SLC26A11

Summary

SLC26A11 (solute carrier family 26 member 11, HGNC:14471) is a protein-coding gene on chromosome 17q25.3, encoding Sodium-independent sulfate anion transporter (Q86WA9). Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport.

This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4’-diisothiocyanostilbene-2,2’-disulfonic acid. Alternate splicing results in multiple transcript variants.

Source: NCBI Gene 284129 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 138 total
• MANE Select transcript: NM_001166347

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14471
Approved symbol	SLC26A11
Name	solute carrier family 26 member 11
Location	17q25.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181045
Ensembl biotype	protein_coding
OMIM	610117
Entrez	284129

Gene structure

Transcript identifiers

Ensembl transcripts: 47 — 41 protein_coding, 3 retained_intron, 3 protein_coding_CDS_not_defined

ENST00000361193, ENST00000411502, ENST00000546047, ENST00000571072, ENST00000571176, ENST00000571215, ENST00000571564, ENST00000571602, ENST00000571888, ENST00000572226, ENST00000572652, ENST00000572725, ENST00000573809, ENST00000574967, ENST00000575019, ENST00000576126, ENST00000577155, ENST00000852728, ENST00000852729, ENST00000852730, ENST00000852731, ENST00000852732, ENST00000852733, ENST00000852734, ENST00000852735, ENST00000852736, ENST00000852737, ENST00000852738, ENST00000852739, ENST00000932706, ENST00000932707, ENST00000932708, ENST00000932709, ENST00000932710, ENST00000932711, ENST00000945512, ENST00000945513, ENST00000945514, ENST00000945515, ENST00000945516, ENST00000945517, ENST00000945518, ENST00000945519, ENST00000945520, ENST00000945521, ENST00000945522, ENST00000945523

RefSeq mRNA: 4 — MANE Select: NM_001166347 NM_001166347, NM_001166348, NM_001166349, NM_173626

CCDS: CCDS11771

Canonical transcript exons

ENST00000361193 — 18 exons

Exon	Start	End
ENSE00001265349	80249154	80249287
ENSE00001265355	80248575	80248674
ENSE00001265361	80248130	80248257
ENSE00001265369	80246509	80246649
ENSE00001265379	80246154	80246209
ENSE00001265386	80245196	80245256
ENSE00001325013	80252625	80253500
ENSE00001367771	80220916	80221115
ENSE00001734446	80220427	80220496
ENSE00003475688	80225837	80225916
ENSE00003495689	80237522	80237594
ENSE00003530665	80223252	80223337
ENSE00003576831	80227818	80227960
ENSE00003617776	80221548	80221794
ENSE00003632786	80251329	80251401
ENSE00003633308	80236928	80237103
ENSE00003669058	80241771	80241821
ENSE00003681210	80222655	80222847

Expression profiles

Bgee: expression breadth ubiquitous, 244 present calls, max score 94.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.8676 / max 216.9864, expressed in 1709 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163227	8.2746	1670
163225	1.5951	177
163226	1.0361	304
163228	0.5886	325
208438	0.3172	136
163224	0.0559	21

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	94.52	gold quality
pituitary gland	UBERON:0000007	94.27	gold quality
adenohypophysis	UBERON:0002196	93.76	gold quality
left adrenal gland	UBERON:0001234	93.50	gold quality
left adrenal gland cortex	UBERON:0035825	93.49	gold quality
right adrenal gland	UBERON:0001233	93.07	gold quality
adrenal cortex	UBERON:0001235	93.03	gold quality
right adrenal gland cortex	UBERON:0035827	92.87	gold quality
left lobe of thyroid gland	UBERON:0001120	92.39	gold quality
adrenal gland	UBERON:0002369	92.32	gold quality
right lobe of thyroid gland	UBERON:0001119	92.27	gold quality
hypothalamus	UBERON:0001898	91.86	gold quality
thyroid gland	UBERON:0002046	91.57	gold quality
metanephros	UBERON:0000081	91.44	gold quality
metanephros cortex	UBERON:0010533	91.21	gold quality
granulocyte	CL:0000094	91.11	gold quality
left ovary	UBERON:0002119	89.75	gold quality
adrenal tissue	UBERON:0018303	89.58	gold quality
right ovary	UBERON:0002118	89.50	gold quality
spleen	UBERON:0002106	89.02	gold quality
kidney epithelium	UBERON:0004819	88.88	gold quality
mucosa of stomach	UBERON:0001199	88.86	gold quality
ileal mucosa	UBERON:0000331	88.69	gold quality
upper lobe of left lung	UBERON:0008952	87.98	gold quality
right uterine tube	UBERON:0001302	87.64	gold quality
upper lobe of lung	UBERON:0008948	87.56	gold quality
anterior cingulate cortex	UBERON:0009835	87.44	gold quality
endocervix	UBERON:0000458	87.03	gold quality
nucleus accumbens	UBERON:0001882	86.94	gold quality
body of uterus	UBERON:0009853	86.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.87

