SLC35G4

Summary

SLC35G4 (solute carrier family 35 member G4, HGNC:31043) is a protein-coding gene on chromosome 18p11.21, encoding Solute carrier family 35 member G4 (P0C7Q5).

Predicted to be active in membrane.

Source: NCBI Gene 646000 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 2 total — 1 pathogenic
• MANE Select transcript: NM_001282300

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31043
Approved symbol	SLC35G4
Name	solute carrier family 35 member G4
Location	18p11.21
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000236396
Ensembl biotype	protein_coding
Entrez	646000

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000588001

RefSeq mRNA: 1 — MANE Select: NM_001282300 NM_001282300

CCDS: CCDS82241

Canonical transcript exons

ENST00000588001 — 1 exons

Exon	Start	End
ENSE00002890034	11609596	11610612

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
leukocyte	CL:0000738	26.78	gold quality
monocyte	CL:0000576	26.70	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.04	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	24.99	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.24	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
cortex of kidney	UBERON:0001225	23.91	gold quality
gastrocnemius	UBERON:0001388	23.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc35g3	ENSMUSG00000018776
rattus_norvegicus	Slc35g3	ENSRNOG00000014519
drosophila_melanogaster	CG5281	FBGN0037902

Paralogs (5): SLC35G3 (ENSG00000164729), SLC35G2 (ENSG00000168917), SLC35G1 (ENSG00000176273), SLC35G5 (ENSG00000177710), SLC35G6 (ENSG00000259224)

Protein

Protein identifiers

Solute carrier family 35 member G4 — P0C7Q5 (reviewed: P0C7Q5)

Alternative names: Acyl-malonyl-condensing enzyme 1-like protein 1

All UniProt accessions (1): P0C7Q5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the SLC35G solute transporter family.

RefSeq proteins (1): NP_001269229* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000620	EamA_dom	Domain
IPR037185	EmrE-like	Homologous_superfamily

Pfam: PF00892

UniProt features (12 total): transmembrane region 7, domain 2, chain 1, region of interest 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7Q5-F1	83.49	0.53

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr18p11

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

142 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC35G4	SLC35E2A	P0CK97	545
SLC35G4	SLC35E2B	P0CK96	544
SLC35G4	SLC25A52	Q3SY17	518
SLC35G4	SLCO1B7	G3V0H7	505
SLC35G4	SLC22A24	Q8N4F4	480
SLC35G4	ZBTB45	Q96K62	479
SLC35G4	SLC22A31	A6NKX4	478
SLC35G4	SLC22A25	Q6T423	449
SLC35G4	SLC9C2	Q5TAH2	448
SLC35G4	SLC7A13	Q8TCU3	425
SLC35G4	SLC35G1	Q2M3R5	399
SLC35G4	SLC22A10	Q63ZE4	373
SLC35G4	SLC35E3	Q7Z769	372
SLC35G4	SLC35F3	Q8IY50	349
SLC35G4	SLC35B3	Q9H1N7	347

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A084AFH0, A1L3G4, A1Z7R6, A5WWC6, A7YW81, B0B8F4, B0K004, D3YVE8, O04508, O74750, O84584, P0C7Q5, P0C7Q6, P39542, P40004, P53403, Q00974, Q0Q7U7, Q0Q7U8, Q0Q7U9, Q0Q7V0, Q0V9U2, Q1PFJ4, Q23444, Q24JQ0, Q3UME2, Q5F297, Q5M7A3, Q5PT55, Q5ZJZ4, Q7RTP0, Q8BHK1, Q8MXJ9, Q8N808, Q94EI9, Q96KT7, Q9C508, Q9C654, Q9C8M1, Q9FG70

Diamond homologs: B0K004, D3YVE8, P0C7Q5, P0C7Q6, Q0Q7U7, Q0Q7U8, Q0Q7U9, Q0Q7V0, Q5F297, Q5M7A3, Q5ZJZ4, Q8N808, Q8TBE7, Q96KT7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
154106	GRCh38/hg38 18p11.32-q23(chr18:136227-80256240)x3	Pathogenic

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2130 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:11610265:T:C	F224L	0.888
18:11610267:C:A	F224L	0.888
18:11610267:C:G	F224L	0.888
18:11610550:A:C	S319R	0.789
18:11610552:C:A	S319R	0.789
18:11610552:C:G	S319R	0.789
18:11610238:T:C	F215L	0.737
18:11610240:T:A	F215L	0.737
18:11610240:T:G	F215L	0.737
18:11610394:T:C	F267L	0.715
18:11610396:C:A	F267L	0.715
18:11610396:C:G	F267L	0.715
18:11609752:T:C	F53L	0.713
18:11609754:C:A	F53L	0.713
18:11609754:C:G	F53L	0.713
18:11610088:A:C	S165R	0.694
18:11610090:C:A	S165R	0.694
18:11610090:C:G	S165R	0.694
18:11610310:T:C	F239L	0.672
18:11610312:T:A	F239L	0.672
18:11610312:T:G	F239L	0.672
18:11610352:T:A	W253R	0.598
18:11610352:T:C	W253R	0.598
18:11610349:A:C	S252R	0.592
18:11610351:T:A	S252R	0.592
18:11610351:T:G	S252R	0.592
18:11610266:T:C	F224S	0.587
18:11610529:G:A	G312R	0.565
18:11610529:G:C	G312R	0.565

dbSNP variants (sampled 300 via entrez): RS1000211239 (18:11608583 A>T), RS1001005573 (18:11610090 C>G,T), RS1002730490 (18:11608476 T>C), RS1005232921 (18:11609003 G>C), RS1006183855 (18:11609969 T>G), RS1006736115 (18:11608835 G>A,T), RS1007040462 (18:11608770 G>A,T), RS1009705975 (18:11609240 A>G), RS1009865077 (18:11608646 T>C), RS1011371649 (18:11608765 C>A), RS1011839641 (18:11608522 C>A,T), RS1014386729 (18:11608513 G>A,C), RS1015186504 (18:11610427 C>A,G), RS1015660057 (18:11608015 G>C), RS1015713713 (18:11607759 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC35 family of nucleotide sugar transporters

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Smoke	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.