SLC2A11

gene
On this page

Also known as GLUT11

Summary

SLC2A11 (solute carrier family 2 member 11, HGNC:14239) is a protein-coding gene on chromosome 22q11.23, encoding Solute carrier family 2, facilitated glucose transporter member 11 (Q9BYW1). Facilitative glucose transporter.

This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 66035 — RefSeq curated summary.

At a glance

  • GWAS associations: 2
  • Clinical variants (ClinVar): 108 total
  • MANE Select transcript: NM_001024939

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:14239
Approved symbolSLC2A11
Namesolute carrier family 2 member 11
Location22q11.23
Locus typegene with protein product
StatusApproved
AliasesGLUT11
Ensembl geneENSG00000133460
Ensembl biotypeprotein_coding
OMIM610367
Entrez66035

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 10 protein_coding, 7 retained_intron, 5 nonsense_mediated_decay, 5 protein_coding_CDS_not_defined

ENST00000255830, ENST00000316185, ENST00000345044, ENST00000398356, ENST00000403208, ENST00000405286, ENST00000405340, ENST00000405847, ENST00000418102, ENST00000423972, ENST00000436643, ENST00000440493, ENST00000461809, ENST00000467660, ENST00000472526, ENST00000473357, ENST00000473740, ENST00000482576, ENST00000486907, ENST00000489322, ENST00000491948, ENST00000492516, ENST00000611880, ENST00000947066, ENST00000947067, ENST00000947068, ENST00000947069

RefSeq mRNA: 4 — MANE Select: NM_001024939 NM_001024938, NM_001024939, NM_001282864, NM_030807

CCDS: CCDS13818, CCDS33616, CCDS46673, CCDS74828

Canonical transcript exons

ENST00000316185 — 12 exons

ExonStartEnd
ENSE000018222922385787523858029
ENSE000018329562388464923886312
ENSE000035009332387772123877869
ENSE000035021282388394923884024
ENSE000035494472388377223883873
ENSE000035534442388430223884429
ENSE000035772212388245923882646
ENSE000035808822387704223877171
ENSE000036126092388275923882869
ENSE000036293032386210423862202
ENSE000036746752387511723875241
ENSE000036823292386848123868641

Expression profiles

Bgee: expression breadth ubiquitous, 141 present calls, max score 94.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.6050 / max 200.0992, expressed in 1772 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter IDTPM avgSamples expressed
1913407.55931669
1913415.47831617
1913340.9412454
1913390.7663405
1913370.2640116
1913330.259091
1913350.136445
1913380.129239
1913320.071416

Top tissues by expression

144 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
right hemisphere of cerebellumUBERON:001489094.55gold quality
cerebellar hemisphereUBERON:000224594.32gold quality
cerebellar cortexUBERON:000212994.27gold quality
cerebellumUBERON:000203794.23gold quality
metanephros cortexUBERON:001053393.86gold quality
sural nerveUBERON:001548892.49gold quality
apex of heartUBERON:000209891.69gold quality
pituitary glandUBERON:000000791.68gold quality
cortex of kidneyUBERON:000122591.21gold quality
body of pancreasUBERON:000115091.09gold quality
nucleus accumbensUBERON:000188290.60gold quality
adenohypophysisUBERON:000219690.44gold quality
heart left ventricleUBERON:000208489.65gold quality
hypothalamusUBERON:000189889.57gold quality
adult mammalian kidneyUBERON:000008289.29gold quality
primary visual cortexUBERON:000243689.21gold quality
right frontal lobeUBERON:000281089.08gold quality
brainUBERON:000095589.03gold quality
kidneyUBERON:000211388.66gold quality
caudate nucleusUBERON:000187388.63gold quality
putamenUBERON:000187488.51gold quality
frontal cortexUBERON:000187088.22gold quality
right atrium auricular regionUBERON:000663188.21gold quality
C1 segment of cervical spinal cordUBERON:000646988.09gold quality
anterior cingulate cortexUBERON:000983588.09gold quality
spinal cordUBERON:000224088.08gold quality
pancreasUBERON:000126487.99gold quality
superior frontal gyrusUBERON:000266187.91gold quality
prefrontal cortexUBERON:000045187.82gold quality
right adrenal gland cortexUBERON:003582787.71gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-MTAB-6379no7.98
E-ANND-3no2.20

