SLC25A39

Summary

SLC25A39 (solute carrier family 25 member 39, HGNC:24279) is a protein-coding gene on chromosome 17q21.31, encoding Mitochondrial glutathione transporter SLC25A39 (Q9BZJ4). Mitochondrial transporter required for glutathione import into mitochondria.

This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wide-ranging substrate specificity. Although the encoded protein is currently considered an orphan transporter, this protein is related to other carriers known to transport amino acids. This protein may play a role in iron homeostasis.

Source: NCBI Gene 51629 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 104 total
• MANE Select transcript: NM_001143780

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24279
Approved symbol	SLC25A39
Name	solute carrier family 25 member 39
Location	17q21.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ22407, CGI-69
Ensembl gene	ENSG00000013306
Ensembl biotype	protein_coding
OMIM	610820
Entrez	51629

Gene structure

Transcript identifiers

Ensembl transcripts: 53 — 47 protein_coding, 5 retained_intron, 1 nonsense_mediated_decay

ENST00000225308, ENST00000377095, ENST00000537904, ENST00000585523, ENST00000585636, ENST00000585695, ENST00000586016, ENST00000586633, ENST00000588049, ENST00000588315, ENST00000588767, ENST00000590194, ENST00000591006, ENST00000591151, ENST00000592372, ENST00000592857, ENST00000593166, ENST00000903240, ENST00000903241, ENST00000903242, ENST00000903243, ENST00000903244, ENST00000903245, ENST00000903246, ENST00000903247, ENST00000903248, ENST00000903249, ENST00000903250, ENST00000903251, ENST00000903252, ENST00000903253, ENST00000903254, ENST00000903255, ENST00000903256, ENST00000903257, ENST00000903258, ENST00000903259, ENST00000903260, ENST00000903261, ENST00000903262, ENST00000903263, ENST00000903264, ENST00000903265, ENST00000903266, ENST00000903267, ENST00000903268, ENST00000926094, ENST00000926095, ENST00000926096, ENST00000926097, ENST00000926098, ENST00000955435, ENST00000955436

RefSeq mRNA: 5 — MANE Select: NM_001143780 NM_001143780, NM_001321240, NM_001321241, NM_001366726, NM_016016

CCDS: CCDS11482, CCDS45700, CCDS82138

Canonical transcript exons

ENST00000377095 — 12 exons

Exon	Start	End
ENSE00000390664	44321058	44321231
ENSE00002885746	44324711	44324823
ENSE00002889229	44319628	44320116
ENSE00003497492	44320196	44320276
ENSE00003536000	44320622	44320731
ENSE00003544244	44323284	44323343
ENSE00003556557	44321700	44321767
ENSE00003601221	44323478	44323577
ENSE00003606629	44322419	44322552
ENSE00003617176	44320355	44320436
ENSE00003681580	44322808	44322852
ENSE00003784772	44321434	44321558

Expression profiles

Bgee: expression breadth ubiquitous, 246 present calls, max score 98.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 153.1663 / max 8318.9075, expressed in 1825 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166362	150.9984	1825
166360	1.5927	784
166361	0.5751	270

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	98.79	gold quality
blood	UBERON:0000178	98.73	gold quality
mucosa of transverse colon	UBERON:0004991	98.52	gold quality
metanephros cortex	UBERON:0010533	98.45	gold quality
right lobe of thyroid gland	UBERON:0001119	97.94	gold quality
adenohypophysis	UBERON:0002196	97.93	gold quality
right testis	UBERON:0004534	97.89	gold quality
right adrenal gland	UBERON:0001233	97.81	gold quality
left lobe of thyroid gland	UBERON:0001120	97.80	gold quality
right adrenal gland cortex	UBERON:0035827	97.79	gold quality
body of pancreas	UBERON:0001150	97.78	gold quality
left adrenal gland cortex	UBERON:0035825	97.76	gold quality
left adrenal gland	UBERON:0001234	97.73	gold quality
left testis	UBERON:0004533	97.67	gold quality
esophagus mucosa	UBERON:0002469	97.51	gold quality
cortex of kidney	UBERON:0001225	97.50	gold quality
ileal mucosa	UBERON:0000331	97.34	gold quality
right lobe of liver	UBERON:0001114	97.32	gold quality
body of stomach	UBERON:0001161	97.21	gold quality
transverse colon	UBERON:0001157	97.19	gold quality
bone marrow	UBERON:0002371	97.17	gold quality
skin of abdomen	UBERON:0001416	97.15	gold quality
skin of leg	UBERON:0001511	97.11	gold quality
bone marrow cell	CL:0002092	97.04	gold quality
minor salivary gland	UBERON:0001830	96.97	gold quality
adrenal cortex	UBERON:0001235	96.93	gold quality
adult mammalian kidney	UBERON:0000082	96.84	gold quality
adrenal gland	UBERON:0002369	96.71	gold quality
esophagus	UBERON:0001043	96.68	gold quality
thyroid gland	UBERON:0002046	96.65	gold quality

