SLC35B1

Summary

SLC35B1 (solute carrier family 35 member B1, HGNC:20798) is a protein-coding gene on chromosome 17q21.33, encoding Solute carrier family 35 member B1 (P78383). ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. It is a common-essential gene (DepMap: required in 98.2% of cancer cell lines).

This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 10237 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 56 total
• Cancer dependency (DepMap): dependent in 98.2% of screened cell lines (common-essential)
• MANE Select transcript: NM_005827

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20798
Approved symbol	SLC35B1
Name	solute carrier family 35 member B1
Location	17q21.33
Locus type	gene with protein product
Status	Approved
Aliases	UGTREL1, AXER
Ensembl gene	ENSG00000121073
Ensembl biotype	protein_coding
OMIM	610790
Entrez	10237

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 15 protein_coding, 10 retained_intron, 2 nonsense_mediated_decay

ENST00000240333, ENST00000435059, ENST00000502268, ENST00000502406, ENST00000503334, ENST00000504260, ENST00000505765, ENST00000507477, ENST00000507773, ENST00000508520, ENST00000508607, ENST00000508749, ENST00000508926, ENST00000509781, ENST00000511657, ENST00000511763, ENST00000513508, ENST00000514907, ENST00000515850, ENST00000649906, ENST00000858530, ENST00000858531, ENST00000858532, ENST00000858533, ENST00000940145, ENST00000940146, ENST00000953815

RefSeq mRNA: 2 — MANE Select: NM_005827 NM_001278784, NM_005827

CCDS: CCDS11552

Canonical transcript exons

ENST00000240333 — 9 exons

Exon	Start	End
ENSE00002068470	49700943	49701510
ENSE00002072326	49707730	49707964
ENSE00003487693	49706204	49706334
ENSE00003584569	49703188	49703294
ENSE00003585754	49705124	49705281
ENSE00003598409	49705866	49705896
ENSE00003644251	49702858	49703011
ENSE00003670103	49706965	49707068
ENSE00003785687	49704100	49704226

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 96.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 41.8899 / max 447.7498, expressed in 1824 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166821	36.8303	1823
166822	1.9792	947
166819	1.3584	533
166820	1.2631	710
208242	0.3568	174
166824	0.1022	38

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	96.92	gold quality
adenohypophysis	UBERON:0002196	96.27	gold quality
right lobe of thyroid gland	UBERON:0001119	95.95	gold quality
left lobe of thyroid gland	UBERON:0001120	95.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.74	gold quality
right lobe of liver	UBERON:0001114	95.66	gold quality
jejunal mucosa	UBERON:0000399	95.65	gold quality
pituitary gland	UBERON:0000007	95.62	gold quality
body of pancreas	UBERON:0001150	95.52	gold quality
oocyte	CL:0000023	95.51	gold quality
gastrocnemius	UBERON:0001388	95.51	gold quality
stromal cell of endometrium	CL:0002255	95.47	gold quality
heart left ventricle	UBERON:0002084	95.42	gold quality
muscle of leg	UBERON:0001383	95.31	gold quality
cardiac ventricle	UBERON:0002082	95.31	gold quality
thyroid gland	UBERON:0002046	95.27	gold quality
right atrium auricular region	UBERON:0006631	95.13	gold quality
pancreas	UBERON:0001264	95.11	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.03	gold quality
duodenum	UBERON:0002114	94.95	gold quality
small intestine Peyer’s patch	UBERON:0003454	94.94	gold quality
granulocyte	CL:0000094	94.89	gold quality
rectum	UBERON:0001052	94.88	gold quality
upper lobe of left lung	UBERON:0008952	94.82	gold quality
cardiac atrium	UBERON:0002081	94.80	gold quality
heart	UBERON:0000948	94.67	gold quality
bone marrow cell	CL:0002092	94.59	gold quality
metanephros cortex	UBERON:0010533	94.59	gold quality
small intestine	UBERON:0002108	94.55	gold quality
upper lobe of lung	UBERON:0008948	94.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting SLC35B1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-1208	99.70	68.28	1533
HSA-MIR-4685-5P	99.25	65.99	1563
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-149-5P	99.25	67.16	1315
HSA-MIR-3191-5P	99.24	66.52	1722
HSA-MIR-6749-3P	99.00	65.73	1443
HSA-MIR-4463	98.56	66.05	1071
HSA-MIR-6776-3P	98.38	66.34	655
HSA-MIR-585-5P	97.54	69.02	955
HSA-MIR-4253	97.48	65.11	692
HSA-MIR-6862-5P	97.48	64.84	713
HSA-MIR-7847-3P	96.63	64.58	952
HSA-MIR-6822-3P	96.60	66.06	680

