SLC35F5

Summary

SLC35F5 (solute carrier family 35 member F5, HGNC:23617) is a protein-coding gene on chromosome 2q14.1, encoding Solute carrier family 35 member F5 (Q8WV83). Putative solute transporter.

Predicted to be located in membrane.

Source: NCBI Gene 80255 — RefSeq curated summary.

At a glance

• Gene–disease (curated): multiple congenital anomalies/dysmorphic syndrome (Limited, GenCC)
• GWAS associations: 4
• Clinical variants (ClinVar): 77 total
• MANE Select transcript: NM_025181

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23617
Approved symbol	SLC35F5
Name	solute carrier family 35 member F5
Location	2q14.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ22004
Ensembl gene	ENSG00000115084
Ensembl biotype	protein_coding
OMIM	619997
Entrez	80255

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 18 protein_coding, 6 retained_intron, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000245680, ENST00000409106, ENST00000409342, ENST00000420066, ENST00000447673, ENST00000459683, ENST00000460863, ENST00000469314, ENST00000469702, ENST00000470204, ENST00000485214, ENST00000498768, ENST00000889529, ENST00000889530, ENST00000889531, ENST00000889532, ENST00000889533, ENST00000889534, ENST00000913632, ENST00000950464, ENST00000950465, ENST00000950466, ENST00000950467, ENST00000950468, ENST00000950469, ENST00000950470, ENST00000950471

RefSeq mRNA: 5 — MANE Select: NM_025181 NM_001330314, NM_001330315, NM_001330316, NM_001330317, NM_025181

CCDS: CCDS2119, CCDS82503, CCDS86878

Canonical transcript exons

ENST00000245680 — 16 exons

Exon	Start	End
ENSE00001162097	113756370	113756642
ENSE00001726841	113729401	113729505
ENSE00001744025	113731584	113731648
ENSE00001779762	113734586	113734673
ENSE00001786368	113735777	113735858
ENSE00001885632	113706709	113715195
ENSE00002158334	113742692	113742879
ENSE00003458423	113725378	113725537
ENSE00003465846	113755165	113755306
ENSE00003501472	113743713	113743794
ENSE00003535696	113750425	113750568
ENSE00003561362	113719154	113719308
ENSE00003602483	113723104	113723194
ENSE00003624358	113717753	113717850
ENSE00003657378	113746277	113746339
ENSE00003665441	113755454	113755544

Expression profiles

Bgee: expression breadth ubiquitous, 271 present calls, max score 98.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.8095 / max 540.9090, expressed in 1823 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
30334	18.3524	1806
30335	14.9680	1792
30333	3.3395	1522
30332	0.9758	435
30331	0.1739	56

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	98.99	gold quality
parietal pleura	UBERON:0002400	97.00	gold quality
jejunal mucosa	UBERON:0000399	96.96	gold quality
tibia	UBERON:0000979	96.93	gold quality
left adrenal gland	UBERON:0001234	96.90	gold quality
right adrenal gland	UBERON:0001233	96.88	gold quality
germinal epithelium of ovary	UBERON:0001304	96.86	gold quality
right adrenal gland cortex	UBERON:0035827	96.76	gold quality
mucosa of paranasal sinus	UBERON:0005030	96.61	gold quality
left adrenal gland cortex	UBERON:0035825	96.61	gold quality
adrenal cortex	UBERON:0001235	96.47	gold quality
adrenal gland	UBERON:0002369	96.46	gold quality
calcaneal tendon	UBERON:0003701	96.24	gold quality
mucosa of sigmoid colon	UBERON:0004993	96.11	gold quality
body of pancreas	UBERON:0001150	95.97	gold quality
colonic mucosa	UBERON:0000317	95.95	gold quality
visceral pleura	UBERON:0002401	95.78	gold quality
stromal cell of endometrium	CL:0002255	95.72	gold quality
bronchial epithelial cell	CL:0002328	95.55	gold quality
rectum	UBERON:0001052	95.43	gold quality
esophagus squamous epithelium	UBERON:0006920	95.35	gold quality
lower esophagus mucosa	UBERON:0035834	95.23	gold quality
upper leg skin	UBERON:0004262	95.17	gold quality
pigmented layer of retina	UBERON:0001782	94.99	gold quality
retina	UBERON:0000966	94.96	gold quality
gall bladder	UBERON:0002110	94.81	gold quality
oral cavity	UBERON:0000167	94.59	gold quality
palpebral conjunctiva	UBERON:0001812	94.59	gold quality
pleura	UBERON:0000977	94.48	gold quality
heart right ventricle	UBERON:0002080	94.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

