SLC2A14

Summary

SLC2A14 (solute carrier family 2 member 14, HGNC:18301) is a protein-coding gene on chromosome 12p13.31, encoding Solute carrier family 2, facilitated glucose transporter member 14 (Q8TDB8). Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane.

Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).

Source: NCBI Gene 144195 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 81 total
• Druggable target: yes
• MANE Select transcript: NM_001286234

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18301
Approved symbol	SLC2A14
Name	solute carrier family 2 member 14
Location	12p13.31
Locus type	gene with protein product
Status	Approved
Aliases	GLUT14
Ensembl gene	ENSG00000173262
Ensembl biotype	protein_coding
OMIM	611039
Entrez	144195

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 20 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000340749, ENST00000396589, ENST00000431042, ENST00000535266, ENST00000535295, ENST00000535344, ENST00000535383, ENST00000535587, ENST00000536594, ENST00000537557, ENST00000539234, ENST00000539738, ENST00000539924, ENST00000542505, ENST00000542546, ENST00000542782, ENST00000542916, ENST00000543909, ENST00000544749, ENST00000546234, ENST00000616981, ENST00000864025, ENST00000940598

RefSeq mRNA: 6 — MANE Select: NM_001286234 NM_001286233, NM_001286234, NM_001286235, NM_001286236, NM_001286237, NM_153449

CCDS: CCDS66300, CCDS66301, CCDS66302, CCDS8585

Canonical transcript exons

ENST00000431042 — 11 exons

Exon	Start	End
ENSE00001181752	7817831	7818034
ENSE00001624160	7831604	7831764
ENSE00001686416	7827495	7827682
ENSE00001713854	7828704	7828866
ENSE00001732389	7829766	7830006
ENSE00002234747	7872807	7872915
ENSE00002276877	7812514	7814534
ENSE00003529636	7821221	7821325
ENSE00003595963	7832722	7832814
ENSE00003602741	7819482	7819583
ENSE00003608127	7869863	7869937

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 92.23.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4777 / max 97.8854, expressed in 136 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129298	0.1309	41
129295	0.0918	39
129294	0.0521	23
129296	0.0518	21
129291	0.0364	3
129288	0.0314	4
129292	0.0296	9
129297	0.0205	7
129289	0.0146	3
129287	0.0122	3

Top tissues by expression

136 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	92.23	gold quality
right testis	UBERON:0004534	92.05	gold quality
testis	UBERON:0000473	91.87	gold quality
adrenal tissue	UBERON:0018303	90.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.02	gold quality
thymus	UBERON:0002370	84.27	silver quality
right adrenal gland cortex	UBERON:0035827	79.09	gold quality
right adrenal gland	UBERON:0001233	77.64	gold quality
body of pancreas	UBERON:0001150	77.08	gold quality
adrenal gland	UBERON:0002369	73.28	gold quality
left adrenal gland	UBERON:0001234	72.77	gold quality
blood	UBERON:0000178	72.40	gold quality
left adrenal gland cortex	UBERON:0035825	72.36	gold quality
bone marrow	UBERON:0002371	70.25	gold quality
pancreas	UBERON:0001264	68.53	gold quality
cerebellar vermis	UBERON:0004720	68.27	gold quality
bone marrow cell	CL:0002092	64.94	silver quality
right ovary	UBERON:0002118	63.72	gold quality
ovary	UBERON:0000992	62.50	gold quality
monocyte	CL:0000576	61.85	gold quality
left ovary	UBERON:0002119	61.76	gold quality
quadriceps femoris	UBERON:0001377	61.63	gold quality
leukocyte	CL:0000738	60.70	gold quality
placenta	UBERON:0001987	59.09	gold quality
tibial nerve	UBERON:0001323	58.60	gold quality
ventricular zone	UBERON:0003053	56.72	gold quality
gall bladder	UBERON:0002110	56.05	gold quality
omental fat pad	UBERON:0010414	55.87	gold quality
adipose tissue	UBERON:0001013	55.52	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.72
E-MTAB-9388	yes	6.54

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTNNB1

miRNA regulators (miRDB)

87 targeting SLC2A14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-498-3P	99.91	71.27	1114
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-182-5P	99.87	74.03	2589

Literature-anchored findings (GeneRIF, showing 5)

