SLC27A3

Summary

SLC27A3 (solute carrier family 27 member 3, HGNC:10997) is a protein-coding gene on chromosome 1q21.3, encoding Long-chain fatty acid transport protein 3 (Q5K4L6). Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates.

This gene belongs to a family of integral membrane proteins and encodes a protein that is involved in lipid metabolism. The increased expression of this gene in human neural stem cells derived from induced pluripotent stem cells suggests that it plays an important role in early brain development. Naturally occurring mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 11000 — RefSeq curated summary.

At a glance

• GWAS associations: 18
• Clinical variants (ClinVar): 180 total
• MANE Select transcript: NM_024330

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10997
Approved symbol	SLC27A3
Name	solute carrier family 27 member 3
Location	1q21.3
Locus type	gene with protein product
Status	Approved
Aliases	FATP3, MGC4365, ACSVL3
Ensembl gene	ENSG00000143554
Ensembl biotype	protein_coding
OMIM	604193
Entrez	11000

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 14 protein_coding, 7 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000271857, ENST00000368659, ENST00000368660, ENST00000458027, ENST00000461269, ENST00000468044, ENST00000468403, ENST00000483574, ENST00000484014, ENST00000524676, ENST00000531251, ENST00000532853, ENST00000624995, ENST00000865507, ENST00000865508, ENST00000865509, ENST00000865510, ENST00000865511, ENST00000865512, ENST00000923985, ENST00000955569, ENST00000955570

RefSeq mRNA: 2 — MANE Select: NM_024330 NM_001317929, NM_024330

CCDS: CCDS1053

Canonical transcript exons

ENST00000623839 — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 136 present calls, max score 96.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.1365 / max 220.1561, expressed in 1614 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5447	6.9446	1347
5445	2.3346	1114
5443	0.4431	199
201742	0.1389	65
5446	0.1137	42
5444	0.0618	20
5451	0.0495	6
5450	0.0474	19
201743	0.0030	2

Top tissues by expression

136 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.89	gold quality
descending thoracic aorta	UBERON:0002345	96.67	gold quality
thoracic aorta	UBERON:0001515	96.12	gold quality
ascending aorta	UBERON:0001496	96.07	gold quality
right lung	UBERON:0002167	95.70	gold quality
mucosa of stomach	UBERON:0001199	95.56	gold quality
right coronary artery	UBERON:0001625	95.23	gold quality
subcutaneous adipose tissue	UBERON:0002190	95.21	gold quality
upper lobe of left lung	UBERON:0008952	94.96	gold quality
adipose tissue	UBERON:0001013	94.89	gold quality
left coronary artery	UBERON:0001626	94.78	gold quality
omental fat pad	UBERON:0010414	94.55	gold quality
leukocyte	CL:0000738	94.30	gold quality
monocyte	CL:0000576	94.26	gold quality
right uterine tube	UBERON:0001302	94.23	gold quality
right lobe of liver	UBERON:0001114	94.15	gold quality
body of stomach	UBERON:0001161	94.08	gold quality
fundus of stomach	UBERON:0001160	93.89	gold quality
thoracic mammary gland	UBERON:0005200	93.84	gold quality
adenohypophysis	UBERON:0002196	93.15	gold quality
liver	UBERON:0002107	93.09	gold quality
lung	UBERON:0002048	92.94	gold quality
apex of heart	UBERON:0002098	92.86	gold quality
left uterine tube	UBERON:0001303	92.85	gold quality
skin of leg	UBERON:0001511	92.76	gold quality
zone of skin	UBERON:0000014	92.72	gold quality
skin of abdomen	UBERON:0001416	92.71	gold quality
fallopian tube	UBERON:0003889	92.68	gold quality
popliteal artery	UBERON:0002250	92.62	gold quality
tibial artery	UBERON:0007610	92.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	16.34

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

4 targeting SLC27A3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-7111-3P	97.80	66.75	1467
HSA-MIR-6736-3P	96.98	65.22	1342
HSA-MIR-4774-5P	95.92	68.27	827

Literature-anchored findings (GeneRIF, showing 4)

