SLC2A8

Summary

SLC2A8 (solute carrier family 2 member 8, HGNC:13812) is a protein-coding gene on chromosome 9q33.3, encoding Solute carrier family 2, facilitated glucose transporter member 8 (Q9NY64). Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose.

This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene.

Source: NCBI Gene 29988 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 79 total
• Druggable target: yes
• MANE Select transcript: NM_014580

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13812
Approved symbol	SLC2A8
Name	solute carrier family 2 member 8
Location	9q33.3
Locus type	gene with protein product
Status	Approved
Aliases	GLUTX1, GLUT8
Ensembl gene	ENSG00000136856
Ensembl biotype	protein_coding
OMIM	605245
Entrez	29988

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 16 protein_coding, 5 protein_coding_CDS_not_defined

ENST00000373352, ENST00000373360, ENST00000373371, ENST00000419132, ENST00000419917, ENST00000423934, ENST00000430147, ENST00000439597, ENST00000451404, ENST00000477027, ENST00000484208, ENST00000484617, ENST00000485806, ENST00000489239, ENST00000610552, ENST00000954537, ENST00000954538, ENST00000954539, ENST00000954540, ENST00000954541, ENST00000954542

RefSeq mRNA: 3 — MANE Select: NM_014580 NM_001271711, NM_001271712, NM_014580

CCDS: CCDS65138, CCDS6870, CCDS75903

Canonical transcript exons

ENST00000373371 — 10 exons

Exon	Start	End
ENSE00001605426	127397376	127397538
ENSE00001742537	127397905	127398111
ENSE00001837271	127397169	127397286
ENSE00003241087	127402557	127402753
ENSE00003483158	127403660	127403803
ENSE00003587449	127404818	127404991
ENSE00003610568	127405420	127405565
ENSE00003641012	127407112	127407898
ENSE00003692257	127399907	127400006
ENSE00003787809	127403959	127404067

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 95.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.8646 / max 216.4301, expressed in 1677 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
98601	8.1991	1613
98603	6.5754	1421
98600	2.2053	1201
98602	0.5402	307
98604	0.2949	149
98605	0.0275	4
98606	0.0222	3

Top tissues by expression

269 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	95.86	gold quality
right testis	UBERON:0004534	95.59	gold quality
right adrenal gland	UBERON:0001233	94.88	gold quality
left adrenal gland cortex	UBERON:0035825	94.73	gold quality
right adrenal gland cortex	UBERON:0035827	94.64	gold quality
left adrenal gland	UBERON:0001234	94.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.31	gold quality
adrenal cortex	UBERON:0001235	93.41	gold quality
testis	UBERON:0000473	93.26	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.55	gold quality
cerebellar hemisphere	UBERON:0002245	92.21	gold quality
cerebellar cortex	UBERON:0002129	92.07	gold quality
adrenal gland	UBERON:0002369	91.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.45	gold quality
right lobe of liver	UBERON:0001114	91.34	gold quality
gastrocnemius	UBERON:0001388	90.59	gold quality
cerebellum	UBERON:0002037	90.55	gold quality
sperm	CL:0000019	90.26	gold quality
right coronary artery	UBERON:0001625	90.22	gold quality
right frontal lobe	UBERON:0002810	89.82	gold quality
amygdala	UBERON:0001876	89.72	gold quality
muscle of leg	UBERON:0001383	89.62	gold quality
endocervix	UBERON:0000458	89.38	gold quality
transverse colon	UBERON:0001157	89.28	gold quality
apex of heart	UBERON:0002098	89.19	gold quality
spinal cord	UBERON:0002240	89.17	gold quality
body of stomach	UBERON:0001161	89.13	gold quality
ectocervix	UBERON:0012249	89.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	88.98	gold quality
male germ cell	CL:0000015	88.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.09

