative TSS)

Promoter ID	TPM avg	Samples expressed
87909	137.6266	1811
87906	10.5509	1744
87931	9.0088	1367
87910	1.3956	570
87911	1.1829	524
87923	0.5089	114
87913	0.4607	86
87908	0.3894	113
87914	0.3833	61
87924	0.3546	90

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
trabecular bone tissue	UBERON:0002483	99.65	gold quality
blood	UBERON:0000178	99.64	gold quality
bone marrow	UBERON:0002371	98.16	gold quality
bone element	UBERON:0001474	98.03	gold quality
monocyte	CL:0000576	97.65	gold quality
mononuclear cell	CL:0000842	97.57	gold quality
vena cava	UBERON:0004087	97.51	gold quality
mucosa of paranasal sinus	UBERON:0005030	97.27	gold quality
sperm	CL:0000019	97.14	gold quality
leukocyte	CL:0000738	97.14	gold quality
jejunal mucosa	UBERON:0000399	97.04	gold quality
duodenum	UBERON:0002114	96.98	gold quality
pericardium	UBERON:0002407	96.70	gold quality
pylorus	UBERON:0001166	96.46	gold quality
cartilage tissue	UBERON:0002418	96.44	gold quality
adrenal cortex	UBERON:0001235	96.43	gold quality
left adrenal gland cortex	UBERON:0035825	96.33	gold quality
right adrenal gland	UBERON:0001233	96.28	gold quality
left adrenal gland	UBERON:0001234	96.14	gold quality
right adrenal gland cortex	UBERON:0035827	96.02	gold quality
jejunum	UBERON:0002115	95.84	gold quality
right lung	UBERON:0002167	95.82	gold quality
spleen	UBERON:0002106	95.73	gold quality
adrenal gland	UBERON:0002369	95.55	gold quality
bone marrow cell	CL:0002092	95.51	gold quality
tendon of biceps brachii	UBERON:0008188	95.19	gold quality
trachea	UBERON:0003126	95.15	gold quality
minor salivary gland	UBERON:0001830	95.12	gold quality
superior surface of tongue	UBERON:0007371	95.04	gold quality
nipple	UBERON:0002030	95.02	gold quality

Single-cell (SCXA)

Detected in 33 experiment(s), a significant marker in 30.

Experiment	Marker?	Max mean expression
E-GEOD-149689	yes	7856.95
E-GEOD-150728	yes	4250.33
E-CURD-122	yes	3930.23
E-MTAB-9221	yes	3787.89
E-MTAB-10042	yes	3541.99
E-CURD-112	yes	3417.36
E-MTAB-8205	yes	2605.52
E-MTAB-7407	yes	2201.16
E-HCAD-9	yes	1968.99
E-CURD-55	yes	1533.97
E-HCAD-4	yes	1471.45
E-HCAD-15	yes	1447.70
E-CURD-120	yes	1423.13
E-MTAB-8894	yes	1226.61
E-MTAB-6653	yes	1086.22

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GATA1

miRNA regulators (miRDB)

142 targeting SLC25A37, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-497-5P	99.92	71.83	2674

Literature-anchored findings (GeneRIF, showing 9)

• hypoxia induces the expression of mitoferrin mRNAs through separate mechanisms in erythroid cells (PMID:19187226)
• Data show that abnormal MFRN1 expression can contribute to erythropoietic protoporphyria phenotype in some patients, probably by causing a reduction in FECH activity. (PMID:21627978)
• Compares and contrasts all the known human SLC25A* genes and includes functional information. (PMID:23266187)
• RNA-sequencing and Reverse transcriptase PCR showed higher expression of a specific isoform of SLC25A37 in SF3B1-mutant patients, a crucial importer of Fe(2+) into the mitochondria (PMID:24854990)
• The findings of this study implicate that the SCL25A37 is a major depressive disorder susceptibility gene whose expression may influence major depressive disorder risk. (PMID:27643475)
• Our data show that there is a metabolic link between the activity ferrochelatase and levels of MFRN1 mRNA. We examined the correlation between ferrochelatase activity and MFRN1 mRNA in cell lines established from patients with the classical protoporphyria. (PMID:30391163)
• Studied iron metabolism in polycythemia vera and essential thrombocytosis using serum levels of hepcidin, GDF15, and mitoferrin-1. (PMID:30761871)
• MiR-7 mediates mitochondrial impairment to trigger apoptosis and necroptosis in Rhabdomyosarcoma. (PMID:32810522)
• Identification of key genes in coronary artery disease: an integrative approach based on weighted gene co-expression network analysis and their correlation with immune infiltration. (PMID:33686958)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc25a37	ENSDARG00000073743
mus_musculus	Slc25a37	ENSMUSG00000034248
rattus_norvegicus	Slc25a37	ENSRNOG00000015495