Single-cell (SCXA)

Detected in 20 experiment(s), a significant marker in 19.

Experiment	Marker?	Max mean expression
E-CURD-122	yes	1282.14
E-CURD-120	yes	1123.09
E-MTAB-9221	yes	838.14
E-MTAB-6653	yes	694.13
E-GEOD-139324	yes	486.69
E-MTAB-8207	yes	436.42
E-HCAD-8	yes	405.31
E-HCAD-36	yes	360.86
E-MTAB-10553	yes	301.57
E-MTAB-10287	yes	277.51
E-HCAD-4	yes	147.57
E-CURD-112	yes	65.96
E-MTAB-10042	yes	43.65
E-HCAD-9	yes	13.55
E-MTAB-9467	yes	10.21

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

21 targeting SLC25A39, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-133A-3P	99.27	71.53	1270
HSA-MIR-133B	99.27	71.53	1270
HSA-MIR-7160-5P	99.11	67.17	2207
HSA-MIR-4254	99.11	65.15	1315
HSA-MIR-7702	99.06	65.95	698
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051
HSA-MIR-555	95.92	65.25	564

Literature-anchored findings (GeneRIF, showing 7)

• Required for functional heme biosynthesis in erythroid cells. Possibly regulate ALAS2 through iron-sulfur cluster biogenesis. (PMID:19656490)
• Compares and contrasts all the known human SLC25A* genes and includes functional information. (PMID:23266187)
• Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period. (PMID:33963205)
• SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. (PMID:34707288)
• Autoregulatory control of mitochondrial glutathione homeostasis. (PMID:37917749)
• Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. (PMID:38157846)
• SLC25A39 links mitochondrial GSH sensing with iron metabolism. (PMID:38364779)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc25a39	ENSMUSG00000018677
rattus_norvegicus	Slc25a39	ENSRNOG00000020994

Paralogs (49): SLC25A13 (ENSG00000004864), SLC25A5 (ENSG00000005022), SLC25A40 (ENSG00000075303), SLC25A3 (ENSG00000075415), SLC25A43 (ENSG00000077713), SLC25A24 (ENSG00000085491), SLC25A1 (ENSG00000100075), SLC25A17 (ENSG00000100372), SLC25A14 (ENSG00000102078), SLC25A15 (ENSG00000102743), SLC25A11 (ENSG00000108528), UCP1 (ENSG00000109424), SLC25A36 (ENSG00000114120), SLC25A12 (ENSG00000115840), SLC25A2 (ENSG00000120329), SLC25A51 (ENSG00000122696), SLC25A16 (ENSG00000122912), SLC25A35 (ENSG00000125434), SLC25A19 (ENSG00000125454), SLC25A23 (ENSG00000125648), SLC25A47 (ENSG00000140107), SLC25A52 (ENSG00000141437), SLC25A38 (ENSG00000144659), SLC25A26 (ENSG00000144741), SLC25A48 (ENSG00000145832), SLC25A37 (ENSG00000147454), SLC25A25 (ENSG00000148339), SLC25A31 (ENSG00000151475), SLC25A4 (ENSG00000151729), SLC25A27 (ENSG00000153291), SLC25A28 (ENSG00000155287), SLC25A44 (ENSG00000160785), SLC25A45 (ENSG00000162241), SLC25A34 (ENSG00000162461), SLC25A32 (ENSG00000164933), SLC25A6 (ENSG00000169100), SLC25A33 (ENSG00000171612), SLC25A30 (ENSG00000174032), UCP3 (ENSG00000175564), UCP2 (ENSG00000175567)

Protein

Protein identifiers

Mitochondrial glutathione transporter SLC25A39 — Q9BZJ4 (reviewed: Q9BZJ4)

Alternative names: Solute carrier family 25 member 39

All UniProt accessions (10): Q9BZJ4, B4DFG5, K7EJI2, K7EKC2, K7EKF4, K7ELM7, K7EMR4, K7EMW3, K7EQS4, K7EQS8

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Expressed in many tissues. Abundant in testis and kidney.

