SLC2A11
gene geneOn this page
Also known as GLUT11
Summary
SLC2A11 (solute carrier family 2 member 11, HGNC:14239) is a protein-coding gene on chromosome 22q11.23, encoding Solute carrier family 2, facilitated glucose transporter member 11 (Q9BYW1). Facilitative glucose transporter.
This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants.
Source: NCBI Gene 66035 — RefSeq curated summary.
At a glance
- GWAS associations: 2
- Clinical variants (ClinVar): 108 total
- MANE Select transcript:
NM_001024939
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:14239 |
| Approved symbol | SLC2A11 |
| Name | solute carrier family 2 member 11 |
| Location | 22q11.23 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | GLUT11 |
| Ensembl gene | ENSG00000133460 |
| Ensembl biotype | protein_coding |
| OMIM | 610367 |
| Entrez | 66035 |
Gene structure
Transcript identifiers
Ensembl transcripts: 27 — 10 protein_coding, 7 retained_intron, 5 nonsense_mediated_decay, 5 protein_coding_CDS_not_defined
ENST00000255830, ENST00000316185, ENST00000345044, ENST00000398356, ENST00000403208, ENST00000405286, ENST00000405340, ENST00000405847, ENST00000418102, ENST00000423972, ENST00000436643, ENST00000440493, ENST00000461809, ENST00000467660, ENST00000472526, ENST00000473357, ENST00000473740, ENST00000482576, ENST00000486907, ENST00000489322, ENST00000491948, ENST00000492516, ENST00000611880, ENST00000947066, ENST00000947067, ENST00000947068, ENST00000947069
RefSeq mRNA: 4 — MANE Select: NM_001024939
NM_001024938, NM_001024939, NM_001282864, NM_030807
CCDS: CCDS13818, CCDS33616, CCDS46673, CCDS74828
Canonical transcript exons
ENST00000316185 — 12 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001822292 | 23857875 | 23858029 |
| ENSE00001832956 | 23884649 | 23886312 |
| ENSE00003500933 | 23877721 | 23877869 |
| ENSE00003502128 | 23883949 | 23884024 |
| ENSE00003549447 | 23883772 | 23883873 |
| ENSE00003553444 | 23884302 | 23884429 |
| ENSE00003577221 | 23882459 | 23882646 |
| ENSE00003580882 | 23877042 | 23877171 |
| ENSE00003612609 | 23882759 | 23882869 |
| ENSE00003629303 | 23862104 | 23862202 |
| ENSE00003674675 | 23875117 | 23875241 |
| ENSE00003682329 | 23868481 | 23868641 |
Expression profiles
Bgee: expression breadth ubiquitous, 141 present calls, max score 94.55.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.6050 / max 200.0992, expressed in 1772 samples.