Paralogs (49): SLC25A13 (ENSG00000004864), SLC25A5 (ENSG00000005022), SLC25A39 (ENSG00000013306), SLC25A40 (ENSG00000075303), SLC25A3 (ENSG00000075415), SLC25A43 (ENSG00000077713), SLC25A24 (ENSG00000085491), SLC25A1 (ENSG00000100075), SLC25A17 (ENSG00000100372), SLC25A14 (ENSG00000102078), SLC25A15 (ENSG00000102743), SLC25A11 (ENSG00000108528), UCP1 (ENSG00000109424), SLC25A36 (ENSG00000114120), SLC25A12 (ENSG00000115840), SLC25A2 (ENSG00000120329), SLC25A51 (ENSG00000122696), SLC25A16 (ENSG00000122912), SLC25A35 (ENSG00000125434), SLC25A19 (ENSG00000125454), SLC25A23 (ENSG00000125648), SLC25A47 (ENSG00000140107), SLC25A52 (ENSG00000141437), SLC25A38 (ENSG00000144659), SLC25A26 (ENSG00000144741), SLC25A48 (ENSG00000145832), SLC25A25 (ENSG00000148339), SLC25A31 (ENSG00000151475), SLC25A4 (ENSG00000151729), SLC25A27 (ENSG00000153291), SLC25A28 (ENSG00000155287), SLC25A44 (ENSG00000160785), SLC25A45 (ENSG00000162241), SLC25A34 (ENSG00000162461), SLC25A32 (ENSG00000164933), SLC25A6 (ENSG00000169100), SLC25A33 (ENSG00000171612), SLC25A30 (ENSG00000174032), UCP3 (ENSG00000175564), UCP2 (ENSG00000175567)

Protein

Protein identifiers

Mitoferrin-1 — Q9NYZ2 (reviewed: Q9NYZ2)

Alternative names: Mitochondrial iron transporter 1, Mitochondrial solute carrier protein, Solute carrier family 25 member 37

All UniProt accessions (3): Q9NYZ2, F8W9Q7, H0YAT5

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.

Subunit / interactions. Interacts with ACB10; this interaction stabilizes SLC25A37 and enhances the function of SLC25A37 to import mitochondrial iron during erythroid differentiation.

Subcellular location. Mitochondrion inner membrane.

Similarity. Belongs to the mitochondrial carrier (TC 2.A.29) family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NYZ2-1	1	yes
Q9NYZ2-2	2
Q9NYZ2-4	4

RefSeq proteins (4): NP_001304741, NP_001304742, NP_001304743, NP_057696* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018108	MCP_transmembrane	Repeat
IPR023395	MCP_dom_sf	Homologous_superfamily

Pfam: PF00153

Catalyzed reactions (Rhea), 1 shown:

• Fe(2+)(in) = Fe(2+)(out) (RHEA:28486)

UniProt features (17 total): transmembrane region 6, splice variant 3, repeat 3, sequence variant 2, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NYZ2-F1	77.81	0.27

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis
R-HSA-1430728	Metabolism

MSigDB gene sets: 285 (showing top): TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN, GOBP_HEMOGLOBIN_METABOLIC_PROCESS, RRAGTTGT_UNKNOWN, GOBP_TRANSITION_METAL_ION_TRANSPORT, IVANOVA_HEMATOPOIESIS_MATURE_CELL, GGGTGGRR_PAX4_03, GOBP_IRON_ION_TRANSPORT, MODULE_503, GOBP_MONOATOMIC_CATION_TRANSPORT, CREB_Q4, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN, chr8p21, FOSTER_TOLERANT_MACROPHAGE_DN, MODULE_195, YANG_BREAST_CANCER_ESR1_DN

