SLC35E3

Summary

SLC35E3 (solute carrier family 35 member E3, HGNC:20864) is a protein-coding gene on chromosome 12q15, encoding Solute carrier family 35 member E3 (Q7Z769). Putative transporter.

Predicted to enable antiporter activity and nucleotide-sugar transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus.

Source: NCBI Gene 55508 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 38 total
• MANE Select transcript: NM_018656

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20864
Approved symbol	SLC35E3
Name	solute carrier family 35 member E3
Location	12q15
Locus type	gene with protein product
Status	Approved
Aliases	BLOV1
Ensembl gene	ENSG00000175782
Ensembl biotype	protein_coding
OMIM	620355
Entrez	55508

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 4 protein_coding_CDS_not_defined, 4 protein_coding, 2 nonsense_mediated_decay

ENST00000319429, ENST00000398004, ENST00000399333, ENST00000431174, ENST00000538043, ENST00000673712, ENST00000674096, ENST00000864466, ENST00000864467, ENST00000940884

RefSeq mRNA: 3 — MANE Select: NM_018656 NM_001354997, NM_001354998, NM_018656

CCDS: CCDS41808

Canonical transcript exons

ENST00000398004 — 5 exons

Exon	Start	End
ENSE00001240096	68747930	68748040
ENSE00001421649	68764704	68781468
ENSE00001531149	68746176	68746779
ENSE00003577278	68759157	68759239
ENSE00003649424	68752032	68752190

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 88.96.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.1578 / max 322.8180, expressed in 1802 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126613	9.7239	1788
126614	1.6564	960
126615	1.4468	743
126612	1.3307	824

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	88.96	gold quality
tibia	UBERON:0000979	88.20	gold quality
subthalamic nucleus	UBERON:0001906	87.48	silver quality
nephron tubule	UBERON:0001231	87.25	gold quality
inferior vagus X ganglion	UBERON:0005363	86.38	silver quality
visceral pleura	UBERON:0002401	85.63	gold quality
cerebellar vermis	UBERON:0004720	85.61	gold quality
esophagus squamous epithelium	UBERON:0006920	85.00	gold quality
lower lobe of lung	UBERON:0008949	84.51	gold quality
epithelium of esophagus	UBERON:0001976	84.42	gold quality
parietal pleura	UBERON:0002400	84.31	gold quality
renal glomerulus	UBERON:0000074	84.02	silver quality
pleura	UBERON:0000977	83.96	gold quality
metanephric glomerulus	UBERON:0004736	83.85	silver quality
dorsal plus ventral thalamus	UBERON:0001897	83.27	silver quality
bronchial epithelial cell	CL:0002328	83.10	gold quality
germinal epithelium of ovary	UBERON:0001304	82.93	gold quality
spinal cord	UBERON:0002240	82.76	gold quality
ventral tegmental area	UBERON:0002691	82.58	silver quality
superior vestibular nucleus	UBERON:0007227	82.38	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	82.37	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.99	gold quality
postcentral gyrus	UBERON:0002581	81.78	silver quality
superior surface of tongue	UBERON:0007371	81.72	silver quality
kidney epithelium	UBERON:0004819	81.64	silver quality
palpebral conjunctiva	UBERON:0001812	81.62	gold quality
epithelium of nasopharynx	UBERON:0001951	81.46	silver quality
parietal lobe	UBERON:0001872	81.27	silver quality
epithelium of mammary gland	UBERON:0003244	81.18	silver quality
mammary duct	UBERON:0001765	81.15	silver quality

Single-cell (SCXA)

Detected in 12 experiment(s), a significant marker in 11.

Experiment	Marker?	Max mean expression
E-GEOD-150728	yes	4012.20
E-HCAD-31	yes	2210.20
E-MTAB-7407	yes	1126.63
E-GEOD-106540	yes	693.45
E-GEOD-111727	yes	632.34
E-MTAB-5061	yes	503.87
E-MTAB-8142	yes	87.46
E-CURD-88	yes	45.76
E-CURD-46	yes	35.03
E-MTAB-6701	yes	8.80
E-ANND-3	yes	7.43
E-HCAD-6	no	1581.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

52 targeting SLC35E3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-8076	99.78	68.52	1170
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-1303	99.65	69.77	1662
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-4643	99.49	67.63	1791
HSA-MIR-3123	99.47	67.15	2693
HSA-MIR-8064	99.45	66.92	875
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-504-3P	99.30	67.18	1745

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc35e3	ENSDARG00000045493
mus_musculus	Slc35e3	ENSMUSG00000060181
rattus_norvegicus	Slc35e3	ENSRNOG00000027622

Paralogs (9): SLC35C2 (ENSG00000080189), SLC35E4 (ENSG00000100036), SLC35D1 (ENSG00000116704), SLC35E1 (ENSG00000127526), SLC35D2 (ENSG00000130958), TMEM241 (ENSG00000134490), SLC35C1 (ENSG00000181830), SLC35D3 (ENSG00000182747), SLC35E2B (ENSG00000189339)

Protein

Protein identifiers

Solute carrier family 35 member E3 — Q7Z769 (reviewed: Q7Z769)

Alternative names: Bladder cancer-overexpressed gene 1 protein

All UniProt accessions (3): Q7Z769, A0A669KB01, A0A669KB59

UniProt curated annotations — full annotation on UniProt →

Function. Putative transporter.