FANTOM5 promoters (9 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 191340 | 7.5593 | 1669 |
| 191341 | 5.4783 | 1617 |
| 191334 | 0.9412 | 454 |
| 191339 | 0.7663 | 405 |
| 191337 | 0.2640 | 116 |
| 191333 | 0.2590 | 91 |
| 191335 | 0.1364 | 45 |
| 191338 | 0.1292 | 39 |
| 191332 | 0.0714 | 16 |
Top tissues by expression
144 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| right hemisphere of cerebellum | UBERON:0014890 | 94.55 | gold quality |
| cerebellar hemisphere | UBERON:0002245 | 94.32 | gold quality |
| cerebellar cortex | UBERON:0002129 | 94.27 | gold quality |
| cerebellum | UBERON:0002037 | 94.23 | gold quality |
| metanephros cortex | UBERON:0010533 | 93.86 | gold quality |
| sural nerve | UBERON:0015488 | 92.49 | gold quality |
| apex of heart | UBERON:0002098 | 91.69 | gold quality |
| pituitary gland | UBERON:0000007 | 91.68 | gold quality |
| cortex of kidney | UBERON:0001225 | 91.21 | gold quality |
| body of pancreas | UBERON:0001150 | 91.09 | gold quality |
| nucleus accumbens | UBERON:0001882 | 90.60 | gold quality |
| adenohypophysis | UBERON:0002196 | 90.44 | gold quality |
| heart left ventricle | UBERON:0002084 | 89.65 | gold quality |
| hypothalamus | UBERON:0001898 | 89.57 | gold quality |
| adult mammalian kidney | UBERON:0000082 | 89.29 | gold quality |
| primary visual cortex | UBERON:0002436 | 89.21 | gold quality |
| right frontal lobe | UBERON:0002810 | 89.08 | gold quality |
| brain | UBERON:0000955 | 89.03 | gold quality |
| kidney | UBERON:0002113 | 88.66 | gold quality |
| caudate nucleus | UBERON:0001873 | 88.63 | gold quality |
| putamen | UBERON:0001874 | 88.51 | gold quality |
| frontal cortex | UBERON:0001870 | 88.22 | gold quality |
| right atrium auricular region | UBERON:0006631 | 88.21 | gold quality |
| C1 segment of cervical spinal cord | UBERON:0006469 | 88.09 | gold quality |
| anterior cingulate cortex | UBERON:0009835 | 88.09 | gold quality |
| spinal cord | UBERON:0002240 | 88.08 | gold quality |
| pancreas | UBERON:0001264 | 87.99 | gold quality |
| superior frontal gyrus | UBERON:0002661 | 87.91 | gold quality |
| prefrontal cortex | UBERON:0000451 | 87.82 | gold quality |
| right adrenal gland cortex | UBERON:0035827 | 87.71 | gold quality |
Single-cell (SCXA)
Detected in 2 experiment(s), a significant marker in 0.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-MTAB-6379 | no | 7.98 |
| E-ANND-3 | no | 2.20 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
43 targeting SLC2A11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-4795-3P | 100.00 | 74.62 | 4024 |
| HSA-MIR-126-5P | 100.00 | 72.71 | 3180 |
| HSA-MIR-3924 | 100.00 | 72.09 | 2394 |
| HSA-MIR-1277-5P | 100.00 | 73.95 | 5056 |
| HSA-MIR-6748-5P | 100.00 | 65.81 | 1057 |
| HSA-MIR-4282 | 99.99 | 75.36 | 6408 |
| HSA-MIR-223-3P | 99.99 | 70.14 | 1140 |
| HSA-MIR-568 | 99.98 | 69.86 | 2084 |
| HSA-MIR-6793-5P | 99.97 | 65.95 | 758 |
| HSA-MIR-6778-3P | 99.96 | 67.29 | 2693 |
| HSA-MIR-101-3P | 99.94 | 75.03 | 2230 |
| HSA-MIR-9983-3P | 99.94 | 71.48 | 3631 |
| HSA-MIR-95-5P | 99.89 | 72.17 | 3973 |
| HSA-MIR-944 | 99.82 | 70.85 | 3042 |
| HSA-MIR-4307 | 99.82 | 70.45 | 3374 |
| HSA-MIR-1200 | 99.71 | 70.42 | 1838 |
| HSA-MIR-33A-3P | 99.70 | 70.27 | 3362 |
| HSA-MIR-3177-5P | 99.65 | 70.38 | 1174 |
| HSA-MIR-1827 | 99.63 | 68.57 | 3265 |
| HSA-MIR-4743-3P | 99.62 | 68.12 | 2095 |
| HSA-MIR-510-3P | 99.54 | 70.06 | 2965 |
| HSA-MIR-7158-5P | 99.25 | 67.95 | 796 |
| HSA-MIR-6878-3P | 99.24 | 64.23 | 920 |
| HSA-MIR-4777-3P | 99.15 | 68.92 | 626 |
| HSA-MIR-10B-3P | 99.04 | 66.98 | 988 |
| HSA-MIR-6506-5P | 99.04 | 65.66 | 1386 |
| HSA-MIR-7151-3P | 99.04 | 69.72 | 2370 |