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting SLC26A11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-3663-3P	99.84	70.39	798
HSA-MIR-5580-3P	99.70	69.41	2052
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-6797-3P	99.17	66.94	668
HSA-MIR-6501-3P	98.71	67.45	1480
HSA-MIR-6076	98.61	65.69	637
HSA-MIR-3668	98.52	68.76	951
HSA-MIR-338-3P	98.14	67.38	1137
HSA-MIR-10395-3P	98.10	66.70	1726
HSA-MIR-630	97.50	66.38	921
HSA-MIR-643	97.35	67.91	805
HSA-MIR-5194	96.77	63.91	1021
HSA-MIR-6738-5P	96.33	63.61	815

Literature-anchored findings (GeneRIF, showing 1)

• SLC26A11 protein localizes in lysosomes in HeLa cells (PMID:21752829)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc26a11	ENSDARG00000043021
mus_musculus	Slc26a11	ENSMUSG00000039908
rattus_norvegicus	Slc26a11	ENSRNOG00000030537
drosophila_melanogaster	Esp	FBGN0013953
drosophila_melanogaster	CG5002	FBGN0034275
drosophila_melanogaster	CG6928	FBGN0036240
drosophila_melanogaster	CG6125	FBGN0038337
drosophila_melanogaster	CG5404	FBGN0038354
drosophila_melanogaster	CG7912	FBGN0039736
drosophila_melanogaster	CG9702	FBGN0039787
drosophila_melanogaster	CG9717	FBGN0039789

Paralogs (9): SLC26A4 (ENSG00000091137), SLC26A3 (ENSG00000091138), SLC26A8 (ENSG00000112053), SLC26A1 (ENSG00000145217), SLC26A7 (ENSG00000147606), SLC26A2 (ENSG00000155850), SLC26A5 (ENSG00000170615), SLC26A9 (ENSG00000174502), SLC26A6 (ENSG00000225697)

Protein

Protein identifiers

Sodium-independent sulfate anion transporter — Q86WA9 (reviewed: Q86WA9)

Alternative names: Solute carrier family 26 member 11

All UniProt accessions (8): Q86WA9, I3L0N9, I3L124, I3L1H1, I3L250, I3L266, I3L2J9, I3L3K8

UniProt curated annotations — full annotation on UniProt →

Function. Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). In the kidney, mediates chloride-bicarbonate exchange, facilitating V-ATPase-mediated acid secretion. May function as a chloride channel, playing an important role in moderating chloride homeostasis and neuronal activity in the cerebellum.

Subcellular location. Cell membrane. Lysosome membrane. Apical cell membrane. Basolateral cell membrane.

Tissue specificity. Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart.

Similarity. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.

RefSeq proteins (4): NP_001159819, NP_001159820, NP_001159821, NP_775897 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001902	SLC26A/SulP_fam	Family
IPR002645	STAS_dom	Domain
IPR011547	SLC26A/SulP_dom	Domain
IPR018045	S04_transporter_CS	Conserved_site
IPR036513	STAS_dom_sf	Homologous_superfamily

Pfam: PF00916, PF01740

Catalyzed reactions (Rhea), 3 shown:

• sulfate(in) + H(+)(in) = sulfate(out) + H(+)(out) (RHEA:28574)
• oxalate(in) + chloride(out) = oxalate(out) + chloride(in) (RHEA:72263)
• hydrogencarbonate(in) + chloride(out) = hydrogencarbonate(out) + chloride(in) (RHEA:72363)

UniProt features (37 total): topological domain 13, transmembrane region 12, sequence conflict 9, chain 1, domain 1, sequence variant 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
9IAS	ELECTRON MICROSCOPY	2.8
9IAR	ELECTRON MICROSCOPY	3.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86WA9-F1	86.73	0.63

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-174362	Transport and metabolism of PAPS
R-HSA-427601	Inorganic anion exchange by SLC26 transporters
R-HSA-382551	Transport of small molecules
R-HSA-425393
R-HSA-425407	SLC-mediated transmembrane transport

MSigDB gene sets: 166 (showing top): GOCC_VACUOLAR_MEMBRANE, GOBP_INORGANIC_ANION_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_CHLORIDE_TRANSPORT, WANG_LMO4_TARGETS_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_SULFUR_COMPOUND_TRANSPORT, GOBP_DICARBOXYLIC_ACID_TRANSPORT, GOBP_OXALATE_TRANSPORT, GOCC_APICAL_PLASMA_MEMBRANE, GOBP_TRANSMEMBRANE_TRANSPORT, REACTOME_METABOLISM_OF_CARBOHYDRATES_AND_CARBOHYDRATE_DERIVATIVES, GOCC_APICAL_PART_OF_CELL, LEIN_CHOROID_PLEXUS_MARKERS

