SLC2A7

Summary

SLC2A7 (solute carrier family 2 member 7, HGNC:13445) is a protein-coding gene on chromosome 1p36.23, encoding Solute carrier family 2, facilitated glucose transporter member 7 (Q6PXP3). Probable sugar transporter.

SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).

Source: NCBI Gene 155184 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 116 total
• MANE Select transcript: NM_207420

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13445
Approved symbol	SLC2A7
Name	solute carrier family 2 member 7
Location	1p36.23
Locus type	gene with protein product
Status	Approved
Aliases	GLUT7
Ensembl gene	ENSG00000197241
Ensembl biotype	protein_coding
OMIM	610371
Entrez	155184

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000400906

RefSeq mRNA: 1 — MANE Select: NM_207420 NM_207420

CCDS: CCDS98

Canonical transcript exons

ENST00000400906 — 12 exons

Exon	Start	End
ENSE00001065122	9018223	9018375
ENSE00001065126	9015117	9015242
ENSE00001065128	9007310	9007385
ENSE00001065159	9010143	9010244
ENSE00001065167	9014681	9014868
ENSE00001180940	9004752	9004879
ENSE00001319861	9019209	9019333
ENSE00001330901	9013525	9013635
ENSE00001545307	9022918	9023078
ENSE00001545308	9024976	9025074
ENSE00001545309	9026295	9026423
ENSE00001609188	9002973	9003518

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 69.63.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0247 / max 12.5415, expressed in 6 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
10186	0.0247	6

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	69.63	gold quality
small intestine	UBERON:0002108	41.13	gold quality
lower esophagus mucosa	UBERON:0035834	40.66	silver quality
hindlimb stylopod muscle	UBERON:0004252	39.16	gold quality
granulocyte	CL:0000094	38.27	gold quality
bone marrow cell	CL:0002092	38.23	gold quality
small intestine Peyer’s patch	UBERON:0003454	37.57	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
bone marrow	UBERON:0002371	35.25	gold quality
sural nerve	UBERON:0015488	35.19	gold quality
skeletal muscle tissue	UBERON:0001134	34.91	gold quality
intestine	UBERON:0000160	33.18	gold quality
tonsil	UBERON:0002372	32.41	gold quality
leukocyte	CL:0000738	31.95	gold quality
monocyte	CL:0000576	31.71	gold quality
right lobe of thyroid gland	UBERON:0001119	31.12	gold quality
urinary bladder	UBERON:0001255	30.59	gold quality
prostate gland	UBERON:0002367	30.10	silver quality
colon	UBERON:0001155	29.94	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
smooth muscle tissue	UBERON:0001135	29.77	silver quality
blood	UBERON:0000178	29.67	gold quality
right uterine tube	UBERON:0001302	29.09	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
gall bladder	UBERON:0002110	28.57	gold quality
lymph node	UBERON:0000029	27.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Unusual substrate specificity and close sequence identity with GLUT5. GLUT7 may represent intermediate between class II GLUTs and class I member GLUT2. Comparison may give key to structural determinants for recognition of fructose as a substrate. (PMID:15033637)
• a hydrophobic residue is a key determinant of fructose transport in SLC2A7 (PMID:16186102)