• ACSVL3 maintains oncogenic properties of malignant glioma cells via a mechanism that involves, in part, the regulation of Akt function. (PMID:19920185)
• all of 69 different lung tumors tested, including adeno-, squamous cell, large cell, and small cell carcinomas, had robustly elevated ACSVL3 levels. (PMID:23936004)
• Our findings indicate that the lipid metabolism enzyme ACSVL3 is involved in GBM stem cell maintenance and the tumor-initiating capacity of GBM stem cell enriched-neurospheres in animals (PMID:24893952)
• we resequenced the SLC27A3 and SLC27A4 genes using 267 autism spectrum disorders(ASD) patient and 1140 control samples and detected 47 and 30 variants for the SLC27A3 and SLC27A4, revealing that they are highly polymorphic with multiple rare variants. (PMID:26548558)

Cross-species orthologs

27 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000046054
mus_musculus	Slc27a3	ENSMUSG00000027932
rattus_norvegicus	Slc27a3	ENSRNOG00000015421
drosophila_melanogaster	bgm	FBGN0027348
drosophila_melanogaster	pdgy	FBGN0027601
drosophila_melanogaster	CG8834	FBGN0033733
drosophila_melanogaster	CG17999	FBGN0034552
drosophila_melanogaster	CG9993	FBGN0034553
drosophila_melanogaster	Fatp3	FBGN0034999
drosophila_melanogaster	CG4563	FBGN0035006
drosophila_melanogaster	CG5568	FBGN0035641
drosophila_melanogaster	CG18586	FBGN0035642
drosophila_melanogaster	CG4830	FBGN0037996
drosophila_melanogaster	Acsx1L	FBGN0038730
drosophila_melanogaster	Acsx1R	FBGN0038731
drosophila_melanogaster	Acsx2	FBGN0038732
drosophila_melanogaster	Acsx3	FBGN0038733
drosophila_melanogaster	Acsx4	FBGN0038734
drosophila_melanogaster	Fatp2	FBGN0265187
drosophila_melanogaster	Fatp1	FBGN0267828
drosophila_melanogaster	hll	FBGN0286723
caenorhabditis_elegans		WBGENE00007082
caenorhabditis_elegans		WBGENE00008669
caenorhabditis_elegans		WBGENE00009218
caenorhabditis_elegans		WBGENE00011173
caenorhabditis_elegans		WBGENE00019920
caenorhabditis_elegans		WBGENE00022849

Paralogs (12): ACSL4 (ENSG00000068366), SLC27A5 (ENSG00000083807), ACSBG1 (ENSG00000103740), SLC27A6 (ENSG00000113396), ACSL3 (ENSG00000123983), SLC27A1 (ENSG00000130304), ACSBG2 (ENSG00000130377), SLC27A2 (ENSG00000140284), ACSL1 (ENSG00000151726), ACSL6 (ENSG00000164398), SLC27A4 (ENSG00000167114), ACSL5 (ENSG00000197142)

Protein

Protein identifiers

Long-chain fatty acid transport protein 3 — Q5K4L6 (reviewed: Q5K4L6)

Alternative names: Arachidonate–CoA ligase, Long-chain-fatty-acid–CoA ligase, Solute carrier family 27 member 3, Very long-chain acyl-CoA synthetase homolog 3

All UniProt accessions (5): Q5K4L6, H0YDM5, H0YDP0, H7BZH4, X6R3N0

UniProt curated annotations — full annotation on UniProt →

Function. Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates. Can mediate the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across membranes.

Subcellular location. Mitochondrion membrane.

Tissue specificity. Expressed in bronchial and bronchiolar epithelial cells (at protein level).

Similarity. Belongs to the ATP-dependent AMP-binding enzyme family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q5K4L6-1	1	yes
Q5K4L6-2	2
Q5K4L6-3	3

RefSeq proteins (2): NP_001304858, NP_077306* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000873	AMP-dep_synth/lig_dom	Domain
IPR020845	AMP-binding_CS	Conserved_site
IPR025110	AMP-bd_C	Domain
IPR042099	ANL_N_sf	Homologous_superfamily
IPR045851	AMP-b_sf	Homologous_superfamily

Pfam: PF00501, PF13193

Catalyzed reactions (Rhea), 8 shown:

• a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate (RHEA:15421)
• (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate (RHEA:19713)
• hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate (RHEA:30751)
• (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate (RHEA:33607)
• tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate (RHEA:33639)
• (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate (RHEA:33651)
• a fatty acid(in) = a fatty acid(out) (RHEA:38879)
• a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate (RHEA:54536)

UniProt features (18 total): binding site 6, splice variant 3, sequence variant 2, sequence conflict 2, compositionally biased region 2, chain 1, transmembrane region 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5K4L6-F1	86.90	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (6): 635; 288–292; 331; 428; 528; 543

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs
R-HSA-1430728	Metabolism
R-HSA-556833	Metabolism of lipids
R-HSA-75105	Fatty acyl-CoA biosynthesis
R-HSA-8978868	Fatty acid metabolism

MSigDB gene sets: 159 (showing top): REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS, GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_TRANSPORT, RICKMAN_METASTASIS_DN, KOYAMA_SEMA3B_TARGETS_UP, BILD_E2F3_ONCOGENIC_SIGNATURE, INGRAM_SHH_TARGETS_UP, GOBP_ORGANIC_ANION_TRANSPORT, GOCC_MITOCHONDRIAL_ENVELOPE, GOBP_LIPID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, PU1_Q6, GOBP_MONOCARBOXYLIC_ACID_TRANSPORT, AFFAR_YY1_TARGETS_UP

GO Biological Process (5): long-chain fatty acid metabolic process (GO:0001676), fatty acid transport (GO:0015908), lipid metabolic process (GO:0006629), fatty acid metabolic process (GO:0006631), lipid transport (GO:0006869)

GO Molecular Function (6): long-chain fatty acid-CoA ligase activity (GO:0004467), ATP binding (GO:0005524), very long-chain fatty acid-CoA ligase activity (GO:0031957), arachidonate-CoA ligase activity (GO:0047676), nucleotide binding (GO:0000166), ligase activity (GO:0016874)

GO Cellular Component (6): mitochondrion (GO:0005739), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), membrane (GO:0016020), mitochondrial membrane (GO:0031966)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Fatty acyl-CoA biosynthesis	1
Metabolism	1
Fatty acid metabolism	1
Metabolism of lipids	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
fatty acid-CoA ligase activity	2
cytoplasm	2
intracellular membrane-bounded organelle	2
organelle membrane	2
fatty acid metabolic process	1
lipid transport	1
monocarboxylic acid transport	1
primary metabolic process	1
lipid metabolic process	1
monocarboxylic acid metabolic process	1
transport	1
lipid localization	1
long-chain fatty acid metabolic process	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
long-chain fatty acid-CoA ligase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
catalytic activity	1
endomembrane system	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
cellular anatomical structure	1
mitochondrion	1
mitochondrial envelope	1

Protein interactions and networks

STRING

1216 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC27A3	AASDH	Q4L235	741
SLC27A3	ACSL1	P33121	736
SLC27A3	SCARB1	Q8WTV0	679
SLC27A3	VEGFB	P49765	657
SLC27A3	CD36	P16671	510
SLC27A3	SLC2A10	O95528	468
SLC27A3	SCARB2	Q14108	463
SLC27A3	ACSL4	O60488	460
SLC27A3	SLC35G1	Q2M3R5	445
SLC27A3	ACP6	Q9NPH0	436
SLC27A3	ACSL5	Q9ULC5	399
SLC27A3	COASY	Q13057	394
SLC27A3	ANXA9	O76027	386
SLC27A3	CD302	Q8IX05	384
SLC27A3	ACSL3	O95573	372

