SLC27A6

Summary

SLC27A6 (solute carrier family 27 member 6, HGNC:11000) is a protein-coding gene on chromosome 5q23.3, encoding Long-chain fatty acid transport protein 6 (Q9Y2P4). Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane.

This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Source: NCBI Gene 28965 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 112 total
• MANE Select transcript: NM_001017372

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11000
Approved symbol	SLC27A6
Name	solute carrier family 27 member 6
Location	5q23.3
Locus type	gene with protein product
Status	Approved
Aliases	FATP6, VLCS-H1, FACVL2, ACSVL2
Ensembl gene	ENSG00000113396
Ensembl biotype	protein_coding
OMIM	604196
Entrez	28965

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 protein_coding

ENST00000262462, ENST00000395266, ENST00000506176, ENST00000508645, ENST00000901438, ENST00000901439, ENST00000901440, ENST00000931384, ENST00000958180, ENST00000958181

RefSeq mRNA: 3 — MANE Select: NM_001017372 NM_001017372, NM_001317984, NM_014031

CCDS: CCDS4145

Canonical transcript exons

ENST00000262462 — 10 exons

Exon	Start	End
ENSE00000762087	129015885	129016079
ENSE00000762088	129023620	129023710
ENSE00000762089	129027133	129027331
ENSE00000762090	129028345	129028442
ENSE00000762091	129029577	129029707
ENSE00000822446	128965488	128966618
ENSE00001172904	128990340	128990464
ENSE00001172916	128988600	128988758
ENSE00001934159	129033106	129033635
ENSE00003474219	128985133	128985336

Expression profiles

Bgee: expression breadth ubiquitous, 175 present calls, max score 98.93.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7839 / max 200.7394, expressed in 353 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58368	0.8156	221
58367	0.5429	211
58369	0.2455	97
58360	0.0630	17
58366	0.0490	25
58370	0.0377	22
58364	0.0230	5
58365	0.0072	1

Top tissues by expression

270 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	98.93	gold quality
oocyte	CL:0000023	95.15	gold quality
right uterine tube	UBERON:0001302	87.16	gold quality
apex of heart	UBERON:0002098	86.91	gold quality
heart left ventricle	UBERON:0002084	85.71	gold quality
heart right ventricle	UBERON:0002080	85.69	gold quality
cardiac ventricle	UBERON:0002082	85.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.73	gold quality
lower esophagus	UBERON:0013473	84.66	gold quality
myocardium	UBERON:0002349	83.50	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.43	silver quality
right adrenal gland cortex	UBERON:0035827	83.32	gold quality
hair follicle	UBERON:0002073	83.22	gold quality
right atrium auricular region	UBERON:0006631	82.98	gold quality
left adrenal gland cortex	UBERON:0035825	82.88	gold quality
cardiac atrium	UBERON:0002081	82.69	gold quality
left adrenal gland	UBERON:0001234	82.67	gold quality
right adrenal gland	UBERON:0001233	81.52	gold quality
heart	UBERON:0000948	80.79	gold quality
adrenal cortex	UBERON:0001235	80.48	gold quality
tibial nerve	UBERON:0001323	80.05	gold quality
cardiac muscle of right atrium	UBERON:0003379	79.29	gold quality
adrenal gland	UBERON:0002369	79.08	gold quality
left ventricle myocardium	UBERON:0006566	78.99	gold quality
esophagus	UBERON:0001043	77.12	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	75.76	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.07	gold quality
left ovary	UBERON:0002119	74.02	gold quality
placenta	UBERON:0001987	73.80	gold quality
trigeminal ganglion	UBERON:0001675	72.75	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.47
E-HCAD-30	no	160.67