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting SLC2A11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4795-3P100.0074.624024
HSA-MIR-126-5P100.0072.713180
HSA-MIR-3924100.0072.092394
HSA-MIR-1277-5P100.0073.955056
HSA-MIR-6748-5P100.0065.811057
HSA-MIR-428299.9975.366408
HSA-MIR-223-3P99.9970.141140
HSA-MIR-56899.9869.862084
HSA-MIR-6793-5P99.9765.95758
HSA-MIR-6778-3P99.9667.292693
HSA-MIR-101-3P99.9475.032230
HSA-MIR-9983-3P99.9471.483631
HSA-MIR-95-5P99.8972.173973
HSA-MIR-94499.8270.853042
HSA-MIR-430799.8270.453374
HSA-MIR-120099.7170.421838
HSA-MIR-33A-3P99.7070.273362
HSA-MIR-3177-5P99.6570.381174
HSA-MIR-182799.6368.573265
HSA-MIR-4743-3P99.6268.122095
HSA-MIR-510-3P99.5470.062965
HSA-MIR-7158-5P99.2567.95796
HSA-MIR-6878-3P99.2464.23920
HSA-MIR-4777-3P99.1568.92626
HSA-MIR-10B-3P99.0466.98988
HSA-MIR-6506-5P99.0465.661386
HSA-MIR-7151-3P99.0469.722370
HSA-MIR-4650-3P99.0168.391062
HSA-MIR-1304-5P98.9068.581054
HSA-MIR-3190-5P98.8764.891345

Literature-anchored findings (GeneRIF, showing 4)

  • a novel sugar transporter that is alternatively spliced in various tissues (PMID:12175779)
  • Different promoters and splicing generate three SLC2A11 isoforms which are expressed in a tissue specific manner but do not appear to differ in their functional characteristics. (PMID:16154905)
  • GLUT11 can also transport fructose, but it has the motif DSV at the same position, which appears to function in the same manner as NXI and when all three residues are replaced with NAV fructose transport lost. (PMID:17710649)
  • Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer. (PMID:22452979)

Cross-species orthologs

43 orthologs

OrganismSymbolGene ID
danio_rerioslc2a11aENSDARG00000053961
drosophila_melanogasterGlut3FBGN0015230
drosophila_melanogastersut4FBGN0028560
drosophila_melanogastersut3FBGN0028561
drosophila_melanogastersut2FBGN0028562
drosophila_melanogastersut1FBGN0028563
drosophila_melanogasterCG4607FBGN0029932
drosophila_melanogasterCG15406FBGN0031517
drosophila_melanogasterCG8837FBGN0031520
drosophila_melanogasterCG3285FBGN0031522
drosophila_melanogasterCG15408FBGN0031523
drosophila_melanogasterCG7882FBGN0033047
drosophila_melanogasterTret1-2FBGN0033644
drosophila_melanogasterCG8249FBGN0034045
drosophila_melanogasterCG6484FBGN0034247
drosophila_melanogasterCG14160FBGN0036066
drosophila_melanogasternebuFBGN0036316
drosophila_melanogasterCG1208FBGN0037386
drosophila_melanogasterCG14606FBGN0037485
drosophila_melanogasterCG14605FBGN0037486
drosophila_melanogasterCG6901FBGN0038414
drosophila_melanogasterCG17929FBGN0038415
drosophila_melanogasterCG17930FBGN0038416
drosophila_melanogasterTret1-1FBGN0050035
drosophila_melanogasterCG32053FBGN0052053
drosophila_melanogasterCG32054FBGN0052054
drosophila_melanogasterCG33281FBGN0053281
drosophila_melanogasterCG33282FBGN0053282
drosophila_melanogasterSrg2FBGN0262007
drosophila_melanogasterCG42826FBGN0262008
caenorhabditis_elegansWBGENE00008730
caenorhabditis_elegansWBGENE00010684
caenorhabditis_elegansWBGENE00010811
caenorhabditis_elegansWBGENE00012536
caenorhabditis_elegansWBGENE00013074
caenorhabditis_elegansWBGENE00016431
caenorhabditis_elegansWBGENE00017382
caenorhabditis_elegansWBGENE00019207
caenorhabditis_elegansWBGENE00019547
caenorhabditis_elegansWBGENE00019548
caenorhabditis_elegansWBGENE00019549
caenorhabditis_elegansWBGENE00019550
caenorhabditis_elegansWBGENE00043980