135 targeting SLC35F5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-124-3P	99.89	73.74	3043

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc35f5	ENSMUSG00000026342
rattus_norvegicus	Slc35f5	ENSRNOG00000003403
drosophila_melanogaster	CG8195	FBGN0034032
caenorhabditis_elegans	B0041.5	WBGENE00015009

Protein

Protein identifiers

Solute carrier family 35 member F5 — Q8WV83 (reviewed: Q8WV83)

Alternative names: Hepatitis C virus NS5A-transactivated protein 3

All UniProt accessions (5): B8ZZV6, B8ZZY4, H7C0S5, H7C2I7, Q8WV83

UniProt curated annotations — full annotation on UniProt →

Function. Putative solute transporter.

Subcellular location. Membrane.

Tissue specificity. Expressed in colorectal cancer cells.

Similarity. Belongs to the SLC35F solute transporter family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8WV83-1	1	yes
Q8WV83-2	2

RefSeq proteins (5): NP_001317243, NP_001317244, NP_001317245, NP_001317246, NP_079457* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR037185	EmrE-like	Homologous_superfamily

UniProt features (18 total): transmembrane region 10, splice variant 4, chain 1, domain 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WV83-F1	72.79	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 207

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 134 (showing top): TTTGTAG_MIR520D, SP1_Q2_01, KIM_GERMINAL_CENTER_T_HELPER_UP, ATF4_Q2, TGCCTTA_MIR124A, chr2q14, ATF_01, CREB_01, LIU_SOX4_TARGETS_DN, NUYTTEN_NIPP1_TARGETS_DN, MATSUDA_NATURAL_KILLER_DIFFERENTIATION, CHEN_LIVER_METABOLISM_QTL_CIS, ELF2_TARGET_GENES, KAT2A_TARGET_GENES, LMTK3_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

828 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC35F5	SLC35G2	Q8TBE7	535
SLC35F5	SLC10A7	Q0GE19	479
SLC35F5	SLC22A15	Q8IZD6	472
SLC35F5	DCDC2B	A2VCK2	408
SLC35F5	SLC35B4	Q969S0	407
SLC35F5	SLC7A2	P52569	404
SLC35F5	SLC19A2	O60779	404
SLC35F5	SLC35H1	Q9NQQ7	404
SLC35F5	SMAP1	Q8IYB5	400
SLC35F5	SLC35D3	Q5M8T2	388
SLC35F5	SLC39A13	Q96H72	383
SLC35F5	SLC35D2	Q76EJ3	376
SLC35F5	SLC35G1	Q2M3R5	372
SLC35F5	SLC35E1	Q96K37	372
SLC35F5	SLC43A3	Q8NBI5	370

IntAct

28 interactions, top by confidence:

A	B	Type	Score
NIPAL1	ESYT2	psi-mi:“MI:0914”(association)	0.640
CXCR4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
YIPF3	TMEM120B	psi-mi:“MI:0914”(association)	0.530
C3AR1	TMEM120B	psi-mi:“MI:0914”(association)	0.530
MANSC1	KLRG2	psi-mi:“MI:0914”(association)	0.530
SPINT2	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.530
	ESYT2	psi-mi:“MI:0914”(association)	0.350
NS3	C15orf61	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
KCNA2	TMEM129	psi-mi:“MI:0914”(association)	0.350
TTMP	TMEM223	psi-mi:“MI:0914”(association)	0.350
TTYH1	TMEM223	psi-mi:“MI:0914”(association)	0.350
AVPR2	GXYLT2	psi-mi:“MI:0914”(association)	0.350
CTLA4	TMEM120B	psi-mi:“MI:0914”(association)	0.350
TMEM74	KLRG2	psi-mi:“MI:0914”(association)	0.350
AVPR1B	KLRG2	psi-mi:“MI:0914”(association)	0.350
C5AR1	TCAF2	psi-mi:“MI:0914”(association)	0.350
CX3CL1	FAM171A2	psi-mi:“MI:0914”(association)	0.350
KCNE3	PIK3R2	psi-mi:“MI:0914”(association)	0.350
IL17RB	ATP1A3	psi-mi:“MI:0914”(association)	0.350
CXCR4	ESYT2	psi-mi:“MI:0914”(association)	0.350
DLK1	PLPP3	psi-mi:“MI:0914”(association)	0.350
SLC35F5	STX10	psi-mi:“MI:0914”(association)	0.350
PLCL2	SLC35F5	psi-mi:“MI:0915”(physical association)	0.000
SLC35F5	SHOC2	psi-mi:“MI:0915”(physical association)	0.000
SLC35F5	ITGB1BP1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (78): SLC35F5 (Affinity Capture-MS), SLC35F5 (Affinity Capture-MS), SLC35F5 (Affinity Capture-MS), SLC35F5 (Affinity Capture-MS), SLC35F5 (Affinity Capture-MS), SLC35F5 (Affinity Capture-MS), SLC35F5 (Affinity Capture-MS), SLC35F5 (Affinity Capture-MS), SHOC2 (Affinity Capture-MS), SLC35F5 (Affinity Capture-MS), SLC35F5 (Affinity Capture-RNA), SLC35F5 (Affinity Capture-MS), SLC35F5 (Proximity Label-MS), SLC35F5 (Proximity Label-MS), SLC35F5 (Proximity Label-MS)

ESM2 similar proteins: A1L272, A6QL92, B8AF63, E2RFJ3, E7EXX2, O35458, O35633, O54902, O80605, P49281, P49282, P51027, P57057, P58355, Q0VA82, Q28CV2, Q569T7, Q5F383, Q5R6J3, Q5RD30, Q5U3U7, Q62052, Q640L2, Q6DEJ6, Q6DIV6, Q6GPQ3, Q6GQE1, Q6P499, Q6PF45, Q6YK44, Q7RTT9, Q8BGN5, Q8BH31, Q8CBH5, Q8MIQ9, Q8NA29, Q8NBI5, Q8NHS3, Q8R070, Q8R139

Diamond homologs: A6QL92, O94654, Q04083, Q4R794, Q5R6J3, Q8R314, Q8WV83, Q03730

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	61
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3122 predictions. Top by Δscore:

Variant	Effect	Δscore
2:113729395:TCTTA:T	donor_loss	1.0000
2:113729396:CT:C	donor_loss	1.0000
2:113729397:TTA:T	donor_loss	1.0000
2:113729398:T:TG	donor_loss	1.0000
2:113729399:ACC:A	donor_loss	1.0000
2:113729502:GAACC:G	acceptor_loss	1.0000
2:113729503:AACC:A	acceptor_loss	1.0000
2:113729506:C:CC	acceptor_gain	1.0000
2:113729506:C:T	acceptor_loss	1.0000
2:113729507:T:A	acceptor_loss	1.0000
2:113731579:CTTA:C	donor_loss	1.0000
2:113731581:TA:T	donor_loss	1.0000
2:113731582:A:C	donor_loss	1.0000
2:113731583:C:G	donor_loss	1.0000
2:113731583:CCTA:C	donor_gain	1.0000
2:113731644:CAATG:C	acceptor_gain	1.0000
2:113731647:TG:T	acceptor_gain	1.0000
2:113731649:C:CC	acceptor_gain	1.0000
2:113735856:CCA:C	acceptor_gain	1.0000
2:113735857:CAC:C	acceptor_gain	1.0000
2:113735859:C:CC	acceptor_gain	1.0000
2:113742723:A:AC	donor_gain	1.0000
2:113742724:C:CC	donor_gain	1.0000
2:113742881:T:C	acceptor_gain	1.0000
2:113743708:CTTA:C	donor_loss	1.0000
2:113743709:TTACT:T	donor_loss	1.0000
2:113743710:TACTT:T	donor_loss	1.0000
2:113743711:A:AC	donor_gain	1.0000
2:113743711:A:T	donor_loss	1.0000
2:113743712:C:CC	donor_gain	1.0000