GO Biological Process (4): positive regulation of hemoglobin biosynthetic process (GO:0046985), iron import into the mitochondrion (GO:0048250), monoatomic ion transport (GO:0006811), iron ion transport (GO:0006826)

GO Molecular Function (3): iron ion transmembrane transporter activity (GO:0005381), ferrous iron transmembrane transporter activity (GO:0015093), protein binding (GO:0005515)

GO Cellular Component (4): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial membrane (GO:0031966), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
iron ion transmembrane transport	2
positive regulation of macromolecule biosynthetic process	1
hemoglobin biosynthetic process	1
regulation of hemoglobin biosynthetic process	1
positive regulation of protein metabolic process	1
intercellular transport	1
transport	1
transition metal ion transport	1
transition metal ion transmembrane transporter activity	1
iron ion transmembrane transporter activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1036 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC25A37	ABCB10	Q9NRK6	999
SLC25A37	FECH	P22830	985
SLC25A37	ABCB7	O75027	882
SLC25A37	FXN	Q16595	774
SLC25A37	ABCB8	Q9NUT2	769
SLC25A37	ZHX2	Q9Y6X8	763
SLC25A37	CPOX	P36551	719
SLC25A37	SLC11A2	P49281	698
SLC25A37	TFRC	P02786	695
SLC25A37	HBA1	P01922	693
SLC25A37	ALAS2	P22557	676
SLC25A37	A0A0J9YYA3	A0A0J9YYA3	668
SLC25A37	ISCU	Q9H1K1	651
SLC25A37	NFS1	Q9Y697	636
SLC25A37	ACO1	P21399	633

IntAct

5 interactions, top by confidence:

A	B	Type	Score
SLC25A37	PNMA3	psi-mi:“MI:0915”(physical association)	0.560
SLC25A37	RAB30	psi-mi:“MI:0914”(association)	0.350
SLC25A37	PNMA3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (11): SLC25A37 (Affinity Capture-RNA), PNMA3 (Two-hybrid), SLC25A37 (Negative Genetic), SLC25A37 (Affinity Capture-RNA), SLC25A28 (Negative Genetic), SLC25A37 (Affinity Capture-RNA), RAB30 (Affinity Capture-MS), TMEM181 (Affinity Capture-MS), TTYH3 (Affinity Capture-MS), SLC25A37 (Affinity Capture-RNA), SLC25A37 (Affinity Capture-RNA)

ESM2 similar proteins: A0JN87, A6QR09, F1R4U0, F1RFX9, O22261, O43772, O43808, O70579, O77792, O95258, O97562, O97649, P55851, P55916, P56499, P56501, P70406, P97521, Q08DK4, Q287T7, Q3SZI5, Q4V9P0, Q5R5A8, Q5RD81, Q5RFB7, Q5U680, Q5ZKP7, Q641C8, Q66H23, Q6DG32, Q6GLA2, Q6IZB5, Q70HW3, Q8BMG8, Q8HXY2, Q8R0Z5, Q920G8, Q922G0, Q95J75, Q96A46

Diamond homologs: A0A0U2IR85, A0A3G9HRV8, A2CEQ0, A6RAY2, A6SL61, A7ER02, B0DK57, B8ZHC9, F1R4U0, G3YC86, G3YD89, G3YFS7, O13844, O94502, P32089, P33303, P34519, P38152, P53007, P55851, P56500, P70406, P79110, Q07534, Q10442, Q287T7, Q2UCW8, Q3SZI5, Q3ZBJ8, Q59KC4, Q5AVW1, Q5R5A8, Q66H23, Q68F18, Q6BH02, Q6C107, Q6C6I3, Q6GLJ0, Q6PGY3, Q7XA87

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	1
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1527 predictions. Top by Δscore:

Variant	Effect	Δscore
8:23566095:T:A	acceptor_gain	1.0000
8:23566099:C:A	acceptor_gain	1.0000
8:23566287:GACTT:G	donor_gain	1.0000
8:23571243:T:TA	acceptor_gain	1.0000
8:23529208:TGAAG:T	donor_loss	0.9900
8:23529210:AAG:A	donor_gain	0.9900
8:23529211:AGGT:A	donor_loss	0.9900
8:23529212:GGTGA:G	donor_loss	0.9900
8:23529213:G:GC	donor_loss	0.9900
8:23529214:T:A	donor_loss	0.9900
8:23555456:G:T	donor_gain	0.9900
8:23566106:A:AG	acceptor_gain	0.9900
8:23566107:G:GA	acceptor_gain	0.9900
8:23566107:GACAC:G	acceptor_gain	0.9900
8:23566316:G:GT	donor_gain	0.9900
8:23566317:A:T	donor_gain	0.9900
8:23571242:AT:A	acceptor_gain	0.9900
8:23571243:T:G	acceptor_gain	0.9900
8:23571244:G:A	acceptor_gain	0.9900
8:23571248:T:TA	acceptor_gain	0.9900
8:23571858:G:GT	donor_gain	0.9900
8:23529187:TC:T	donor_gain	0.9800
8:23529208:TGA:T	donor_gain	0.9800
8:23555485:GAGGC:G	donor_gain	0.9800
8:23555488:GC:G	donor_gain	0.9800
8:23562994:T:TA	donor_gain	0.9800
8:23566104:CCA:C	acceptor_loss	0.9800
8:23566105:CA:C	acceptor_loss	0.9800
8:23566106:AG:A	acceptor_loss	0.9800
8:23566107:G:GC	acceptor_loss	0.9800

AlphaMissense

2219 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:23566261:T:C	F122L	1.000
8:23566263:T:A	F122L	1.000
8:23566263:T:G	F122L	1.000
8:23571779:C:A	A314D	1.000
8:23571787:T:A	W317R	1.000
8:23571787:T:C	W317R	1.000
8:23529153:G:C	A51P	0.999
8:23529154:C:A	A51E	0.999
8:23529156:G:A	G52R	0.999
8:23529156:G:C	G52R	0.999
8:23529157:G:A	G52E	0.999
8:23529159:G:C	A53P	0.999
8:23529165:G:C	A55P	0.999
8:23529166:C:A	A55D	0.999
8:23529169:G:A	G56E	0.999
8:23529201:G:C	D67H	0.999
8:23529212:G:C	K70N	0.999
8:23529212:G:T	K70N	0.999
8:23566112:G:C	R72P	0.999
8:23566119:G:C	Q74H	0.999
8:23566119:G:T	Q74H	0.999
8:23566213:G:C	G106R	0.999
8:23566247:C:A	A117D	0.999
8:23566252:G:C	A119P	0.999
8:23566253:C:A	A119D	0.999
8:23566262:T:C	F122S	0.999
8:23568328:C:A	A149D	0.999
8:23568331:G:A	G150E	0.999
8:23568333:A:C	S151R	0.999
8:23568335:T:A	S151R	0.999

dbSNP variants (sampled 300 via entrez): RS1000106566 (8:23575951 C>T), RS1000169121 (8:23565181 T>G), RS1000212422 (8:23538881 A>C,G), RS1000221708 (8:23528955 C>A,G,T), RS1000311635 (8:23570745 T>C), RS1000495193 (8:23530374 G>A,T), RS1000576252 (8:23550204 C>A), RS1000585658 (8:23572287 G>C), RS1000603903 (8:23559570 C>A,T), RS1000611347 (8:23536005 G>A), RS1000673851 (8:23560679 G>A), RS1000683517 (8:23570970 T>G), RS1000748371 (8:23559569 A>G), RS1000770276 (8:23528554 A>G,T), RS1000788049 (8:23555550 A>G)

Disease associations

OMIM: gene MIM:610387 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

38 associations (top):