Subcellular location. Membrane.

Similarity. Belongs to the TPT transporter family. SLC35E subfamily.

RefSeq proteins (3): NP_001341926, NP_001341927, NP_061126* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004853	Sugar_P_trans_dom	Domain
IPR037185	EmrE-like	Homologous_superfamily
IPR050186	TPT_transporter	Family

Pfam: PF03151

UniProt features (13 total): transmembrane region 9, sequence conflict 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z769-F1	87.34	0.56

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 106 (showing top): WANG_CLIM2_TARGETS_UP, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, ONKEN_UVEAL_MELANOMA_UP, INGRAM_SHH_TARGETS_UP, GOMF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, NIKOLSKY_BREAST_CANCER_12Q13_Q21_AMPLICON, DOUGLAS_BMI1_TARGETS_DN, ACEVEDO_LIVER_CANCER_UP, GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, ZHANG_GATA6_TARGETS_DN, GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN, GOMF_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

GO Biological Process (4): transmembrane transport (GO:0055085), organophosphate ester transport (GO:0015748), nucleobase-containing compound transport (GO:0015931), carbohydrate derivative transport (GO:1901264)

GO Molecular Function (3): nucleotide-sugar transmembrane transporter activity (GO:0005338), antiporter activity (GO:0015297), protein binding (GO:0005515)

GO Cellular Component (2): Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	3
cellular process	1
nitrogen compound transport	1
organophosphate ester transmembrane transporter activity	1
nucleobase-containing compound transmembrane transporter activity	1
carbohydrate derivative transmembrane transporter activity	1
secondary active transmembrane transporter activity	1
binding	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

722 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC35E3	SLC35H1	Q9NQQ7	575
SLC35E3	NUP107	P57740	558
SLC35E3	SLC35C1	Q96A29	528
SLC35E3	SLC35G1	Q2M3R5	523
SLC35E3	CDK10	Q15131	512
SLC35E3	RNF217	Q8TC41	486
SLC35E3	SLC35D1	Q9NTN3	482
SLC35E3	SLC35F3	Q8IY50	476
SLC35E3	KRT7	P08729	467
SLC35E3	SHISA4	Q96DD7	416
SLC35E3	DCXR	Q7Z4W1	415
SLC35E3	YEATS4	O95619	407
SLC35E3	SLC35G2	Q8TBE7	406
SLC35E3	SLC35E2A	P0CK97	405
SLC35E3	SLC35B2	Q8TB61	395

IntAct

75 interactions, top by confidence:

A	B	Type	Score
SLC35E3	RNF5	psi-mi:“MI:0915”(physical association)	0.560
FXYD6	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
CSGALNACT2	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
GPR25	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	SSMEM1	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	SPG21	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	SELENOK	psi-mi:“MI:0915”(physical association)	0.560
BIK	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	TMEM14B	psi-mi:“MI:0915”(physical association)	0.560
FAM209A	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	ARLN	psi-mi:“MI:0915”(physical association)	0.560
BNIP2	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
TTPA	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
GET1	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	TMEM60	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	FXYD6	psi-mi:“MI:0915”(physical association)	0.560
PLP1	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	BCL2L2	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	CSGALNACT2	psi-mi:“MI:0915”(physical association)	0.560
ADIPOQ	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
FFAR2	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	SLC66A2	psi-mi:“MI:0915”(physical association)	0.560
ATP6V0C	SLC35E3	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	LNPEP	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (78): SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid), SLC35E3 (Two-hybrid)

ESM2 similar proteins: A0JMG9, A4IFK2, A4IHW3, A6QM03, A7S1L6, A7TES5, O74750, Q02334, Q05B73, Q17CE7, Q1JQ66, Q29EY2, Q29Q28, Q3E6T0, Q5M8T2, Q5RA79, Q61420, Q6CR04, Q6FSF8, Q6GQ70, Q6PGC7, Q753T9, Q755H7, Q7Q5D4, Q7Z769, Q84L08, Q8AWB6, Q8AXS6, Q8BGF8, Q8BLX4, Q8VCX2, Q8WZJ9, Q90X48, Q91ZR7, Q93890, Q94EI9, Q968A5, Q96A29, Q96G79, Q9C8M1

Diamond homologs: A4IFK2, F4IHS9, Q1JQ66, Q6PGC7, Q7Z769, Q8GUJ1, Q8RWW7, Q8RXL8, Q9FDZ5, Q9SZ96, Q9FIH5, Q9LPU2, Q9LU76, Q9SRE4, Q9FG70

