SLC35G5

Summary

SLC35G5 (solute carrier family 35 member G5, HGNC:15546) is a protein-coding gene on chromosome 8p23.1, encoding Solute carrier family 35 member G5 (Q96KT7).

This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17.

Source: NCBI Gene 83650 — RefSeq curated summary.

At a glance

• GWAS associations: 16
• MANE Select transcript: NM_054028

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15546
Approved symbol	SLC35G5
Name	solute carrier family 35 member G5
Location	8p23.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000177710
Ensembl biotype	protein_coding
OMIM	615199
Entrez	83650

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000382435

RefSeq mRNA: 1 — MANE Select: NM_054028 NM_054028

CCDS: CCDS5980

Canonical transcript exons

ENST00000382435 — 1 exons

Exon	Start	End
ENSE00001492046	11331012	11332360

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 59.23.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	59.23	gold quality
right testis	UBERON:0004534	51.29	gold quality
left testis	UBERON:0004533	50.89	gold quality
testis	UBERON:0000473	50.27	gold quality
lower esophagus mucosa	UBERON:0035834	49.71	gold quality
apex of heart	UBERON:0002098	48.75	gold quality
blood	UBERON:0000178	48.22	silver quality
mucosa of transverse colon	UBERON:0004991	46.80	gold quality
spleen	UBERON:0002106	45.45	gold quality
heart left ventricle	UBERON:0002084	44.08	gold quality
muscle layer of sigmoid colon	UBERON:0035805	43.64	gold quality
right atrium auricular region	UBERON:0006631	43.31	gold quality
prostate gland	UBERON:0002367	43.04	gold quality
ganglionic eminence	UBERON:0004023	42.89	silver quality
heart	UBERON:0000948	42.28	gold quality
muscle tissue	UBERON:0002385	42.17	silver quality
substantia nigra	UBERON:0002038	41.80	gold quality
skeletal muscle tissue	UBERON:0001134	41.75	silver quality
lymph node	UBERON:0000029	41.55	gold quality
cortical plate	UBERON:0005343	40.98	silver quality
pituitary gland	UBERON:0000007	40.81	silver quality
endocervix	UBERON:0000458	40.44	silver quality
hypothalamus	UBERON:0001898	40.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	40.16	silver quality
stromal cell of endometrium	CL:0002255	39.85	gold quality
colon	UBERON:0001155	39.84	gold quality
adenohypophysis	UBERON:0002196	39.66	silver quality
kidney	UBERON:0002113	39.60	silver quality
ectocervix	UBERON:0012249	39.60	silver quality
uterine cervix	UBERON:0000002	39.58	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc35g3	ENSMUSG00000018776
rattus_norvegicus	Slc35g3	ENSRNOG00000014519
drosophila_melanogaster	CG5281	FBGN0037902

Paralogs (5): SLC35G3 (ENSG00000164729), SLC35G2 (ENSG00000168917), SLC35G1 (ENSG00000176273), SLC35G4 (ENSG00000236396), SLC35G6 (ENSG00000259224)

Protein

Protein identifiers

Solute carrier family 35 member G5 — Q96KT7 (reviewed: Q96KT7)

Alternative names: Acyl-malonyl-condensing enzyme 1-like protein 2

All UniProt accessions (1): Q96KT7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Expressed in placenta and testis.

Miscellaneous. The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

Similarity. Belongs to the SLC35G solute transporter family.

