SLC35F6

Summary

SLC35F6 (solute carrier family 35 member F6, HGNC:26055) is a protein-coding gene on chromosome 2p23.3, encoding Solute carrier family 35 member F6 (Q8N357). Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells.

Predicted to enable transmembrane transporter activity. Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including lysosomal membrane; mitochondrion; and nucleoplasm.

Source: NCBI Gene 54978 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 64 total
• MANE Select transcript: NM_017877

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26055
Approved symbol	SLC35F6
Name	solute carrier family 35 member F6
Location	2p23.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20555, ANT2BP, TANGO9
Ensembl gene	ENSG00000213699
Ensembl biotype	protein_coding
OMIM	619667
Entrez	54978

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000344420, ENST00000414029, ENST00000429494, ENST00000482746, ENST00000887823, ENST00000887824

RefSeq mRNA: 1 — MANE Select: NM_017877 NM_017877

CCDS: CCDS1728

Canonical transcript exons

ENST00000344420 — 6 exons

Exon	Start	End
ENSE00001364897	26778042	26781231
ENSE00001610342	26764284	26764426
ENSE00003632893	26775044	26775215
ENSE00003645124	26774251	26774323
ENSE00003653805	26775464	26775676
ENSE00003658115	26776372	26776482

Expression profiles

Bgee: expression breadth ubiquitous, 258 present calls, max score 97.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.7939 / max 488.0229, expressed in 1724 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19276	46.3871	1817
19278	8.4768	1714
19277	0.3171	139

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nipple	UBERON:0002030	97.15	gold quality
decidua	UBERON:0002450	93.88	gold quality
pharyngeal mucosa	UBERON:0000355	93.35	gold quality
pericardium	UBERON:0002407	93.24	gold quality
superior surface of tongue	UBERON:0007371	93.15	gold quality
saphenous vein	UBERON:0007318	93.10	gold quality
gingival epithelium	UBERON:0001949	92.70	gold quality
gingiva	UBERON:0001828	92.54	gold quality
body of tongue	UBERON:0011876	92.41	gold quality
vena cava	UBERON:0004087	91.71	silver quality
tongue	UBERON:0001723	91.57	gold quality
oral cavity	UBERON:0000167	91.43	gold quality
cardia of stomach	UBERON:0001162	91.27	gold quality
mammalian vulva	UBERON:0000997	90.95	gold quality
pylorus	UBERON:0001166	90.95	gold quality
stromal cell of endometrium	CL:0002255	90.47	gold quality
esophagus squamous epithelium	UBERON:0006920	90.31	gold quality
synovial joint	UBERON:0002217	89.88	gold quality
trachea	UBERON:0003126	89.88	gold quality
inferior vagus X ganglion	UBERON:0005363	89.65	gold quality
ventral tegmental area	UBERON:0002691	89.63	gold quality
superior vestibular nucleus	UBERON:0007227	89.61	gold quality
renal medulla	UBERON:0000362	89.11	gold quality
trigeminal ganglion	UBERON:0001675	89.03	gold quality
substantia nigra pars reticulata	UBERON:0001966	89.03	silver quality
dorsal root ganglion	UBERON:0000044	88.92	gold quality
substantia nigra pars compacta	UBERON:0001965	88.60	gold quality
tendon of biceps brachii	UBERON:0008188	88.60	gold quality
squamous epithelium	UBERON:0006914	88.49	gold quality
subthalamic nucleus	UBERON:0001906	88.45	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	16.58
E-MTAB-7051	no	2002.17

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F4

miRNA regulators (miRDB)

121 targeting SLC35F6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-383-3P	99.85	65.84	1359
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-609	99.82	64.26	505
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248

Literature-anchored findings (GeneRIF, showing 2)

• C2orf18, termed ANT2-binding protein (ANT2BP), might serve as a candidate molecular target for pancreatic cancer therapy. (PMID:19154410)
• Residence of the Nucleotide Sugar Transporter Family Members SLC35F1 and SLC35F6 in the Endosomal/Lysosomal Pathway. (PMID:38928424)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc35f6	ENSDARG00000016745
mus_musculus	Slc35f6	ENSMUSG00000029175
rattus_norvegicus	Slc35f6	ENSRNOG00000009459
drosophila_melanogaster	Tango9	FBGN0260744
caenorhabditis_elegans		WBGENE00016235

Protein

Protein identifiers

Solute carrier family 35 member F6 — Q8N357 (reviewed: Q8N357)

Alternative names: ANT2-binding protein, Transport and Golgi organization 9 homolog

All UniProt accessions (3): F8WB19, F8WCT7, Q8N357

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.

