◎ Sugi Atlas

Atlas / Gene / SLC37A1

SLC37A1

gene
On this page

Also known as SPX1

Summary

SLC37A1 (solute carrier family 37 member 1, HGNC:11024) is a protein-coding gene on chromosome 21q22.3, encoding Glucose-6-phosphate exchanger SLC37A1 (P57057). Inorganic phosphate and glucose-6-phosphate antiporter.

The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 54020 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 137 total
  • MANE Select transcript: NM_001320537

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:11024
Approved symbolSLC37A1
Namesolute carrier family 37 member 1
Location21q22.3
Locus typegene with protein product
StatusApproved
AliasesSPX1
Ensembl geneENSG00000160190
Ensembl biotypeprotein_coding
OMIM608094
Entrez54020

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 27 protein_coding, 4 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000352133, ENST00000398341, ENST00000398343, ENST00000419522, ENST00000454800, ENST00000471277, ENST00000484887, ENST00000487951, ENST00000496416, ENST00000893151, ENST00000893152, ENST00000893153, ENST00000893154, ENST00000893155, ENST00000893156, ENST00000893157, ENST00000893158, ENST00000893159, ENST00000922856, ENST00000922857, ENST00000922858, ENST00000922859, ENST00000922860, ENST00000922861, ENST00000922862, ENST00000922863, ENST00000960757, ENST00000960758, ENST00000960759, ENST00000960760, ENST00000960761, ENST00000960762

RefSeq mRNA: 2 — MANE Select: NM_001320537 NM_001320537, NM_018964

CCDS: CCDS13689

Canonical transcript exons

ENST00000352133 — 20 exons

ExonStartEnd
ENSE000010504144253469842534830
ENSE000010504174256381542563877
ENSE000010504194254240442542480
ENSE000010504204253547242535550
ENSE000010504234253951242539647
ENSE000010504254252577642525857
ENSE000010504274254710342547140
ENSE000010504284257973642579800
ENSE000010504294255895842559089
ENSE000010504304254343642543602
ENSE000010504314256470842564793
ENSE000011389384251385242514717
ENSE000012964584255406242554142
ENSE000024397894256207842562168
ENSE000035099434256836042568438
ENSE000035313804256582742565875
ENSE000035349694257481842574915
ENSE000036147774251827742518510
ENSE000036897954256698542567058
ENSE000038452554258034542581426

Expression profiles

Bgee: expression breadth ubiquitous, 199 present calls, max score 91.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.0285 / max 151.2561, expressed in 1286 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter IDTPM avgSamples expressed
1893075.47391216
1893081.0591532
1893091.0284453
1893130.278389
1893110.056728
1893120.047727
1893060.04436
1893100.040021

Top tissues by expression

266 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
olfactory segment of nasal mucosaUBERON:000538691.85gold quality
left testisUBERON:000453390.80gold quality
right uterine tubeUBERON:000130290.66gold quality
rectumUBERON:000105290.59gold quality
small intestine Peyer’s patchUBERON:000345490.56gold quality
adenohypophysisUBERON:000219690.26gold quality
right testisUBERON:000453489.98gold quality
gall bladderUBERON:000211089.36gold quality
lower esophagus mucosaUBERON:003583489.11gold quality
small intestineUBERON:000210889.09gold quality
transverse colonUBERON:000115788.89gold quality
minor salivary glandUBERON:000183088.33gold quality
pituitary glandUBERON:000000788.20gold quality
nasal cavity mucosaUBERON:000182687.49gold quality
duodenumUBERON:000211487.13gold quality
cortical plateUBERON:000534387.11gold quality
granulocyteCL:000009486.95gold quality
testisUBERON:000047386.85gold quality
mucosa of transverse colonUBERON:000499186.67gold quality
nasal cavity epitheliumUBERON:000538486.57gold quality
body of stomachUBERON:000116186.35gold quality
left lobe of thyroid glandUBERON:000112085.94gold quality
saliva-secreting glandUBERON:000104485.91gold quality
mouth mucosaUBERON:000372985.66gold quality
right lobe of thyroid glandUBERON:000111985.44gold quality
monocyteCL:000057685.32gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047385.29gold quality
mucosa of stomachUBERON:000119985.28gold quality
islet of LangerhansUBERON:000000684.92gold quality
esophagus mucosaUBERON:000246984.92gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

ExperimentMarker?Max mean expression
E-HCAD-6yes18.27
E-MTAB-9067yes11.84
E-ANND-3yes7.92