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting SLC2A8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-4470	99.66	69.35	1767
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-6505-3P	99.34	67.39	1071
HSA-MIR-5001-5P	99.05	66.76	1972
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-591	96.29	68.16	611
HSA-MIR-99A-3P	92.55	62.10	99
HSA-MIR-99B-3P	92.55	62.30	99

Literature-anchored findings (GeneRIF, showing 10)

• This carrier protein is expressed in human tissues of the testis in a gonadotropin-dependent manner. (PMID:11845330)
• The recruitment of GLUT8 to the endocytic machinery occurs via direct interaction of the dileucine motif with beta2-adaptin, and that endocytosis might be the main site at which GLUT8 is likely to be regulated. (PMID:16723738)
• The expression pattern of GLUT8 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry. (PMID:19554504)
• Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer. (PMID:22452979)
• SLC2A8 is upregulated in fast progressing Alzheimer’s disease patients, compared to slow progressors. (PMID:23234877)
• GLUT8 is thus essential for hepatocyte fructose transport and fructose-induced macrosteatosis. (PMID:24519932)
• The findings support the hypothesis of the transport of intravascularGLUT8 through the epithelial cells of the choroid plexus and the ependymal cells. (PMID:27160096)
• glucose/fructose is transported into the cytoplasm of vimentin- or GFAP-positive astrocytic and CD68- or HLA-DR-positive microglial cells located around the lateral ventricle (PMID:27818355)
• these data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction. (PMID:27922102)
• Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction (PMID:29590129)

Cross-species orthologs

37 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc2a8	ENSDARG00000104278
mus_musculus	Slc2a8	ENSMUSG00000026791
rattus_norvegicus	Slc2a8	ENSRNOG00000022274
drosophila_melanogaster	Glut3	FBGN0015230
drosophila_melanogaster	sut4	FBGN0028560
drosophila_melanogaster	sut3	FBGN0028561
drosophila_melanogaster	sut2	FBGN0028562
drosophila_melanogaster	sut1	FBGN0028563
drosophila_melanogaster	CG4607	FBGN0029932
drosophila_melanogaster	CG15406	FBGN0031517
drosophila_melanogaster	CG8837	FBGN0031520
drosophila_melanogaster	CG3285	FBGN0031522
drosophila_melanogaster	CG15408	FBGN0031523
drosophila_melanogaster	CG7882	FBGN0033047
drosophila_melanogaster	Tret1-2	FBGN0033644
drosophila_melanogaster	CG8249	FBGN0034045
drosophila_melanogaster	CG6484	FBGN0034247
drosophila_melanogaster	nebu	FBGN0036316
drosophila_melanogaster	CG14606	FBGN0037485
drosophila_melanogaster	CG14605	FBGN0037486
drosophila_melanogaster	CG6901	FBGN0038414
drosophila_melanogaster	CG17929	FBGN0038415
drosophila_melanogaster	CG17930	FBGN0038416
drosophila_melanogaster	Tret1-1	FBGN0050035
drosophila_melanogaster	CG33281	FBGN0053281
drosophila_melanogaster	CG33282	FBGN0053282
caenorhabditis_elegans		WBGENE00010684
caenorhabditis_elegans		WBGENE00010811
caenorhabditis_elegans		WBGENE00012536
caenorhabditis_elegans		WBGENE00013074
caenorhabditis_elegans		WBGENE00016431
caenorhabditis_elegans		WBGENE00017382
caenorhabditis_elegans		WBGENE00019547
caenorhabditis_elegans		WBGENE00019548
caenorhabditis_elegans		WBGENE00019549
caenorhabditis_elegans		WBGENE00019550
caenorhabditis_elegans		WBGENE00043980

Paralogs (13): SLC2A3 (ENSG00000059804), SLC2A9 (ENSG00000109667), SLC2A1 (ENSG00000117394), SLC2A11 (ENSG00000133460), SLC2A5 (ENSG00000142583), SLC2A12 (ENSG00000146411), SLC2A13 (ENSG00000151229), SLC2A6 (ENSG00000160326), SLC2A2 (ENSG00000163581), SLC2A14 (ENSG00000173262), SLC2A4 (ENSG00000181856), SLC2A7 (ENSG00000197241), SLC2A10 (ENSG00000197496)