| HSA-MIR-4650-3P | 99.01 | 68.39 | 1062 |
| HSA-MIR-1304-5P | 98.90 | 68.58 | 1054 |
| HSA-MIR-3190-5P | 98.87 | 64.89 | 1345 |
Literature-anchored findings (GeneRIF, showing 4)
- a novel sugar transporter that is alternatively spliced in various tissues (PMID:12175779)
- Different promoters and splicing generate three SLC2A11 isoforms which are expressed in a tissue specific manner but do not appear to differ in their functional characteristics. (PMID:16154905)
- GLUT11 can also transport fructose, but it has the motif DSV at the same position, which appears to function in the same manner as NXI and when all three residues are replaced with NAV fructose transport lost. (PMID:17710649)
- Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer. (PMID:22452979)
Cross-species orthologs
43 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | slc2a11a | ENSDARG00000053961 |
| drosophila_melanogaster | Glut3 | FBGN0015230 |
| drosophila_melanogaster | sut4 | FBGN0028560 |
| drosophila_melanogaster | sut3 | FBGN0028561 |
| drosophila_melanogaster | sut2 | FBGN0028562 |
| drosophila_melanogaster | sut1 | FBGN0028563 |
| drosophila_melanogaster | CG4607 | FBGN0029932 |
| drosophila_melanogaster | CG15406 | FBGN0031517 |
| drosophila_melanogaster | CG8837 | FBGN0031520 |
| drosophila_melanogaster | CG3285 | FBGN0031522 |
| drosophila_melanogaster | CG15408 | FBGN0031523 |
| drosophila_melanogaster | CG7882 | FBGN0033047 |
| drosophila_melanogaster | Tret1-2 | FBGN0033644 |
| drosophila_melanogaster | CG8249 | FBGN0034045 |
| drosophila_melanogaster | CG6484 | FBGN0034247 |
| drosophila_melanogaster | CG14160 | FBGN0036066 |
| drosophila_melanogaster | nebu | FBGN0036316 |
| drosophila_melanogaster | CG1208 | FBGN0037386 |
| drosophila_melanogaster | CG14606 | FBGN0037485 |
| drosophila_melanogaster | CG14605 | FBGN0037486 |
| drosophila_melanogaster | CG6901 | FBGN0038414 |
| drosophila_melanogaster | CG17929 | FBGN0038415 |
| drosophila_melanogaster | CG17930 | FBGN0038416 |
| drosophila_melanogaster | Tret1-1 | FBGN0050035 |
| drosophila_melanogaster | CG32053 | FBGN0052053 |
| drosophila_melanogaster | CG32054 | FBGN0052054 |
| drosophila_melanogaster | CG33281 | FBGN0053281 |
| drosophila_melanogaster | CG33282 | FBGN0053282 |
| drosophila_melanogaster | Srg2 | FBGN0262007 |
| drosophila_melanogaster | CG42826 | FBGN0262008 |
| caenorhabditis_elegans | WBGENE00008730 | |
| caenorhabditis_elegans | WBGENE00010684 | |
| caenorhabditis_elegans | WBGENE00010811 | |
| caenorhabditis_elegans | WBGENE00012536 | |
| caenorhabditis_elegans | WBGENE00013074 | |
| caenorhabditis_elegans | WBGENE00016431 | |
| caenorhabditis_elegans | WBGENE00017382 | |
| caenorhabditis_elegans | WBGENE00019207 | |
| caenorhabditis_elegans | WBGENE00019547 | |
| caenorhabditis_elegans | WBGENE00019548 | |
| caenorhabditis_elegans | WBGENE00019549 | |
| caenorhabditis_elegans | WBGENE00019550 | |
| caenorhabditis_elegans | WBGENE00043980 |
Paralogs (13): SLC2A3 (ENSG00000059804), SLC2A9 (ENSG00000109667), SLC2A1 (ENSG00000117394), SLC2A8 (ENSG00000136856), SLC2A5 (ENSG00000142583), SLC2A12 (ENSG00000146411), SLC2A13 (ENSG00000151229), SLC2A6 (ENSG00000160326), SLC2A2 (ENSG00000163581), SLC2A14 (ENSG00000173262), SLC2A4 (ENSG00000181856), SLC2A7 (ENSG00000197241), SLC2A10 (ENSG00000197496)
Protein
Protein identifiers
Solute carrier family 2, facilitated glucose transporter member 11 — Q9BYW1 (reviewed: Q9BYW1)
Alternative names: Glucose transporter type 11
All UniProt accessions (9): A0A087X018, B5MCM1, B5MCM7, Q9BYW1, F8WB79, F8WBG9, F8WBK0, F8WCV3, F8WFA8
UniProt curated annotations — full annotation on UniProt →
Function. Facilitative glucose transporter.