• SLC2A14 polymorphism has a possible role in changing the genetic susceptibility to late Alzheimer disease age of onset in a Han Chinese population. (PMID:22421804)
• High expression of GLUT-14 was associated with Gastric Adenocarcinoma. (PMID:26183839)
• report presents an expanded SLC2A14 gene locus and a more diverse tissue expression, concurring with the existing evidence for disease associations (PMID:27460888)
• Three alleles in the SLC2A14 gene associated independently with inflammatory bowel disease. (PMID:28971850)
• Under hypoxia and HIF1 blockade, cancer cells adapt their energy metabolism via upregulation of the GLUT14 glucose transporter and creatine metabolism providing new avenues for drug targeting. (PMID:30885992)

Cross-species orthologs

46 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000001937
danio_rerio	slc2a3b	ENSDARG00000037861
danio_rerio	slc2a11l	ENSDARG00000062873
danio_rerio	slc2a9l1	ENSDARG00000070672
drosophila_melanogaster	Glut3	FBGN0015230
drosophila_melanogaster	sut4	FBGN0028560
drosophila_melanogaster	sut3	FBGN0028561
drosophila_melanogaster	sut2	FBGN0028562
drosophila_melanogaster	sut1	FBGN0028563
drosophila_melanogaster	CG4607	FBGN0029932
drosophila_melanogaster	CG15406	FBGN0031517
drosophila_melanogaster	CG8837	FBGN0031520
drosophila_melanogaster	CG3285	FBGN0031522
drosophila_melanogaster	CG15408	FBGN0031523
drosophila_melanogaster	CG7882	FBGN0033047
drosophila_melanogaster	Tret1-2	FBGN0033644
drosophila_melanogaster	CG8249	FBGN0034045
drosophila_melanogaster	CG6484	FBGN0034247
drosophila_melanogaster	CG14160	FBGN0036066
drosophila_melanogaster	nebu	FBGN0036316
drosophila_melanogaster	CG1208	FBGN0037386
drosophila_melanogaster	CG14606	FBGN0037485
drosophila_melanogaster	CG14605	FBGN0037486
drosophila_melanogaster	CG6901	FBGN0038414
drosophila_melanogaster	CG17929	FBGN0038415
drosophila_melanogaster	CG17930	FBGN0038416
drosophila_melanogaster	Tret1-1	FBGN0050035
drosophila_melanogaster	CG32053	FBGN0052053
drosophila_melanogaster	CG32054	FBGN0052054
drosophila_melanogaster	CG33281	FBGN0053281
drosophila_melanogaster	CG33282	FBGN0053282
drosophila_melanogaster	Srg2	FBGN0262007
drosophila_melanogaster	CG42826	FBGN0262008
caenorhabditis_elegans		WBGENE00008730
caenorhabditis_elegans		WBGENE00010684
caenorhabditis_elegans		WBGENE00010811
caenorhabditis_elegans		WBGENE00012536
caenorhabditis_elegans		WBGENE00013074
caenorhabditis_elegans		WBGENE00016431
caenorhabditis_elegans		WBGENE00017382
caenorhabditis_elegans		WBGENE00019207
caenorhabditis_elegans		WBGENE00019547
caenorhabditis_elegans		WBGENE00019548
caenorhabditis_elegans		WBGENE00019549
caenorhabditis_elegans		WBGENE00019550
caenorhabditis_elegans		WBGENE00043980

Paralogs (13): SLC2A3 (ENSG00000059804), SLC2A9 (ENSG00000109667), SLC2A1 (ENSG00000117394), SLC2A11 (ENSG00000133460), SLC2A8 (ENSG00000136856), SLC2A5 (ENSG00000142583), SLC2A12 (ENSG00000146411), SLC2A13 (ENSG00000151229), SLC2A6 (ENSG00000160326), SLC2A2 (ENSG00000163581), SLC2A4 (ENSG00000181856), SLC2A7 (ENSG00000197241), SLC2A10 (ENSG00000197496)

Protein

Protein identifiers

Solute carrier family 2, facilitated glucose transporter member 14 — Q8TDB8 (reviewed: Q8TDB8)

Alternative names: Glucose transporter type 14

All UniProt accessions (11): Q8TDB8, F5GXP7, F5GXP8, F5GXT4, F5H076, F5H3J0, F5H565, F5H5Q3, F5H5V7, F5H6F6, F5H7N2

UniProt curated annotations — full annotation on UniProt →

Function. Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane.