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

30 targeting SLC27A6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-12124	99.68	69.17	2700
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-452-5P	99.65	69.63	1762
HSA-MIR-4676-3P	99.65	69.31	1733
HSA-MIR-892C-3P	99.65	69.38	1745
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-6083	99.47	68.73	2393
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-6507-5P	99.36	70.46	2524
HSA-MIR-148A-5P	99.30	68.27	1141
HSA-MIR-4477B	99.23	70.49	1733
HSA-MIR-3675-3P	99.09	67.70	968
HSA-MIR-491-3P	98.88	68.86	1224
HSA-MIR-12125	98.59	67.54	1044
HSA-MIR-12120	98.05	68.44	1768

Literature-anchored findings (GeneRIF, showing 4)

• FATP6 is involved in heart LCFA uptake, in which it may play a role in the pathogenesis of lipid-related cardiac disorders. (PMID:12556534)
• The FATP6-7T>A polymorphism may protect from traits of the metabolic syndrome and CVD. (PMID:21920065)
• Inverse correlation between SLC27A6 expression and breast tumoral tissues.SLC27A6role in the cell growth and cell cycle regulation in non-tumorigenic breast cells. (PMID:30911270)
• Solute Carrier Family 27 Member 6 (SLC27A6) Possibly Promotes the Proliferation of Papillary Thyroid Cancer by Regulating c-MYC. (PMID:35348939)

Cross-species orthologs

27 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc27a6	ENSDARG00000046053
mus_musculus	Slc27a6	ENSMUSG00000024600
rattus_norvegicus	Slc27a6	ENSRNOG00000058193
drosophila_melanogaster	bgm	FBGN0027348
drosophila_melanogaster	pdgy	FBGN0027601
drosophila_melanogaster	CG8834	FBGN0033733
drosophila_melanogaster	CG17999	FBGN0034552
drosophila_melanogaster	CG9993	FBGN0034553
drosophila_melanogaster	Fatp3	FBGN0034999
drosophila_melanogaster	CG4563	FBGN0035006
drosophila_melanogaster	CG5568	FBGN0035641
drosophila_melanogaster	CG18586	FBGN0035642
drosophila_melanogaster	CG4830	FBGN0037996
drosophila_melanogaster	Acsx1L	FBGN0038730
drosophila_melanogaster	Acsx1R	FBGN0038731
drosophila_melanogaster	Acsx2	FBGN0038732
drosophila_melanogaster	Acsx3	FBGN0038733
drosophila_melanogaster	Acsx4	FBGN0038734
drosophila_melanogaster	Fatp2	FBGN0265187
drosophila_melanogaster	Fatp1	FBGN0267828
drosophila_melanogaster	hll	FBGN0286723
caenorhabditis_elegans		WBGENE00007082
caenorhabditis_elegans		WBGENE00008669
caenorhabditis_elegans		WBGENE00009218
caenorhabditis_elegans		WBGENE00011173
caenorhabditis_elegans		WBGENE00019920
caenorhabditis_elegans		WBGENE00022849

Paralogs (12): ACSL4 (ENSG00000068366), SLC27A5 (ENSG00000083807), ACSBG1 (ENSG00000103740), ACSL3 (ENSG00000123983), SLC27A1 (ENSG00000130304), ACSBG2 (ENSG00000130377), SLC27A2 (ENSG00000140284), SLC27A3 (ENSG00000143554), ACSL1 (ENSG00000151726), ACSL6 (ENSG00000164398), SLC27A4 (ENSG00000167114), ACSL5 (ENSG00000197142)

Protein

Protein identifiers

Long-chain fatty acid transport protein 6 — Q9Y2P4 (reviewed: Q9Y2P4)

Alternative names: Arachidonate–CoA ligase, Fatty-acid-coenzyme A ligase, very long-chain 2, Long-chain-fatty-acid–CoA ligase, Solute carrier family 27 member 6, Very long-chain acyl-CoA synthetase homolog 1

All UniProt accessions (2): Q9Y2P4, D6RAJ2

UniProt curated annotations — full annotation on UniProt →

Function. Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation such as the heart.

Subcellular location. Cell membrane. Sarcolemma.

Tissue specificity. Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.