Subcellular location. Cell membrane.
Tissue specificity. Expressed in heart and skeletal muscle.
Similarity. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Isoforms (4)
| UniProt ID | Names | Canonical? |
|---|---|---|
| Q9BYW1-1 | 1 | yes |
| Q9BYW1-2 | 2, GLUT11-s | |
| Q9BYW1-3 | 3 | |
| Q9BYW1-4 | 4, GLUT11-L |
RefSeq proteins (4): NP_001020109, NP_001020110, NP_001269793, NP_110434 (=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR003663 | Sugar/inositol_transpt | Family |
| IPR005828 | MFS_sugar_transport-like | Family |
| IPR005829 | Sugar_transporter_CS | Conserved_site |
| IPR020846 | MFS_dom | Domain |
| IPR036259 | MFS_trans_sf | Homologous_superfamily |
| IPR045263 | GLUT | Family |
Pfam: PF00083
Catalyzed reactions (Rhea), 1 shown:
- D-glucose(out) = D-glucose(in) (RHEA:60376)
UniProt features (37 total): topological domain 13, transmembrane region 12, sequence variant 5, splice variant 4, chain 1, glycosylation site 1, sequence conflict 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q9BYW1-F1 | 88.14 | 0.62 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Glycosylation sites (1): 47
Function
Pathways and Gene Ontology
Reactome pathways
1 pathways
| ID | Pathway |
|---|---|
| R-HSA-189200 | Cellular hexose transport |
MSigDB gene sets: 64 (showing top):
GOBP_CARBOHYDRATE_TRANSPORT, GOBP_D_GLUCOSE_IMPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_VITAMIN_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, GOMF_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP, GOMF_TRANSPORTER_ACTIVITY, GOMF_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, REACTOME_CELLULAR_HEXOSE_TRANSPORT, REACTOME_TRANSPORT_OF_SMALL_MOLECULES, MTOR_UP.N4.V1_DN, GOBP_DEHYDROASCORBIC_ACID_TRANSPORT, NPAT_TARGET_GENES, ZNF563_TARGET_GENES
GO Biological Process (7): hexose transmembrane transport (GO:0008645), fructose transmembrane transport (GO:0015755), obsolete D-glucose import (GO:0046323), dehydroascorbic acid transport (GO:0070837), D-glucose transmembrane transport (GO:1904659), transmembrane transport (GO:0055085), fructose import across plasma membrane (GO:1990539)
GO Molecular Function (5): fructose transmembrane transporter activity (GO:0005353), sugar transmembrane transporter activity (GO:0051119), D-glucose transmembrane transporter activity (GO:0055056), hexose transmembrane transporter activity (GO:0015149), transmembrane transporter activity (GO:0022857)
GO Cellular Component (5): nucleoplasm (GO:0005654), plasma membrane (GO:0005886), cell junction (GO:0030054), membrane (GO:0016020), sarcolemma (GO:0042383)
Reactome top-level categories
Rollup of top-1 pathways:
| Category | Pathways |
|---|---|
| SLC-mediated transmembrane transport | 1 |
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| hexose transmembrane transport | 3 |