GO Biological Process (6): monoatomic ion transport (GO:0006811), oxalate transport (GO:0019532), sulfate transmembrane transport (GO:1902358), chloride transmembrane transport (GO:1902476), transmembrane transport (GO:0055085), obsolete inorganic anion transmembrane transport (GO:0098661)

GO Molecular Function (7): chloride channel activity (GO:0005254), secondary active sulfate transmembrane transporter activity (GO:0008271), monoatomic anion transmembrane transporter activity (GO:0008509), sulfate transmembrane transporter activity (GO:0015116), chloride:bicarbonate antiporter activity (GO:0140900), protein binding (GO:0005515), antiporter activity (GO:0015297)

GO Cellular Component (10): nucleoplasm (GO:0005654), lysosomal membrane (GO:0005765), endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), membrane (GO:0016020), basolateral plasma membrane (GO:0016323), apical plasma membrane (GO:0016324), extracellular exosome (GO:0070062), lysosome (GO:0005764)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Glycosaminoglycan metabolism	1
SLC-mediated transport of inorganic anions	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
monoatomic anion transmembrane transport	2
chloride transmembrane transporter activity	2
secondary active transmembrane transporter activity	2
cellular anatomical structure	2
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
plasma membrane region	2
dicarboxylic acid transport	1
inorganic anion transport	1
transmembrane transport	1
sulfur compound transport	1
chloride transport	1
cellular process	1
monoatomic anion channel activity	1
sulfate transmembrane transporter activity	1
monoatomic ion transmembrane transporter activity	1
sulfur compound transmembrane transporter activity	1
sulfate transmembrane transport	1
solute:inorganic anion antiporter activity	1
bicarbonate:monoatomic anion antiporter activity	1
binding	1
nuclear lumen	1
lysosome	1
lytic vacuole membrane	1
membrane	1
cell periphery	1
basal plasma membrane	1
apical part of cell	1
extracellular vesicle	1
lytic vacuole	1

Protein interactions and networks

STRING

1026 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC26A11	SLC4A3	P48751	644
SLC26A11	SGSH	P51688	616
SLC26A11	SLC4A2	P04920	548
SLC26A11	RNF213	Q63HN8	537
SLC26A11	SLC4A9	Q96Q91	464
SLC26A11	PCYT2	Q99447	420
SLC26A11	SLC4A8	Q2Y0W8	403
SLC26A11	PRR19	A6NJB7	391
SLC26A11	SLC9A8	Q9Y2E8	374
SLC26A11	C3orf70	A6NLC5	366
SLC26A11	SLC15A2	Q16348	365
SLC26A11	SLC35F2	Q8IXU6	365
SLC26A11	SIRT7	Q9NRC8	364
SLC26A11	CCDC73	Q6ZRK6	355
SLC26A11	SLC7A6OS	Q96CW6	352

IntAct

9 interactions, top by confidence:

A	B	Type	Score
SMIM1	SLC26A11	psi-mi:“MI:0915”(physical association)	0.560
SLC26A11	DNAH6	psi-mi:“MI:0915”(physical association)	0.400
SLC26A11	C5AR2	psi-mi:“MI:0915”(physical association)	0.370
SLC26A11	CFTR	psi-mi:“MI:0915”(physical association)	0.370
CFTR	SLC26A11	psi-mi:“MI:0915”(physical association)	0.370
SLC26A11	CNOT1	psi-mi:“MI:0914”(association)	0.350

BioGRID (180): SLC26A11 (Affinity Capture-MS), SMIM1 (Two-hybrid), SLC26A11 (Proximity Label-MS), SLC26A11 (Proximity Label-MS), SLC26A11 (Proximity Label-MS), SLC26A11 (Proximity Label-MS), SLC26A11 (Proximity Label-MS), SLC26A11 (Proximity Label-MS), SLC26A11 (Proximity Label-MS), SLC26A11 (Two-hybrid), SLC26A11 (Proximity Label-MS), SLC26A11 (Proximity Label-MS), SLC26A11 (Proximity Label-MS), DNAH6 (Affinity Capture-MS), SLC26A11 (PCA)

