SLC26A8

Summary

SLC26A8 (solute carrier family 26 member 8, HGNC:14468) is a protein-coding gene on chromosome 6p21.31, encoding Testis anion transporter 1 (Q96RN1). Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane.

This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described.

Source: NCBI Gene 116369 — RefSeq curated summary.

At a glance

• Gene–disease (curated): non-syndromic male infertility due to sperm motility disorder (Strong, GenCC) — +1 more curated relationship
• GWAS associations: 3
• Clinical variants (ClinVar): 184 total — 3 pathogenic
• Phenotypes (HPO): 4
• MANE Select transcript: NM_052961

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14468
Approved symbol	SLC26A8
Name	solute carrier family 26 member 8
Location	6p21.31
Locus type	gene with protein product
Status	Approved
Aliases	TAT1
Ensembl gene	ENSG00000112053
Ensembl biotype	protein_coding
OMIM	608480
Entrez	116369

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron

ENST00000355574, ENST00000394602, ENST00000465492, ENST00000466805, ENST00000469847, ENST00000480663, ENST00000486155, ENST00000490799, ENST00000950665

RefSeq mRNA: 3 — MANE Select: NM_052961 NM_001193476, NM_052961, NM_138718

CCDS: CCDS4813, CCDS4814

Canonical transcript exons

ENST00000490799 — 20 exons

Exon	Start	End
ENSE00001821577	36024504	36024641
ENSE00001855027	35943516	35944340
ENSE00003483215	35977204	35977351
ENSE00003506981	35992510	35992674
ENSE00003511407	35968877	35968954
ENSE00003516274	35951163	35951347
ENSE00003551807	35960993	35961099
ENSE00003575355	35962526	35962621
ENSE00003592312	35951445	35951499
ENSE00003592917	35975375	35975488
ENSE00003593443	35982121	35982203
ENSE00003603235	36019520	36019709
ENSE00003613149	35959714	35959806
ENSE00003627045	35999992	36000108
ENSE00003637272	35997738	35997919
ENSE00003651590	35960843	35960912
ENSE00003653485	36012233	36012372
ENSE00003655369	35991659	35991808
ENSE00003677614	35959460	35959591
ENSE00003678355	35955152	35955520

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 89.95.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5167 / max 206.1458, expressed in 125 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73331	0.4294	98
73332	0.0873	54

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	89.95	gold quality
right testis	UBERON:0004534	89.07	gold quality
testis	UBERON:0000473	87.05	gold quality
adult organism	UBERON:0007023	82.14	gold quality
cerebellar hemisphere	UBERON:0002245	78.30	gold quality
cerebellar cortex	UBERON:0002129	78.19	gold quality
right hemisphere of cerebellum	UBERON:0014890	78.19	gold quality
secondary oocyte	CL:0000655	76.47	gold quality
cerebellum	UBERON:0002037	76.11	gold quality
sperm	CL:0000019	75.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.56	silver quality
blood	UBERON:0000178	74.09	gold quality
oocyte	CL:0000023	72.83	gold quality
bone marrow cell	CL:0002092	72.44	gold quality
right frontal lobe	UBERON:0002810	71.04	gold quality
nucleus accumbens	UBERON:0001882	69.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.41	gold quality
anterior cingulate cortex	UBERON:0009835	68.98	gold quality
prefrontal cortex	UBERON:0000451	68.84	gold quality
hypothalamus	UBERON:0001898	68.29	gold quality
caudate nucleus	UBERON:0001873	67.66	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.48	gold quality
putamen	UBERON:0001874	67.16	gold quality
cortical plate	UBERON:0005343	67.11	gold quality
primary visual cortex	UBERON:0002436	66.81	gold quality
monocyte	CL:0000576	66.80	gold quality
leukocyte	CL:0000738	66.72	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	66.50	silver quality
neocortex	UBERON:0001950	66.50	gold quality
frontal cortex	UBERON:0001870	66.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.96