Similarity. Belongs to the ATP-dependent AMP-binding enzyme family.

RefSeq proteins (3): NP_001017372, NP_001304913, NP_054750 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000873	AMP-dep_synth/lig_dom	Domain
IPR020845	AMP-binding_CS	Conserved_site
IPR025110	AMP-bd_C	Domain
IPR042099	ANL_N_sf	Homologous_superfamily
IPR045851	AMP-b_sf	Homologous_superfamily

Pfam: PF00501, PF13193

Catalyzed reactions (Rhea), 9 shown:

• a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate (RHEA:15421)
• (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate (RHEA:19713)
• (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate (RHEA:33607)
• tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate (RHEA:33639)
• (9Z)-octadecenoate(out) = (9Z)-octadecenoate(in) (RHEA:33655)
• a fatty acid(in) = a fatty acid(out) (RHEA:38879)
• hexadecanoate(out) = hexadecanoate(in) (RHEA:45256)
• (9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in) (RHEA:45264)
• a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate (RHEA:54536)

UniProt features (12 total): sequence conflict 7, transmembrane region 2, chain 1, binding site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2P4-F1	90.97	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 221–232

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-804914	Transport of fatty acids
R-HSA-382551	Transport of small molecules
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules
R-HSA-425407	SLC-mediated transmembrane transport

MSigDB gene sets: 102 (showing top): GOZGIT_ESR1_TARGETS_DN, GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_TRANSPORT, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, KEGG_PPAR_SIGNALING_PATHWAY, TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP, GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_LIPID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, GOBP_MONOCARBOXYLIC_ACID_TRANSPORT, GOBP_LONG_CHAIN_FATTY_ACID_TRANSPORT, GOBP_IMPORT_INTO_CELL, GOBP_LIPID_LOCALIZATION

GO Biological Process (8): very long-chain fatty acid metabolic process (GO:0000038), long-chain fatty acid metabolic process (GO:0001676), long-chain fatty acid transport (GO:0015909), long-chain fatty acid import into cell (GO:0044539), lipid metabolic process (GO:0006629), fatty acid metabolic process (GO:0006631), lipid transport (GO:0006869), fatty acid transport (GO:0015908)

GO Molecular Function (7): nucleotide binding (GO:0000166), long-chain fatty acid-CoA ligase activity (GO:0004467), long-chain fatty acid transmembrane transporter activity (GO:0005324), fatty acid transmembrane transporter activity (GO:0015245), very long-chain fatty acid-CoA ligase activity (GO:0031957), arachidonate-CoA ligase activity (GO:0047676), ligase activity (GO:0016874)

GO Cellular Component (4): endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), sarcolemma (GO:0042383), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Transport of vitamins, nucleosides, and related molecules	1
SLC-mediated transmembrane transport	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
fatty acid metabolic process	2
fatty acid transport	2
long-chain fatty acid transport	2
fatty acid-CoA ligase activity	2
import into cell	1
lipid import into cell	1
primary metabolic process	1
lipid metabolic process	1
monocarboxylic acid metabolic process	1
transport	1
lipid localization	1
lipid transport	1
monocarboxylic acid transport	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
long-chain fatty acid metabolic process	1
fatty acid transmembrane transporter activity	1
monocarboxylic acid transmembrane transporter activity	1
lipid transmembrane transporter activity	1
long-chain fatty acid-CoA ligase activity	1
catalytic activity	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
plasma membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1314 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC27A6	ACSL1	P33121	857
SLC27A6	FABP3	P05413	677
SLC27A6	AASDH	Q4L235	657
SLC27A6	CD36	P16671	577
SLC27A6	LPIN1	Q14693	577
SLC27A6	FASN	P49327	553
SLC27A6	SCARB1	Q8WTV0	516
SLC27A6	SCARB2	Q14108	516
SLC27A6	SLC2A1	P11166	504
SLC27A6	DGAT2	Q96PD7	479
SLC27A6	INS	P01308	472
SLC27A6	COASY	Q13057	449
SLC27A6	GOT2	P00505	435
SLC27A6	ACSL3	O95573	410
SLC27A6	FABP5	Q01469	404

