SLC25A51

Summary

SLC25A51 (solute carrier family 25 member 51, HGNC:23323) is a protein-coding gene on chromosome 9p13.2-p13.1, encoding Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (Q9H1U9). Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria.

Enables NAD transmembrane transporter activity. Involved in mitochondrial NAD transmembrane transport. Located in mitochondrion. Is active in mitochondrial inner membrane.

Source: NCBI Gene 92014 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 39 total
• MANE Select transcript: NM_033412

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23323
Approved symbol	SLC25A51
Name	solute carrier family 25 member 51
Location	9p13.2-p13.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC14836, CG7943
Ensembl gene	ENSG00000122696
Ensembl biotype	protein_coding
OMIM	619153
Entrez	92014

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 11 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000242275, ENST00000377716, ENST00000496760, ENST00000883995, ENST00000883996, ENST00000929115, ENST00000929116, ENST00000929117, ENST00000929118, ENST00000929119, ENST00000950375, ENST00000950376

RefSeq mRNA: 1 — MANE Select: NM_033412 NM_033412

CCDS: CCDS6614

Canonical transcript exons

ENST00000242275 — 3 exons

Exon	Start	End
ENSE00000948550	37887604	37888592
ENSE00001868225	37904068	37904127
ENSE00003673298	37899829	37899950

Expression profiles

Bgee: expression breadth ubiquitous, 192 present calls, max score 88.21.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.8294 / max 166.9792, expressed in 1816 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100751	12.0489	1787
100753	8.5630	1784
100750	0.9154	516
100752	0.6428	353
100748	0.3171	113
100749	0.2283	114
100746	0.1138	28

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.21	gold quality
islet of Langerhans	UBERON:0000006	87.50	gold quality
cortical plate	UBERON:0005343	85.88	gold quality
stromal cell of endometrium	CL:0002255	85.34	gold quality
bone marrow cell	CL:0002092	84.28	gold quality
secondary oocyte	CL:0000655	84.23	gold quality
adrenal tissue	UBERON:0018303	84.22	gold quality
oocyte	CL:0000023	83.32	gold quality
gastrocnemius	UBERON:0001388	81.97	gold quality
muscle of leg	UBERON:0001383	81.90	gold quality
heart right ventricle	UBERON:0002080	81.86	silver quality
monocyte	CL:0000576	81.82	gold quality
leukocyte	CL:0000738	81.78	gold quality
ganglionic eminence	UBERON:0004023	81.67	gold quality
pancreas	UBERON:0001264	81.25	gold quality
colonic epithelium	UBERON:0000397	80.82	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	80.13	gold quality
ileal mucosa	UBERON:0000331	80.03	gold quality
calcaneal tendon	UBERON:0003701	79.99	gold quality
heart left ventricle	UBERON:0002084	79.70	gold quality
ventricular zone	UBERON:0003053	79.57	gold quality
smooth muscle tissue	UBERON:0001135	79.56	gold quality
cardiac ventricle	UBERON:0002082	79.43	gold quality
body of pancreas	UBERON:0001150	79.34	gold quality
right atrium auricular region	UBERON:0006631	79.22	gold quality
omental fat pad	UBERON:0010414	79.17	gold quality
peritoneum	UBERON:0002358	79.10	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.92	gold quality
adipose tissue of abdominal region	UBERON:0007808	78.91	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-7303	no	158.03
E-ANND-3	no	3.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Compares and contrasts all the known human SLC25A* genes and includes functional information. (PMID:23266187)
• SLC25A51 is a mammalian mitochondrial NAD(+) transporter. (PMID:32906142)
• Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. (PMID:33262325)
• Differential levels of CHMP2B, LLPH, and SLC25A51 proteins in secondary renal amyloidosis. (PMID:33583303)
• Welcome to the Family: Identification of the NAD(+) Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25. (PMID:34198503)
• SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis. (PMID:37419986)
• Dynamics of SLC25A51 reveal preference for oxidized NAD[+] and substrate led transport. (PMID:37575034)
• Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD+ levels. (PMID:37587695)
• Layered mechanisms regulating the human mitochondrial NAD+ transporter SLC25A51. (PMID:38108469)
• SLC25A51 decouples the mitochondrial NAD[+]/NADH ratio to control proliferation of AML cells. (PMID:38354740)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc25a51	ENSMUSG00000045973
rattus_norvegicus	Slc25a52	ENSRNOG00000033251
rattus_norvegicus	Slc25a51	ENSRNOG00000039278
rattus_norvegicus	Slc25a51l1	ENSRNOG00000070747

