SLC2A12

Summary

SLC2A12 (solute carrier family 2 member 12, HGNC:18067) is a protein-coding gene on chromosome 6q23.2, encoding Solute carrier family 2, facilitated glucose transporter member 12 (Q8TD20). Insulin-independent facilitative glucose transporter.

SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).

Source: NCBI Gene 154091 — RefSeq curated summary.

At a glance

• GWAS associations: 14
• Clinical variants (ClinVar): 98 total
• MANE Select transcript: NM_145176

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18067
Approved symbol	SLC2A12
Name	solute carrier family 2 member 12
Location	6q23.2
Locus type	gene with protein product
Status	Approved
Aliases	GLUT12, GLUT8
Ensembl gene	ENSG00000146411
Ensembl biotype	protein_coding
OMIM	610372
Entrez	154091

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000275230, ENST00000858670, ENST00000858671, ENST00000936272

RefSeq mRNA: 1 — MANE Select: NM_145176 NM_145176

CCDS: CCDS5169

Canonical transcript exons

ENST00000275230 — 5 exons

Exon	Start	End
ENSE00000975725	134006812	134006934
ENSE00001012898	134001997	134002129
ENSE00001170249	134028381	134029721
ENSE00001208315	134052378	134052624
ENSE00001281160	133987581	133991308

Expression profiles

Bgee: expression breadth ubiquitous, 205 present calls, max score 96.51.

FANTOM5 (CAGE): breadth broad, TPM avg 3.0149 / max 129.4181, expressed in 844 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
75641	2.7706	815
75640	0.2442	115

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	96.51	gold quality
pigmented layer of retina	UBERON:0001782	96.43	gold quality
left ventricle myocardium	UBERON:0006566	91.68	silver quality
cardiac muscle of right atrium	UBERON:0003379	89.29	gold quality
oviduct epithelium	UBERON:0004804	85.82	gold quality
buccal mucosa cell	CL:0002336	84.85	gold quality
duodenum	UBERON:0002114	83.61	gold quality
myocardium	UBERON:0002349	83.37	silver quality
cauda epididymis	UBERON:0004360	82.52	gold quality
kidney epithelium	UBERON:0004819	82.32	silver quality
jejunum	UBERON:0002115	81.08	gold quality
adrenal tissue	UBERON:0018303	80.79	gold quality
prostate gland	UBERON:0002367	79.38	gold quality
bronchial epithelial cell	CL:0002328	79.33	gold quality
lower esophagus muscularis layer	UBERON:0035833	78.93	gold quality
lower esophagus	UBERON:0013473	78.84	gold quality
bronchus	UBERON:0002185	78.47	gold quality
epithelial cell of pancreas	CL:0000083	77.54	gold quality
heart left ventricle	UBERON:0002084	77.38	gold quality
cardiac ventricle	UBERON:0002082	77.12	gold quality
epithelium of nasopharynx	UBERON:0001951	76.97	silver quality
body of stomach	UBERON:0001161	76.89	gold quality
mucosa of paranasal sinus	UBERON:0005030	76.55	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	76.46	gold quality
biceps brachii	UBERON:0001507	76.36	gold quality
cardia of stomach	UBERON:0001162	76.17	gold quality
ventricular zone	UBERON:0003053	76.17	gold quality
oral cavity	UBERON:0000167	75.99	gold quality
seminal vesicle	UBERON:0000998	75.78	gold quality
esophagus squamous epithelium	UBERON:0006920	75.66	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-135922	yes	14.13
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

miRNA regulators (miRDB)

190 targeting SLC2A12, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-4282	99.99	75.36	6408
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650

Literature-anchored findings (GeneRIF, showing 18)

