SLC26A4-AS1

Summary

SLC26A4-AS1 (SLC26A4 antisense RNA 1, HGNC:22385) is a long non-coding RNA gene on chromosome 7q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:22385
Approved symbol	SLC26A4-AS1
Name	SLC26A4 antisense RNA 1
Location	7q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233705
Ensembl biotype	lncRNA
Entrez	286002
RNAcentral	URS000075A7B4 — lncRNA, 3888 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000440512, ENST00000449741, ENST00000587899, ENST00000591896, ENST00000626388, ENST00000627161, ENST00000629014, ENST00000630476, ENST00000658036, ENST00000662671, ENST00000668981, ENST00000689362, ENST00000690082, ENST00000702951, ENST00000756049, ENST00000756050, ENST00000756051, ENST00000756052, ENST00000756053, ENST00000756054

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000440512 — 5 exons

Exon	Start	End
ENSE00001674745	107656122	107660206
ENSE00002947047	107655096	107655312
ENSE00003871393	107654051	107654233
ENSE00003880798	107662024	107662204
ENSE00004105725	107661602	107661822

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 97.17.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.8366 / max 198.8499, expressed in 122 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85609	0.6862	77
85610	0.4068	73
85607	0.2543	62
85608	0.1900	55
85613	0.1310	36
85612	0.0644	5
85606	0.0361	21
85615	0.0233	16
85614	0.0157	9
85616	0.0148	9

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	97.17	gold quality
thyroid gland	UBERON:0002046	96.38	gold quality
left lobe of thyroid gland	UBERON:0001120	96.16	gold quality
cortical plate	UBERON:0005343	91.47	gold quality
anterior cingulate cortex	UBERON:0009835	90.76	gold quality
buccal mucosa cell	CL:0002336	90.62	gold quality
prefrontal cortex	UBERON:0000451	90.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	87.80	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.98	gold quality
amygdala	UBERON:0001876	85.66	gold quality
neocortex	UBERON:0001950	85.15	gold quality
right frontal lobe	UBERON:0002810	85.05	gold quality
frontal cortex	UBERON:0001870	84.67	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.96	gold quality
cerebral cortex	UBERON:0000956	82.03	gold quality
palpebral conjunctiva	UBERON:0001812	80.80	gold quality
temporal lobe	UBERON:0001871	77.33	gold quality
bone marrow cell	CL:0002092	77.22	gold quality
Ammon’s horn	UBERON:0001954	75.60	gold quality
sural nerve	UBERON:0015488	75.12	gold quality
endothelial cell	CL:0000115	74.30	silver quality
forebrain	UBERON:0001890	74.25	gold quality
nucleus accumbens	UBERON:0001882	73.92	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.55	gold quality
colonic epithelium	UBERON:0000397	71.73	gold quality
Brodmann (1909) area 46	UBERON:0006483	71.52	gold quality
brain	UBERON:0000955	71.43	gold quality
superior frontal gyrus	UBERON:0002661	71.03	gold quality
primary visual cortex	UBERON:0002436	69.26	gold quality
Brodmann (1909) area 23	UBERON:0013554	67.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• For infants with bi-allelic SLC26A4 mutations in China, the degree of hearing loss was mainly severe-to-profound and the audiometric configuration was mainly sloping (PMID:30554688)
• LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5. (PMID:32939012)
• Overexpression of lncRNA SLC26A4-AS1 inhibits papillary thyroid carcinoma progression through recruiting ETS1 to promote ITPR1-mediated autophagy. (PMID:34378314)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.