SLC35G6

Summary

SLC35G6 (solute carrier family 35 member G6, HGNC:31351) is a protein-coding gene on chromosome 17p13.1, encoding Solute carrier family 35 member G6 (P0C7Q6).

Predicted to be active in membrane.

Source: NCBI Gene 643664 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 59 total
• MANE Select transcript: NM_001102614

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31351
Approved symbol	SLC35G6
Name	solute carrier family 35 member G6
Location	17p13.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000259224
Ensembl biotype	protein_coding
Entrez	643664

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000412468

RefSeq mRNA: 1 — MANE Select: NM_001102614 NM_001102614

CCDS: CCDS45603

Canonical transcript exons

ENST00000412468 — 2 exons

Exon	Start	End
ENSE00001657258	7481446	7481519
ENSE00001797618	7481988	7483496

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 84.11.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.11	gold quality
right testis	UBERON:0004534	62.79	gold quality
left testis	UBERON:0004533	62.15	gold quality
testis	UBERON:0000473	61.73	gold quality
sural nerve	UBERON:0015488	56.38	silver quality
stromal cell of endometrium	CL:0002255	55.65	gold quality
skeletal muscle tissue	UBERON:0001134	53.23	gold quality
colonic epithelium	UBERON:0000397	49.68	gold quality
bone marrow cell	CL:0002092	49.54	gold quality
granulocyte	CL:0000094	47.43	silver quality
muscle tissue	UBERON:0002385	46.88	gold quality
bone marrow	UBERON:0002371	46.84	silver quality
primary visual cortex	UBERON:0002436	45.81	silver quality
hindlimb stylopod muscle	UBERON:0004252	44.99	gold quality
tonsil	UBERON:0002372	44.49	gold quality
apex of heart	UBERON:0002098	43.53	silver quality
blood	UBERON:0000178	40.45	gold quality
liver	UBERON:0002107	40.11	gold quality
adrenal tissue	UBERON:0018303	39.74	gold quality
prefrontal cortex	UBERON:0000451	39.10	silver quality
endometrium	UBERON:0001295	39.01	silver quality
calcaneal tendon	UBERON:0003701	38.92	gold quality
right adrenal gland cortex	UBERON:0035827	38.88	silver quality
muscle of leg	UBERON:0001383	38.65	silver quality
right adrenal gland	UBERON:0001233	38.33	silver quality
left adrenal gland cortex	UBERON:0035825	37.28	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
myometrium	UBERON:0001296	36.16	silver quality
cortex of kidney	UBERON:0001225	36.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc35g3	ENSMUSG00000018776
rattus_norvegicus	Slc35g3	ENSRNOG00000014519
drosophila_melanogaster	CG5281	FBGN0037902

Paralogs (5): SLC35G3 (ENSG00000164729), SLC35G2 (ENSG00000168917), SLC35G1 (ENSG00000176273), SLC35G5 (ENSG00000177710), SLC35G4 (ENSG00000236396)

Protein

Protein identifiers

Solute carrier family 35 member G6 — P0C7Q6 (reviewed: P0C7Q6)

Alternative names: Acyl-malonyl-condensing enzyme 1-like protein 3, Transmembrane protein 21B

All UniProt accessions (1): P0C7Q6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Tissue specificity. Expressed in placenta and testis.

Miscellaneous. This gene appears to be the source locus of an SVA-mediated retrotransposition event that gave rise to SLC35G3, SLC35G4 and SLC35G5 genes.

Similarity. Belongs to the SLC35G solute transporter family.