• Embedded in microvillous (maternal-facing) and basal (fetal-facing) membranes of syncytiotrophoblast, main placental barrier layer. (review) (PMID:12583599)
• expression in adipose tissue (PMID:12890477)
• Glucose transport properties and hexose affinities of GLUT12. (PMID:12914765)
• GLUT12 protein was localized to the apical membrane of human and rat distal tubules and collecting ducts. Levels of both GLUT1 and GLUT12 are elevated in animal models of hypertension and diabetic nephropathy. (PMID:16091581)
• GLUT4 and GLUT12 were predominantly expressed in type I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers (PMID:16803853)
• Translocation of GLUT12 in cultured myoblasts was dependent on activation of PI3-K. (PMID:19549745)
• study provides the first direct evidence for GLUT9 and GLUT12 expression in vascular smooth muscle cells in conjunction with the previously identified GLUT1 and GLUT10 (PMID:23302780)
• Intestinal dehydroascorbic acid (DHA) transport is mediated by the facilitative sugar transporters, GLUT2 and GLUT8 (PMID:23396969)
• findings show the level of expression of GLUT12 was significantly higher in Alzheimer’s disease compare to aged controls (PMID:24820014)
• GLUT12 is a versatile transporter: it transports a wide diversity of hexoses, it can work as a Na+ or H+/glucose symporter, and it shows electrogenic properties. (PMID:25855082)
• GLUT12-knockdown completely abrogated high glucose-induced migration, indicating that GLUT12 functionally participates in sensing high glucose concentrations. (PMID:29187448)
• GLUT12 rapid translocation to the enterocytes apical membrane in response to glucose and insulin could be related to GLUT12 participation in sugar absorption during postprandial periods. In the pathological condition of obesity, in which insulin sensitivity is reduced, the contribution of GLUT12 to sugar absorption would be affected. (PMID:30352123)
• We hypothesize that GLUT12 would contribute to modulate sugar absorption in physiological and pathophysiological situations such as obesity. (PMID:31002200)
• Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect. (PMID:32946964)
• Alternative Splicing and Cleavage of GLUT8. (PMID:33077497)
• Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro. (PMID:34791627)
• Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12. (PMID:36594084)
• Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12. (PMID:37940066)

Cross-species orthologs

45 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc2a12	ENSDARG00000036865
mus_musculus	Slc2a12	ENSMUSG00000037490
rattus_norvegicus	Slc2a12	ENSRNOG00000011161
drosophila_melanogaster	Glut3	FBGN0015230
drosophila_melanogaster	sut4	FBGN0028560
drosophila_melanogaster	sut3	FBGN0028561
drosophila_melanogaster	sut2	FBGN0028562
drosophila_melanogaster	sut1	FBGN0028563
drosophila_melanogaster	CG4607	FBGN0029932
drosophila_melanogaster	CG15406	FBGN0031517
drosophila_melanogaster	CG8837	FBGN0031520
drosophila_melanogaster	CG3285	FBGN0031522
drosophila_melanogaster	CG15408	FBGN0031523
drosophila_melanogaster	CG7882	FBGN0033047
drosophila_melanogaster	Tret1-2	FBGN0033644
drosophila_melanogaster	CG8249	FBGN0034045
drosophila_melanogaster	CG6484	FBGN0034247
drosophila_melanogaster	CG14160	FBGN0036066
drosophila_melanogaster	nebu	FBGN0036316
drosophila_melanogaster	CG1208	FBGN0037386
drosophila_melanogaster	CG14606	FBGN0037485
drosophila_melanogaster	CG14605	FBGN0037486
drosophila_melanogaster	CG6901	FBGN0038414
drosophila_melanogaster	CG17929	FBGN0038415
drosophila_melanogaster	CG17930	FBGN0038416
drosophila_melanogaster	Tret1-1	FBGN0050035
drosophila_melanogaster	CG32053	FBGN0052053
drosophila_melanogaster	CG32054	FBGN0052054
drosophila_melanogaster	CG33281	FBGN0053281
drosophila_melanogaster	CG33282	FBGN0053282
drosophila_melanogaster	Srg2	FBGN0262007
drosophila_melanogaster	CG42826	FBGN0262008
caenorhabditis_elegans		WBGENE00008730
caenorhabditis_elegans		WBGENE00010684
caenorhabditis_elegans		WBGENE00010811
caenorhabditis_elegans		WBGENE00012536
caenorhabditis_elegans		WBGENE00013074
caenorhabditis_elegans		WBGENE00016431
caenorhabditis_elegans		WBGENE00017382
caenorhabditis_elegans		WBGENE00019207
caenorhabditis_elegans		WBGENE00019547
caenorhabditis_elegans		WBGENE00019548
caenorhabditis_elegans		WBGENE00019549
caenorhabditis_elegans		WBGENE00019550
caenorhabditis_elegans		WBGENE00043980

