SLC35G3

Summary

SLC35G3 (solute carrier family 35 member G3, HGNC:26848) is a protein-coding gene on chromosome 17q12, encoding Solute carrier family 35 member G3 (Q8N808).

Predicted to be active in membrane.

Source: NCBI Gene 146861 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 76 total
• MANE Select transcript: NM_152462

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26848
Approved symbol	SLC35G3
Name	solute carrier family 35 member G3
Location	17q12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ40154
Ensembl gene	ENSG00000164729
Ensembl biotype	protein_coding
Entrez	146861

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000297307

RefSeq mRNA: 1 — MANE Select: NM_152462 NM_152462

CCDS: CCDS11293

Canonical transcript exons

ENST00000297307 — 1 exons

Exon	Start	End
ENSE00001086982	35192520	35194393

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 87.76.

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	87.76	gold quality
sperm	CL:0000019	70.99	gold quality
tendon of biceps brachii	UBERON:0008188	54.04	gold quality
right testis	UBERON:0004534	53.57	gold quality
left testis	UBERON:0004533	53.36	gold quality
testis	UBERON:0000473	52.65	gold quality
endothelial cell	CL:0000115	51.98	gold quality
lower lobe of lung	UBERON:0008949	51.42	silver quality
hindlimb stylopod muscle	UBERON:0004252	49.91	silver quality
deltoid	UBERON:0001476	49.78	gold quality
apex of heart	UBERON:0002098	49.76	gold quality
gastrocnemius	UBERON:0001388	48.93	gold quality
muscle of leg	UBERON:0001383	47.92	gold quality
upper leg skin	UBERON:0004262	47.45	silver quality
heart left ventricle	UBERON:0002084	46.07	gold quality
cardiac ventricle	UBERON:0002082	45.86	silver quality
vastus lateralis	UBERON:0001379	45.24	gold quality
quadriceps femoris	UBERON:0001377	45.12	gold quality
right atrium auricular region	UBERON:0006631	44.36	gold quality
cardiac atrium	UBERON:0002081	44.25	gold quality
heart	UBERON:0000948	43.46	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
pharyngeal mucosa	UBERON:0000355	43.05	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
biceps brachii	UBERON:0001507	42.41	gold quality
medial globus pallidus	UBERON:0002477	42.02	gold quality
globus pallidus	UBERON:0001875	41.43	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.10

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting SLC35G3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-6892-3P	99.68	66.40	1178
HSA-MIR-7157-5P	99.66	69.33	1829
HSA-MIR-4310	99.59	68.84	2527
HSA-MIR-217-5P	99.49	69.93	1419
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-5683	99.36	68.59	2083
HSA-MIR-532-3P	99.34	65.76	1195
HSA-MIR-4777-5P	99.33	67.53	1148
HSA-MIR-130A-5P	99.33	70.26	2623
HSA-MIR-361-3P	99.19	66.45	1381
HSA-MIR-6807-3P	99.15	69.23	1275
HSA-MIR-6749-3P	99.00	65.73	1443
HSA-MIR-500A-5P	98.76	69.13	1241
HSA-MIR-513B-3P	98.76	68.12	1577
HSA-MIR-4710	98.61	65.96	1048
HSA-MIR-4780	98.57	64.75	611
HSA-MIR-1245B-3P	98.01	68.91	1387
HSA-MIR-449C-3P	97.75	67.86	462
HSA-MIR-510-5P	97.66	65.82	916
HSA-MIR-6131	97.22	66.72	960
HSA-MIR-3118	97.11	66.58	984
HSA-MIR-4522	95.76	66.23	742
HSA-MIR-5002-3P	95.75	67.04	542

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc35g3	ENSMUSG00000018776
rattus_norvegicus	Slc35g3	ENSRNOG00000014519
drosophila_melanogaster	CG5281	FBGN0037902

Paralogs (5): SLC35G2 (ENSG00000168917), SLC35G1 (ENSG00000176273), SLC35G5 (ENSG00000177710), SLC35G4 (ENSG00000236396), SLC35G6 (ENSG00000259224)

Protein

Protein identifiers

Solute carrier family 35 member G3 — Q8N808 (reviewed: Q8N808)

Alternative names: Acyl-malonyl-condensing enzyme 1, Transmembrane protein 21A

All UniProt accessions (1): Q8N808

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Expressed in testis.