IntAct

60 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
SLC27A6	TTC4	psi-mi:“MI:0914”(association)	0.640
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
KCNA5	TMEM223	psi-mi:“MI:0914”(association)	0.530
EVA1C	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
ZNRF4	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
UST	GOLIM4	psi-mi:“MI:0914”(association)	0.530
atp6v0d_human	ATP6AP2	psi-mi:“MI:0914”(association)	0.530
EVA1C	STK25	psi-mi:“MI:0914”(association)	0.530
ARMC6	SLC27A2	psi-mi:“MI:0914”(association)	0.530
SLC27A6	NPM1	psi-mi:“MI:0915”(physical association)	0.400
ATP6V0D1		psi-mi:“MI:0914”(association)	0.350
PCDHGB4	FAM171A2	psi-mi:“MI:0914”(association)	0.350
PMEL	MAN1A2	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
ITM2B	ILVBL	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
KCNA2	TMEM129	psi-mi:“MI:0914”(association)	0.350
IGHM	ESYT2	psi-mi:“MI:0914”(association)	0.350
TTYH1	TMEM223	psi-mi:“MI:0914”(association)	0.350
PCDHA8	TMEM223	psi-mi:“MI:0914”(association)	0.350
LRRC55	TMEM120B	psi-mi:“MI:0914”(association)	0.350
PCDHB6	KLRG2	psi-mi:“MI:0914”(association)	0.350

BioGRID (257): SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), WDR41 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), TTC4 (Affinity Capture-MS), LRRC15 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS), SLC27A6 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2K047, A7MB45, E9Q9W4, M4ISH1, O14975, O22898, O35488, O42633, O60488, O88561, O95573, P30624, P38225, P39002, P97524, Q05567, Q14DH7, Q17577, Q1ZXQ4, Q21166, Q26304, Q2XU92, Q4LDG0, Q54Z60, Q55DR6, Q5R668, Q5REB8, Q63151, Q6BQF2, Q6BS00, Q6FLU2, Q8J0E9, Q8K009, Q99NB1, Q9C509, Q9C7W4, Q9CAP8, Q9CZW4, Q9ES38, Q9H6R3

Diamond homologs: E9Q9W4, O05307, O14975, O35488, O42633, O88561, P38225, P97524, P97849, Q3ZKN0, Q4LDG0, Q4R3Y4, Q5K4L6, Q5RDY4, Q60714, Q6P1M0, Q6PCB7, Q8J0E9, Q91VE0, Q9ES38, Q9Y2P4, Q9Y2P5, A0A0U1LQE6, A0A1R3RGK1, G3J9P0, I1S2J4, O53551, Q0S4D7, Q7TWC5, B2HHZ8, A0A193PS46, Q80WC9, B2HIN2, C5BK10, A0A0A2J5U8, Q4L235, Q9L9G0, P0C061, P39845, Q9SEY5

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
SLC27A6	“up-regulates quantity”	“Fatty acid”	relocalization

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	98
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3066 predictions. Top by Δscore:

Variant	Effect	Δscore
5:128988754:GTTGG:G	donor_gain	1.0000
5:128990338:A:AG	acceptor_gain	1.0000
5:128990338:AG:A	acceptor_gain	1.0000
5:128990338:AGGT:A	acceptor_gain	1.0000
5:128990339:G:GT	acceptor_gain	1.0000
5:128990339:GG:G	acceptor_gain	1.0000
5:128990339:GGT:G	acceptor_gain	1.0000
5:128990339:GGTG:G	acceptor_gain	1.0000
5:128990339:GGTGC:G	acceptor_gain	1.0000
5:128990398:G:GT	donor_gain	1.0000
5:128990460:CTAAG:C	donor_loss	1.0000
5:128990461:TAAG:T	donor_loss	1.0000
5:128990462:AAGG:A	donor_loss	1.0000
5:128990463:AG:A	donor_loss	1.0000
5:128990464:GGTAG:G	donor_loss	1.0000
5:128990466:T:G	donor_loss	1.0000
5:129023618:A:AG	acceptor_gain	1.0000
5:129023619:G:GG	acceptor_gain	1.0000
5:129023619:GCTTC:G	acceptor_gain	1.0000
5:129027127:TTGCA:T	acceptor_loss	1.0000
5:129027128:TGCAG:T	acceptor_loss	1.0000
5:129027129:GCA:G	acceptor_loss	1.0000
5:129027130:CA:C	acceptor_loss	1.0000
5:129027131:A:AC	acceptor_loss	1.0000
5:129027131:A:AG	acceptor_gain	1.0000
5:129027132:G:GG	acceptor_gain	1.0000
5:129027132:GGA:G	acceptor_gain	1.0000
5:129027327:TTCAG:T	donor_loss	1.0000
5:129027328:TCAG:T	donor_loss	1.0000
5:129027329:CAGGT:C	donor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000149973 (5:129006174 G>A), RS1000218825 (5:129007455 A>T), RS1000240653 (5:128995480 A>G,T), RS1000281598 (5:129024142 T>C), RS1000291089 (5:128969571 G>T), RS1000340909 (5:128978330 G>T), RS1000349367 (5:129017916 A>T), RS1000367242 (5:129001869 C>T), RS1000444903 (5:129005863 C>T), RS1000535880 (5:128988431 T>C), RS1000551200 (5:128979090 A>C,G), RS1000558181 (5:129028907 G>T), RS1000622167 (5:129022689 G>A), RS1000629753 (5:129030433 G>A), RS1000696455 (5:128965936 G>C,T)

Disease associations

OMIM: gene MIM:604196 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST003487_9	Response to fenofibrate (total cholesterol levels)	5.000000e-06
GCST003542_108	Night sleep phenotypes	3.000000e-06
GCST006061_150	Atrial fibrillation	2.000000e-07
GCST006414_138	Atrial fibrillation	5.000000e-10
GCST010320_62	PR interval	1.000000e-07
GCST010321_4	PR interval	4.000000e-09
GCST010701_65	Cortical surface area (MOSTest)	1.000000e-09
GCST010702_168	Subcortical volume (MOSTest)	1.000000e-17
GCST010703_157	Brain morphology (MOSTest)	3.000000e-09
GCST011987_1	Congenital right-sided heart lesions	1.000000e-08
GCST90000025_9	Appendicular lean mass	3.000000e-13

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0007806	total cholesterol change measurement
EFO:0004462	PR interval
EFO:0004346	neuroimaging measurement
EFO:0600032	congenital right-sided heart lesions
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC27 family of fatty acid transporters

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	7
trichostatin A	affects cotreatment, increases expression	3
Benzo(a)pyrene	increases methylation, affects methylation, decreases expression, decreases methylation	2
Estradiol	affects cotreatment, increases expression	2
Aflatoxin B1	affects expression, decreases expression	2
CGP 52608	affects binding, increases reaction	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Atrazine	increases expression	1
Diethylhexyl Phthalate	decreases expression, increases expression	1
Methotrexate	increases expression	1
Nickel	decreases expression	1
Tetrachlorodibenzodioxin	affects cotreatment, increases expression	1
Tretinoin	decreases expression	1
Triclosan	decreases expression	1
Cyclosporine	increases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4KW	HCT116-SLC27A6-KO-c10	Cancer cell line	Male
CVCL_D4KX	HCT116-SLC27A6-KO-c2	Cancer cell line	Male
CVCL_TM72	HAP1 SLC27A6 (-) 1	Cancer cell line	Male
CVCL_TM73	HAP1 SLC27A6 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.