Post-translational modifications. Cleaved and degraded by AFG3L2; degradation by AFG3L2 is regulated by the ability of SLC25A39 to bind iron-sulfur. In absence of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2. The presence of mitochondrial glutathione prevents iron-sulfur-binding to SLC25A39, promoting cleavage and degradation by AFG3L2.

Activity regulation. The activity of SLC25A39 is regulated by levels of mitochondrial glutathione via its ability to bind [2Fe-2S] iron-sulfur cluster. Upon physiological levels of mitochondrial glutathione, glutathione prevents iron-sulfur-binding to SLC25A39 promoting cleavage and degradation by AFG3L2. Upon depletion of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2.

Similarity. Belongs to the mitochondrial carrier (TC 2.A.29) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BZJ4-1	1, CGI-69L	yes
Q9BZJ4-2	2

RefSeq proteins (5): NP_001137252, NP_001308169, NP_001308170, NP_001353655, NP_057100 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018108	MCP_transmembrane	Repeat
IPR023395	MCP_dom_sf	Homologous_superfamily
IPR045315	Mtm1-like	Family

Pfam: PF00153

Catalyzed reactions (Rhea), 1 shown:

• glutathione(in) = glutathione(out) (RHEA:74819)

UniProt features (27 total): topological domain 7, transmembrane region 6, binding site 4, repeat 3, mutagenesis site 3, chain 1, splice variant 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BZJ4-F1	73.84	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 74; 78; 88; 94

Mutagenesis-validated functional residues (3):

Position	Phenotype
74–94	abolished binding to [2fe-2s] cluster, promoting degradation by afg3l2.
226	abolished glutathione import into mitochondria without affecting the levels of nad.
329	abolished glutathione import into mitochondria without affecting the levels of nad.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 172 (showing top): RNGTGGGC_UNKNOWN, GOBP_MODIFIED_AMINO_ACID_TRANSPORT, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS, GOBP_MITOCHONDRIAL_TRANSPORT, GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT, GOBP_RESPONSE_TO_METAL_ION, GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS, GTGCCTT_MIR506, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_TETRAPYRROLE_METABOLIC_PROCESS, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_SULFUR_COMPOUND_TRANSPORT, GOBP_PIGMENT_METABOLIC_PROCESS, GOCC_MITOCHONDRIAL_ENVELOPE

GO Biological Process (7): heme biosynthetic process (GO:0006783), cellular response to iron ion (GO:0071281), glutathione import into mitochondrion (GO:0160007), import into the mitochondrion (GO:0170036), transmembrane transport (GO:0055085), cellular response to glutathione (GO:0072753), mitochondrial transmembrane transport (GO:1990542)

GO Molecular Function (4): glutathione transmembrane transporter activity (GO:0034634), metal ion binding (GO:0046872), 2 iron, 2 sulfur cluster binding (GO:0051537), iron-sulfur cluster binding (GO:0051536)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intercellular transport	2
glutathione transmembrane transport	2
porphyrin-containing compound biosynthetic process	1
heme metabolic process	1
pigment biosynthetic process	1
response to iron ion	1
cellular response to metal ion	1
mitochondrial transmembrane transport	1
transport	1
cellular process	1
response to glutathione	1
cellular response to nitrogen compound	1
cellular response to oxygen-containing compound	1
mitochondrial transport	1
transmembrane transport	1
tripeptide transmembrane transporter activity	1
modified amino acid transmembrane transporter activity	1
sulfur compound transmembrane transporter activity	1
cation binding	1
iron-sulfur cluster binding	1
metal cluster binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