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.2% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 2)

• SLC35B1 significantly contributes to the uptake of UDPGA into the endoplasmic reticulum for glucuronidation catalyzed by UDP-glucuronosyltransferases. (PMID:32179043)
• The broad range di- and tri-nucleotide exchanger SLC35B1 displays asymmetrical affinities for ATP transport across the ER membrane. (PMID:35041824)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc35b1	ENSDARG00000038213
mus_musculus	Slc35b1	ENSMUSG00000020873
rattus_norvegicus	Slc35b1	ENSRNOG00000004510
drosophila_melanogaster	meigo	FBGN0250820
caenorhabditis_elegans		WBGENE00013740

Paralogs (3): SLC35B3 (ENSG00000124786), SLC35B2 (ENSG00000157593), SLC35B4 (ENSG00000205060)

Protein

Protein identifiers

Solute carrier family 35 member B1 — P78383 (reviewed: P78383)

Alternative names: ATP/ADP exchanger ER, Endoplasmic reticulum ATP/ADP translocase, UDP-galactose transporter-related protein 1

All UniProt accessions (9): D6R981, D6R9G9, D6RB73, D6RDY9, D6RE58, D6RF81, D6RG34, D6RHG0, P78383

UniProt curated annotations — full annotation on UniProt →

Function. ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction. Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER. Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established. ATP:ADP antiporter. ATP:ADP antiporter.

Subunit / interactions. Monomer.

Subcellular location. Endoplasmic reticulum membrane.

Domain organisation. The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

Similarity. Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
P78383-1	1	yes
P78383-2	2

RefSeq proteins (2): NP_001265713, NP_005818* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013657	HUT1	Family
IPR037185	EmrE-like	Homologous_superfamily

Pfam: PF08449

Catalyzed reactions (Rhea), 4 shown:

• ADP(in) + ATP(out) = ADP(out) + ATP(in) (RHEA:34999)
• UDP(out) + ATP(in) = UDP(in) + ATP(out) (RHEA:73707)
• UTP(out) + ATP(in) = UTP(in) + ATP(out) (RHEA:73711)
• dATP(out) + ATP(in) = dATP(in) + ATP(out) (RHEA:73715)

UniProt features (47 total): topological domain 11, mutagenesis site 11, transmembrane region 10, binding site 6, sequence conflict 3, modified residue 2, chain 1, short sequence motif 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

7 structures.

PDB	Method	Resolution (Å)
9I20	ELECTRON MICROSCOPY	2.85
9GRY	ELECTRON MICROSCOPY	3
9GS5	ELECTRON MICROSCOPY	3.1
9GS3	ELECTRON MICROSCOPY	3.15
9GS7	ELECTRON MICROSCOPY	3.15
9GSL	ELECTRON MICROSCOPY	3.37
9GRZ	ELECTRON MICROSCOPY	3.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P78383-F1	86.63	0.57

Antibody-complex structures (SAbDab): 6 — 9GRY, 9GS3, 9GS5, 9GS7, 9GSL, 9I20

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (6): 120; 254; 257; 269; 273; 277

Post-translational modifications (2): 15, 29

Mutagenesis-validated functional residues (11):