Protein

Protein identifiers

Solute carrier family 2, facilitated glucose transporter member 8 — Q9NY64 (reviewed: Q9NY64)

Alternative names: Glucose transporter type 8, Glucose transporter type X1

All UniProt accessions (10): A0A087WT42, Q9NY64, H0Y7M6, Q5VVV3, Q5VVV4, Q5VVV5, Q5VVV6, Q5VVV9, Q5VVW0, Q5VVW5

UniProt curated annotations — full annotation on UniProt →

Function. Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate.

Subunit / interactions. Interacts with AP2B1.

Subcellular location. Cell membrane. Cytoplasmic vesicle membrane.

Tissue specificity. Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.

Activity regulation. Inhibited by cytochalasin B.

Induction. In testis, down-regulated by estrogen.

Similarity. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

RefSeq proteins (3): NP_001258640, NP_001258641, NP_055395* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003663	Sugar/inositol_transpt	Family
IPR005828	MFS_sugar_transport-like	Family
IPR005829	Sugar_transporter_CS	Conserved_site
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily
IPR050549	MFS_Trehalose_Transporter	Family

Pfam: PF00083

Catalyzed reactions (Rhea), 4 shown:

• alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out) (RHEA:17629)
• D-fructose(out) = D-fructose(in) (RHEA:60372)
• D-glucose(out) = D-glucose(in) (RHEA:60376)
• L-dehydroascorbate(out) = L-dehydroascorbate(in) (RHEA:60380)

UniProt features (36 total): topological domain 13, transmembrane region 12, binding site 4, sequence conflict 3, chain 1, short sequence motif 1, glycosylation site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NY64-F1	85.78	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 162; 267–268; 273; 394

Glycosylation sites (1): 349

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-189200	Cellular hexose transport
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828	Clathrin-mediated endocytosis
R-HSA-199991	Membrane Trafficking
R-HSA-382551	Transport of small molecules
R-HSA-425407	SLC-mediated transmembrane transport
R-HSA-5653656	Vesicle-mediated transport

MSigDB gene sets: 163 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_CARBOHYDRATE_TRANSPORT, GOCC_VACUOLAR_MEMBRANE, GOBP_MALE_GAMETE_GENERATION, REACTOME_MEMBRANE_TRAFFICKING, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS, GOBP_ORGANELLE_FISSION, GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS, GOBP_RESPONSE_TO_INSULIN, GOBP_RESPONSE_TO_OXYGEN_LEVELS, GOCC_COATED_VESICLE, GOBP_CARBOHYDRATE_METABOLIC_PROCESS, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND

GO Biological Process (9): response to hypoxia (GO:0001666), carbohydrate metabolic process (GO:0005975), male meiosis I (GO:0007141), insulin receptor signaling pathway (GO:0008286), hexose transmembrane transport (GO:0008645), fructose transmembrane transport (GO:0015755), dehydroascorbic acid transport (GO:0070837), D-glucose transmembrane transport (GO:1904659), transmembrane transport (GO:0055085)

GO Molecular Function (5): fructose transmembrane transporter activity (GO:0005353), D-glucose binding (GO:0005536), dehydroascorbic acid transmembrane transporter activity (GO:0033300), D-glucose transmembrane transporter activity (GO:0055056), transmembrane transporter activity (GO:0022857)