Miscellaneous. The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

Similarity. Belongs to the SLC35G solute transporter family.

RefSeq proteins (1): NP_689675* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000620	EamA_dom	Domain
IPR037185	EmrE-like	Homologous_superfamily

Pfam: PF00892

UniProt features (13 total): transmembrane region 9, domain 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N808-F1	84.73	0.61

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 18 (showing top): TGACATY_UNKNOWN, ESC_J1_UP_EARLY.V1_DN, ESC_V6.5_UP_EARLY.V1_UP, SREBP_Q3, MIR4659A_3P_MIR4659B_3P, MIR3119, MIR5683, MIR510_5P, MIR4522, chr17q12, WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME, GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_CD8_TCELL_DN, GSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_DN, HNF4_Q6, GSE37532_VISCERAL_ADIPOSE_TISSUE_VS_LN_DERIVED_TCONV_CD4_TCELL_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

230 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC35G3	CDRT15L2	A8MXV6	603
SLC35G3	TBC1D28	Q2M2D7	542
SLC35G3	C2CD4D	B7Z1M9	528
SLC35G3	CCDC144A	A2RUR9	507
SLC35G3	SPDYE4	A6NLX3	505
SLC35G3	OR3A2	P47893	505
SLC35G3	CHCT1	Q86WR6	480
SLC35G3	TBC1D26	Q86UD7	479
SLC35G3	TBC1D3G	Q6DHY5	476
SLC35G3	LRRC3C	A6NJW4	448
SLC35G3	SLC25A52	Q3SY17	448
SLC35G3	A0A087WT91	A0A087WT91	447
SLC35G3	TBC1D3B	A6NDS4	447
SLC35G3	FBXW10B	O95170	447
SLC35G3	TMEM95	Q3KNT9	447

IntAct

2 interactions, top by confidence:

A	B	Type	Score
SLC35G3	SMCHD1	psi-mi:“MI:0914”(association)	0.350

BioGRID (100): ABI1 (Affinity Capture-MS), AGPS (Affinity Capture-MS), AMOT (Affinity Capture-MS), APEX1 (Affinity Capture-MS), ARID1A (Affinity Capture-MS), ARID2 (Affinity Capture-MS), ASH2L (Affinity Capture-MS), BCAS2 (Affinity Capture-MS), BMS1 (Affinity Capture-MS), CCAR1 (Affinity Capture-MS), CDC5L (Affinity Capture-MS), CDK12 (Affinity Capture-MS), CDK13 (Affinity Capture-MS), CDV3 (Affinity Capture-MS), CGNL1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0D1DNX1, A0A125YQS6, A0A3S7WQS5, A0A7J6K338, A0A7J6K629, A0A7J6KE60, A4HAG7, A8PRN6, B0K004, C5DGI8, E6ZZ11, G4SDH4, L7WGA7, O76819, O77438, P0C7Q6, P0CM32, P0CM33, P14773, P21441, P42864, Q0C8L9, Q0Q7U9, Q0Q7V0, Q1KKV8, Q2GN49, Q381F9, Q38AH0, Q38BU9, Q3S2U3, Q4D3E8, Q4DKF7, Q4DZ91, Q4HX89, Q4P0S6, Q4X0S3, Q57VW6, Q5F297, Q6C6S3, Q6CGU8

Diamond homologs: B0K004, D3YVE8, P0C7Q5, P0C7Q6, Q0Q7U7, Q0Q7U8, Q0Q7U9, Q0Q7V0, Q5F297, Q5M7A3, Q5ZJZ4, Q8N808, Q8TBE7, Q96KT7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	74
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