Subunit / interactions. Interacts with SLC25A5.

Subcellular location. Mitochondrion. Lysosome membrane.

Tissue specificity. Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.

Similarity. Belongs to the SLC35F solute transporter family.

RefSeq proteins (1): NP_060347* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009262	SLC35_F1/F2/F6	Family
IPR012404	UCP036436	Family
IPR037185	EmrE-like	Homologous_superfamily

Pfam: PF06027

UniProt features (20 total): transmembrane region 9, sequence conflict 5, signal peptide 1, chain 1, domain 1, region of interest 1, modified residue 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N357-F1	84.23	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 365

Glycosylation sites (1): 110

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 153 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_DN, GOCC_VACUOLAR_MEMBRANE, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_MITOCHONDRIAL_TRANSPORT, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_REGULATION_OF_MITOCHONDRION_ORGANIZATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOBP_APOPTOTIC_SIGNALING_PATHWAY, TGANTCA_AP1_C, GOBP_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY, GOBP_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY, GOBP_MEMBRANE_ORGANIZATION, GOBP_REGULATION_OF_TRANSPORT, ACEVEDO_LIVER_CANCER_UP

GO Biological Process (4): positive regulation of cell population proliferation (GO:0008284), negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901029), transmembrane transport (GO:0055085), pyrimidine nucleotide-sugar transmembrane transport (GO:0090481)

GO Molecular Function (3): transmembrane transporter activity (GO:0022857), protein binding (GO:0005515), pyrimidine nucleotide-sugar transmembrane transporter activity (GO:0015165)

GO Cellular Component (8): nucleoplasm (GO:0005654), mitochondrion (GO:0005739), lysosomal membrane (GO:0005765), cytosol (GO:0005829), membrane (GO:0016020), extracellular exosome (GO:0070062), Golgi membrane (GO:0000139), lysosome (GO:0005764)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
negative regulation of organelle organization	1
negative regulation of mitochondrial membrane permeability	1
mitochondrial outer membrane permeabilization	1
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	1
negative regulation of apoptotic signaling pathway	1
transport	1
cellular process	1
nucleotide-sugar transmembrane transport	1
transporter activity	1
transmembrane transport	1
binding	1
nucleotide-sugar transmembrane transporter activity	1
pyrimidine nucleotide-sugar transmembrane transport	1
nuclear lumen	1
intracellular membrane-bounded organelle	1
lysosome	1
lytic vacuole membrane	1
extracellular vesicle	1
Golgi apparatus	1
bounding membrane of organelle	1
lytic vacuole	1

Protein interactions and networks

STRING

658 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC35F6	FAF2	Q96CS3	648
SLC35F6	OTUD4	Q01804	639
SLC35F6	FBXO6	Q9NRD1	624
SLC35F6	UBQLN4	Q9NRR5	603
SLC35F6	SLC25A5	P05141	567
SLC35F6	HDAC5	Q9UQL6	540
SLC35F6	NUDT3	O95989	531
SLC35F6	MRPL58	Q14197	528
SLC35F6	HUWE1	Q7Z6Z7	526
SLC35F6	SLC25A6	P12236	521
SLC35F6	DMWD	Q09019	511
SLC35F6	NTRK1	P04629	510
SLC35F6	A0A1W2PNV4	A0A1W2PNV4	504
SLC35F6	SLC35B4	Q969S0	491
SLC35F6	UAP1L1	Q3KQV9	489

IntAct

87 interactions, top by confidence:

A	B	Type	Score
IFT70B	IFT56	psi-mi:“MI:0914”(association)	0.790
SLC35F6	AQP6	psi-mi:“MI:0915”(physical association)	0.560
SLC35F6	TIMMDC1	psi-mi:“MI:0915”(physical association)	0.560
AQP6	SLC35F6	psi-mi:“MI:0915”(physical association)	0.560
FOLR1	SLC35F6	psi-mi:“MI:0915”(physical association)	0.560
GJA8	SLC35F6	psi-mi:“MI:0915”(physical association)	0.560
SLC35F6	TMEM14B	psi-mi:“MI:0915”(physical association)	0.560
SLC35F6	GPR152	psi-mi:“MI:0915”(physical association)	0.560
SLC35F6	CERS4	psi-mi:“MI:0915”(physical association)	0.560
CBARP	SLC35F6	psi-mi:“MI:0915”(physical association)	0.560
EDA	AP3B1	psi-mi:“MI:0914”(association)	0.530
PARP2	SLC35F6	psi-mi:“MI:0557”(adp ribosylation reaction)	0.440
GPC1	SNAP23	psi-mi:“MI:0915”(physical association)	0.400
GPC1	GANAB	psi-mi:“MI:0915”(physical association)	0.400
SLC25A5	SLC35F6	psi-mi:“MI:0915”(physical association)	0.400
Rab5c		psi-mi:“MI:0914”(association)	0.350
TCEAL4	USP11	psi-mi:“MI:0914”(association)	0.350
Cct3	PFDN1	psi-mi:“MI:0914”(association)	0.350
Kcnk1	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
KRBOX4	ASXL2	psi-mi:“MI:0914”(association)	0.350
ATP6AP2	TMUB1	psi-mi:“MI:0914”(association)	0.350
Atp7a	RTL8C	psi-mi:“MI:0914”(association)	0.350
Ncstn	DERL1	psi-mi:“MI:0914”(association)	0.350
Cxxc1	HCFC1	psi-mi:“MI:0914”(association)	0.350
Atp2a2	ESYT2	psi-mi:“MI:0914”(association)	0.350
TOMM40	NOS1AP	psi-mi:“MI:0914”(association)	0.350

BioGRID (106): SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS), SLC35F6 (Affinity Capture-MS)

ESM2 similar proteins: A6ZTW6, A7TES5, A7TR80, B3LHR7, C7GUZ7, C8Z742, C8Z830, O08520, O16658, O77592, P40107, P78382, P78383, P87041, P97858, Q02334, Q10354, Q18779, Q1JQ66, Q58DA6, Q5R8M3, Q5RFT1, Q5RKH7, Q61420, Q66HX0, Q6AXR5, Q6CYD0, Q6FRE5, Q6GQ70, Q6V7K3, Q6YC49, Q753T9, Q7ZW46, Q8AWB6, Q8AXS6, Q8CIA5, Q8GYS1, Q8LGE9, Q8MII5, Q8N357

Diamond homologs: O16658, Q09875, Q5RFT1, Q5RKH7, Q8N357, Q8VE96, Q6AXR5, Q8R1T4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

64 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

885 predictions. Top by Δscore:

Variant	Effect	Δscore
2:26764422:GCAAA:G	donor_gain	1.0000
2:26764423:CAAAG:C	donor_loss	1.0000
2:26764424:AAAGT:A	donor_loss	1.0000
2:26764426:AG:A	donor_loss	1.0000
2:26764427:G:GG	donor_gain	1.0000
2:26774249:AGAT:A	acceptor_gain	1.0000
2:26774250:GATG:G	acceptor_gain	1.0000
2:26775459:CCTA:C	acceptor_loss	1.0000
2:26775461:TA:T	acceptor_loss	1.0000
2:26775462:A:AG	acceptor_gain	1.0000
2:26775463:G:GT	acceptor_gain	1.0000
2:26775463:GC:G	acceptor_gain	1.0000
2:26775463:GCT:G	acceptor_gain	1.0000
2:26775463:GCTC:G	acceptor_gain	1.0000
2:26775463:GCTCT:G	acceptor_gain	1.0000
2:26775664:G:GT	donor_gain	1.0000
2:26775672:CACAG:C	donor_loss	1.0000
2:26775673:ACAGG:A	donor_loss	1.0000
2:26775674:CAGG:C	donor_loss	1.0000
2:26775675:AGGT:A	donor_loss	1.0000
2:26775677:GTGC:G	donor_loss	1.0000
2:26776367:CACAG:C	acceptor_loss	1.0000
2:26776368:ACAG:A	acceptor_gain	1.0000
2:26776368:ACAGG:A	acceptor_gain	1.0000
2:26776369:C:G	acceptor_gain	1.0000
2:26776369:CA:C	acceptor_loss	1.0000
2:26776370:A:AG	acceptor_gain	1.0000
2:26776370:AG:A	acceptor_gain	1.0000
2:26776370:AGG:A	acceptor_gain	1.0000
2:26776370:AGGG:A	acceptor_gain	1.0000