Subcellular location. Cell membrane.

Tissue specificity. Mainly expressed in testis. Also expressed in small intestine, liver and kidney.

Miscellaneous. GLUT14 is a recent (less than 5 M year old) duplication of GLUT3.

Similarity. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Isoforms (5)

UniProt ID	Names	Canonical?
Q8TDB8-1	1, GLUT14-L	yes
Q8TDB8-2	2, GLUT14-S
Q8TDB8-3	3
Q8TDB8-4	4
Q8TDB8-5	5

RefSeq proteins (6): NP_001273162, NP_001273163, NP_001273164, NP_001273165, NP_001273166, NP_703150 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002945	Glc_transpt_3	Family
IPR003663	Sugar/inositol_transpt	Family
IPR005828	MFS_sugar_transport-like	Family
IPR005829	Sugar_transporter_CS	Conserved_site
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily
IPR045263	GLUT	Family

Pfam: PF00083

Catalyzed reactions (Rhea), 2 shown:

• D-glucose(out) = D-glucose(in) (RHEA:60376)
• L-dehydroascorbate(out) = L-dehydroascorbate(in) (RHEA:60380)

UniProt features (42 total): topological domain 13, transmembrane region 12, binding site 6, splice variant 4, sequence conflict 3, chain 1, region of interest 1, glycosylation site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TDB8-F1	87.74	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (6): 183; 304–305; 310; 339; 402; 410

Glycosylation sites (1): 67

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-189200	Cellular hexose transport

MSigDB gene sets: 83 (showing top): GOBP_CARBOHYDRATE_TRANSPORT, GOBP_MALE_GAMETE_GENERATION, ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN, DAUER_STAT3_TARGETS_UP, GOBP_D_GLUCOSE_IMPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_VITAMIN_TRANSPORT, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOBP_TRANSMEMBRANE_TRANSPORT, CAMPS_COLON_CANCER_COPY_NUMBER_DN, PAX2_02, GCCNNNWTAAR_UNKNOWN, GOMF_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_TRANSPORTER_ACTIVITY, WIERENGA_STAT5A_TARGETS_UP

GO Biological Process (6): spermatogenesis (GO:0007283), cell differentiation (GO:0030154), obsolete D-glucose import (GO:0046323), dehydroascorbic acid transport (GO:0070837), D-glucose transmembrane transport (GO:1904659), transmembrane transport (GO:0055085)

GO Molecular Function (5): dehydroascorbic acid transmembrane transporter activity (GO:0033300), D-glucose transmembrane transporter activity (GO:0055056), D-glucose binding (GO:0005536), hexose transmembrane transporter activity (GO:0015149), transmembrane transporter activity (GO:0022857)

GO Cellular Component (6): nucleus (GO:0005634), plasma membrane (GO:0005886), aggresome (GO:0016235), membrane (GO:0016020), cell projection (GO:0042995), perikaryon (GO:0043204)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
SLC-mediated transmembrane transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
hexose transmembrane transport	2
developmental process involved in reproduction	1
male gamete generation	1
cellular developmental process	1
vitamin transport	1
transport	1
cellular process	1
dehydroascorbic acid transport	1
vitamin transmembrane transporter activity	1
hexose transmembrane transporter activity	1
monosaccharide binding	1
monosaccharide transmembrane transporter activity	1
transporter activity	1
transmembrane transport	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1
inclusion body	1
neuronal cell body	1

Protein interactions and networks

STRING

1142 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC2A14	SLC5A1	P13866	470
SLC2A14	SLC5A4	Q9NY91	445
SLC2A14	SLC1A5	Q15758	419
SLC2A14	KIT	P10721	405
SLC2A14	NANOGP8	Q6NSW7	398
SLC2A14	SLC23A1	Q9UHI7	390
SLC2A14	SLC23A2	Q9UGH3	388
SLC2A14	SLC5A6	Q9Y289	356
SLC2A14	INS	P01308	356
SLC2A14	SLC5A11	Q8WWX8	353
SLC2A14	LDHA	P00338	352
SLC2A14	RPS6KA2	Q15349	349
SLC2A14	RPS6KA5	O75582	349
SLC2A14	SLC50A1	Q9BRV3	345
SLC2A14	SLC16A14	Q7RTX9	344