| cellular anatomical structure | 3 |
| fructose transmembrane transport | 2 |
| hexose transmembrane transporter activity | 2 |
| monosaccharide transmembrane transport | 1 |
| vitamin transport | 1 |
| transport | 1 |
| cellular process | 1 |
| hexose import across plasma membrane | 1 |
| carbohydrate transmembrane transporter activity | 1 |
| monosaccharide transmembrane transporter activity | 1 |
| transporter activity | 1 |
| transmembrane transport | 1 |
| nuclear lumen | 1 |
| membrane | 1 |
| cell periphery | 1 |
| plasma membrane | 1 |
Protein interactions and networks
STRING
686 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| SLC2A11 | SLC5A4 | Q9NY91 | 536 |
| SLC2A11 | SLC5A9 | Q2M3M2 | 501 |
| SLC2A11 | SLC5A1 | P13866 | 454 |
| SLC2A11 | LRRC75B | Q2VPJ9 | 417 |
| SLC2A11 | ARL8B | Q9NVJ2 | 396 |
| SLC2A11 | SLC2A12 | Q8TD20 | 393 |
| SLC2A11 | C22orf15 | Q8WYQ4 | 392 |
| SLC2A11 | SLC5A11 | Q8WWX8 | 385 |
| SLC2A11 | SLC2A8 | Q9NY64 | 380 |
| SLC2A11 | SLC2A6 | Q9UGQ3 | 377 |
| SLC2A11 | NDUFA8 | P51970 | 376 |
| SLC2A11 | MSI2 | Q96DH6 | 375 |
| SLC2A11 | MSI1 | O43347 | 364 |
| SLC2A11 | SLC5A10 | A0PJK1 | 358 |
| SLC2A11 | H7C0V5 | H7C0V5 | 354 |
IntAct
3 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| ARRDC1 | WWP2 | psi-mi:“MI:0914”(association) | 0.850 |
| SLC2A11 | SEC24B | psi-mi:“MI:0914”(association) | 0.350 |
BioGRID (14): SLC2A11 (Affinity Capture-RNA), SLC2A11 (Affinity Capture-MS), CLPB (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC7 (Affinity Capture-MS), FAM189B (Affinity Capture-MS), FZD8 (Affinity Capture-MS), GOLGA2 (Affinity Capture-MS), NDFIP1 (Affinity Capture-MS), PBXIP1 (Affinity Capture-MS), SEC23A (Affinity Capture-MS), SEC23B (Affinity Capture-MS), SEC24B (Affinity Capture-MS), VANGL1 (Affinity Capture-MS)
ESM2 similar proteins: A0A3Q2IDB4, A0A8B7HA97, A4ZYQ5, A6NK97, G1SZD9, O35956, O57379, O88909, P22732, P23945, P43427, Q0IHM1, Q2KIV1, Q3ZAV1, Q4U2R8, Q4W8A2, Q4W8A3, Q5R9C4, Q5RC45, Q5RCH6, Q5RET7, Q63ZE4, Q66J52, Q6DFR1, Q6NUB3, Q6NYN7, Q6PXP3, Q6T423, Q70BM6, Q76M72, Q76M99, Q80UJ1, Q863Y9, Q864Z3, Q8CFZ5, Q8HY24, Q8IVM8, Q8MK48, Q8N4F4, Q8R0S9
Diamond homologs: A1Z8N1, A4ZYQ5, A5LGM7, A9ZSY3, B3MG58, B3NSE1, B4HNS0, B4HNS1, B4J913, B4KR05, B4LPX5, B4P624, B4QBN2, B4QBN3, C0SPB2, O44616, O44827, O62786, O62787, P0C6A1, P11166, P11167, P11168, P11169, P12336, P13355, P14142, P14246, P14672, P17809, P19357, P20303, P22732, P27674, P28568, P32037, P32466, P43427, P46333, P46408
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
108 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 81 |
| Likely benign | 4 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
2389 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 22:23862102:A:AG | acceptor_gain | 1.0000 |
| 22:23862103:G:GC | acceptor_loss | 1.0000 |