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

29 targeting SLC26A8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-7154-5P	99.69	70.52	1900
HSA-MIR-4756-3P	99.62	66.30	1319
HSA-MIR-12131	99.48	68.72	1673
HSA-MIR-4728-3P	99.47	68.94	981
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-8066	99.05	68.66	1532
HSA-MIR-6830-5P	99.01	68.73	1884
HSA-MIR-887-5P	98.82	65.90	1347
HSA-MIR-3611	98.76	68.76	1290
HSA-MIR-5187-5P	98.54	67.94	952
HSA-MIR-4266	98.53	67.29	1035
HSA-MIR-6757-5P	98.08	65.50	724
HSA-MIR-4736	97.96	65.89	1287
HSA-MIR-3159	97.94	66.79	1098
HSA-MIR-4638-3P	97.90	65.75	905
HSA-MIR-8055	97.62	66.09	1023
HSA-MIR-1202	97.19	66.43	827
HSA-MIR-3972	97.19	66.46	808
HSA-MIR-4750-3P	96.65	64.38	512
HSA-MIR-6742-5P	96.32	64.01	869
HSA-MIR-5191	95.22	64.69	354
HSA-MIR-6846-3P	94.80	65.19	389
HSA-MIR-1229-5P	94.57	65.78	487

Literature-anchored findings (GeneRIF, showing 5)

• SLC26A8 mutations are not a common cause of male infertility. (PMID:15579655)
• structural defects in sperm are not caused by abnormal transcription or point mutations of the TAT1 and SEPT4 genes; however, although both proteins are expressed, they are not properly localized at sperm annulus (PMID:19221096)
• Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia. (PMID:23582645)
• Novel biallelic mutations in SLC26A8 cause severe asthenozoospermia in humans owing to midpiece defects: Insights into a putative dominant genetic disease. (PMID:34923715)
• The heterozygous mutations of SLC26A8 are not the main actors for male infertility. (PMID:35181959)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc26a8	ENSMUSG00000036196
rattus_norvegicus	Slc26a8	ENSRNOG00000000512

Paralogs (9): SLC26A4 (ENSG00000091137), SLC26A3 (ENSG00000091138), SLC26A1 (ENSG00000145217), SLC26A7 (ENSG00000147606), SLC26A2 (ENSG00000155850), SLC26A5 (ENSG00000170615), SLC26A9 (ENSG00000174502), SLC26A11 (ENSG00000181045), SLC26A6 (ENSG00000225697)

Protein

Protein identifiers

Testis anion transporter 1 — Q96RN1 (reviewed: Q96RN1)

Alternative names: Anion exchange transporter, Solute carrier family 26 member 8

All UniProt accessions (4): Q96RN1, C9JMV8, H7C4T4, H7C5E6

UniProt curated annotations — full annotation on UniProt →

Function. Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane. Stimulates anion transport activity of CFTR. May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation. May play a role in sperm tail differentiation and motility and hence male fertility.

Subunit / interactions. Interacts with RACGAP1. Interacts with CFTR; stimulates anion transport activity of CFTR.

Subcellular location. Membrane.

Tissue specificity. Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids.

Post-translational modifications. N-glycosylated.

Disease relevance. Spermatogenic failure 3 (SPGF3) [MIM:606766] A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low. The disease is caused by variants affecting the gene represented in this entry.

Activity regulation. Activity is inhibited by 4,4’-Di-isothiocyanatostilbene-2,2’-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters) and gluconate.

Induction. Repressed by tunicamycin, an inhibitor of N-glycosylation.

Similarity. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q96RN1-1	1	yes
Q96RN1-2	2
Q96RN1-3	3
Q96RN1-4	4

RefSeq proteins (3): NP_001180405, NP_443193, NP_619732 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001902	SLC26A/SulP_fam	Family
IPR002645	STAS_dom	Domain
IPR011547	SLC26A/SulP_dom	Domain
IPR036513	STAS_dom_sf	Homologous_superfamily

Pfam: PF00916, PF01740

Catalyzed reactions (Rhea), 2 shown:

• oxalate(in) + chloride(out) = oxalate(out) + chloride(in) (RHEA:72263)
• sulfate(out) + chloride(in) = sulfate(in) + chloride(out) (RHEA:75295)