Paralogs (49): SLC25A13 (ENSG00000004864), SLC25A5 (ENSG00000005022), SLC25A39 (ENSG00000013306), SLC25A40 (ENSG00000075303), SLC25A3 (ENSG00000075415), SLC25A43 (ENSG00000077713), SLC25A24 (ENSG00000085491), SLC25A1 (ENSG00000100075), SLC25A17 (ENSG00000100372), SLC25A14 (ENSG00000102078), SLC25A15 (ENSG00000102743), SLC25A11 (ENSG00000108528), UCP1 (ENSG00000109424), SLC25A36 (ENSG00000114120), SLC25A12 (ENSG00000115840), SLC25A2 (ENSG00000120329), SLC25A16 (ENSG00000122912), SLC25A35 (ENSG00000125434), SLC25A19 (ENSG00000125454), SLC25A23 (ENSG00000125648), SLC25A47 (ENSG00000140107), SLC25A52 (ENSG00000141437), SLC25A38 (ENSG00000144659), SLC25A26 (ENSG00000144741), SLC25A48 (ENSG00000145832), SLC25A37 (ENSG00000147454), SLC25A25 (ENSG00000148339), SLC25A31 (ENSG00000151475), SLC25A4 (ENSG00000151729), SLC25A27 (ENSG00000153291), SLC25A28 (ENSG00000155287), SLC25A44 (ENSG00000160785), SLC25A45 (ENSG00000162241), SLC25A34 (ENSG00000162461), SLC25A32 (ENSG00000164933), SLC25A6 (ENSG00000169100), SLC25A33 (ENSG00000171612), SLC25A30 (ENSG00000174032), UCP3 (ENSG00000175564), UCP2 (ENSG00000175567)

Protein

Protein identifiers

Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 — Q9H1U9 (reviewed: Q9H1U9)

Alternative names: Mitochondrial NAD(+) transporter SLC25A51, Mitochondrial carrier triple repeat protein 1, Solute carrier family 25 member 51

All UniProt accessions (1): Q9H1U9

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria. The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated.

Subcellular location. Mitochondrion inner membrane.

Similarity. Belongs to the mitochondrial carrier (TC 2.A.29) family.

RefSeq proteins (1): NP_219480* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018108	MCP_transmembrane	Repeat
IPR023395	MCP_dom_sf	Homologous_superfamily
IPR052465	Mito_NAD+_Carrier	Family

Pfam: PF00153

Catalyzed reactions (Rhea), 1 shown:

• NAD(+)(in) = NAD(+)(out) (RHEA:65408)

UniProt features (15 total): transmembrane region 6, repeat 3, mutagenesis site 2, chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H1U9-F1	82.90	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (2):

Position	Phenotype
91	impaired import of nad(+) into mitochondria.
278	impaired import of nad(+) into mitochondria.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-196807	Nicotinate metabolism

MSigDB gene sets: 183 (showing top): AP1_01, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_NUCLEOTIDE_TRANSPORT, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, KOYAMA_SEMA3B_TARGETS_UP, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4, GOBP_OXIDATIVE_PHOSPHORYLATION, TGCTGAY_UNKNOWN, chr9p13, GOBP_ELECTRON_TRANSPORT_CHAIN, GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOBP_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT

GO Biological Process (3): aerobic electron transport chain (GO:0019646), nicotinate metabolic process (GO:1901847), mitochondrial NAD transmembrane transport (GO:1990549)

GO Molecular Function (1): NAD transmembrane transporter activity (GO:0051724)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of water-soluble vitamins and cofactors	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
NAD transmembrane transport	2
oxidative phosphorylation	1
aerobic respiration	1
respiratory electron transport chain	1
alkaloid metabolic process	1
monocarboxylic acid metabolic process	1
pyridine-containing compound metabolic process	1
adenine nucleotide transmembrane transporter activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