942 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC25A39	RUNDC3A	Q59EK9	892
SLC25A39	GRN	P23781	672
SLC25A39	TMEM14C	Q9P0S9	636
SLC25A39	ISCA1	Q9BUE6	591
SLC25A39	ALAS2	P22557	573
SLC25A39	SLC25A35	Q3KQZ1	571
SLC25A39	TARDBP	Q13148	549
SLC25A39	IBA57	Q5T440	548
SLC25A39	ABCB7	O75027	525
SLC25A39	GATA1	P15976	491
SLC25A39	FECH	P22830	490
SLC25A39	UBB	P02248	470
SLC25A39	SIGMAR1	Q99720	446
SLC25A39	ABCB6	Q9NP58	428
SLC25A39	SFXN1	Q9H9B4	415

IntAct

7 interactions, top by confidence:

A	B	Type	Score
HSPD1	NUDT19	psi-mi:“MI:0914”(association)	0.710
IMPDH1	BCAT2	psi-mi:“MI:0914”(association)	0.530
SLC25A39	ADORA2A	psi-mi:“MI:0915”(physical association)	0.370
IMPDH1	MGST3	psi-mi:“MI:0914”(association)	0.350
lipA	SLC25A39	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (12): SLC25A39 (Affinity Capture-RNA), SLC25A39 (Affinity Capture-RNA), SLC25A39 (Affinity Capture-RNA), SLC25A39 (Affinity Capture-MS), SLC25A39 (Two-hybrid), SLC25A39 (Negative Genetic), SLC25A39 (Affinity Capture-RNA), SLC25A39 (Affinity Capture-MS), SLC25A39 (Affinity Capture-MS), SLC25A39 (Affinity Capture-RNA), SLC25A39 (Protein-peptide), SLC25A39 (Affinity Capture-RNA)

ESM2 similar proteins: A0PC02, A1DI57, A2ADF7, A2R5A0, A3KPP4, G3XP90, O95847, P04633, P10861, P12242, P16260, P56500, Q01888, Q08DK7, Q0CEN9, Q17QI7, Q23125, Q29RM1, Q2UCW8, Q3KQZ1, Q3SZK0, Q4V8K4, Q505J6, Q58DS3, Q5HZE0, Q5IS35, Q5NVC1, Q5SWT3, Q5XIF9, Q6AYL0, Q6IS41, Q6J329, Q6PH61, Q6PIV7, Q6Q0C1, Q7SXW0, Q8BL03, Q8C0K5, Q8N8R3, Q9BV35

Diamond homologs: A0A0G2K5L2, A0JN87, A2ADF7, A4QNX2, F1LX07, F1LZW6, F4HT41, G3YFS7, K3VFR5, O18757, O22261, O43772, O75746, O95258, O97562, O97649, P0C546, P0CI40, P23500, P55851, P55916, P56500, P70406, P97521, Q03028, Q08CI8, Q08DK4, Q08DK7, Q12482, Q17QI7, Q19529, Q1ECW7, Q21153, Q27257, Q3SZI5, Q3SZK0, Q505J6, Q54PY7, Q54QN2, Q54RB9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

104 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1452 predictions. Top by Δscore:

Variant	Effect	Δscore
17:44320112:GAAGC:G	acceptor_gain	1.0000
17:44320113:AAGC:A	acceptor_gain	1.0000
17:44320114:AGC:A	acceptor_gain	1.0000
17:44320115:GC:G	acceptor_gain	1.0000
17:44320116:CC:C	acceptor_gain	1.0000
17:44320117:C:CC	acceptor_gain	1.0000
17:44320117:CTGCA:C	acceptor_loss	1.0000
17:44320120:CAG:C	acceptor_gain	1.0000
17:44320121:A:T	acceptor_gain	1.0000
17:44320122:G:C	acceptor_gain	1.0000
17:44320122:G:GC	acceptor_gain	1.0000
17:44320192:TGA:T	donor_loss	1.0000
17:44320193:GAC:G	donor_loss	1.0000
17:44320194:A:C	donor_loss	1.0000
17:44320195:CCT:C	donor_loss	1.0000
17:44320207:C:A	donor_gain	1.0000
17:44320272:GTTCA:G	acceptor_gain	1.0000
17:44320273:TTCA:T	acceptor_gain	1.0000
17:44320273:TTCAC:T	acceptor_loss	1.0000
17:44320274:TCA:T	acceptor_gain	1.0000
17:44320275:CA:C	acceptor_gain	1.0000
17:44320275:CAC:C	acceptor_gain	1.0000
17:44320276:ACTGC:A	acceptor_loss	1.0000
17:44320277:C:CC	acceptor_gain	1.0000
17:44320277:CTGC:C	acceptor_loss	1.0000
17:44320278:T:A	acceptor_loss	1.0000
17:44320284:C:CT	acceptor_gain	1.0000
17:44320349:CCTCA:C	donor_loss	1.0000
17:44320350:CTCAC:C	donor_loss	1.0000
17:44320352:CACCT:C	donor_loss	1.0000