RefSeq proteins (1): NP_001096084* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000620	EamA_dom	Domain
IPR037185	EmrE-like	Homologous_superfamily

Pfam: PF00892

UniProt features (16 total): transmembrane region 9, sequence variant 3, domain 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7Q6-F1	82.71	0.48

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 24 (showing top): MIKKELSEN_ES_ICP_WITH_H3K4ME3, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS, GSE10239_NAIVE_VS_MEMORY_CD8_TCELL_DN, GSE1448_CTRL_VS_ANTI_VBETA5_DP_THYMOCYTE_DN, GSE1448_ANTI_VALPHA2_VS_VBETA5_DP_THYMOCYTE_DN, GSE17721_CTRL_VS_PAM3CSK4_1H_BMDC_DN, GSE17721_CTRL_VS_GARDIQUIMOD_6H_BMDC_DN, GSE17721_CTRL_VS_GARDIQUIMOD_24H_BMDC_DN, GSE17721_LPS_VS_GARDIQUIMOD_8H_BMDC_UP, ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_CORRELATED_WITH_CD8_T_CELL_RESPONSE_3DY_NEGATIVE, ANDERSON_BLOOD_CN54GP140_ADJUVANTED_WITH_GLA_AF_AGE_18_45YO_6HR_DN, GSE27786_LSK_VS_MONO_MAC_DN, GSE27786_LIN_NEG_VS_BCELL_UP, GSE27786_LIN_NEG_VS_MONO_MAC_DN, GSE8835_CD4_VS_CD8_TCELL_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

262 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC35G6	CDRT15L2	A8MXV6	604
SLC35G6	A0A3B3IRQ3	A0A3B3IRQ3	590
SLC35G6	TBC1D28	Q2M2D7	542
SLC35G6	KRTAP4-8	Q9BYQ9	507
SLC35G6	CCDC144A	A2RUR9	507
SLC35G6	SPDYE4	A6NLX3	506
SLC35G6	OR3A2	P47893	505
SLC35G6	CHCT1	Q86WR6	480
SLC35G6	TBC1D26	Q86UD7	479
SLC35G6	TBC1D3G	Q6DHY5	476
SLC35G6	LRRC3C	A6NJW4	449
SLC35G6	POTEC	B2RU33	448
SLC35G6	FBXW10B	O95170	448
SLC35G6	TMEM95	Q3KNT9	447
SLC35G6	KRTAP4-3	Q9BYR4	447
SLC35G6	A0A087WT91	A0A087WT91	447
SLC35G6	TBC1D3B	A6NDS4	447

IntAct

2 interactions, top by confidence:

A	B	Type	Score
SLC35G5	SLC35G6	psi-mi:“MI:0914”(association)	0.350

BioGRID (1): SLC35G6 (Affinity Capture-MS)

ESM2 similar proteins: A0A0D1DNX1, A0A125YQS6, A0A3S7WQS5, A0A7J6K338, A0A7J6K629, A0A7J6KE60, A4HAG7, A8PRN6, B0K004, C5DGI8, E6ZZ11, G4SDH4, L7WGA7, O76819, O77438, P0C7Q6, P0CM32, P0CM33, P14773, P21441, P42864, Q0C8L9, Q0Q7U9, Q0Q7V0, Q1KKV8, Q2GN49, Q381F9, Q38AH0, Q38BU9, Q3S2U3, Q4D3E8, Q4DKF7, Q4DZ91, Q4HX89, Q4P0S6, Q4X0S3, Q57VW6, Q5F297, Q6C6S3, Q6CGU8

Diamond homologs: B0K004, D3YVE8, P0C7Q5, P0C7Q6, Q0Q7U7, Q0Q7U8, Q0Q7U9, Q0Q7V0, Q5F297, Q5M7A3, Q5ZJZ4, Q8N808, Q8TBE7, Q96KT7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	53
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

121 predictions. Top by Δscore:

Variant	Effect	Δscore
17:7481516:GATG:G	donor_gain	0.9900
17:7481513:A:T	donor_gain	0.9800
17:7481517:ATGG:A	donor_loss	0.9800
17:7481520:G:GA	donor_loss	0.9800
17:7481521:TGAG:T	donor_loss	0.9800
17:7481522:GAGT:G	donor_loss	0.9800
17:7481520:G:GG	donor_gain	0.9500
17:7481523:AGTG:A	donor_loss	0.9500
17:7481512:G:GT	donor_gain	0.9400
17:7481518:TG:T	donor_gain	0.8500
17:7481519:GG:G	donor_gain	0.8500
17:7481524:G:C	donor_loss	0.8200
17:7481982:TAACA:T	acceptor_loss	0.7900
17:7481984:ACAG:A	acceptor_loss	0.7900
17:7481987:G:A	acceptor_loss	0.7900
17:7481987:GGCT:G	acceptor_gain	0.7800
17:7481517:ATG:A	donor_gain	0.7700
17:7481986:A:AG	acceptor_gain	0.7700
17:7481987:G:GG	acceptor_gain	0.7700
17:7481986:AGGCT:A	acceptor_gain	0.7600
17:7481987:GGCTG:G	acceptor_gain	0.7600
17:7481837:TAGGC:T	acceptor_gain	0.7300
17:7481515:AGATG:A	donor_gain	0.7100
17:7481516:GATGG:G	donor_gain	0.7100
17:7481491:G:GT	donor_gain	0.6900
17:7482233:T:A	acceptor_gain	0.6600
17:7481888:AC:A	acceptor_gain	0.6400
17:7481972:CCTTT:C	acceptor_loss	0.6400
17:7481973:CTTTC:C	acceptor_loss	0.6400
17:7481974:TTTCT:T	acceptor_loss	0.6400

AlphaMissense

2124 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:7482939:A:C	S319R	0.933
17:7482941:C:A	S319R	0.933
17:7482941:C:G	S319R	0.933
17:7482654:T:C	F224L	0.931
17:7482656:C:A	F224L	0.931
17:7482656:C:G	F224L	0.931
17:7482477:A:C	S165R	0.897
17:7482479:C:A	S165R	0.897
17:7482479:C:G	S165R	0.897
17:7482783:T:C	F267L	0.850
17:7482785:C:A	F267L	0.850
17:7482785:C:G	F267L	0.850
17:7482141:T:C	F53L	0.830
17:7482143:C:A	F53L	0.830
17:7482143:C:G	F53L	0.830
17:7482324:A:C	S114R	0.822
17:7482326:C:A	S114R	0.822
17:7482326:C:G	S114R	0.822
17:7482627:T:C	F215L	0.809
17:7482629:T:A	F215L	0.809
17:7482629:T:G	F215L	0.809
17:7482405:T:C	C141R	0.751
17:7482936:G:C	G318R	0.749
17:7482403:T:A	V140D	0.733
17:7482655:T:C	F224S	0.732
17:7482850:A:T	E289V	0.718
17:7482389:A:C	K135N	0.708
17:7482389:A:T	K135N	0.708
17:7482937:G:A	G318D	0.703
17:7482486:G:A	G168R	0.700

dbSNP variants (sampled 300 via entrez): RS1000442425 (17:7479604 C>A,T), RS1000743261 (17:7481254 T>C), RS1000919990 (17:7483979 A>C), RS1001286903 (17:7483352 GAC>G), RS1003286180 (17:7481132 C>T), RS1003726598 (17:7481326 C>G,T), RS1004590519 (17:7481202 T>C), RS1004642828 (17:7480882 C>T), RS1004696141 (17:7479977 G>A), RS1005116763 (17:7483726 C>CG), RS1007033583 (17:7481868 G>A), RS1007069497 (17:7480394 G>A), RS1007143316 (17:7480587 G>T), RS1007585253 (17:7481550 C>T), RS1008070708 (17:7483714 C>A,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST009222_6	Corpus callosum posterior volume	8.000000e-06
GCST010002_119	Refractive error	3.000000e-22
GCST010703_158	Brain morphology (MOSTest)	3.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC35 family of nucleotide sugar transporters

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation	1
jinfukang	affects cotreatment, increases expression	1
2,6-dichloro-(1,4)benzoquinone	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Cisplatin	affects cotreatment, increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.