IntAct

76 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
LRFN4	RIMOC1	psi-mi:“MI:0914”(association)	0.530
KIR3DL2	METTL15	psi-mi:“MI:0914”(association)	0.530
SPINT2	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
ZNRF4	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
ADAM33	LRP5	psi-mi:“MI:0914”(association)	0.530
CHRND	TPST2	psi-mi:“MI:0914”(association)	0.530
SLC27A3	ATP5F1B	psi-mi:“MI:0914”(association)	0.530
TMEM9	ESYT2	psi-mi:“MI:0914”(association)	0.530
EVA1C	STK25	psi-mi:“MI:0914”(association)	0.530
SIDT2	AP3D1	psi-mi:“MI:0914”(association)	0.530
FLT4	ILVBL	psi-mi:“MI:0914”(association)	0.420
SLC12A8	SLC27A3	psi-mi:“MI:0915”(physical association)	0.400
	HAX1	psi-mi:“MI:0914”(association)	0.350
FAM189B	KLRG2	psi-mi:“MI:0914”(association)	0.350
SLC27A3	RCCD1	psi-mi:“MI:0914”(association)	0.350
TMPRSS3	UPK3BL1	psi-mi:“MI:0914”(association)	0.350
ASIC1	TNFRSF10B	psi-mi:“MI:0914”(association)	0.350
CHRND	EXTL3	psi-mi:“MI:0914”(association)	0.350
ERLEC1	UBE2G2	psi-mi:“MI:0914”(association)	0.350
SMIM22	SPINT2	psi-mi:“MI:0914”(association)	0.350
ERBB2	ILVBL	psi-mi:“MI:0914”(association)	0.350
KCNA2	TMEM129	psi-mi:“MI:0914”(association)	0.350
PCDH10	TMEM223	psi-mi:“MI:0914”(association)	0.350
TTYH1	TMEM223	psi-mi:“MI:0914”(association)	0.350
ZDHHC12	NBAS	psi-mi:“MI:0914”(association)	0.350

BioGRID (134): SLC27A3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), LIMD1 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), HSPA8 (Affinity Capture-MS), ATP5B (Affinity Capture-MS), BAG3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS)

ESM2 similar proteins: A1A4L8, A2BDX3, A4RPM5, A5GFZ6, A6NK58, B0W377, B3MLX7, B4FAT0, B4LRB9, B4N7R4, B4NXF7, B6TNK6, D3KU66, D3KU67, O08600, O19179, O43323, O95396, P22989, P29038, P52785, P55203, P85971, Q02846, Q08DH8, Q0VFH3, Q14249, Q14BV6, Q17CA7, Q3KQV9, Q3TW96, Q561R2, Q58E95, Q5K4L6, Q5PQQ1, Q5ZKI2, Q61488, Q6PAT0, Q7PY41, Q7QFL7

Diamond homologs: E9Q9W4, O05307, O14975, O35488, O42633, O88561, P38225, P97524, P97849, Q3ZKN0, Q4LDG0, Q4R3Y4, Q5K4L6, Q5RDY4, Q60714, Q6P1M0, Q6PCB7, Q8J0E9, Q91VE0, Q9ES38, Q9Y2P4, Q9Y2P5, A0A0U1LQE6, A0A1R3RGK1, G3J9P0, I1S2J4, O53551, Q0S4D7, Q7TWC5, B2HHZ8, A1JIK3, A1RIK1, A1SZA2, A1U2S9, A1UWN5, A2RYW5, A3D3E8, A3MG40, A3NH07, A3P2K7

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
SLC27A3	“up-regulates quantity”	“Fatty acid”	relocalization

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 106 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
chloride transmembrane transport	5	13.5×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

180 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	144
Likely benign	7
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1602 predictions. Top by Δscore:

Variant	Effect	Δscore
1:153777142:G:GT	donor_gain	1.0000
1:153778159:A:AG	acceptor_gain	1.0000
1:153778160:G:GG	acceptor_gain	1.0000
1:153778160:GA:G	acceptor_gain	1.0000
1:153778160:GAGCA:G	acceptor_gain	1.0000
1:153778315:G:GT	donor_gain	1.0000
1:153778351:ACAAG:A	donor_loss	1.0000
1:153778353:AAGGT:A	donor_loss	1.0000
1:153778354:AGGTG:A	donor_loss	1.0000
1:153778357:T:A	donor_loss	1.0000
1:153778796:T:TA	acceptor_gain	1.0000
1:153777057:CACA:C	acceptor_loss	0.9900
1:153777059:CA:C	acceptor_loss	0.9900
1:153777060:A:AG	acceptor_gain	0.9900
1:153777060:AGGC:A	acceptor_loss	0.9900
1:153777061:G:A	acceptor_loss	0.9900
1:153777061:G:GG	acceptor_gain	0.9900
1:153777061:GGC:G	acceptor_gain	0.9900
1:153777221:G:GC	donor_loss	0.9900
1:153777221:G:GG	donor_gain	0.9900
1:153777222:T:G	donor_loss	0.9900
1:153777745:T:TA	acceptor_gain	0.9900
1:153777755:T:A	acceptor_gain	0.9900
1:153777758:CAGG:C	acceptor_loss	0.9900
1:153777760:G:GC	acceptor_loss	0.9900
1:153777837:GTTCC:G	donor_gain	0.9900
1:153777843:G:GG	donor_gain	0.9900
1:153777883:CCGG:C	donor_loss	0.9900
1:153777884:CGG:C	donor_loss	0.9900
1:153777885:GGTG:G	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000047626 (1:153776238 CT>C), RS1000117329 (1:153777350 C>T), RS1000406635 (1:153777765 C>G), RS1000550832 (1:153774982 G>A,C), RS1000652873 (1:153779590 C>T), RS1000687067 (1:153778884 A>C,G), RS1000751182 (1:153774108 G>A), RS1000756506 (1:153777967 G>A,T), RS1000866146 (1:153774280 A>T), RS1001146776 (1:153778746 G>A,C), RS1001930434 (1:153779387 C>T), RS1002033446 (1:153774728 C>G,T), RS1002552547 (1:153774984 G>A), RS1003487041 (1:153780165 T>A,C), RS1003601829 (1:153780457 A>G)

Disease associations

OMIM: gene MIM:604193 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

18 associations (top):

Study	Trait	p-value
GCST003796_1	Number of children ever born	2.000000e-08
GCST006047_1	Number of children ever born	8.000000e-06
GCST007576_218	Chronotype	2.000000e-09
GCST008839_315	Height	2.000000e-12
GCST010136_18	Fruit consumption	3.000000e-08
GCST010137_3	Cooked vegetable consumption	3.000000e-09
GCST010138_14	Raw vegetable consumption	5.000000e-11
GCST010142_60	Fish- and plant-related diet	4.000000e-09
GCST010142_92	Fish- and plant-related diet	6.000000e-14
GCST010696_22	Cortical thickness (min-P)	4.000000e-10
GCST010697_50	Cortical surface area (min-P)	1.000000e-12
GCST010698_81	Subcortical volume (min-P)	1.000000e-23
GCST010699_7	Brain morphology (min-P)	1.000000e-10
GCST010700_11	Cortical thickness (MOSTest)	4.000000e-13
GCST010701_73	Cortical surface area (MOSTest)	4.000000e-09
GCST010702_45	Subcortical volume (MOSTest)	4.000000e-10
GCST010703_276	Brain morphology (MOSTest)	2.000000e-15
GCST011780_10	Neonatal white matter microstructure	4.000000e-06

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0009102	number of children ever born measurement
EFO:0008328	chronotype measurement
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness
EFO:0005674	white matter microstructure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC27 family of fatty acid transporters

CTD chemical–gene interactions

53 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	4
bisphenol S	affects expression, increases expression, affects cotreatment	3
Benzo(a)pyrene	decreases methylation, increases expression, increases methylation	2
Dexamethasone	increases expression, affects cotreatment	2
Tobacco Smoke Pollution	decreases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	increases expression	1
GSK-J4	decreases expression	1
FR900359	increases phosphorylation	1
bisphenol F	increases expression	1
pirinixic acid	decreases expression, increases activity, affects binding	1
bisphenol A	affects cotreatment, increases expression	1
trichostatin A	decreases expression	1
mono-(2-ethylhexyl)phthalate	increases expression	1
sodium arsenite	decreases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
aflatoxin B2	decreases methylation	1
dicyclohexyl phthalate	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
bisphenol B	increases expression	1
(+)-JQ1 compound	decreases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	increases expression	1
Vorinostat	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression	1
Cannabidiol	decreases expression	1

Cellosaurus cell lines

4 cell lines: 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4E6	HEK-SLC27A3-KO-c1	Transformed cell line	Female
CVCL_D4VI	LS180-SLC27A3-KO-c1	Cancer cell line	Female
CVCL_D4VJ	LS180-SLC27A3-KO-c6	Cancer cell line	Female
CVCL_TM68	HAP1 SLC27A3 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.