758 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC25A51	SLC25A32	Q9H2D1	637
SLC25A51	SLC25A17	O43808	568
SLC25A51	FRMPD1	Q5SYB0	566
SLC25A51	SLC25A35	Q3KQZ1	531
SLC25A51	SLC25A34	Q6PIV7	499
SLC25A51	A0A2R8YFG2	A0A2R8YFG2	489
SLC25A51	NMNAT1	Q9HAN9	481
SLC25A51	SLC25A48	Q6ZT89	479
SLC25A51	ZNF805	Q5CZA5	454
SLC25A51	SLC25A43	Q8WUT9	423
SLC25A51	SLC12A8	A0AV02	422
SLC25A51	SLC25A44	Q96H78	417
SLC25A51	FLAD1	Q8NFF5	403
SLC25A51	MTCH1	Q9NZJ7	402
SLC25A51	MAGEB6B	A0A0J9YX57	400

IntAct

45 interactions, top by confidence:

A	B	Type	Score
CD27	TCAF2	psi-mi:“MI:0914”(association)	0.640
SCN2B	EXOC5	psi-mi:“MI:0914”(association)	0.640
SLC1A1	AGPAT2	psi-mi:“MI:0914”(association)	0.640
FAM234B	ABCD4	psi-mi:“MI:0914”(association)	0.620
SLC39A5	TMEM223	psi-mi:“MI:0914”(association)	0.530
SLC2A12	METTL15	psi-mi:“MI:0914”(association)	0.530
BTNL3	FAM171A2	psi-mi:“MI:0914”(association)	0.530
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.530
MRAP2	GOLIM4	psi-mi:“MI:0914”(association)	0.530
EVA1B	NRP1	psi-mi:“MI:0914”(association)	0.530
SLC25A51	PCOLCE2	psi-mi:“MI:0915”(physical association)	0.400
ATXN1	SLC25A51	psi-mi:“MI:0915”(physical association)	0.370
KCNC4	GXYLT2	psi-mi:“MI:0914”(association)	0.350
SLC39A12	POM121C	psi-mi:“MI:0914”(association)	0.350
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.350
MRAP2	GOSR1	psi-mi:“MI:0914”(association)	0.350
FMC1	NDUFAB1	psi-mi:“MI:0914”(association)	0.350
FMC1	POLRMT	psi-mi:“MI:0914”(association)	0.350
BSCL2	TMEM223	psi-mi:“MI:0914”(association)	0.350
LDLRAD1	GXYLT2	psi-mi:“MI:0914”(association)	0.350
HCST	TMEM120B	psi-mi:“MI:0914”(association)	0.350
CTLA4	TMEM120B	psi-mi:“MI:0914”(association)	0.350

BioGRID (164): SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), ABCB7 (Proximity Label-MS)

ESM2 similar proteins: A1CIF6, A1CWA4, A2Q9F0, A3M019, A4RPU0, A5D9W9, A6RAY2, A6S8E0, A6SL61, A6ZXL1, A7F9Y3, A7TIQ0, B0DK57, B0Y4J4, B2MVX9, B2VSU4, B3LH09, P0CAT2, P38152, P38921, Q03829, Q07534, Q08CI8, Q0CT66, Q12289, Q1DRJ3, Q2H608, Q2UU67, Q3SY17, Q4WQC5, Q52KK3, Q59KC4, Q5B717, Q5EAC0, Q5HZI9, Q6BH02, Q6C6I3, Q6CNY8, Q6DE75, Q6DJ08

Diamond homologs: A1CIF6, A1CWA4, A2ASZ8, A2CEQ0, A2Q9F0, A4QNX2, A4RPU0, A5D9W9, A5PJZ1, A6RAY2, A6S8E0, A6ZXL1, A7F9Y3, A7TIQ0, B0DK57, B0Y4J4, B2MVX9, B2VSU4, B3LH09, B8ZHC9, F1LX07, F1LZW6, O14281, O18757, O49447, O75746, O94502, O95258, P04710, P0CAT2, P18239, P27081, P29518, P38152, Q07534, Q08CI8, Q09188, Q09461, Q0CT66, Q0V7M4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 53 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SLC-mediated transmembrane transport	6	11.8×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	27
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

817 predictions. Top by Δscore:

Variant	Effect	Δscore
9:37885748:C:CC	acceptor_gain	1.0000
9:37885746:CA:C	acceptor_gain	0.9900
9:37887897:T:TA	donor_gain	0.9900
9:37888041:T:A	donor_gain	0.9900
9:37893747:A:T	acceptor_gain	0.9900
9:37899950:CCT:C	acceptor_gain	0.9900
9:37899952:T:C	acceptor_gain	0.9900
9:37885745:TCA:T	acceptor_gain	0.9800
9:37885746:CAC:C	acceptor_gain	0.9800
9:37887881:TGGC:T	donor_gain	0.9800
9:37897703:TGAC:T	donor_gain	0.9800
9:37899952:T:TC	acceptor_gain	0.9800
9:37887914:TG:T	donor_gain	0.9700
9:37899791:T:C	donor_gain	0.9700
9:37899824:TTCAC:T	donor_loss	0.9700
9:37899825:TCA:T	donor_loss	0.9700
9:37899826:CACCT:C	donor_loss	0.9700
9:37899827:A:AG	donor_loss	0.9700
9:37899951:C:CG	acceptor_loss	0.9700
9:37885652:CGGA:C	donor_gain	0.9600
9:37887644:A:C	donor_gain	0.9600
9:37887915:G:T	donor_gain	0.9600
9:37887927:A:AC	donor_gain	0.9600
9:37887928:C:CC	donor_gain	0.9600
9:37888589:TAACC:T	acceptor_loss	0.9600
9:37888591:ACCTA:A	acceptor_loss	0.9600
9:37888592:CCTA:C	acceptor_loss	0.9600
9:37888593:C:G	acceptor_loss	0.9600
9:37888594:T:A	acceptor_loss	0.9600
9:37885743:CATCA:C	acceptor_gain	0.9500

AlphaMissense

1947 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:37888254:A:C	F99L	0.997
9:37888254:A:T	F99L	0.997
9:37888256:A:G	F99L	0.997
9:37887704:A:G	W283R	0.996
9:37887704:A:T	W283R	0.996
9:37888304:C:G	G83R	0.995
9:37888304:C:T	G83R	0.995
9:37888117:A:G	L145P	0.994
9:37888303:C:T	G83E	0.994
9:37887701:C:G	G284R	0.993
9:37887718:C:G	R278P	0.993
9:37887981:A:C	F190L	0.993
9:37887981:A:T	F190L	0.993
9:37887983:A:G	F190L	0.993
9:37888131:T:A	R140S	0.993
9:37888131:T:G	R140S	0.993
9:37887740:C:G	G271R	0.992
9:37888028:C:G	G175R	0.992
9:37887700:C:T	G284D	0.991
9:37887702:C:A	W283C	0.991
9:37887702:C:G	W283C	0.991
9:37887978:G:C	F191L	0.991
9:37887978:G:T	F191L	0.991
9:37887980:A:G	F191L	0.991
9:37888377:T:A	Q58H	0.991
9:37888377:T:G	Q58H	0.991
9:37888404:A:C	F49L	0.991
9:37888404:A:T	F49L	0.991
9:37888406:A:G	F49L	0.991
9:37887843:T:A	K236N	0.990

dbSNP variants (sampled 300 via entrez): RS1000030454 (9:37880334 A>G), RS1000057257 (9:37906122 G>T), RS1000092181 (9:37880568 T>C), RS1000397581 (9:37899131 G>A), RS1000417256 (9:37878897 C>A,T), RS1000618015 (9:37893468 A>C), RS1000688811 (9:37883208 T>C), RS1000859552 (9:37889187 G>A,C), RS1000869355 (9:37889487 G>A), RS1001025261 (9:37904683 G>A,C), RS1001051728 (9:37895176 T>C), RS1001328751 (9:37882994 C>T), RS1001351464 (9:37900548 T>C), RS1001403683 (9:37900814 T>G), RS1001573003 (9:37877751 T>G)

Disease associations

OMIM: gene MIM:619153 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003772_13	Loneliness (linear analysis)	2.000000e-06
GCST004125_12	Type 2 diabetes (age of onset)	4.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007865	loneliness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC25 mitochondrial vitamin and co-factor carriers subfamily

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, decreases methylation	5
chloropicrin	increases expression	2
Hydrogen Peroxide	affects expression, decreases expression	2
methylmercuric chloride	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	decreases expression, increases abundance	1
potassium chromate(VI)	decreases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
PCI 5002	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	decreases expression, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases expression	1
Carbamazepine	affects expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diuron	decreases expression	1
Doxorubicin	decreases expression	1
Folic Acid	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Zinc	increases expression, affects cotreatment	1
Cyclosporine	increases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4KH	HCT116-SLC25A51-KO-c4	Cancer cell line	Male
CVCL_D4KI	HCT116-SLC25A51-KO-c5	Cancer cell line	Male
CVCL_TM56	HAP1 SLC25A51 (-) 1	Cancer cell line	Male
CVCL_TM57	HAP1 SLC25A51 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.