Position	Phenotype
25	decreases adp uptake.
94	decreases adp uptake.
117	loss of atp:adp antiporter activity. decreases adp uptake.
120	loss of atp:adp antiporter activity. decreases adp uptake.
190	decreases adp uptake.
254	decreases adp uptake.
257	decreases adp uptake.
261	decreases adp uptake.
273	decreases adp uptake.
276	loss of atp:adp antiporter activity. decreases adp uptake.
277	loss of atp:adp antiporter activity. decreases adp uptake.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 210 (showing top): ELVIDGE_HYPOXIA_DN, PAX4_01, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_UP, KYNG_DNA_DAMAGE_DN, DARWICHE_PAPILLOMA_RISK_HIGH_DN, DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN, GOBP_NUCLEOTIDE_TRANSPORT, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, WEI_MYCN_TARGETS_WITH_E_BOX, AP1_Q4_01, MARTINEZ_RB1_TARGETS_DN, GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

GO Biological Process (5): UDP-galactose transmembrane transport (GO:0072334), UDP-glucose transmembrane transport (GO:0015786), ADP transport (GO:0015866), ATP transport (GO:0015867), transmembrane transport (GO:0055085)

GO Molecular Function (5): UDP-galactose transmembrane transporter activity (GO:0005459), UDP-glucose transmembrane transporter activity (GO:0005460), ATP:ADP antiporter activity (GO:0005471), protein binding (GO:0005515), antiporter activity (GO:0015297)

GO Cellular Component (6): Golgi membrane (GO:0000139), nucleoplasm (GO:0005654), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), intracellular membrane-bounded organelle (GO:0043231), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
pyrimidine nucleotide-sugar transmembrane transport	2
purine ribonucleotide transport	2
adenine nucleotide transport	2
pyrimidine nucleotide-sugar transmembrane transporter activity	2
cellular anatomical structure	2
transport	1
cellular process	1
UDP-galactose transmembrane transport	1
UDP-glucose transmembrane transport	1
ATP transmembrane transporter activity	1
ADP transmembrane transporter activity	1
antiporter activity	1
binding	1
secondary active transmembrane transporter activity	1
Golgi apparatus	1
bounding membrane of organelle	1
nuclear lumen	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
intracellular anatomical structure	1
membrane-bounded organelle	1
intracellular organelle	1

Protein interactions and networks

STRING

1286 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC35B1	SLC35D1	Q9NTN3	950
SLC35B1	SLC35D3	Q5M8T2	798
SLC35B1	SLC35A2	P78381	793
SLC35B1	SLC35D2	Q76EJ3	770
SLC35B1	SLC35A5	Q9BS91	583
SLC35B1	SLC35A4	Q96G79	573
SLC35B1	SLC35E1	Q96K37	550
SLC35B1	SLC35H1	Q9NQQ7	547
SLC35B1	SLC35C1	Q96A29	540
SLC35B1	SLC35F1	Q5T1Q4	531
SLC35B1	SLC35A1	P78382	526
SLC35B1	EMC7	Q9NPA0	487
SLC35B1	TMEM208	Q9BTX3	477
SLC35B1	IER3IP1	Q9Y5U9	465
SLC35B1	YIPF6	Q96EC8	448

IntAct

56 interactions, top by confidence:

A	B	Type	Score
SLC35B1	FXYD3	psi-mi:“MI:0915”(physical association)	0.560
BNIP3	SLC35B1	psi-mi:“MI:0915”(physical association)	0.560
PTPN5	SLC35B1	psi-mi:“MI:0915”(physical association)	0.560
CD74	SLC35B1	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	CREB3L1	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	FZD5	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	ARL13B	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	VSIR	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	VAPA	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	FKBP8	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	AQP6	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	BNIP3	psi-mi:“MI:0915”(physical association)	0.560
CD79A	SLC35B1	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	CCDC107	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	MFF	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	GPR152	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	PDZK1IP1	psi-mi:“MI:0915”(physical association)	0.560
SLC35B1	PGRMC1	psi-mi:“MI:0914”(association)	0.530
E2	SLC35B1	psi-mi:“MI:0915”(physical association)	0.370
SLC35B1	DRD2	psi-mi:“MI:0915”(physical association)	0.370
SLC35B1	FZD7	psi-mi:“MI:0915”(physical association)	0.370
SLC35B1	HRH1	psi-mi:“MI:0915”(physical association)	0.370
PCNA	SLC35B1	psi-mi:“MI:0915”(physical association)	0.370
SLC35B1	NDUFS8	psi-mi:“MI:0914”(association)	0.350
SLC35B1	MFF	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (107): SLC35B1 (Affinity Capture-MS), SLC35B1 (Affinity Capture-MS), SLC35B1 (Two-hybrid), SLC35B1 (Two-hybrid), SLC35B1 (Two-hybrid), SLC35B1 (Two-hybrid), SLC35B1 (Two-hybrid), SLC35B1 (Two-hybrid), SLC35B1 (Two-hybrid), SLC35B1 (Two-hybrid), CREB3L1 (Two-hybrid), CCDC107 (Two-hybrid), PDZK1IP1 (Two-hybrid), FZD5 (Two-hybrid), MFF (Two-hybrid)

ESM2 similar proteins: A0JMG9, A4IFK2, A4IHW3, A6QM03, A7S1L6, A7TES5, A9UUB8, C8Z742, O08520, O74750, P78383, P87041, P97858, Q02334, Q12520, Q17CE7, Q18779, Q1JQ66, Q20787, Q29Q28, Q3E6T0, Q550W6, Q61420, Q61LC0, Q66HX0, Q6CR04, Q6FRE5, Q6GQ70, Q6PGC7, Q6V7K3, Q753T9, Q7Z769, Q84L08, Q8AWB6, Q8BLX4, Q8MII5, Q8WZJ9, Q94EI9, Q968A5, Q96A29

Diamond homologs: O64503, P78383, P97858, Q4P9R2, Q54I86, Q55DM5, Q5R9A1, Q66HX0, Q6BMV3, Q6C4X5, Q6GQ70, Q6NM25, Q6NMB6, Q6V7K3, Q8AWB6, Q8AXS6, Q8MII5, Q8MXJ9, Q8TB61, Q8WZJ9, Q91ZN5, Q9M9S6, Q9VDD7, Q9VEI3, P0CP32, P0CP33, Q4WJM7, Q5ADN8, Q5B5W2, Q6CR04, Q755H7, Q5R831, Q922Q5, Q9H1N7, Q12520, Q6FSF8, Q17CE7, Q20787, Q29EY2, Q29Q28

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1645 predictions. Top by Δscore:

Variant	Effect	Δscore
17:49703010:CT:C	acceptor_gain	1.0000
17:49703181:CACT:C	donor_loss	1.0000
17:49703182:ACTC:A	donor_loss	1.0000
17:49703183:CTCA:C	donor_loss	1.0000
17:49703184:TCACC:T	donor_loss	1.0000
17:49703185:CA:C	donor_loss	1.0000
17:49703186:ACCT:A	donor_loss	1.0000
17:49703187:CC:C	donor_loss	1.0000
17:49703292:TTC:T	acceptor_gain	1.0000
17:49703305:A:C	acceptor_gain	1.0000
17:49704098:AC:A	donor_gain	1.0000
17:49704099:CC:C	donor_gain	1.0000
17:49705118:TCATA:T	donor_loss	1.0000
17:49705119:CATA:C	donor_loss	1.0000
17:49705121:TA:T	donor_loss	1.0000
17:49705122:A:AC	donor_gain	1.0000
17:49705122:ACCA:A	donor_loss	1.0000
17:49705123:C:A	donor_loss	1.0000
17:49705123:C:CC	donor_gain	1.0000
17:49705132:G:C	donor_gain	1.0000
17:49705174:T:A	donor_gain	1.0000
17:49705277:CATGA:C	acceptor_gain	1.0000
17:49705278:ATGA:A	acceptor_gain	1.0000
17:49705279:TGA:T	acceptor_gain	1.0000
17:49705279:TGAC:T	acceptor_loss	1.0000
17:49705280:GA:G	acceptor_gain	1.0000
17:49705281:AC:A	acceptor_loss	1.0000
17:49705282:C:CC	acceptor_gain	1.0000
17:49705282:CTACA:C	acceptor_loss	1.0000
17:49705283:T:C	acceptor_loss	1.0000