Study	Trait	p-value
GCST004067_104	Hip circumference adjusted for BMI	6.000000e-09
GCST004067_35	Hip circumference adjusted for BMI	5.000000e-07
GCST004094_12	Prostate-specific antigen levels (conditioned on lead SNPs)	1.000000e-15
GCST004267_4	Blood osmolality (transformed sodium)	5.000000e-06
GCST004601_105	Red blood cell count	4.000000e-13
GCST004602_65	Mean corpuscular volume	8.000000e-18
GCST004605_37	Mean corpuscular hemoglobin concentration	2.000000e-16
GCST004619_21	Reticulocyte fraction of red cells	3.000000e-10
GCST004621_120	Red cell distribution width	1.000000e-18
GCST004622_11	Reticulocyte count	6.000000e-09
GCST004863_18	Mosquito bite size	3.000000e-06
GCST005689_3	Major depressive disorder (unexposed to adversity)	7.000000e-09
GCST005691_1	Major depressive disorder	2.000000e-06
GCST005957_7	Waist-to-hip ratio adjusted for BMI (age <50)	3.000000e-06
GCST005958_10	Waist-to-hip ratio adjusted for BMI (age >50)	3.000000e-08
GCST005962_21	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	5.000000e-11
GCST005992_13	Mean corpuscular hemoglobin concentration	8.000000e-10
GCST005993_41	Mean corpuscular hemoglobin	1.000000e-10
GCST006804_123	Red cell distribution width	6.000000e-15
GCST006899_3	Thyroid stimulating hormone levels	1.000000e-10
GCST007094_34	Diastolic blood pressure	7.000000e-11
GCST007294_137	Body fat distribution (trunk fat ratio)	3.000000e-08
GCST007295_129	Body fat distribution (leg fat ratio)	6.000000e-08
GCST007932_53	Medication use (thyroid preparations)	2.000000e-08
GCST008363_65	Offspring birth weight	4.000000e-09
GCST008839_157	Height	4.000000e-10
GCST010653_31	Thyroid stimulating hormone levels	1.000000e-21
GCST011369_14	Iron status biomarkers (ferritin levels)	3.000000e-11
GCST012227_142	Hip circumference adjusted for BMI	3.000000e-08
GCST90002390_599	Mean corpuscular hemoglobin	1.000000e-34

EFO canonical traits (17, from GWAS)

EFO ID	Trait name
EFO:0008039	BMI-adjusted hip circumference
EFO:0004305	erythrocyte count
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0007986	reticulocyte count
EFO:0009188	Red cell distribution width
EFO:0008378	mosquito bite reaction size measurement
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004527	mean corpuscular hemoglobin
EFO:0006336	diastolic blood pressure
EFO:0004341	body fat distribution
EFO:0009933	Thyroid preparation use measurement
EFO:0004344	birth weight
EFO:0005939	parental genotype effect measurement
EFO:0004459	ferritin measurement
EFO:0007985	platelet crit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC25 mitochondrial iron transporters subfamily

CTD chemical–gene interactions

60 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects cotreatment, increases expression, affects methylation, decreases expression	4
sodium arsenite	affects expression, decreases expression	3
entinostat	decreases expression, affects cotreatment	2
Cocaine	increases expression	2
Valproic Acid	increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
Aflatoxin B1	increases methylation	2
Asbestos, Crocidolite	affects expression, decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	decreases expression, increases abundance, affects cotreatment	1
pirinixic acid	increases activity, increases expression, affects binding	1
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	affects expression, affects response to substance	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cobaltous chloride	increases expression	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	decreases expression	1
aflatoxin B2	increases methylation	1
coumarin	increases phosphorylation	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
avobenzone	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CD 437	decreases expression	1
2-palmitoylglycerol	increases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
3-(4’-hydroxy-3’-adamantylbiphenyl-4-yl)acrylic acid	decreases expression	1
ICG 001	affects expression	1
dorsomorphin	affects cotreatment, decreases expression	1

Cellosaurus cell lines

6 cell lines: 4 cancer cell line, 2 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4E0	HEK-SLC25A37-KO-c3	Transformed cell line	Female
CVCL_D4E1	HEK-SLC25A37-KO-c6	Transformed cell line	Female
CVCL_D4K1	HCT116-SLC25A37-KO-c2	Cancer cell line	Male
CVCL_D4K2	HCT116-SLC25A37-KO-c6	Cancer cell line	Male
CVCL_TM38	HAP1 SLC25A37 (-) 1	Cancer cell line	Male
CVCL_TM39	HAP1 SLC25A37 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.