| 22:23862103:G:GG | acceptor_gain | 1.0000 |
| 22:23862103:GA:G | acceptor_gain | 1.0000 |
| 22:23862103:GAT:G | acceptor_gain | 1.0000 |
| 22:23862103:GATTC:G | acceptor_gain | 1.0000 |
| 22:23862203:G:GG | donor_gain | 1.0000 |
| 22:23875097:T:TA | acceptor_gain | 1.0000 |
| 22:23875099:T:TA | acceptor_gain | 1.0000 |
| 22:23875105:A:AG | acceptor_gain | 1.0000 |
| 22:23875106:C:G | acceptor_gain | 1.0000 |
| 22:23875112:CCAA:C | acceptor_loss | 1.0000 |
| 22:23875113:CAAG:C | acceptor_loss | 1.0000 |
| 22:23875114:A:AG | acceptor_gain | 1.0000 |
| 22:23875114:AAG:A | acceptor_gain | 1.0000 |
| 22:23875115:A:G | acceptor_gain | 1.0000 |
| 22:23875115:A:T | acceptor_loss | 1.0000 |
| 22:23875115:AGGA:A | acceptor_loss | 1.0000 |
| 22:23875116:G:GG | acceptor_gain | 1.0000 |
| 22:23875116:GG:G | acceptor_loss | 1.0000 |
| 22:23875116:GGAA:G | acceptor_gain | 1.0000 |
| 22:23875215:G:GT | donor_gain | 1.0000 |
| 22:23875215:G:T | donor_gain | 1.0000 |
| 22:23875237:TGCAG:T | donor_loss | 1.0000 |
| 22:23875239:C:T | donor_gain | 1.0000 |
| 22:23875239:CAG:C | donor_loss | 1.0000 |
| 22:23875239:CAGG:C | donor_loss | 1.0000 |
| 22:23875240:AGGTA:A | donor_loss | 1.0000 |
| 22:23875241:GGTAT:G | donor_loss | 1.0000 |
| 22:23875242:GTAT:G | donor_loss | 1.0000 |
AlphaMissense
3197 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 22:23877818:A:C | S212R | 0.988 |
| 22:23877820:C:A | S212R | 0.988 |
| 22:23877820:C:G | S212R | 0.988 |
| 22:23884006:A:C | S382R | 0.984 |
| 22:23884008:C:A | S382R | 0.984 |
| 22:23884008:C:G | S382R | 0.984 |
| 22:23877748:G:C | W188C | 0.978 |
| 22:23877748:G:T | W188C | 0.978 |
| 22:23877080:A:C | S149R | 0.977 |
| 22:23877082:C:A | S149R | 0.977 |
| 22:23877082:C:G | S149R | 0.977 |
| 22:23877140:G:A | G169R | 0.977 |
| 22:23877140:G:C | G169R | 0.977 |
| 22:23875117:G:C | R94S | 0.976 |
| 22:23875117:G:T | R94S | 0.976 |
| 22:23877068:T:G | Y145D | 0.976 |
| 22:23877746:T:A | W188R | 0.972 |
| 22:23877746:T:C | W188R | 0.972 |
| 22:23877764:A:C | S194R | 0.972 |
| 22:23877766:C:A | S194R | 0.972 |
| 22:23877766:C:G | S194R | 0.972 |
| 22:23877152:G:A | G173R | 0.971 |
| 22:23877152:G:C | G173R | 0.971 |
| 22:23877141:G:A | G169E | 0.970 |
| 22:23884009:T:C | F383L | 0.970 |
| 22:23884011:T:A | F383L | 0.970 |
| 22:23884011:T:G | F383L | 0.970 |
| 22:23875178:A:C | S115R | 0.967 |
| 22:23875180:C:A | S115R | 0.967 |
| 22:23875180:C:G | S115R | 0.967 |
dbSNP variants (sampled 300 via entrez): RS1000011946 (22:23871603 A>C,G), RS1000094916 (22:23858295 G>T), RS1000246526 (22:23864619 A>G), RS1000274473 (22:23884362 G>A), RS1000338510 (22:23866791 G>A,C), RS1000394722 (22:23869768 T>C), RS1000468259 (22:23869534 C>G,T), RS1000564441 (22:23876194 A>G), RS1000583742 (22:23856400 G>A), RS1000608881 (22:23874561 C>A,G,T), RS1000661699 (22:23880270 A>G), RS1000980920 (22:23874754 A>T), RS1000997408 (22:23876525 G>C), RS1001049098 (22:23859930 G>A,T), RS1001153777 (22:23859296 G>A)