AlphaMissense

2081 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:49704207:T:A	D183V	1.000
17:49704207:T:G	D183A	1.000
17:49704208:C:G	D183H	1.000
17:49704216:A:G	L180P	1.000
17:49705190:G:C	F154L	1.000
17:49705190:G:T	F154L	1.000
17:49705192:A:G	F154L	1.000
17:49705203:C:T	G150E	1.000
17:49705204:C:G	G150R	1.000
17:49705204:C:T	G150R	1.000
17:49705876:C:A	K120N	1.000
17:49705876:C:G	K120N	1.000
17:49705892:A:T	L115H	1.000
17:49701507:A:T	L307H	0.999
17:49701510:C:T	G306D	0.999
17:49702858:C:G	G306R	0.999
17:49702862:G:C	F304L	0.999
17:49702862:G:T	F304L	0.999
17:49702864:A:G	F304L	0.999
17:49702866:A:T	V303E	0.999
17:49702878:C:T	G299D	0.999
17:49702879:C:G	G299R	0.999
17:49702935:G:T	T280K	0.999
17:49702947:C:G	R276P	0.999
17:49702953:G:T	T274K	0.999
17:49702967:G:C	C269W	0.999
17:49702969:A:G	C269R	0.999
17:49702980:C:A	G265V	0.999
17:49703000:A:C	F258L	0.999
17:49703000:A:T	F258L	0.999

dbSNP variants (sampled 300 via entrez): RS1000276040 (17:49705559 A>C), RS1000571047 (17:49701866 G>A), RS1000918106 (17:49702116 C>T), RS1001098651 (17:49705933 G>A), RS1001950978 (17:49707665 A>G,T), RS1002205455 (17:49705477 G>A), RS1002412725 (17:49701281 C>G,T), RS1002536045 (17:49703918 T>C), RS1003312952 (17:49706056 A>G), RS1005099750 (17:49702433 TAA>T), RS1005192593 (17:49707598 A>C), RS1005243211 (17:49707206 G>A,C), RS1005699439 (17:49700950 GTT>G,GT,GTTT), RS1006023918 (17:49704722 T>A,C), RS1006166150 (17:49700542 G>A,C)

Disease associations

OMIM: gene MIM:610790 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC35 family of nucleotide sugar transporters

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	affects cotreatment, increases expression	5
Air Pollutants	increases abundance, increases expression, decreases expression	2
Smoke	decreases expression, increases abundance	2
Tunicamycin	increases expression	2
Valproic Acid	decreases methylation, increases expression	2
Thapsigargin	increases expression	2
FR900359	affects phosphorylation	1
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
beta-lapachone	decreases expression	1
sodium arsenite	decreases expression	1
nefazodone	affects cotreatment, increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Carbamazepine	affects expression	1
Chenodeoxycholic Acid	affects cotreatment, increases expression	1
Deoxycholic Acid	affects cotreatment, increases expression	1
Diuron	decreases expression	1
Doxorubicin	decreases expression	1
Glycochenodeoxycholic Acid	affects cotreatment, increases expression	1
Glycocholic Acid	affects cotreatment, increases expression	1
Glycodeoxycholic Acid	affects cotreatment, increases expression	1
Rotenone	increases expression	1
Zinc	increases expression	1
Isotretinoin	decreases expression	1
Sodium Selenite	increases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.