Cross-species orthologs

51 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000001937
danio_rerio	slc2a15a	ENSDARG00000029894
danio_rerio	slc2a3b	ENSDARG00000037861
danio_rerio	slc2a15b	ENSDARG00000053269
danio_rerio	slc2a11l	ENSDARG00000062873
danio_rerio	slc2a11b	ENSDARG00000063288
danio_rerio	slc2a9l1	ENSDARG00000070672
mus_musculus	Slc2a7	ENSMUSG00000062064
rattus_norvegicus	Slc2a7	ENSRNOG00000036951
drosophila_melanogaster	Glut3	FBGN0015230
drosophila_melanogaster	sut4	FBGN0028560
drosophila_melanogaster	sut3	FBGN0028561
drosophila_melanogaster	sut2	FBGN0028562
drosophila_melanogaster	sut1	FBGN0028563
drosophila_melanogaster	CG4607	FBGN0029932
drosophila_melanogaster	CG15406	FBGN0031517
drosophila_melanogaster	CG8837	FBGN0031520
drosophila_melanogaster	CG3285	FBGN0031522
drosophila_melanogaster	CG15408	FBGN0031523
drosophila_melanogaster	CG7882	FBGN0033047
drosophila_melanogaster	Tret1-2	FBGN0033644
drosophila_melanogaster	CG8249	FBGN0034045
drosophila_melanogaster	CG6484	FBGN0034247
drosophila_melanogaster	CG14160	FBGN0036066
drosophila_melanogaster	nebu	FBGN0036316
drosophila_melanogaster	CG1208	FBGN0037386
drosophila_melanogaster	CG14606	FBGN0037485
drosophila_melanogaster	CG14605	FBGN0037486
drosophila_melanogaster	CG6901	FBGN0038414
drosophila_melanogaster	CG17929	FBGN0038415
drosophila_melanogaster	CG17930	FBGN0038416
drosophila_melanogaster	Tret1-1	FBGN0050035
drosophila_melanogaster	CG32053	FBGN0052053
drosophila_melanogaster	CG32054	FBGN0052054
drosophila_melanogaster	CG33281	FBGN0053281
drosophila_melanogaster	CG33282	FBGN0053282
drosophila_melanogaster	Srg2	FBGN0262007
drosophila_melanogaster	CG42826	FBGN0262008
caenorhabditis_elegans		WBGENE00008730
caenorhabditis_elegans		WBGENE00010684
caenorhabditis_elegans		WBGENE00010811
caenorhabditis_elegans		WBGENE00012536
caenorhabditis_elegans		WBGENE00013074
caenorhabditis_elegans		WBGENE00016431
caenorhabditis_elegans		WBGENE00017382
caenorhabditis_elegans		WBGENE00019207
caenorhabditis_elegans		WBGENE00019547
caenorhabditis_elegans		WBGENE00019548
caenorhabditis_elegans		WBGENE00019549
caenorhabditis_elegans		WBGENE00019550
caenorhabditis_elegans		WBGENE00043980

Paralogs (13): SLC2A3 (ENSG00000059804), SLC2A9 (ENSG00000109667), SLC2A1 (ENSG00000117394), SLC2A11 (ENSG00000133460), SLC2A8 (ENSG00000136856), SLC2A5 (ENSG00000142583), SLC2A12 (ENSG00000146411), SLC2A13 (ENSG00000151229), SLC2A6 (ENSG00000160326), SLC2A2 (ENSG00000163581), SLC2A14 (ENSG00000173262), SLC2A4 (ENSG00000181856), SLC2A10 (ENSG00000197496)

Protein

Protein identifiers

Solute carrier family 2, facilitated glucose transporter member 7 — Q6PXP3 (reviewed: Q6PXP3)

Alternative names: Glucose transporter type 7

All UniProt accessions (1): Q6PXP3

UniProt curated annotations — full annotation on UniProt →

Function. Probable sugar transporter. Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose. Does not transport galactose, 2-deoxy-d-glucose and xylose.

Subcellular location. Cell membrane. Apical cell membrane.

Tissue specificity. Expressed in small intestine and colon. Weakly expressed in testis and prostate.

Activity regulation. Glucose and fructose transport are inhibited by the flavonoid apigenin.

Induction. Expression is increased in presence of fructose.