Paralogs (13): SLC2A3 (ENSG00000059804), SLC2A9 (ENSG00000109667), SLC2A1 (ENSG00000117394), SLC2A11 (ENSG00000133460), SLC2A8 (ENSG00000136856), SLC2A5 (ENSG00000142583), SLC2A13 (ENSG00000151229), SLC2A6 (ENSG00000160326), SLC2A2 (ENSG00000163581), SLC2A14 (ENSG00000173262), SLC2A4 (ENSG00000181856), SLC2A7 (ENSG00000197241), SLC2A10 (ENSG00000197496)

Protein

Protein identifiers

Solute carrier family 2, facilitated glucose transporter member 12 — Q8TD20 (reviewed: Q8TD20)

Alternative names: Glucose transporter type 12

All UniProt accessions (1): Q8TD20

UniProt curated annotations — full annotation on UniProt →

Function. Insulin-independent facilitative glucose transporter.

Subcellular location. Cell membrane. Endomembrane system. Cytoplasm. Perinuclear region.

Tissue specificity. Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.

Similarity. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

RefSeq proteins (1): NP_660159* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003663	Sugar/inositol_transpt	Family
IPR005828	MFS_sugar_transport-like	Family
IPR005829	Sugar_transporter_CS	Conserved_site
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily
IPR050820	MFS_Sugar_Transporter	Family

Pfam: PF00083

Catalyzed reactions (Rhea), 1 shown:

• D-glucose(out) = D-glucose(in) (RHEA:60376)

UniProt features (32 total): topological domain 13, transmembrane region 12, glycosylation site 4, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TD20-F1	74.55	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (4): 371, 383, 396, 401

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-189200	Cellular hexose transport

MSigDB gene sets: 105 (showing top): GOBP_CARBOHYDRATE_TRANSPORT, TAL1ALPHAE47_01, NF1_Q6_01, RIGGI_EWING_SARCOMA_PROGENITOR_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP, AACTTT_UNKNOWN, CUI_TCF21_TARGETS_2_DN, DBP_Q6, VECCHI_GASTRIC_CANCER_EARLY_DN, GOBP_TRANSMEMBRANE_TRANSPORT, YNGTTNNNATT_UNKNOWN, GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT, CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP, TGGAAA_NFAT_Q4_01, chr6q23

GO Biological Process (4): hexose transmembrane transport (GO:0008645), circulatory system development (GO:0072359), D-glucose transmembrane transport (GO:1904659), transmembrane transport (GO:0055085)

GO Molecular Function (2): D-glucose transmembrane transporter activity (GO:0055056), transmembrane transporter activity (GO:0022857)

GO Cellular Component (5): plasma membrane (GO:0005886), endomembrane system (GO:0012505), membrane (GO:0016020), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
SLC-mediated transmembrane transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
monosaccharide transmembrane transport	1
system development	1
hexose transmembrane transport	1
transport	1
cellular process	1
hexose transmembrane transporter activity	1
transporter activity	1
transmembrane transport	1
membrane	1
cell periphery	1
vacuole	1
plasma membrane	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2146 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC2A12	H7C1H1	H7C1H1	793
SLC2A12	INS	P01308	676
SLC2A12	SLC5A1	P13866	620
SLC2A12	SLC5A4	Q9NY91	495
SLC2A12	AKT1	P31749	481
SLC2A12	SLC5A11	Q8WWX8	480
SLC2A12	SLC38A2	Q96QD8	476
SLC2A12	SLC50A1	Q9BRV3	448
SLC2A12	CAPN9	O14815	436
SLC2A12	SLC1A5	Q15758	436
SLC2A12	SLC5A9	Q2M3M2	435
SLC2A12	MFSD11	O43934	431
SLC2A12	SLC23A1	Q9UHI7	429
SLC2A12	SLC1A1	P43005	426
SLC2A12	KHK	P50053	415

IntAct

11 interactions, top by confidence:

A	B	Type	Score
BIRC2	HTRA2	psi-mi:“MI:0914”(association)	0.650
SLC2A12	METTL15	psi-mi:“MI:0914”(association)	0.530
ABCF2	AHCYL1	psi-mi:“MI:0914”(association)	0.530
HOXD13	EEF1D	psi-mi:“MI:0914”(association)	0.530
GPR12	TLCD2	psi-mi:“MI:0914”(association)	0.350
SLC2A12	NBAS	psi-mi:“MI:0914”(association)	0.350
UPK2	IFT56	psi-mi:“MI:0914”(association)	0.350
SLC2A12	TRAFD1	psi-mi:“MI:0914”(association)	0.350