IntAct

10 interactions, top by confidence:

A	B	Type	Score
SLC2A14	SLC2A3	psi-mi:“MI:0914”(association)	0.530
SLC2A3	LGALS3	psi-mi:“MI:0914”(association)	0.530
TEX101	GGT3P	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
	SDCBP	psi-mi:“MI:0914”(association)	0.350
ATG16L1		psi-mi:“MI:0914”(association)	0.350
KLHL22	TRAV18	psi-mi:“MI:0914”(association)	0.350
SLC2A14	ADCY3	psi-mi:“MI:0914”(association)	0.350

BioGRID (30): SLC2A14 (Proximity Label-MS), SLC2A3 (Affinity Capture-MS), EPN1 (Affinity Capture-MS), HBB (Affinity Capture-MS), HBA2 (Affinity Capture-MS), SMAP2 (Affinity Capture-MS), WDR73 (Affinity Capture-MS), SLC2A14 (Co-fractionation), HBA2 (Affinity Capture-MS), ARRB1 (Affinity Capture-MS), SMAP2 (Affinity Capture-MS), SLC2A3 (Affinity Capture-MS), EPN1 (Affinity Capture-MS), HBB (Affinity Capture-MS), WDR73 (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4ILB2, A0A8M9Q308, A2CER7, A2SWM2, A2ZN77, A4FV52, A8WGF7, B0S6T2, O23596, O62786, P11170, P30638, P36836, P46029, P46059, P51574, P60815, Q05B21, Q0ILJ3, Q10R54, Q16348, Q1L8X9, Q28FF3, Q3TXX4, Q5M7K3, Q5XGK0, Q62634, Q63424, Q6INC8, Q7TSF2, Q7ZU13, Q8AVC3, Q8BFU8, Q8TDB8, Q8WMX5, Q91X85, Q9C5L3, Q9C8X2, Q9ES07, Q9FE59

Diamond homologs: A0A0H2VG78, A1Z8N1, A4ZYQ5, A5LGM7, A9ZSY2, A9ZSY3, B0WC46, B3MG58, B3NSE1, B4GAP7, B4HNS0, B4HNS1, B4J913, B4KR05, B4LPX5, B4MYA4, B4P624, B4QBN2, B4QBN3, C0SPB2, O04036, O04249, O34718, O44827, O52733, O62787, P0AE24, P0AE25, P0AEP1, P0AEP2, P0C6A1, P11166, P11167, P11169, P13355, P14142, P14246, P14672, P15686, P17809

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

81 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	65
Likely benign	6
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1512 predictions. Top by Δscore:

Variant	Effect	Δscore
12:7814530:TAGTA:T	acceptor_gain	1.0000
12:7814531:AGTA:A	acceptor_gain	1.0000
12:7814532:GTA:G	acceptor_gain	1.0000
12:7814533:TA:T	acceptor_gain	1.0000
12:7814535:C:CC	acceptor_gain	1.0000
12:7814538:G:C	acceptor_gain	1.0000
12:7814538:G:GC	acceptor_gain	1.0000
12:7817827:TTACA:T	donor_loss	1.0000
12:7817828:TACAG:T	donor_loss	1.0000
12:7817829:A:AC	donor_gain	1.0000
12:7817829:A:C	donor_loss	1.0000
12:7817829:ACAG:A	donor_gain	1.0000
12:7817830:C:CA	donor_gain	1.0000
12:7817830:C:G	donor_loss	1.0000
12:7817830:CA:C	donor_gain	1.0000
12:7817830:CAG:C	donor_gain	1.0000
12:7817830:CAGC:C	donor_gain	1.0000
12:7817830:CAGCA:C	donor_gain	1.0000
12:7818030:TGATT:T	acceptor_gain	1.0000
12:7818031:GATT:G	acceptor_gain	1.0000
12:7818032:ATT:A	acceptor_gain	1.0000
12:7818032:ATTC:A	acceptor_loss	1.0000
12:7818033:TT:T	acceptor_gain	1.0000
12:7818034:TC:T	acceptor_loss	1.0000
12:7818035:C:CC	acceptor_gain	1.0000
12:7818035:C:T	acceptor_loss	1.0000
12:7818036:T:A	acceptor_loss	1.0000
12:7819580:ATAG:A	acceptor_gain	1.0000
12:7819581:TAG:T	acceptor_gain	1.0000
12:7819584:C:CC	acceptor_gain	1.0000