AlphaMissense

3437 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:113723193:C:G	G418R	1.000
2:113725385:A:G	W415R	1.000
2:113725385:A:T	W415R	1.000
2:113725529:C:G	G367R	1.000
2:113725537:C:T	G364D	1.000
2:113729401:C:G	G364R	1.000
2:113742710:G:C	S244R	1.000
2:113742710:G:T	S244R	1.000
2:113742712:T:G	S244R	1.000
2:113723149:G:C	S432R	0.999
2:113723149:G:T	S432R	0.999
2:113723151:T:G	S432R	0.999
2:113723183:A:G	L421P	0.999
2:113723192:C:T	G418D	0.999
2:113725417:C:T	G404D	0.999
2:113725418:C:G	G404R	0.999
2:113725505:A:G	W375R	0.999
2:113725505:A:T	W375R	0.999
2:113725528:C:T	G367D	0.999
2:113725537:C:A	G364V	0.999
2:113735858:A:G	W251R	0.999
2:113735858:A:T	W251R	0.999
2:113742711:C:A	S244I	0.999
2:113742854:G:C	F196L	0.999
2:113742854:G:T	F196L	0.999
2:113742856:A:G	F196L	0.999
2:113755191:A:G	W83R	0.999
2:113755191:A:T	W83R	0.999
2:113755223:C:T	G72E	0.999
2:113755224:C:A	G72W	0.999

dbSNP variants (sampled 300 via entrez): RS1000150155 (2:113727165 CTT>C), RS1000194637 (2:113703321 C>G), RS1000225897 (2:113703612 C>T), RS1000282417 (2:113754003 T>C), RS1000290699 (2:113709062 C>A), RS1000342936 (2:113740233 T>A,C), RS1000368312 (2:113715852 T>C), RS1000432476 (2:113747317 G>A), RS1000445130 (2:113716318 C>T), RS1000509265 (2:113745513 G>A), RS1000563283 (2:113702318 C>T), RS1000597353 (2:113706926 A>T), RS1000641897 (2:113756127 T>A,C), RS1000704285 (2:113714152 T>C), RS1000770629 (2:113745823 G>A)

Disease associations

OMIM: gene MIM:619997 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
multiple congenital anomalies/dysmorphic syndrome	Limited	Autosomal recessive

Mondo (1): multiple congenital anomalies/dysmorphic syndrome (MONDO:0019042)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST90020025_1550	Waist-to-hip ratio adjusted for BMI	1.000000e-09
GCST90020027_90	Waist-hip index	5.000000e-10
GCST90020027_91	Waist-hip index	2.000000e-08
GCST90020029_509	Waist circumference adjusted for body mass index	8.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC35 family of nucleotide sugar transporters

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases methylation, increases expression	3
Cadmium	increases expression, increases response to substance, increases abundance	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
urushiol	increases expression	1
alpha-pinene	increases abundance, affects cotreatment, increases oxidation	1
o,p’-DDT	increases expression	1
sodium arsenite	increases abundance, increases expression	1
butyraldehyde	decreases expression	1
manganese chloride	increases abundance, increases expression	1
potassium chromate(VI)	decreases expression, affects cotreatment	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	increases abundance, increases oxidation, affects cotreatment	1
Arsenic	increases abundance, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Fluorouracil	affects response to substance	1
Formaldehyde	increases expression	1
Manganese	increases abundance, increases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	increases abundance, affects cotreatment, increases oxidation	1
Plant Extracts	increases expression, affects cotreatment	1
Quercetin	decreases expression	1
Smoke	decreases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4F4	1321N1-SLC35F5-KO-c10	Cancer cell line	Male
CVCL_D4F5	1321N1-SLC35F5-KO-c11	Cancer cell line	Male
CVCL_TN29	HAP1 SLC35F5 (-) 1	Cancer cell line	Male
CVCL_XT26	HAP1 SLC35F5 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.