AlphaMissense

2417 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:26775056:T:C	F55L	0.999
2:26775058:C:A	F55L	0.999
2:26775058:C:G	F55L	0.999
2:26775200:A:C	S103R	0.999
2:26775202:C:A	S103R	0.999
2:26775202:C:G	S103R	0.999
2:26775518:T:A	I126K	0.999
2:26778209:A:C	S272R	0.999
2:26778211:C:A	S272R	0.999
2:26778211:C:G	S272R	0.999
2:26778226:C:A	N277K	0.999
2:26778226:C:G	N277K	0.999
2:26776482:G:C	G216R	0.998
2:26778284:A:C	S297R	0.998
2:26778286:C:A	S297R	0.998
2:26778286:C:G	S297R	0.998
2:26764401:G:C	G18R	0.997
2:26764402:G:A	G18D	0.997
2:26764412:C:A	N21K	0.997
2:26764412:C:G	N21K	0.997
2:26775182:T:C	C97R	0.997
2:26775186:A:C	D98A	0.997
2:26775186:A:T	D98V	0.997
2:26775187:C:A	D98E	0.997
2:26775187:C:G	D98E	0.997
2:26775490:T:C	F117L	0.997
2:26775492:C:A	F117L	0.997
2:26775492:C:G	F117L	0.997
2:26775518:T:G	I126R	0.997
2:26775601:G:A	G154R	0.997

dbSNP variants (sampled 300 via entrez): RS1000025449 (2:26770575 G>A), RS1000124742 (2:26770306 T>C,G), RS1000255062 (2:26776877 G>A), RS1000382162 (2:26781323 G>A), RS1000558987 (2:26774888 T>TCTCTA), RS1000737323 (2:26781563 A>G,T), RS1000790107 (2:26768599 C>T), RS1000838968 (2:26764475 C>A,G), RS1000910182 (2:26762428 AT>A,ATT), RS1001167841 (2:26763172 C>T), RS1001312930 (2:26762931 A>C,T), RS1001470601 (2:26763043 C>A), RS1001529418 (2:26775324 C>A,T), RS1001702301 (2:26769313 G>A), RS1001795483 (2:26769073 G>A)

Disease associations

OMIM: gene MIM:619667 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST010697_14	Cortical surface area (min-P)	2.000000e-09
GCST010698_75	Subcortical volume (min-P)	2.000000e-13
GCST010699_41	Brain morphology (min-P)	2.000000e-08
GCST010700_38	Cortical thickness (MOSTest)	3.000000e-08
GCST010701_56	Cortical surface area (MOSTest)	4.000000e-16
GCST010702_20	Subcortical volume (MOSTest)	2.000000e-64
GCST010703_76	Brain morphology (MOSTest)	1.000000e-16

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC35 family of nucleotide sugar transporters

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	6
bisphenol A	decreases expression, increases expression, affects expression	3
sodium arsenite	affects binding, increases reaction, increases expression	3
Acetaminophen	decreases expression, increases expression	2
Estradiol	increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
FR900359	increases phosphorylation	1
bisphenol F	increases expression	1
dicrotophos	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
2-bromopalmitate	increases palmitoylation, decreases reaction, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
bisphenol B	increases expression	1
abrine	increases expression	1
dorsomorphin	increases expression, affects cotreatment	1
bisphenol S	increases expression	1
bisphenol AF	increases expression	1
Sunitinib	increases expression	1
Atrazine	decreases expression	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Caffeine	increases phosphorylation	1
Carbamazepine	affects expression	1
Rotenone	increases expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Thiram	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4ML	HCT116-SLC35F6-KO-c1	Cancer cell line	Male
CVCL_D4MM	HCT116-SLC35F6-KO-c10	Cancer cell line	Male
CVCL_D4MN	HCT116-SLC35F6-KO-c8	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.