BioGRID (125): TMEM242 (Affinity Capture-MS), TAMM41 (Affinity Capture-MS), MTFR2 (Affinity Capture-MS), ORMDL2 (Affinity Capture-MS), SLC25A23 (Affinity Capture-MS), SLC25A28 (Affinity Capture-MS), SLC25A51 (Affinity Capture-MS), TSPO (Affinity Capture-MS), PIGW (Affinity Capture-MS), SLC19A2 (Affinity Capture-MS), ABHD17B (Affinity Capture-MS), METTL15 (Affinity Capture-MS), PEX16 (Affinity Capture-MS), SELT (Affinity Capture-MS), SPPL3 (Affinity Capture-MS)

ESM2 similar proteins: A1DWM3, A4IF94, A4IHK6, A4QN56, A9JTG4, B0UYT5, B1AT66, B2RXV4, G8XYX6, O70324, O75387, P36021, P70187, Q0P5V9, Q0VCM6, Q1LUQ4, Q4LE88, Q569T7, Q5BIZ0, Q5BKX6, Q5J316, Q5RCN7, Q5RF58, Q5VW38, Q5XGZ9, Q68EU6, Q6DBX0, Q6P6V6, Q6PDC8, Q6ZSM3, Q6ZSS7, Q7SXB7, Q8BSM7, Q8CA03, Q8CBH5, Q8CGA3, Q8K1P8, Q8N370, Q8N468, Q8NBP5

Diamond homologs: A0A0H2VG78, A0A1D8PH98, A9ZSY3, B4HNS1, B4QBN3, C0SPB2, F1R0H0, J9VHZ4, O04249, O23492, O34718, O52733, O62786, O62787, O65413, P0AE24, P0AE25, P0AEP1, P0AEP2, P0AGF4, P0AGF5, P11166, P11167, P11169, P12336, P13355, P14246, P15686, P15729, P17809, P23586, P27674, P30605, P30606, P32037, P39924, P45598, P46333, P46896, P47185

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	85
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1069 predictions. Top by Δscore:

Variant	Effect	Δscore
6:134009966:A:AC	donor_gain	1.0000
6:134009967:C:CC	donor_gain	1.0000
6:134016117:CTGT:C	donor_gain	1.0000
6:134006935:C:CC	acceptor_gain	0.9900
6:134016116:A:AC	donor_gain	0.9900
6:134016117:C:CC	donor_gain	0.9900
6:134017095:A:C	acceptor_gain	0.9900
6:134017099:T:C	acceptor_gain	0.9900
6:134052374:TTA:T	donor_loss	0.9900
6:134052375:TACCT:T	donor_loss	0.9900
6:134052376:A:T	donor_loss	0.9900
6:134052377:C:CA	donor_loss	0.9900
6:134052377:CCT:C	donor_gain	0.9900
6:133999160:T:A	donor_gain	0.9800
6:134028379:A:AC	donor_gain	0.9800
6:134028380:C:CC	donor_gain	0.9800
6:134029718:CAGC:C	acceptor_gain	0.9800
6:134029721:CCTGC:C	acceptor_loss	0.9800
6:134029722:C:A	acceptor_loss	0.9800
6:134029722:C:CC	acceptor_gain	0.9800
6:134029723:T:A	acceptor_loss	0.9800
6:134029730:A:T	acceptor_gain	0.9800
6:134006811:CCAG:C	donor_gain	0.9700
6:134006933:CA:C	acceptor_gain	0.9700
6:134016115:G:T	donor_gain	0.9700
6:134029729:C:CT	acceptor_gain	0.9700
6:134045999:CCAA:C	acceptor_gain	0.9700
6:134046000:CAA:C	acceptor_gain	0.9700
6:134052371:A:AC	donor_gain	0.9700
6:134052372:C:CC	donor_gain	0.9700

