SLC25A5-AS1

Summary

SLC25A5-AS1 (SLC25A5 antisense RNA 1, HGNC:43438) is a long non-coding RNA gene on chromosome Xq24.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43438
Approved symbol	SLC25A5-AS1
Name	SLC25A5 antisense RNA 1
Location	Xq24
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224281
Ensembl biotype	lncRNA
Entrez	100303728
RNAcentral	URS000075A9E9 — lncRNA, 3115 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 lncRNA, 1 retained_intron

ENST00000395539, ENST00000445759, ENST00000446986, ENST00000609227, ENST00000665871, ENST00000666209, ENST00000668529, ENST00000701191, ENST00000837075

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000395539 — 1 exons

Exon	Start	End
ENSE00004257176	119466002	119469095

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 75.90.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2104 / max 8.2152, expressed in 99 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
200280	0.2104	99

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibialis anterior	UBERON:0001385	75.90	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.67	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.97	gold quality
ileal mucosa	UBERON:0000331	73.65	gold quality
prefrontal cortex	UBERON:0000451	69.63	gold quality
muscle of leg	UBERON:0001383	69.63	gold quality
gastrocnemius	UBERON:0001388	69.24	gold quality
monocyte	CL:0000576	69.18	gold quality
islet of Langerhans	UBERON:0000006	69.04	gold quality
anterior cingulate cortex	UBERON:0009835	68.79	gold quality
leukocyte	CL:0000738	68.76	gold quality
cortical plate	UBERON:0005343	68.65	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.13	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.89	gold quality
caudate nucleus	UBERON:0001873	67.86	gold quality
bone marrow cell	CL:0002092	67.59	silver quality
amygdala	UBERON:0001876	67.50	gold quality
right frontal lobe	UBERON:0002810	67.49	gold quality
nucleus accumbens	UBERON:0001882	67.45	gold quality
putamen	UBERON:0001874	67.25	gold quality
ventricular zone	UBERON:0003053	67.01	gold quality
granulocyte	CL:0000094	66.88	gold quality
ganglionic eminence	UBERON:0004023	66.79	gold quality
metanephros cortex	UBERON:0010533	66.45	gold quality
neocortex	UBERON:0001950	66.34	gold quality
hypothalamus	UBERON:0001898	66.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.12	gold quality
frontal cortex	UBERON:0001870	65.86	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.61	gold quality
primary visual cortex	UBERON:0002436	65.57	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	6985.90
E-ANND-3	no	4.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Low SLC25A5-AS1 expression is associated with gastric cancer. (PMID:30793479)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.