Disease associations
OMIM: gene MIM:610367 | disease phenotypes:
GenCC curated gene-disease
Mondo (0):
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
2 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST003483_2 | S-phenylmercapturic acid levels in smokers | 2.000000e-46 |
| GCST012038_5 | Sleep duration (> 10 hours) | 5.000000e-08 |
EFO canonical traits (1, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0007651 | urinary S-phenylmercapturic acid measurement |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
GtoPdb / IUPHAR curated pharmacology
(IUPHAR/BPS Guide to Pharmacology — expert-curated)
Target class: transporter — Class II transporters
CTD chemical–gene interactions
28 total (human), top 28 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Cisplatin | increases expression, affects cotreatment | 3 |
| Tetrachlorodibenzodioxin | increases expression | 3 |
| Benzo(a)pyrene | decreases methylation, increases expression | 2 |
| Cadmium Chloride | decreases expression | 2 |
| aristolochic acid I | increases expression | 1 |
| GSK-J4 | decreases expression | 1 |
| triphenyl phosphate | affects expression | 1 |
| beta-lapachone | increases expression | 1 |
| arsenite | affects binding, decreases reaction | 1 |
| tris(1,3-dichloro-2-propyl)phosphate | increases expression | 1 |
| butyraldehyde | decreases expression | 1 |
| gossypol acetic acid | increases expression | 1 |
| di-n-butylphosphoric acid | affects expression | 1 |
| 2,2’,4,4’,5-brominated diphenyl ether | increases expression | 1 |
| jinfukang | affects cotreatment, increases expression | 1 |
| Zoledronic Acid | decreases expression | 1 |
| Leflunomide | increases expression | 1 |
| Cidofovir | affects expression | 1 |
| Clodronic Acid | increases expression | 1 |
| Fructose | increases transport | 1 |
| Glucose | increases transport | 1 |
| Oxygen | decreases expression | 1 |
| Smoke | decreases expression | 1 |
| Tobacco Smoke Pollution | decreases expression | 1 |
| Zidovudine | increases expression | 1 |
| Cyclosporine | decreases expression | 1 |
| Okadaic Acid | decreases expression | 1 |
| Copper Sulfate | decreases expression | 1 |
Cellosaurus cell lines
4 cell lines: 4 cancer cell line
First 10 cell lines (id-ordered, not curated):
| Cellosaurus | Name | Category | Sex |
|---|---|---|---|
| CVCL_D4L4 | HCT116-SLC2A11-KO-c7 | Cancer cell line | Male |
| CVCL_D4L5 | HCT116-SLC2A11-KO-c9 | Cancer cell line | Male |
| CVCL_XT12 | HAP1 SLC2A11 (-) 1 | Cancer cell line | Male |
| CVCL_XT13 | HAP1 SLC2A11 (-) 2 | Cancer cell line | Male |
Clinical trials (associated diseases)
0 trials via MONDO — disease-level, not drug-specific.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.