Paralogs (13): SLC2A3 (ENSG00000059804), SLC2A9 (ENSG00000109667), SLC2A1 (ENSG00000117394), SLC2A8 (ENSG00000136856), SLC2A5 (ENSG00000142583), SLC2A12 (ENSG00000146411), SLC2A13 (ENSG00000151229), SLC2A6 (ENSG00000160326), SLC2A2 (ENSG00000163581), SLC2A14 (ENSG00000173262), SLC2A4 (ENSG00000181856), SLC2A7 (ENSG00000197241), SLC2A10 (ENSG00000197496)

Protein

Protein identifiers

Solute carrier family 2, facilitated glucose transporter member 11Q9BYW1 (reviewed: Q9BYW1)

Alternative names: Glucose transporter type 11

All UniProt accessions (9): A0A087X018, B5MCM1, B5MCM7, Q9BYW1, F8WB79, F8WBG9, F8WBK0, F8WCV3, F8WFA8

UniProt curated annotations — full annotation on UniProt →

Function. Facilitative glucose transporter.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in heart and skeletal muscle.

Similarity. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Isoforms (4)

UniProt IDNamesCanonical?
Q9BYW1-11yes
Q9BYW1-22, GLUT11-s
Q9BYW1-33
Q9BYW1-44, GLUT11-L

RefSeq proteins (4): NP_001020109, NP_001020110, NP_001269793, NP_110434 (=MANE)

Domains & families (InterPro)

IDNameType
IPR003663Sugar/inositol_transptFamily
IPR005828MFS_sugar_transport-likeFamily
IPR005829Sugar_transporter_CSConserved_site
IPR020846MFS_domDomain
IPR036259MFS_trans_sfHomologous_superfamily
IPR045263GLUTFamily

Pfam: PF00083

Catalyzed reactions (Rhea), 1 shown:

  • D-glucose(out) = D-glucose(in) (RHEA:60376)

UniProt features (37 total): topological domain 13, transmembrane region 12, sequence variant 5, splice variant 4, chain 1, glycosylation site 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9BYW1-F188.140.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 47

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-189200Cellular hexose transport

MSigDB gene sets: 64 (showing top): GOBP_CARBOHYDRATE_TRANSPORT, GOBP_D_GLUCOSE_IMPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_VITAMIN_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, GOMF_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP, GOMF_TRANSPORTER_ACTIVITY, GOMF_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, REACTOME_CELLULAR_HEXOSE_TRANSPORT, REACTOME_TRANSPORT_OF_SMALL_MOLECULES, MTOR_UP.N4.V1_DN, GOBP_DEHYDROASCORBIC_ACID_TRANSPORT, NPAT_TARGET_GENES, ZNF563_TARGET_GENES

GO Biological Process (7): hexose transmembrane transport (GO:0008645), fructose transmembrane transport (GO:0015755), obsolete D-glucose import (GO:0046323), dehydroascorbic acid transport (GO:0070837), D-glucose transmembrane transport (GO:1904659), transmembrane transport (GO:0055085), fructose import across plasma membrane (GO:1990539)

GO Molecular Function (5): fructose transmembrane transporter activity (GO:0005353), sugar transmembrane transporter activity (GO:0051119), D-glucose transmembrane transporter activity (GO:0055056), hexose transmembrane transporter activity (GO:0015149), transmembrane transporter activity (GO:0022857)

GO Cellular Component (5): nucleoplasm (GO:0005654), plasma membrane (GO:0005886), cell junction (GO:0030054), membrane (GO:0016020), sarcolemma (GO:0042383)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
SLC-mediated transmembrane transport1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
hexose transmembrane transport3
cellular anatomical structure3
fructose transmembrane transport2
hexose transmembrane transporter activity2
monosaccharide transmembrane transport1
vitamin transport1
transport1
cellular process1
hexose import across plasma membrane1
carbohydrate transmembrane transporter activity1
monosaccharide transmembrane transporter activity1
transporter activity1
transmembrane transport1
nuclear lumen1
membrane1
cell periphery1
plasma membrane1