AlphaMissense

3996 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:134029165:G:C	S220R	0.995
6:134029165:G:T	S220R	0.995
6:134029167:T:G	S220R	0.995
6:134002083:A:C	S538R	0.993
6:134002083:A:T	S538R	0.993
6:134002085:T:G	S538R	0.993
6:134028424:G:C	S467R	0.993
6:134028424:G:T	S467R	0.993
6:134028426:T:G	S467R	0.993
6:134028855:C:G	G324R	0.993
6:134028855:C:T	G324R	0.993
6:134029573:G:C	S84R	0.993
6:134029573:G:T	S84R	0.993
6:134029575:T:G	S84R	0.993
6:134028869:G:T	A319D	0.992
6:134028895:A:C	F310L	0.992
6:134028895:A:T	F310L	0.992
6:134028897:A:G	F310L	0.992
6:134029239:A:G	W196R	0.992
6:134029239:A:T	W196R	0.992
6:134029292:C:T	G178D	0.992
6:134029415:C:G	R137P	0.992
6:134006825:A:C	F518L	0.991
6:134006825:A:T	F518L	0.991
6:134006827:A:G	F518L	0.991
6:134028741:C:G	G362R	0.991
6:134028896:A:G	F310S	0.991
6:134029349:G:T	A159D	0.991
6:134028400:A:C	F475L	0.990
6:134028400:A:T	F475L	0.990

dbSNP variants (sampled 300 via entrez): RS1000041630 (6:134005167 T>C), RS1000092196 (6:134009203 C>T), RS1000204824 (6:134008987 A>C), RS1000233069 (6:134023552 A>T), RS1000271008 (6:134014917 A>G), RS1000283628 (6:134021524 T>G), RS1000371414 (6:134015485 T>C), RS1000400758 (6:134021150 G>A), RS1000458581 (6:134016760 T>C), RS1000481088 (6:134047922 C>A,T), RS1000509643 (6:134027823 T>C), RS1000549499 (6:134051923 T>C), RS1000583577 (6:134023821 AT>A), RS1000665978 (6:133992409 G>A), RS1000676254 (6:134033918 C>T)

Disease associations

OMIM: gene MIM:610372 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

14 associations (top):

Study	Trait	p-value
GCST002812_4	Schizophrenia (inflammation and infection response interaction)	8.000000e-06
GCST003488_13	Response to fenofibrate (triglyceride levels)	5.000000e-06
GCST003542_172	Night sleep phenotypes	1.000000e-06
GCST005194_23	Coronary artery disease	1.000000e-07
GCST005196_134	Coronary artery disease	1.000000e-06
GCST006192_38	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	2.000000e-08
GCST006192_42	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	3.000000e-08
GCST006195_42	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	1.000000e-07
GCST006195_85	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	7.000000e-08
GCST007429_40	Lung function (FVC)	2.000000e-07
GCST007432_74	FEV1	4.000000e-09
GCST008954_1	High chromosomal aberration frequency (chromosome type)	2.000000e-06
GCST009391_1045	Metabolite levels	8.000000e-07
GCST012490_44	Femur bone mineral density x serum urate levels interaction	1.000000e-11

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0007047	Toxoplasma gondii seropositivity
EFO:0007681	triglyceride change measurement
EFO:0006335	systolic blood pressure
EFO:0006527	smoking status measurement
EFO:0004312	vital capacity
EFO:0004314	forced expiratory volume
EFO:0009861	chromosome-type aberration frequency
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Class II transporters

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	5
bisphenol A	affects expression, affects cotreatment, increases methylation, decreases expression, decreases methylation (+1 more)	4
trichostatin A	affects cotreatment, decreases expression, increases expression	3
sodium arsenite	increases expression, decreases expression	2
entinostat	decreases expression, increases expression, affects cotreatment	2
Vorinostat	affects cotreatment, decreases expression, increases expression	2
Acetaminophen	decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
Nickel	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Cyclosporine	decreases expression	2
bisphenol F	decreases expression	1
urushiol	increases expression	1
methylmercuric chloride	decreases expression, increases expression	1
2,5,2’,5’-tetrachlorobiphenyl	decreases expression	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
perfluorooctanoic acid	decreases expression	1
hydroquinone	decreases expression	1
avobenzone	increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, increases expression, affects cotreatment	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression, increases expression	1
bisphenol S	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Benzo(a)pyrene	affects methylation	1
Cadmium	increases abundance, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4VP	LS180-SLC2A12-KO-c3	Cancer cell line	Female
CVCL_D4VQ	LS180-SLC2A12-KO-c4	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.