RefSeq proteins (1): NP_473369* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000620	EamA_dom	Domain
IPR037185	EmrE-like	Homologous_superfamily

Pfam: PF00892

UniProt features (15 total): transmembrane region 9, domain 2, sequence variant 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96KT7-F1	82.20	0.46

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 5 (showing top): DESCARTES_FETAL_CEREBRUM_MEGAKARYOCYTES, WP_8P231_COPY_NUMBER_VARIATION_SYNDROME, GSE22601_DOUBLE_NEGATIVE_VS_CD8_SINGLE_POSITIVE_THYMOCYTE_DN, chr8p23, HNF4_Q6

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

332 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC35G5	XKR6	Q5GH73	572
SLC35G5	TTC39B	Q5VTQ0	445
SLC35G5	DEFB134	Q4QY38	418
SLC35G5	SLC35E2A	P0CK97	398
SLC35G5	SLC35E2B	P0CK96	374
SLC35G5	MMAB	Q96EY8	353
SLC35G5	SLC25A52	Q3SY17	349
SLC35G5	MTMR9	Q96QG7	324
SLC35G5	FAM153A	Q9UHL3	324
SLC35G5	SLCO1B7	G3V0H7	321
SLC35G5	PBX4	Q9BYU1	311
SLC35G5	SLC22A24	Q8N4F4	309
SLC35G5	SLC22A31	A6NKX4	307
SLC35G5	NCAN	O14594	305
SLC35G5	TRIB1	Q96RU8	305

IntAct

5 interactions, top by confidence:

A	B	Type	Score
SLC35G5	BCL2L13	psi-mi:“MI:0915”(physical association)	0.560
SLC35G5	SLC35G6	psi-mi:“MI:0914”(association)	0.350
SLC35G5	BCL2L13	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (5): SLC35G5 (Two-hybrid), SLC35G5 (Co-fractionation), CCPG1 (Affinity Capture-MS), SLC35F3 (Affinity Capture-MS), SLC35G6 (Affinity Capture-MS)

ESM2 similar proteins: A0A084AFH0, A1L3G4, A1Z7R6, A5WWC6, A7YW81, B0B8F4, B0K004, D3YVE8, O04508, O74750, O84584, P0C7Q5, P0C7Q6, P39542, P40004, P53403, Q00974, Q0Q7U7, Q0Q7U8, Q0Q7U9, Q0Q7V0, Q0V9U2, Q1PFJ4, Q23444, Q24JQ0, Q3UME2, Q5F297, Q5M7A3, Q5PT55, Q5ZJZ4, Q7RTP0, Q8BHK1, Q8MXJ9, Q8N808, Q94EI9, Q96KT7, Q9C508, Q9C654, Q9C8M1, Q9FG70

Diamond homologs: B0K004, D3YVE8, P0C7Q5, P0C7Q6, Q0Q7U7, Q0Q7U8, Q0Q7U9, Q0Q7V0, Q5F297, Q5M7A3, Q5ZJZ4, Q8N808, Q8TBE7, Q96KT7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

252 predictions. Top by Δscore:

Variant	Effect	Δscore
8:11331609:G:GT	donor_gain	0.6400
8:11331857:C:CG	donor_gain	0.6400
8:11331862:TTG:T	donor_gain	0.6200
8:11331650:G:GT	donor_gain	0.6100
8:11331464:A:AG	acceptor_gain	0.5900
8:11331465:G:GG	acceptor_gain	0.5900
8:11331857:C:G	donor_gain	0.5800
8:11331103:A:T	donor_gain	0.5600
8:11331081:G:GT	donor_gain	0.5300
8:11331582:G:GA	donor_gain	0.5300
8:11331574:C:G	donor_gain	0.5200
8:11331658:CACAG:C	donor_loss	0.5200
8:11331659:ACAGG:A	donor_loss	0.5200
8:11331660:CAG:C	donor_loss	0.5200
8:11331661:AGGTG:A	donor_loss	0.5200
8:11331662:GGTGT:G	donor_loss	0.5200
8:11331663:G:GG	donor_loss	0.5200
8:11331664:T:A	donor_loss	0.5200
8:11331651:A:T	donor_gain	0.5100
8:11331681:GC:G	donor_gain	0.5100
8:11331453:G:GT	donor_gain	0.5000
8:11331701:G:GT	donor_gain	0.5000
8:11331868:T:G	donor_gain	0.5000
8:11331657:CCACA:C	donor_loss	0.4900
8:11331769:A:AG	acceptor_gain	0.4900
8:11331770:G:GG	acceptor_gain	0.4900
8:11331654:G:T	donor_gain	0.4800
8:11331682:C:G	donor_gain	0.4800
8:11331860:A:AG	donor_gain	0.4700
8:11331861:G:GG	donor_gain	0.4700