Protein interactions and networks

STRING

686 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
SLC2A11SLC5A4Q9NY91536
SLC2A11SLC5A9Q2M3M2501
SLC2A11SLC5A1P13866454
SLC2A11LRRC75BQ2VPJ9417
SLC2A11ARL8BQ9NVJ2396
SLC2A11SLC2A12Q8TD20393
SLC2A11C22orf15Q8WYQ4392
SLC2A11SLC5A11Q8WWX8385
SLC2A11SLC2A8Q9NY64380
SLC2A11SLC2A6Q9UGQ3377
SLC2A11NDUFA8P51970376
SLC2A11MSI2Q96DH6375
SLC2A11MSI1O43347364
SLC2A11SLC5A10A0PJK1358
SLC2A11H7C0V5H7C0V5354

IntAct

3 interactions, top by confidence:

ABTypeScore
ARRDC1WWP2psi-mi:“MI:0914”(association)0.850
SLC2A11SEC24Bpsi-mi:“MI:0914”(association)0.350

BioGRID (14): SLC2A11 (Affinity Capture-RNA), SLC2A11 (Affinity Capture-MS), CLPB (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), DNAJC7 (Affinity Capture-MS), FAM189B (Affinity Capture-MS), FZD8 (Affinity Capture-MS), GOLGA2 (Affinity Capture-MS), NDFIP1 (Affinity Capture-MS), PBXIP1 (Affinity Capture-MS), SEC23A (Affinity Capture-MS), SEC23B (Affinity Capture-MS), SEC24B (Affinity Capture-MS), VANGL1 (Affinity Capture-MS)

ESM2 similar proteins: A0A3Q2IDB4, A0A8B7HA97, A4ZYQ5, A6NK97, G1SZD9, O35956, O57379, O88909, P22732, P23945, P43427, Q0IHM1, Q2KIV1, Q3ZAV1, Q4U2R8, Q4W8A2, Q4W8A3, Q5R9C4, Q5RC45, Q5RCH6, Q5RET7, Q63ZE4, Q66J52, Q6DFR1, Q6NUB3, Q6NYN7, Q6PXP3, Q6T423, Q70BM6, Q76M72, Q76M99, Q80UJ1, Q863Y9, Q864Z3, Q8CFZ5, Q8HY24, Q8IVM8, Q8MK48, Q8N4F4, Q8R0S9

Diamond homologs: A1Z8N1, A4ZYQ5, A5LGM7, A9ZSY3, B3MG58, B3NSE1, B4HNS0, B4HNS1, B4J913, B4KR05, B4LPX5, B4P624, B4QBN2, B4QBN3, C0SPB2, O44616, O44827, O62786, O62787, P0C6A1, P11166, P11167, P11168, P11169, P12336, P13355, P14142, P14246, P14672, P17809, P19357, P20303, P22732, P27674, P28568, P32037, P32466, P43427, P46333, P46408

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

108 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance81
Likely benign4
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2389 predictions. Top by Δscore:

VariantEffectΔscore
22:23862102:A:AGacceptor_gain1.0000
22:23862103:G:GCacceptor_loss1.0000
22:23862103:G:GGacceptor_gain1.0000
22:23862103:GA:Gacceptor_gain1.0000
22:23862103:GAT:Gacceptor_gain1.0000
22:23862103:GATTC:Gacceptor_gain1.0000
22:23862203:G:GGdonor_gain1.0000
22:23875097:T:TAacceptor_gain1.0000
22:23875099:T:TAacceptor_gain1.0000
22:23875105:A:AGacceptor_gain1.0000
22:23875106:C:Gacceptor_gain1.0000
22:23875112:CCAA:Cacceptor_loss1.0000
22:23875113:CAAG:Cacceptor_loss1.0000
22:23875114:A:AGacceptor_gain1.0000
22:23875114:AAG:Aacceptor_gain1.0000
22:23875115:A:Gacceptor_gain1.0000
22:23875115:A:Tacceptor_loss1.0000
22:23875115:AGGA:Aacceptor_loss1.0000
22:23875116:G:GGacceptor_gain1.0000
22:23875116:GG:Gacceptor_loss1.0000
22:23875116:GGAA:Gacceptor_gain1.0000
22:23875215:G:GTdonor_gain1.0000
22:23875215:G:Tdonor_gain1.0000
22:23875237:TGCAG:Tdonor_loss1.0000
22:23875239:C:Tdonor_gain1.0000
22:23875239:CAG:Cdonor_loss1.0000
22:23875239:CAGG:Cdonor_loss1.0000
22:23875240:AGGTA:Adonor_loss1.0000
22:23875241:GGTAT:Gdonor_loss1.0000
22:23875242:GTAT:Gdonor_loss1.0000