UniProt features (48 total): topological domain 13, transmembrane region 12, sequence variant 7, splice variant 5, compositionally biased region 3, region of interest 2, sequence conflict 2, chain 1, domain 1, glycosylation site 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96RN1-F1	68.44	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 192

Mutagenesis-validated functional residues (1):

Position	Phenotype
914	not a cause of male infertility.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 103 (showing top): MODULE_255, MODULE_317, GOBP_INORGANIC_ANION_TRANSPORT, GOBP_MALE_GAMETE_GENERATION, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_CHLORIDE_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_SULFUR_COMPOUND_TRANSPORT, GOBP_DICARBOXYLIC_ACID_TRANSPORT, GOBP_OXALATE_TRANSPORT, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_MEIOTIC_CELL_CYCLE, GOCC_MOTILE_CILIUM, MARSON_BOUND_BY_FOXP3_STIMULATED

GO Biological Process (9): chloride transport (GO:0006821), spermatogenesis (GO:0007283), oxalate transport (GO:0019532), cell differentiation (GO:0030154), meiotic cell cycle (GO:0051321), sulfate transmembrane transport (GO:1902358), chloride transmembrane transport (GO:1902476), monoatomic ion transport (GO:0006811), transmembrane transport (GO:0055085)

GO Molecular Function (7): chloride channel activity (GO:0005254), sulfate transmembrane transporter activity (GO:0015116), oxalate transmembrane transporter activity (GO:0019531), chloride:bicarbonate antiporter activity (GO:0140900), sulfate:chloride antiporter activity (GO:0160044), protein binding (GO:0005515), antiporter activity (GO:0015297)

GO Cellular Component (3): plasma membrane (GO:0005886), sperm annulus (GO:0097227), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
chloride transmembrane transporter activity	3
inorganic anion transport	2
transport	2
solute:inorganic anion antiporter activity	2
cellular anatomical structure	2
monoatomic anion transport	1
developmental process involved in reproduction	1
male gamete generation	1
dicarboxylic acid transport	1
cellular developmental process	1
cell cycle	1
sexual reproduction	1
reproductive process	1
meiotic nuclear division	1
transmembrane transport	1
sulfur compound transport	1
chloride transport	1
monoatomic anion transmembrane transport	1
cellular process	1
monoatomic anion channel activity	1
sulfur compound transmembrane transporter activity	1
sulfate transmembrane transport	1
dicarboxylic acid transmembrane transporter activity	1
oxalate transport	1
bicarbonate:monoatomic anion antiporter activity	1
secondary active sulfate transmembrane transporter activity	1
binding	1
secondary active transmembrane transporter activity	1
membrane	1
cell periphery	1
sperm flagellum	1

Protein interactions and networks

STRING

1222 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC26A8	RACGAP1	Q9H0H5	932
SLC26A8	ANLN	Q9NQW6	767
SLC26A8	ECT2	Q9H8V3	684
SLC26A8	CFTR	P13569	623
SLC26A8	KIF23	Q02241	587
SLC26A8	DNAJB13	P59910	506
SLC26A8	SLC26A9	Q7LBE3	498
SLC26A8	MYL2	P10916	497
SLC26A8	SLC26A3	P40879	490
SLC26A8	SLC26A4	O43511	479
SLC26A8	DRC9	Q9H095	468
SLC26A8	GARIN2	Q8N9W8	455
SLC26A8	SEPTIN4	O43236	443
SLC26A8	DPY19L2	Q6NUT2	440
SLC26A8	MYH13	Q9UKX3	440

IntAct

6 interactions, top by confidence:

A	B	Type	Score
SLC26A8	RACGAP1	psi-mi:“MI:0915”(physical association)	0.510
RACGAP1	SLC26A8	psi-mi:“MI:0915”(physical association)	0.510
CFTR	SLC26A8	psi-mi:“MI:0915”(physical association)	0.400
SLC26A8	PSMD12	psi-mi:“MI:0914”(association)	0.350