AlphaMissense

2118 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:11331776:T:C	F224L	0.904
8:11331778:C:A	F224L	0.904
8:11331778:C:G	F224L	0.904
8:11332061:A:C	S319R	0.830
8:11332063:C:A	S319R	0.830
8:11332063:C:G	S319R	0.830
8:11331905:T:C	F267L	0.787
8:11331907:C:A	F267L	0.787
8:11331907:C:G	F267L	0.787
8:11331599:A:C	S165R	0.781
8:11331601:C:A	S165R	0.781
8:11331601:C:G	S165R	0.781
8:11331263:T:C	F53L	0.778
8:11331265:C:A	F53L	0.778
8:11331265:C:G	F53L	0.778
8:11331749:T:C	F215L	0.778
8:11331751:T:A	F215L	0.778
8:11331751:T:G	F215L	0.778
8:11331446:A:C	S114R	0.716
8:11331448:C:A	S114R	0.716
8:11331448:C:G	S114R	0.716
8:11332040:G:A	G312R	0.692
8:11332040:G:C	G312R	0.692
8:11331821:T:C	F239L	0.672
8:11331823:T:A	F239L	0.672
8:11331823:T:G	F239L	0.672
8:11332040:G:T	G312W	0.639
8:11331608:G:A	G168R	0.625
8:11331608:G:C	G168R	0.625
8:11331511:A:C	K135N	0.614

dbSNP variants (sampled 300 via entrez): RS1001286940 (8:11330883 C>A,G,T), RS1002317865 (8:11330168 C>A,T), RS1002438174 (8:11332786 G>A,T), RS1002691727 (8:11330034 G>A,C), RS1003040528 (8:11329026 T>C), RS1003092280 (8:11332761 G>A,T), RS1003351349 (8:11329623 T>G), RS1004128385 (8:11332210 ATAAT>A), RS1005109846 (8:11329064 T>A,C), RS1006153403 (8:11330679 G>A,T), RS1007124861 (8:11329676 C>A,T), RS1007155910 (8:11329766 T>C,G), RS1007994529 (8:11332296 T>C), RS1008025485 (8:11332441 T>G), RS1008617356 (8:11329176 A>G)

Disease associations

OMIM: gene MIM:615199 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

16 associations (top):

Study	Trait	p-value
GCST000286_1	Triglycerides	3.000000e-08
GCST003103_2	Systemic lupus erythematosus	8.000000e-06
GCST010132_11	Processed meat consumption	4.000000e-10
GCST010132_14	Processed meat consumption	2.000000e-15
GCST010132_15	Processed meat consumption	1.000000e-09
GCST010136_40	Fruit consumption	1.000000e-10
GCST010136_5	Fruit consumption	9.000000e-09
GCST010136_9	Fruit consumption	1.000000e-08
GCST010142_4	Fish- and plant-related diet	2.000000e-12
GCST010142_6	Fish- and plant-related diet	3.000000e-12
GCST010142_63	Fish- and plant-related diet	2.000000e-12
GCST010142_67	Fish- and plant-related diet	1.000000e-10
GCST010142_70	Fish- and plant-related diet	8.000000e-10
GCST010142_89	Fish- and plant-related diet	4.000000e-16
GCST010142_90	Fish- and plant-related diet	7.000000e-15
GCST010703_306	Brain morphology (MOSTest)	5.000000e-26

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004530	triglyceride measurement
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC35 family of nucleotide sugar transporters

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
kojic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Cadmium	decreases expression, increases abundance	1
Endosulfan	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.