AlphaMissense

2286 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:44320064:G:C	S339R	0.998
17:44320064:G:T	S339R	0.998
17:44320066:T:G	S339R	0.998
17:44320077:G:T	A335D	0.997
17:44320094:C:A	K329N	0.997
17:44320094:C:G	K329N	0.997
17:44321062:G:C	F229L	0.997
17:44321062:G:T	F229L	0.997
17:44321064:A:G	F229L	0.997
17:44320070:C:A	M337I	0.995
17:44320070:C:G	M337I	0.995
17:44320070:C:T	M337I	0.995
17:44320089:G:T	A331D	0.995
17:44320398:C:A	K280N	0.995
17:44320398:C:G	K280N	0.995
17:44323321:C:A	K36N	0.995
17:44323321:C:G	K36N	0.995
17:44323501:C:T	G21E	0.995
17:44323513:G:T	A17D	0.995
17:44320074:A:T	I336N	0.994
17:44320432:G:T	A269D	0.994
17:44323337:G:T	P31H	0.994
17:44323502:C:G	G21R	0.994
17:44323502:C:T	G21R	0.994
17:44320196:C:G	G322R	0.993
17:44320408:T:A	D277V	0.993
17:44320638:C:T	G262D	0.993
17:44321075:C:G	R225P	0.993
17:44321722:A:G	W124R	0.993
17:44321722:A:T	W124R	0.993

dbSNP variants (sampled 300 via entrez): RS1000425732 (17:44321930 C>A,T), RS1000457072 (17:44322117 T>G), RS1000509295 (17:44322232 G>A), RS1000657851 (17:44326694 A>G), RS1001584367 (17:44324147 T>A,C), RS1002154031 (17:44323075 A>G), RS1002188577 (17:44323155 T>A), RS1002752839 (17:44324833 C>T), RS1002829945 (17:44324965 C>G,T), RS1002845031 (17:44325073 T>G), RS1002878881 (17:44323402 C>A,G,T), RS1002967668 (17:44320570 GC>G,GCC), RS1003345954 (17:44320369 A>G), RS1003974412 (17:44320706 C>G), RS1004762385 (17:44323856 G>A,T)

Disease associations

OMIM: gene MIM:610820 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003991_24	Childhood ear infection	9.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007904	susceptibility to childhood ear infection measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC25 mitochondrial vitamin and co-factor carriers subfamily

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	4
sodium arsenite	increases expression, affects cotreatment, decreases expression, increases abundance	2
Benzo(a)pyrene	decreases expression, increases methylation	2
bisphenol A	increases expression	1
beta-lapachone	increases expression	1
cobaltous chloride	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation	1
N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine	decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
MT19c compound	decreases expression	1
Acetaminophen	increases expression	1
Acrolein	affects cotreatment, increases oxidation	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Atrazine	increases expression	1
Coumestrol	affects cotreatment, increases expression	1
Ozone	affects cotreatment, increases oxidation	1
Quercetin	increases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tunicamycin	decreases expression	1
Thapsigargin	decreases expression	1
Okadaic Acid	increases expression	1

Cellosaurus cell lines

6 cell lines: 5 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3H9	Abcam HEK293T SLC25A39 KO	Transformed cell line	Female
CVCL_D4K5	HCT116-SLC25A39-KO-c7	Cancer cell line	Male
CVCL_D4K6	HCT116-SLC25A39-KO-c8	Cancer cell line	Male
CVCL_TM41	HAP1 SLC25A39 (-) 1	Cancer cell line	Male
CVCL_TM42	HAP1 SLC25A39 (-) 2	Cancer cell line	Male
CVCL_TM43	HAP1 SLC25A39 (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.