GO Cellular Component (7): lysosomal membrane (GO:0005765), plasma membrane (GO:0005886), synaptic vesicle (GO:0008021), membrane (GO:0016020), clathrin-coated endocytic vesicle membrane (GO:0030669), cytoplasmic vesicle membrane (GO:0030659), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
SLC-mediated transmembrane transport	1
Clathrin-mediated endocytosis	1
Membrane Trafficking	1
Vesicle-mediated transport	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
hexose transmembrane transport	2
hexose transmembrane transporter activity	2
response to stress	1
response to decreased oxygen levels	1
primary metabolic process	1
meiosis I	1
male meiotic nuclear division	1
male gamete generation	1
meiotic cell cycle	1
cell surface receptor protein tyrosine kinase signaling pathway	1
cellular response to insulin stimulus	1
monosaccharide transmembrane transport	1
vitamin transport	1
transport	1
cellular process	1
fructose transmembrane transport	1
monosaccharide binding	1
dehydroascorbic acid transport	1
vitamin transmembrane transporter activity	1
transporter activity	1
transmembrane transport	1
lysosome	1
lytic vacuole membrane	1
membrane	1
cell periphery	1
exocytic vesicle	1
presynapse	1
cellular anatomical structure	1
clathrin-coated vesicle membrane	1
endocytic vesicle membrane	1
clathrin-coated endocytic vesicle	1
vesicle membrane	1
cytoplasmic vesicle	1
cytoplasm	1
intracellular vesicle	1

Protein interactions and networks

STRING

2134 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC2A8	H7C1H1	H7C1H1	777
SLC2A8	SLC5A1	P13866	584
SLC2A8	INS	P01308	527
SLC2A8	SLC5A4	Q9NY91	490
SLC2A8	SLC5A9	Q2M3M2	461
SLC2A8	TREH	O43280	454
SLC2A8	SLC23A1	Q9UHI7	433
SLC2A8	SLC5A11	Q8WWX8	427
SLC2A8	SLC5A2	P31639	411
SLC2A8	SLC23A2	Q9UGH3	407
SLC2A8	KHK	P50053	399
SLC2A8	SLC50A1	Q9BRV3	393
SLC2A8	SLC2A11	Q9BYW1	380
SLC2A8	SLC60A2	Q5TF39	377
SLC2A8	SLC22A23	A1A5C7	372

IntAct

25 interactions, top by confidence:

A	B	Type	Score
PRKAG1	PRKAB2	psi-mi:“MI:0914”(association)	0.940
CD79A	METTL15	psi-mi:“MI:0914”(association)	0.530
DHRS9	MFSD4B	psi-mi:“MI:0914”(association)	0.530
SLC2A8	BDKRB2	psi-mi:“MI:0915”(physical association)	0.370
CLEC2D	TMEM120B	psi-mi:“MI:0914”(association)	0.350
TIMM23	PIKFYVE	psi-mi:“MI:0914”(association)	0.350
ARMC6	SLC27A2	psi-mi:“MI:0914”(association)	0.350
MINDY2	SLC27A2	psi-mi:“MI:0914”(association)	0.350
KLK8	MT-ND1	psi-mi:“MI:0914”(association)	0.350
CHIA	TPP2	psi-mi:“MI:0914”(association)	0.350
DHRS9	ATP2B2	psi-mi:“MI:0914”(association)	0.350
LAMP1	DST	psi-mi:“MI:0914”(association)	0.350
SLC2A8	LAMP1	psi-mi:“MI:0914”(association)	0.350
GPR17	TMEM120B	psi-mi:“MI:0914”(association)	0.350
CLEC4A	RBFOX3	psi-mi:“MI:0914”(association)	0.350
CRISP3	ADD2	psi-mi:“MI:0914”(association)	0.350
SLC2A8	FOLH1	psi-mi:“MI:0914”(association)	0.350
SLC2A8	AGPAT2	psi-mi:“MI:0914”(association)	0.350
SLC2A8	AP3D1	psi-mi:“MI:0914”(association)	0.350

BioGRID (91): SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), SLC2A8 (Affinity Capture-MS), AP1B1 (Two-hybrid)