72 predictions. Top by Δscore:

Variant	Effect	Δscore
17:35193763:T:TA	donor_gain	0.7600
17:35193804:T:TA	donor_gain	0.5100
17:35193935:C:CT	donor_gain	0.4900
17:35193802:AGT:A	donor_gain	0.4600
17:35193936:C:CT	donor_gain	0.4600
17:35193731:AG:A	donor_gain	0.4500
17:35193747:G:C	donor_gain	0.4400
17:35193832:C:CT	donor_gain	0.4400
17:35193732:G:C	donor_gain	0.4200
17:35193712:C:A	donor_gain	0.4100
17:35193753:C:T	donor_gain	0.4100
17:35193828:A:T	donor_gain	0.4100
17:35193731:AGC:A	donor_gain	0.4000
17:35193833:A:T	donor_gain	0.4000
17:35193437:C:CT	donor_gain	0.3900
17:35193839:AG:A	donor_gain	0.3700
17:35193840:G:C	donor_gain	0.3600
17:35193826:C:A	donor_gain	0.3500
17:35193319:CAG:C	donor_gain	0.3400
17:35193306:C:A	donor_gain	0.3300
17:35193438:C:CT	donor_gain	0.3300
17:35193829:C:T	donor_gain	0.3200
17:35193854:GGCTC:G	acceptor_gain	0.3100
17:35193749:C:T	donor_gain	0.3000
17:35193960:T:TA	donor_gain	0.3000
17:35194058:CAA:C	acceptor_gain	0.3000
17:35194059:A:T	acceptor_gain	0.3000
17:35194222:TGG:T	donor_gain	0.3000
17:35193678:ATAG:A	donor_gain	0.2900
17:35193711:T:TA	donor_gain	0.2900

AlphaMissense

2123 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:35193636:G:C	F224L	0.900
17:35193636:G:T	F224L	0.900
17:35193638:A:G	F224L	0.900
17:35193507:G:C	F267L	0.798
17:35193507:G:T	F267L	0.798
17:35193509:A:G	F267L	0.798
17:35194149:G:C	F53L	0.790
17:35194149:G:T	F53L	0.790
17:35194151:A:G	F53L	0.790
17:35193351:G:C	S319R	0.788
17:35193351:G:T	S319R	0.788
17:35193353:T:G	S319R	0.788
17:35193966:G:C	S114R	0.697
17:35193966:G:T	S114R	0.697
17:35193968:T:G	S114R	0.697
17:35193591:A:C	F239L	0.679
17:35193591:A:T	F239L	0.679
17:35193593:A:G	F239L	0.679
17:35193663:A:C	F215L	0.664
17:35193663:A:T	F215L	0.664
17:35193665:A:G	F215L	0.664
17:35194057:G:T	A84D	0.630
17:35193552:A:C	S252R	0.625
17:35193552:A:T	S252R	0.625
17:35193554:T:G	S252R	0.625
17:35193717:G:C	F197L	0.614
17:35193717:G:T	F197L	0.614
17:35193719:A:G	F197L	0.614
17:35193637:A:G	F224S	0.603
17:35193480:C:A	K276N	0.572

dbSNP variants (sampled 300 via entrez): RS1000041055 (17:35192277 G>A), RS1001858785 (17:35195025 G>A,C), RS1003562164 (17:35195966 T>G), RS1003928428 (17:35195159 C>A,G,T), RS1005558679 (17:35194549 G>A,C), RS1005944921 (17:35192964 A>G), RS1007569714 (17:35192025 A>C), RS1008771640 (17:35194887 G>A), RS1009724750 (17:35196015 G>A,C), RS1010439443 (17:35196000 A>G), RS1010799384 (17:35195017 C>G,T), RS1011162693 (17:35195142 C>A,G,T), RS1015343357 (17:35195472 C>A,G,T), RS1015769199 (17:35195160 A>C,T), RS1017433250 (17:35194557 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC35 family of nucleotide sugar transporters

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	increases expression	1
Triclosan	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.