Similarity. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

RefSeq proteins (1): NP_997303* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003663	Sugar/inositol_transpt	Family
IPR005828	MFS_sugar_transport-like	Family
IPR005829	Sugar_transporter_CS	Conserved_site
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily
IPR045263	GLUT	Family

Pfam: PF00083

Catalyzed reactions (Rhea), 2 shown:

• D-fructose(out) = D-fructose(in) (RHEA:60372)
• D-glucose(out) = D-glucose(in) (RHEA:60376)

UniProt features (70 total): helix 27, topological domain 13, transmembrane region 12, turn 6, binding site 3, sequence variant 2, mutagenesis site 2, strand 2, chain 1, region of interest 1, glycosylation site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
9J2N	ELECTRON MICROSCOPY	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6PXP3-F1	87.93	0.70

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 294–295; 300; 331

Glycosylation sites (1): 57

Mutagenesis-validated functional residues (2):

Position	Phenotype
302	does not affect glucose or fructose transport.
302	abolished fructose transport.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-189200	Cellular hexose transport

MSigDB gene sets: 24 (showing top): GOBP_CARBOHYDRATE_TRANSPORT, GOBP_D_GLUCOSE_IMPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_VITAMIN_TRANSPORT, GOCC_APICAL_PLASMA_MEMBRANE, GOBP_TRANSMEMBRANE_TRANSPORT, GOCC_APICAL_PART_OF_CELL, GOCC_PLASMA_MEMBRANE_REGION, GOMF_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_TRANSPORTER_ACTIVITY, chr1p36, GOMF_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, REACTOME_CELLULAR_HEXOSE_TRANSPORT, REACTOME_TRANSPORT_OF_SMALL_MOLECULES, GOBP_DEHYDROASCORBIC_ACID_TRANSPORT

GO Biological Process (6): hexose transmembrane transport (GO:0008645), fructose transmembrane transport (GO:0015755), obsolete D-glucose import (GO:0046323), dehydroascorbic acid transport (GO:0070837), D-glucose transmembrane transport (GO:1904659), transmembrane transport (GO:0055085)

GO Molecular Function (4): fructose transmembrane transporter activity (GO:0005353), sugar transmembrane transporter activity (GO:0051119), D-glucose transmembrane transporter activity (GO:0055056), transmembrane transporter activity (GO:0022857)

GO Cellular Component (3): plasma membrane (GO:0005886), apical plasma membrane (GO:0016324), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
SLC-mediated transmembrane transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
hexose transmembrane transport	2
hexose transmembrane transporter activity	2
monosaccharide transmembrane transport	1
vitamin transport	1
transport	1
cellular process	1
fructose transmembrane transport	1
carbohydrate transmembrane transporter activity	1
transporter activity	1
transmembrane transport	1
membrane	1
cell periphery	1
apical part of cell	1
plasma membrane region	1
cellular anatomical structure	1

Protein interactions and networks

STRING

586 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC2A7	SLC5A4	Q9NY91	512
SLC2A7	SLC5A1	P13866	508
SLC2A7	SLC5A9	Q2M3M2	507
SLC2A7	SLC45A1	Q9Y2W3	456
SLC2A7	OR10C1	Q96KK4	434
SLC2A7	CCDC166	P0CW27	370
SLC2A7	SLC2A5	P22732	361
SLC2A7	OR52B4	Q8NGK2	358
SLC2A7	TMEM215	Q68D42	353
SLC2A7	KIRREL2	Q6UWL6	353
SLC2A7	SLC2A6	Q9UGQ3	335
SLC2A7	SLC5A11	Q8WWX8	327
SLC2A7	SLC50A1	Q9BRV3	326
SLC2A7	SLC2A12	Q8TD20	322
SLC2A7	KHK	P50053	310

IntAct

126 interactions, top by confidence:

A	B	Type	Score
SLC2A7	SNX27	psi-mi:“MI:0407”(direct interaction)	0.440
PTPN3	SLC2A7	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	MAST2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	SCRIB	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	PDZK1	psi-mi:“MI:0407”(direct interaction)	0.440
NHERF2	SLC2A7	psi-mi:“MI:0407”(direct interaction)	0.440
MAST1	SLC2A7	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	DLG1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	LIN7B	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	LIN7C	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	DLG3	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	DLG4	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	MAGI2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	DLG2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	NHERF4	psi-mi:“MI:0407”(direct interaction)	0.440
RHPN1	SLC2A7	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	PARD3B	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	WHRN	psi-mi:“MI:0407”(direct interaction)	0.440
APBA3	SLC2A7	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	MPP2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	GOPC	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	PDZD2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	TJP1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	MPDZ	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	PDZRN4	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	PICK1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC2A7	APBA2	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (97): DHX16 (Affinity Capture-MS), SUGP1 (Affinity Capture-MS), DHX38 (Affinity Capture-MS), LGALS3 (Affinity Capture-MS), DPP9 (Affinity Capture-MS), RNF25 (Affinity Capture-MS), SLC2A7 (Affinity Capture-MS), ABCC1 (Affinity Capture-MS), ADCY7 (Affinity Capture-MS), AGPAT4 (Affinity Capture-MS), ALG11 (Affinity Capture-MS), ANO10 (Affinity Capture-MS), APOB (Affinity Capture-MS), APP (Affinity Capture-MS), ARL6IP5 (Affinity Capture-MS)

ESM2 similar proteins: A0A3Q2IDB4, A0A8B7HA97, A4ZYQ5, A6NK97, G1SZD9, O35956, O57379, O88909, P22732, P23945, P43427, Q0IHM1, Q2KIV1, Q3ZAV1, Q4U2R8, Q4W8A2, Q4W8A3, Q5R9C4, Q5RC45, Q5RCH6, Q5RET7, Q63ZE4, Q66J52, Q6DFR1, Q6NUB3, Q6NYN7, Q6PXP3, Q6T423, Q70BM6, Q76M72, Q76M99, Q80UJ1, Q863Y9, Q864Z3, Q8CFZ5, Q8HY24, Q8IVM8, Q8MK48, Q8N4F4, Q8R0S9

Diamond homologs: A0A0H2VG78, A1Z8N1, A4ZYQ5, A5LGM7, A9ZSY2, A9ZSY3, B0WC46, B3MG58, B3NSE1, B4GAP7, B4HNS0, B4HNS1, B4J913, B4KR05, B4LPX5, B4MYA4, B4P624, B4QBN2, B4QBN3, C0SPB2, O04036, O04249, O34718, O44827, O52733, O62787, P0AE24, P0AE25, P0AEP1, P0AEP2, P0C6A1, P11166, P11167, P11169, P13355, P14142, P14246, P14672, P15686, P17809

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 80 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Ras activation upon Ca2+ influx through NMDA receptor	5	56.0×	1e-06
Unblocking of NMDA receptors, glutamate binding and activation	5	53.3×	1e-06
Negative regulation of NMDA receptor-mediated neuronal transmission	5	53.3×	1e-06
Long-term potentiation	5	46.6×	2e-06
Assembly and cell surface presentation of NMDA receptors	9	44.8×	4e-11
Neurexins and neuroligins	10	38.6×	1e-11
Protein-protein interactions at synapses	6	31.2×	1e-06
RHOA GTPase cycle	5	7.3×	8e-03

GO biological processes:

GO term	Partners	Fold	FDR
establishment or maintenance of epithelial cell apical/basal polarity	11	84.1×	1e-16
protein localization to synapse	6	60.5×	6e-08
receptor clustering	7	57.5×	6e-09
regulation of postsynaptic membrane neurotransmitter receptor levels	7	45.6×	2e-08
cell-cell adhesion	10	13.4×	3e-07
protein-containing complex assembly	8	12.0×	2e-05
chemical synaptic transmission	7	7.1×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

116 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	98
Likely benign	9
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

2140 predictions. Top by Δscore:

Variant	Effect	Δscore
1:9003525:C:CT	acceptor_gain	1.0000
1:9004749:CACCT:C	donor_loss	1.0000
1:9004750:A:AC	donor_gain	1.0000
1:9004750:ACC:A	donor_loss	1.0000
1:9004751:C:CC	donor_gain	1.0000
1:9004751:CCTGG:C	donor_gain	1.0000
1:9004880:C:CA	acceptor_loss	1.0000
1:9007308:A:AC	donor_gain	1.0000
1:9007309:C:CC	donor_gain	1.0000
1:9010141:ACCT:A	donor_loss	1.0000
1:9010142:CC:C	donor_loss	1.0000
1:9010157:C:CT	donor_gain	1.0000
1:9010158:C:CT	donor_gain	1.0000
1:9010241:CAGC:C	acceptor_gain	1.0000
1:9010244:CCTG:C	acceptor_loss	1.0000
1:9010245:C:A	acceptor_loss	1.0000
1:9010245:C:CC	acceptor_gain	1.0000
1:9010246:T:G	acceptor_loss	1.0000
1:9013521:TCAC:T	donor_loss	1.0000
1:9013522:CACCG:C	donor_loss	1.0000
1:9013523:A:AC	donor_gain	1.0000
1:9013524:C:CC	donor_gain	1.0000
1:9013524:C:CT	donor_loss	1.0000
1:9013524:CCGAG:C	donor_gain	1.0000
1:9013631:TTGAT:T	acceptor_gain	1.0000
1:9013632:TGAT:T	acceptor_gain	1.0000
1:9013633:GAT:G	acceptor_gain	1.0000
1:9013633:GATCT:G	acceptor_loss	1.0000
1:9013634:AT:A	acceptor_gain	1.0000
1:9013635:TCT:T	acceptor_loss	1.0000

AlphaMissense

3274 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:9015240:A:G	W198R	0.988
1:9015240:A:T	W198R	0.988
1:9003495:G:C	F448L	0.983
1:9003495:G:T	F448L	0.983
1:9003497:A:G	F448L	0.983
1:9015166:G:C	S222R	0.983
1:9015166:G:T	S222R	0.983
1:9015168:T:G	S222R	0.983
1:9015238:C:A	W198C	0.981
1:9015238:C:G	W198C	0.981
1:9019270:G:C	S125R	0.980
1:9019270:G:T	S125R	0.980
1:9019272:T:G	S125R	0.980
1:9018251:G:C	S187R	0.978
1:9018251:G:T	S187R	0.978
1:9018253:T:G	S187R	0.978
1:9004764:G:C	F436L	0.973
1:9004764:G:T	F436L	0.973
1:9004766:A:G	F436L	0.973
1:9003486:A:C	F451L	0.967
1:9003486:A:T	F451L	0.967
1:9003488:A:G	F451L	0.967
1:9018264:G:T	A183E	0.967
1:9018277:C:G	G179R	0.967
1:9018277:C:T	G179R	0.967
1:9025003:G:C	N41K	0.967
1:9025003:G:T	N41K	0.967
1:9023064:A:C	F55L	0.966
1:9023064:A:T	F55L	0.966
1:9023066:A:G	F55L	0.966

dbSNP variants (sampled 300 via entrez): RS1000027449 (1:9003941 T>C), RS1000045234 (1:9009059 A>G), RS1000096014 (1:8995757 T>A), RS1000254245 (1:9001331 A>G), RS1000344780 (1:9026067 C>T), RS1000357106 (1:9028398 G>A), RS1000358957 (1:9010954 C>A,T), RS1000389559 (1:8999156 T>C), RS1000529930 (1:8995475 G>A), RS1000579499 (1:9010696 G>C), RS1000624264 (1:9021803 G>A), RS1000641369 (1:8993993 T>G), RS1000655445 (1:9021996 T>A), RS1000685299 (1:9004915 G>A), RS1000798268 (1:9023063 A>C,G)

Disease associations

OMIM: gene MIM:610371 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Class II transporters

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Fructose	increases transport	2
Glucose	increases transport	2
benzo(e)pyrene	increases methylation	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Methapyrilene	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.