ESM2 similar proteins: A4ZYQ5, A5LGM7, B4HNS1, B4QBN3, O44827, O62786, O62787, P0C6A1, P11166, P11167, P11168, P11169, P12336, P13355, P14142, P14246, P14672, P17809, P19357, P20303, P22732, P27674, P28568, P32037, P43427, P46896, P47842, P47843, P58351, P58352, P58353, P58354, P79365, Q07647, Q27994, Q5R608, Q5RET7, Q6DFR1, Q6NUB3, Q6PXP3

Diamond homologs: A0A0H2VG78, A0A1D8PH98, A9ZSY3, B4HNS1, B4QBN3, C0SPB2, F1R0H0, J9VHZ4, O04249, O23492, O34718, O52733, O62786, O62787, O65413, P0AE24, P0AE25, P0AEP1, P0AEP2, P0AGF4, P0AGF5, P11166, P11167, P11169, P12336, P13355, P14246, P15686, P15729, P17809, P23586, P27674, P30605, P30606, P32037, P39924, P45598, P46333, P46896, P47185

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	59
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1544 predictions. Top by Δscore:

Variant	Effect	Δscore
9:127403658:A:AG	acceptor_gain	1.0000
9:127403659:G:GG	acceptor_gain	1.0000
9:127403659:GA:G	acceptor_gain	1.0000
9:127403659:GAGC:G	acceptor_gain	1.0000
9:127403802:AGGT:A	donor_loss	1.0000
9:127403803:GGTAA:G	donor_loss	1.0000
9:127403804:G:C	donor_loss	1.0000
9:127403805:T:A	donor_loss	1.0000
9:127403954:CCCAG:C	acceptor_loss	1.0000
9:127403955:CCA:C	acceptor_loss	1.0000
9:127403957:A:AG	acceptor_gain	1.0000
9:127403957:AG:A	acceptor_gain	1.0000
9:127403958:G:GT	acceptor_gain	1.0000
9:127403958:GG:G	acceptor_gain	1.0000
9:127403958:GGAC:G	acceptor_gain	1.0000
9:127403958:GGACA:G	acceptor_gain	1.0000
9:127404065:CAGGT:C	donor_loss	1.0000
9:127404066:AGGTG:A	donor_loss	1.0000
9:127404067:GGTGA:G	donor_loss	1.0000
9:127404068:G:GA	donor_loss	1.0000
9:127404069:T:A	donor_loss	1.0000
9:127397284:CAGGT:C	donor_loss	0.9900
9:127397285:AGGT:A	donor_loss	0.9900
9:127397287:G:A	donor_loss	0.9900
9:127397288:T:G	donor_loss	0.9900
9:127398008:T:TA	acceptor_gain	0.9900
9:127398109:CCGGT:C	donor_loss	0.9900
9:127398110:CGGT:C	donor_loss	0.9900
9:127398111:GGT:G	donor_loss	0.9900
9:127398112:G:A	donor_loss	0.9900

AlphaMissense

3056 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:127397441:G:A	G41D	0.998
9:127405422:T:C	F385L	0.998
9:127405424:T:A	F385L	0.998
9:127405424:T:G	F385L	0.998
9:127397440:G:C	G41R	0.997
9:127397458:A:C	S47R	0.997
9:127397460:C:A	S47R	0.997
9:127397460:C:G	S47R	0.997
9:127404835:A:C	S332R	0.997
9:127404837:C:A	S332R	0.997
9:127404837:C:G	S332R	0.997
9:127405449:T:A	W394R	0.997
9:127405449:T:C	W394R	0.997
9:127397441:G:T	G41V	0.996
9:127398076:G:C	G131R	0.996
9:127399982:G:C	G168R	0.996
9:127403765:T:C	F277L	0.996
9:127403767:C:A	F277L	0.996
9:127403767:C:G	F277L	0.996
9:127405465:A:T	E399V	0.996
9:127398013:G:C	G110R	0.995
9:127398014:G:A	G110D	0.995
9:127398077:G:A	G131D	0.995
9:127399983:G:A	G168D	0.995
9:127405453:T:C	L395P	0.995
9:127405506:T:C	C413R	0.995
9:127397434:A:C	S39R	0.994
9:127397436:C:A	S39R	0.994
9:127397436:C:G	S39R	0.994
9:127397452:G:C	G45R	0.994