BioGRID (89): SLC26A8 (Two-hybrid), SLC26A8 (Reconstituted Complex), AAAS (Affinity Capture-MS), ABCC4 (Affinity Capture-MS), ADCK2 (Affinity Capture-MS), AMFR (Affinity Capture-MS), BAG2 (Affinity Capture-MS), BAG5 (Affinity Capture-MS), BAG6 (Affinity Capture-MS), C6orf120 (Affinity Capture-MS), CDKAL1 (Affinity Capture-MS), CLPTM1 (Affinity Capture-MS), DNAJB1 (Affinity Capture-MS), DNAJB12 (Affinity Capture-MS), DNAJB4 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2K1Q8, A0AV02, A2A6C4, A5D7L5, A6QNW6, B1MTL0, B2RXE2, C1BKZ7, O18917, P04920, P0DX17, P13808, P16283, P23347, P23348, P35523, P35524, P48746, P48751, P58295, Q0P5V9, Q14940, Q15043, Q15477, Q3MJ16, Q504Y0, Q50L42, Q5FWH7, Q5RB85, Q5RD44, Q64347, Q6A4L1, Q6SJP2, Q761V0, Q8BXR1, Q8CJI3, Q8K0H7, Q8R420, Q8VI23, Q91WD2

Diamond homologs: A6QNW6, Q4R445, Q8R0C3, Q96RN1, P40879, Q8BU91, Q924C9, Q9WVC8, A0FKN5, A4IIF2, A8J6J0, G3C7W6, O43511, O70531, P45380, P50443, P58735, P58743, Q5EBI0, Q5RAL2, Q62273, Q65AC2, Q69DJ1, Q7LBE3, Q7T2C4, Q86WA9, Q8CIW6, Q8HY59, Q8NG04, Q8R2Z3, Q8TE54, Q99NH7, Q9BEG8, Q9BXS9, Q9EPH0, Q9GJY3, Q9H2B4, Q9JKQ2, Q9R154, Q9R155

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

184 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	3
Likely pathogenic	0
Uncertain significance	112
Likely benign	24
Benign	30

Top pathogenic / likely-pathogenic (3)

Variant ID	HGVS	Classification
1686928	NM_052961.4(SLC26A8):c.290T>C (p.Leu97Pro)	Pathogenic
1686929	NM_052961.4(SLC26A8):c.1664del (p.Ile555fs)	Pathogenic
50909	NM_052961.4(SLC26A8):c.260G>A (p.Arg87Gln)	Pathogenic

SpliceAI

3449 predictions. Top by Δscore:

Variant	Effect	Δscore
6:35951158:CTGA:C	donor_loss	1.0000
6:35951161:ACCTT:A	donor_loss	1.0000
6:35951162:CC:C	donor_loss	1.0000
6:35951348:C:CC	acceptor_gain	1.0000
6:35951443:A:AC	donor_gain	1.0000
6:35951444:C:CC	donor_gain	1.0000
6:35959457:AAC:A	donor_gain	1.0000
6:35959458:AC:A	donor_gain	1.0000
6:35959459:CC:C	donor_gain	1.0000
6:35962524:A:AC	donor_gain	1.0000
6:35962525:C:CC	donor_gain	1.0000
6:35962525:CA:C	donor_gain	1.0000
6:35975370:CATA:C	donor_loss	1.0000
6:35975371:ATAC:A	donor_loss	1.0000
6:35975372:TA:T	donor_loss	1.0000
6:35975374:CCTGT:C	donor_loss	1.0000
6:36019584:T:TA	donor_gain	1.0000
6:36019707:TTC:T	acceptor_gain	1.0000
6:36019718:G:GC	acceptor_gain	1.0000
6:36027841:G:GT	donor_gain	1.0000
6:36028269:GTGTG:G	donor_gain	1.0000
6:35944337:CATT:C	acceptor_gain	0.9900
6:35944339:TT:T	acceptor_gain	0.9900
6:35944339:TTCTG:T	acceptor_loss	0.9900
6:35944341:C:CC	acceptor_gain	0.9900
6:35944341:CT:C	acceptor_loss	0.9900
6:35948901:AAAC:A	donor_gain	0.9900
6:35948915:TTCC:T	donor_gain	0.9900
6:35948916:TCC:T	donor_gain	0.9900
6:35951219:A:C	donor_gain	0.9900