AlphaMissense

3245 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:7817924:G:C	F417L	0.997
12:7817924:G:T	F417L	0.997
12:7817926:A:G	F417L	0.997
12:7829782:C:T	G189E	0.997
12:7829893:C:T	G152D	0.997
12:7829881:C:T	G156E	0.996
12:7829894:C:G	G152R	0.996
12:7831652:C:T	G98D	0.996
12:7817964:C:T	G404E	0.995
12:7817972:A:C	F401L	0.995
12:7817972:A:T	F401L	0.995
12:7817974:A:G	F401L	0.995
12:7828753:A:C	S232R	0.995
12:7828753:A:T	S232R	0.995
12:7828755:T:G	S232R	0.995
12:7828825:C:A	W208C	0.995
12:7828825:C:G	W208C	0.995
12:7828827:A:G	W208R	0.995
12:7828827:A:T	W208R	0.995
12:7831655:C:T	G97E	0.995
12:7832756:C:T	G49D	0.995
12:7817875:A:G	W434R	0.994
12:7817875:A:T	W434R	0.994
12:7817889:G:T	A429D	0.994
12:7829783:C:G	G189R	0.994
12:7829783:C:T	G189R	0.994
12:7829882:C:G	G156R	0.994
12:7829882:C:T	G156R	0.994
12:7829893:C:A	G152V	0.994
12:7831643:C:T	G101D	0.994

dbSNP variants (sampled 300 via entrez): RS1000005719 (12:7877929 G>A), RS1000058344 (12:7877552 AG>A), RS1000063296 (12:7828754 C>G), RS1000079882 (12:7882736 C>T), RS1000086137 (12:7826942 T>C), RS1000136441 (12:7867850 A>C), RS1000212778 (12:7853619 A>G), RS1000238931 (12:7890979 T>C), RS1000243359 (12:7822045 T>C), RS1000272327 (12:7892490 G>C), RS1000282057 (12:7815286 C>G,T), RS1000317632 (12:7864887 TCTC>T), RS1000329247 (12:7844725 G>A), RS1000333904 (12:7815476 AT>A,ATT), RS1000336778 (12:7875767 G>A,T)

Disease associations

OMIM: gene MIM:611039 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007354_12	Intracranial aneurysm	1.000000e-14

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4295906 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Class I transporters

CTD chemical–gene interactions

58 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	4
sodium arsenite	decreases expression, increases abundance, increases expression	3
Aflatoxin B1	decreases expression, decreases methylation	3
lasiocarpine	decreases expression	2
methyleugenol	decreases expression	2
bisphenol A	affects expression, decreases methylation	2
bisphenol S	affects cotreatment, increases expression	2
N-Nitrosopyrrolidine	decreases expression	2
Oxygen	increases expression	2
Testosterone	affects cotreatment, increases expression, decreases expression	2
tungsten carbide	affects binding, increases expression	1
testosterone enanthate	affects expression	1
arsenite	affects binding, decreases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	increases expression	1
manganese chloride	increases abundance, increases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	decreases methylation, increases methylation	1
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	decreases expression	1
vandetanib	increases expression	1
clothianidin	decreases expression	1
abrine	decreases expression	1
Rosiglitazone	affects cotreatment, increases expression, decreases reaction	1
Pioglitazone	affects cotreatment, increases expression	1
Troglitazone	affects cotreatment, increases expression, decreases reaction	1
Leflunomide	increases expression	1
Acetaminophen	decreases expression	1
Gemcitabine	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	increases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4132902	ADMET	Antagonist activity at human GLUT3 expressed in HEK293 cells transfected with GLUT1 shRNA assessed as inhibition of [3H]2-deoxy-D-glucose uptake preincubated for 5 mins followed by [3H]2-deoxy-D-glucose addition and measured after 6 mins	Development of GLUT4-selective antagonists for multiple myeloma therapy. — Eur J Med Chem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4SY	HuH7-SLC2A14-KO-c2	Cancer cell line	Male
CVCL_D4SZ	HuH7-SLC2A14-KO-c4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.