ESM2 similar proteins: A0A494BA31, G3C7W6, O08812, O43246, O97704, P02730, P04919, P15575, P23562, P26430, P31639, P45380, P53792, P58735, P70423, P92946, Q06495, Q06496, Q28615, Q28728, Q58DD2, Q5EBI0, Q60825, Q63008, Q7LBE3, Q80SU6, Q80ZD3, Q86U10, Q86WA9, Q8BLQ7, Q8BU91, Q8CIW6, Q8K4R8, Q8K4V2, Q8N130, Q8NG04, Q8R2Z3, Q923I7, Q92911, Q96Q91

Diamond homologs: G3C7W6, O74377, P23622, P38359, P45380, P53391, P53392, Q02920, Q12325, Q58DD2, Q7T2C4, Q80ZD3, Q86WA9, Q8CIW6, Q8GYH8, Q8HY59, Q94LW6, Q9BXS9, Q9FY46, Q9LW86, Q9SAY1, Q9SXS2, Q9URY8, A8J6J0, O04289, O04722, P53393, P92946, Q9FEP7, Q9MAX3, Q9SV13, A0FKN5, P0AFR2, P0AFR3, P58743, Q9EPH0, P9WGF6, P9WGF7, A4IIF2, D7PC76

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

138 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	113
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3957 predictions. Top by Δscore:

Variant	Effect	Δscore
17:80220221:CTCA:C	donor_loss	1.0000
17:80220222:TCA:T	donor_loss	1.0000
17:80220223:CAC:C	donor_loss	1.0000
17:80220224:A:AC	donor_gain	1.0000
17:80220224:ACCGA:A	donor_loss	1.0000
17:80220225:C:CC	donor_gain	1.0000
17:80220493:GTGG:G	donor_gain	1.0000
17:80220495:GG:G	donor_gain	1.0000
17:80220496:GG:G	donor_gain	1.0000
17:80220497:G:GG	donor_gain	1.0000
17:80222653:A:AG	acceptor_gain	1.0000
17:80222653:AGTAT:A	acceptor_gain	1.0000
17:80222654:G:GA	acceptor_gain	1.0000
17:80222654:GT:G	acceptor_gain	1.0000
17:80222654:GTAT:G	acceptor_gain	1.0000
17:80222654:GTATG:G	acceptor_gain	1.0000
17:80222701:T:TA	acceptor_gain	1.0000
17:80222844:TTGGG:T	donor_loss	1.0000
17:80222846:GG:G	donor_gain	1.0000
17:80222847:GG:G	donor_gain	1.0000
17:80222848:G:GC	donor_loss	1.0000
17:80222848:G:GG	donor_gain	1.0000
17:80222849:T:G	donor_loss	1.0000
17:80223202:G:A	acceptor_gain	1.0000
17:80224168:A:T	donor_gain	1.0000
17:80225830:T:TA	acceptor_gain	1.0000
17:80225835:A:AG	acceptor_gain	1.0000
17:80225836:G:GG	acceptor_gain	1.0000
17:80227816:AG:A	acceptor_gain	1.0000
17:80227817:GG:G	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000020158 (17:80235214 T>C,G), RS1000114468 (17:80253409 C>T), RS1000231519 (17:80246056 G>A,T), RS1000233616 (17:80236249 G>C), RS1000270769 (17:80219780 G>A), RS1000331036 (17:80224691 G>A), RS1000383394 (17:80224923 C>A,G), RS1000437481 (17:80241047 T>C,G), RS1000482949 (17:80225234 C>G,T), RS1000533075 (17:80240436 C>T), RS1000661013 (17:80221197 G>C,T), RS1000667900 (17:80225744 G>C), RS1000866920 (17:80225430 G>A), RS1000927635 (17:80220843 C>A,T), RS1000967920 (17:80244949 T>C,G)

Disease associations

OMIM: gene MIM:610117 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003324_3	Ischemic stroke	6.000000e-07
GCST006104_5	Interleukin-1-receptor antagonist levels	8.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004754	interleukin 1 receptor antagonist measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Other SLC26 anion exchangers

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	3
Valproic Acid	affects expression, increases expression	3
sodium arsenite	decreases expression, increases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases expression	2
Cyclosporine	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
GSK-J4	increases expression	1
FR900359	increases phosphorylation	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
bisphenol A	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
perfluorooctanoic acid	increases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
beta-methylcholine	affects expression	1
Am 580	increases expression	1
K 7174	increases expression	1
3-iodothyronamine	affects uptake	1
jinfukang	affects cotreatment, increases expression	1
Bortezomib	increases expression	1
Rosiglitazone	increases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Arsenic	affects methylation	1
Cisplatin	affects cotreatment, increases expression	1
Coumestrol	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Iron	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4KL	HCT116-SLC26A11-KO-c3	Cancer cell line	Male
CVCL_D4KM	HCT116-SLC26A11-KO-c4	Cancer cell line	Male
CVCL_TM59	HAP1 SLC26A11 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.