AlphaMissense

6404 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:35951264:C:G	A791P	0.997
6:35977273:G:C	S368R	0.997
6:35977273:G:T	S368R	0.997
6:35977275:T:G	S368R	0.997
6:35951263:G:T	A791D	0.996
6:35951280:G:C	F785L	0.993
6:35951280:G:T	F785L	0.993
6:35951282:A:G	F785L	0.993
6:35951284:A:G	L784P	0.993
6:35955207:A:G	L726P	0.993
6:35960869:A:C	Y538D	0.993
6:35997748:C:T	G206E	0.993
6:35997749:C:A	G206W	0.993
6:35951251:G:T	A795D	0.992
6:35955210:A:T	I725N	0.992
6:35959724:A:G	L574P	0.992
6:35975453:A:C	S403R	0.992
6:35975453:A:T	S403R	0.992
6:35975455:T:G	S403R	0.992
6:35975472:C:T	G397D	0.992
6:35997749:C:G	G206R	0.992
6:35997749:C:T	G206R	0.992
6:36000015:C:T	G141E	0.991
6:35951266:T:A	D790V	0.990
6:35951281:A:G	F785S	0.990
6:35951462:A:G	L757P	0.990
6:35975473:C:G	G397R	0.990
6:35951267:C:G	D790H	0.989
6:35951274:G:C	S787R	0.989
6:35951274:G:T	S787R	0.989

dbSNP variants (sampled 300 via entrez): RS1000029900 (6:36001772 T>C), RS1000096172 (6:36025400 G>A), RS1000128682 (6:35948773 G>A), RS1000131575 (6:35992194 G>A), RS1000215599 (6:35980606 G>T), RS1000262311 (6:35975550 T>C), RS1000314065 (6:35975849 G>A,T), RS1000314159 (6:35979069 C>G), RS1000341548 (6:35998346 A>T), RS1000346545 (6:36008867 A>G), RS1000428773 (6:35979293 C>T), RS1000429223 (6:36015704 C>A,G,T), RS1000490034 (6:36022831 G>A), RS1000520385 (6:35987276 T>G), RS1000524052 (6:35943746 G>A)

Disease associations

OMIM: gene MIM:608480 | disease phenotypes: MIM:606766

GenCC curated gene-disease

Disease	Classification	Inheritance
non-syndromic male infertility due to sperm motility disorder	Strong	Autosomal recessive
spermatogenic failure 3	Limited	Autosomal dominant

Mondo (2): spermatogenic failure 3 (MONDO:0011720), (MONDO:0017173)

Orphanet (1): Non-syndromic male infertility due to sperm motility disorder (Orphanet:276234)

HPO phenotypes

4 total (4 of 4 shown, HPO-id order):

HPO	Term
HP:0000006	Autosomal dominant inheritance
HP:0003251	Male infertility
HP:0011462	Young adult onset
HP:0012207	Reduced sperm motility

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST007355_3	Antidepressant treatment resistance (> 2 drugs prescribed)	4.000000e-07
GCST012490_19	Femur bone mineral density x serum urate levels interaction	6.000000e-13
GCST90000025_496	Appendicular lean mass	2.000000e-18

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement
EFO:0004980	appendicular lean mass

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C564665	Azoospermia, Nonobstructive (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Other SLC26 anion exchangers

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation	1
potassium perchlorate	decreases expression	1
sodium arsenite	increases expression	1
CGP 52608	affects binding, increases reaction	1
Norethindrone Acetate	increases expression, affects cotreatment	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Estradiol	affects cotreatment, increases expression	1
Cadmium Chloride	increases abundance, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4E2	HEK-SLC26A8-KO-c1	Transformed cell line	Female
CVCL_D4E3	HEK-SLC26A8-KO-c2	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.