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	30
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1247 predictions. Top by Δscore:

Variant	Effect	Δscore
12:68746775:CGCTG:C	donor_gain	1.0000
12:68746776:GCTG:G	donor_gain	1.0000
12:68746776:GCTGG:G	donor_gain	1.0000
12:68746777:CTG:C	donor_gain	1.0000
12:68746778:TG:T	donor_gain	1.0000
12:68746778:TGGTG:T	donor_loss	1.0000
12:68746779:GG:G	donor_gain	1.0000
12:68746779:GGT:G	donor_loss	1.0000
12:68746780:G:GG	donor_gain	1.0000
12:68746780:GTGA:G	donor_loss	1.0000
12:68746781:T:G	donor_loss	1.0000
12:68752030:A:AG	acceptor_gain	1.0000
12:68752030:AGTG:A	acceptor_gain	1.0000
12:68752031:G:GA	acceptor_gain	1.0000
12:68752031:GT:G	acceptor_gain	1.0000
12:68752031:GTGG:G	acceptor_gain	1.0000
12:68752189:TGGTA:T	donor_loss	1.0000
12:68752190:GGTAA:G	donor_loss	1.0000
12:68752192:T:A	donor_loss	1.0000
12:68746782:GAGTA:G	donor_loss	0.9900
12:68748014:GTTTT:G	donor_gain	0.9900
12:68748038:GTG:G	donor_gain	0.9900
12:68752006:GACAT:G	acceptor_gain	0.9900
12:68752026:TTTCA:T	acceptor_loss	0.9900
12:68752027:TTCA:T	acceptor_loss	0.9900
12:68752028:TCA:T	acceptor_loss	0.9900
12:68752030:AGT:A	acceptor_gain	0.9900
12:68752031:GTG:G	acceptor_gain	0.9900
12:68752191:G:GG	donor_gain	0.9900
12:68752193:AA:A	donor_loss	0.9900

AlphaMissense

2020 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:68746698:G:C	K107N	0.999
12:68746698:G:T	K107N	0.999
12:68746627:T:C	F84L	0.998
12:68746629:C:A	F84L	0.998
12:68746629:C:G	F84L	0.998
12:68746636:T:C	F87L	0.998
12:68746638:T:A	F87L	0.998
12:68746638:T:G	F87L	0.998
12:68746653:C:A	N92K	0.998
12:68746653:C:G	N92K	0.998
12:68746655:T:C	L93P	0.998
12:68746661:T:C	L95P	0.998
12:68746671:C:A	N98K	0.998
12:68746671:C:G	N98K	0.998
12:68747945:G:C	G140R	0.998
12:68747946:G:A	G140D	0.998
12:68752078:T:C	L187P	0.998
12:68752081:T:C	L188P	0.998
12:68759198:C:A	N238K	0.998
12:68759198:C:G	N238K	0.998
12:68764795:G:C	G283R	0.998
12:68746475:A:T	K33I	0.997
12:68746476:A:C	K33N	0.997
12:68746476:A:T	K33N	0.997
12:68746499:T:C	F41S	0.997
12:68746510:A:C	S45R	0.997
12:68746512:C:A	S45R	0.997
12:68746512:C:G	S45R	0.997
12:68746514:T:C	L46P	0.997
12:68746576:T:C	F67L	0.997

dbSNP variants (sampled 300 via entrez): RS1000112167 (12:68778504 T>C), RS1000115315 (12:68770447 G>A), RS1000116096 (12:68748035 C>G), RS1000135395 (12:68757536 T>C), RS1000163438 (12:68757953 G>A,C), RS1000210025 (12:68753384 T>A), RS1000532240 (12:68760105 C>T), RS1000544501 (12:68778734 G>A,T), RS1000602571 (12:68765738 T>C), RS1000608193 (12:68746136 C>G,T), RS1000797781 (12:68779217 CA>C), RS1000823801 (12:68772820 C>A,G,T), RS1000828897 (12:68778972 G>T), RS1001159878 (12:68766757 A>G), RS1001199037 (12:68757678 A>G)

Disease associations

OMIM: gene MIM:620355 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000589_1	White blood cell count	3.000000e-08
GCST90002396_530	Mean reticulocyte volume	5.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010701	mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC35 family of nucleotide sugar transporters

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression	2
Cisplatin	affects cotreatment, increases expression	2
Valproic Acid	affects expression, increases expression	2
triphenyl phosphate	affects expression	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Environmental Pollutants	affects expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Nickel	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Tetrachlorodibenzodioxin	affects expression	1
Tretinoin	decreases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	affects expression	1
Okadaic Acid	increases expression	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4MF	HCT116-SLC35E3-KO-c7	Cancer cell line	Male
CVCL_D4MG	HCT116-SLC35E3-KO-c9	Cancer cell line	Male
CVCL_TN23	HAP1 SLC35E3 (-) 1	Cancer cell line	Male
CVCL_XT24	HAP1 SLC35E3 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.