dbSNP variants (sampled 300 via entrez): RS1000251139 (9:127399945 G>A,C,T), RS1000253482 (9:127396508 C>T), RS1000553168 (9:127401183 A>G), RS1000601314 (9:127405914 C>A,T), RS1000823450 (9:127406166 A>C), RS1000962436 (9:127395844 T>A,C), RS1000987548 (9:127401530 C>T), RS1000992096 (9:127395446 C>G,T), RS1001015784 (9:127400231 C>G,T), RS1001503550 (9:127404664 A>G), RS1001950330 (9:127405631 T>C), RS1002054359 (9:127399050 G>C), RS1002394841 (9:127400658 G>A), RS1002772109 (9:127400427 G>A), RS1003066741 (9:127397989 C>T)

Disease associations

OMIM: gene MIM:605245 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001824_11	Metabolite levels (HVA)	5.000000e-06
GCST005547_17	Major depressive disorder	6.000000e-06
GCST006865_9	Bipolar disorder	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005131	HVA measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4295964 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Class II transporters

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.22	IC50	6000	nM	CHEMBL4171968

PubChem BioAssay actives

2 with measured affinity, of 5 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
N-[[3-[2-(4-fluorophenyl)ethoxy]phenyl]methyl]-4-methoxy-N-(pyridin-4-ylmethyl)benzamide	1501196: Antagonist activity at GLUT8 (unknown origin) assessed as reduction in 2-[3H]deoxyglucose uptake measured after 6 mins	ic50	6.0000	uM

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	3
Tetrachlorodibenzodioxin	increases expression	3
4’-methoxy-1-naphthylfenoterol	decreases expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects cotreatment, increases methylation	1
9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	increases expression	1
benazol P	affects expression	1
avobenzone	increases expression	1
2-palmitoylglycerol	increases expression	1
ICG 001	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Leflunomide	increases expression	1
Acetaminophen	increases expression	1
Cisplatin	increases expression	1
Gallic Acid	decreases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Hydrogen Peroxide	affects expression	1
Ivermectin	increases expression	1
Methyl Methanesulfonate	increases expression	1
Polycyclic Aromatic Hydrocarbons	decreases expression, increases abundance, affects cotreatment	1
Quercetin	increases expression	1
Smoke	decreases expression	1
Testosterone	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Zidovudine	increases expression	1
Cyclosporine	increases expression	1
Antirheumatic Agents	increases expression	1

ChEMBL screening assays

2 unique, capped per target: 1 binding, 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4132894	Binding	Antagonist activity at GLUT8 (unknown origin) assessed as reduction in 2-[3H]deoxyglucose uptake measured after 6 mins	Development of GLUT4-selective antagonists for multiple myeloma therapy. — Eur J Med Chem
CHEMBL4132904	ADMET	Antagonist activity at human GLUT8 expressed in HEK293 cells transfected with GLUT1 shRNA assessed as inhibition of [3H]2-deoxy-D-glucose uptake preincubated for 5 mins followed by [3H]2-deoxy-D-glucose addition and measured after 6 mins	Development of GLUT4-selective antagonists for multiple myeloma therapy. — Eur J Med Chem

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2FU	Abcam HeLa SLC2A8 KO	Cancer cell line	Female
CVCL_D4T4	HuH7-SLC2A8-KO-c5	Cancer cell line	Male
CVCL_D4T5	HuH7-SLC2A8-KO-c6	Cancer cell line	Male
CVCL_TM84	HAP1 SLC2A8 (-) 1	Cancer cell line	Male
CVCL_TM85	HAP1 SLC2A8 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.