AlphaMissense

3197 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
22:23877818:A:CS212R0.988
22:23877820:C:AS212R0.988
22:23877820:C:GS212R0.988
22:23884006:A:CS382R0.984
22:23884008:C:AS382R0.984
22:23884008:C:GS382R0.984
22:23877748:G:CW188C0.978
22:23877748:G:TW188C0.978
22:23877080:A:CS149R0.977
22:23877082:C:AS149R0.977
22:23877082:C:GS149R0.977
22:23877140:G:AG169R0.977
22:23877140:G:CG169R0.977
22:23875117:G:CR94S0.976
22:23875117:G:TR94S0.976
22:23877068:T:GY145D0.976
22:23877746:T:AW188R0.972
22:23877746:T:CW188R0.972
22:23877764:A:CS194R0.972
22:23877766:C:AS194R0.972
22:23877766:C:GS194R0.972
22:23877152:G:AG173R0.971
22:23877152:G:CG173R0.971
22:23877141:G:AG169E0.970
22:23884009:T:CF383L0.970
22:23884011:T:AF383L0.970
22:23884011:T:GF383L0.970
22:23875178:A:CS115R0.967
22:23875180:C:AS115R0.967
22:23875180:C:GS115R0.967

dbSNP variants (sampled 300 via entrez): RS1000011946 (22:23871603 A>C,G), RS1000094916 (22:23858295 G>T), RS1000246526 (22:23864619 A>G), RS1000274473 (22:23884362 G>A), RS1000338510 (22:23866791 G>A,C), RS1000394722 (22:23869768 T>C), RS1000468259 (22:23869534 C>G,T), RS1000564441 (22:23876194 A>G), RS1000583742 (22:23856400 G>A), RS1000608881 (22:23874561 C>A,G,T), RS1000661699 (22:23880270 A>G), RS1000980920 (22:23874754 A>T), RS1000997408 (22:23876525 G>C), RS1001049098 (22:23859930 G>A,T), RS1001153777 (22:23859296 G>A)

Disease associations

OMIM: gene MIM:610367 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

StudyTraitp-value
GCST003483_2S-phenylmercapturic acid levels in smokers2.000000e-46
GCST012038_5Sleep duration (> 10 hours)5.000000e-08

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0007651urinary S-phenylmercapturic acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Class II transporters

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

ChemicalActions (top 5)PubMed papers
Cisplatinincreases expression, affects cotreatment3
Tetrachlorodibenzodioxinincreases expression3
Benzo(a)pyrenedecreases methylation, increases expression2
Cadmium Chloridedecreases expression2
aristolochic acid Iincreases expression1
GSK-J4decreases expression1
triphenyl phosphateaffects expression1
beta-lapachoneincreases expression1
arseniteaffects binding, decreases reaction1
tris(1,3-dichloro-2-propyl)phosphateincreases expression1
butyraldehydedecreases expression1
gossypol acetic acidincreases expression1
di-n-butylphosphoric acidaffects expression1
2,2’,4,4’,5-brominated diphenyl etherincreases expression1
jinfukangaffects cotreatment, increases expression1
Zoledronic Aciddecreases expression1
Leflunomideincreases expression1
Cidofoviraffects expression1
Clodronic Acidincreases expression1
Fructoseincreases transport1
Glucoseincreases transport1
Oxygendecreases expression1
Smokedecreases expression1
Tobacco Smoke Pollutiondecreases expression1
Zidovudineincreases expression1
Cyclosporinedecreases expression1
Okadaic Aciddecreases expression1
Copper Sulfatedecreases expression1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_D4L4HCT116-SLC2A11-KO-c7Cancer cell lineMale
CVCL_D4L5HCT116-SLC2A11-KO-c9Cancer cell lineMale
CVCL_XT12HAP1 SLC2A11 (-) 1Cancer cell lineMale
CVCL_XT13HAP1 SLC2A11 (-) 2Cancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.