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting SLC37A1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-5692A100.0074.406850
HSA-MIR-29A-3P100.0073.111835
HSA-MIR-29B-3P100.0073.181833
HSA-MIR-29C-3P100.0073.151833
HSA-MIR-6867-5P100.0082.213464
HSA-MIR-19A-3P99.9875.332762
HSA-MIR-19B-3P99.9875.442754
HSA-MIR-548AN99.9770.912817
HSA-MIR-797899.8666.90856
HSA-MIR-548AJ-5P99.7871.123085
HSA-MIR-548F-5P99.7871.023093
HSA-MIR-548G-5P99.7871.123085
HSA-MIR-548X-5P99.7871.123085
HSA-MIR-488-3P99.6168.791731
HSA-MIR-425-5P99.5967.67900
HSA-MIR-5007-3P99.5168.141242
HSA-MIR-302A-5P99.3968.211913
HSA-MIR-450599.2767.812678
HSA-MIR-3191-5P99.2466.521722
HSA-MIR-578799.2267.862628
HSA-MIR-6815-3P99.1368.981530
HSA-MIR-4711-3P98.9766.871020
HSA-MIR-367-5P98.8467.18902
HSA-MIR-6761-5P98.7168.031504
HSA-MIR-4726-3P98.4963.891385
HSA-MIR-211798.4867.971307
HSA-MIR-550A-3P98.3769.61632
HSA-MIR-4436B-3P98.2565.261494
HSA-MIR-6735-5P98.2465.361488
HSA-MIR-7843-5P98.1265.261421

Literature-anchored findings (GeneRIF, showing 1)

  • Data show that SLC37A1 and SLC37A2 are endoplasmic reticulum associated, P(i)-linked antiporters, that can transport glucose-6-phosphate. (PMID:21949678)

Cross-species orthologs

51 orthologs

OrganismSymbolGene ID
danio_rerioslc37a1ENSDARG00000086103
mus_musculusSlc37a1ENSMUSG00000024036
rattus_norvegicusSlc37a1ENSRNOG00000001169
drosophila_melanogasterdmGlutFBGN0010497
drosophila_melanogasterMFS14FBGN0010651
drosophila_melanogasterPicotFBGN0024315
drosophila_melanogasterCG9254FBGN0028513
drosophila_melanogasterCG6978FBGN0029727
drosophila_melanogasterVGlutFBGN0031424
drosophila_melanogasterCG7881FBGN0033048
drosophila_melanogasterMFS12FBGN0033234
drosophila_melanogasterMFS15FBGN0034392
drosophila_melanogasterCG15096FBGN0034394
drosophila_melanogasterMFS16FBGN0034611
drosophila_melanogasterCG12490FBGN0034782
drosophila_melanogasterCG9825FBGN0034783
drosophila_melanogasterCG9826FBGN0034784
drosophila_melanogasterCG3649FBGN0034785
drosophila_melanogasterCG2003FBGN0039886
drosophila_melanogasterCG30265FBGN0050265
drosophila_melanogasterMFS1FBGN0050272
caenorhabditis_elegansWBGENE00001135
caenorhabditis_elegansWBGENE00007669
caenorhabditis_elegansWBGENE00008000
caenorhabditis_elegansWBGENE00008677
caenorhabditis_elegansWBGENE00010755
caenorhabditis_elegansWBGENE00010931
caenorhabditis_elegansWBGENE00011185
caenorhabditis_elegansWBGENE00011556
caenorhabditis_elegansWBGENE00012443
caenorhabditis_elegansWBGENE00015271
caenorhabditis_elegansWBGENE00015272
caenorhabditis_elegansWBGENE00016003
caenorhabditis_elegansWBGENE00018429
caenorhabditis_elegansWBGENE00018918
caenorhabditis_elegansWBGENE00018920
caenorhabditis_elegansWBGENE00019187
caenorhabditis_elegansWBGENE00019655
caenorhabditis_elegansWBGENE00020583
caenorhabditis_elegansWBGENE00020584
caenorhabditis_elegansWBGENE00020697
caenorhabditis_elegansWBGENE00020698
caenorhabditis_elegansWBGENE00020699
caenorhabditis_elegansWBGENE00020700
caenorhabditis_elegansWBGENE00021157
caenorhabditis_elegansWBGENE00021158
caenorhabditis_elegansWBGENE00021219
caenorhabditis_elegansWBGENE00021220
caenorhabditis_elegansWBGENE00021223
caenorhabditis_elegansWBGENE00021226
caenorhabditis_elegansWBGENE00302978

Paralogs (12): SLC17A6 (ENSG00000091664), SLC17A9 (ENSG00000101194), SLC17A7 (ENSG00000104888), SLC17A2 (ENSG00000112337), SLC17A5 (ENSG00000119899), SLC17A3 (ENSG00000124564), SLC17A1 (ENSG00000124568), SLC37A2 (ENSG00000134955), SLC37A4 (ENSG00000137700), SLC17A4 (ENSG00000146039), SLC37A3 (ENSG00000157800), SLC17A8 (ENSG00000179520)

Protein

Protein identifiers

Glucose-6-phosphate exchanger SLC37A1 — P57057 (reviewed: P57057)

Alternative names: Glycerol-3-phosphate permease, Solute carrier family 37 member 1

All UniProt accessions (2): P57057, A0A0C4DG69

UniProt curated annotations — full annotation on UniProt →

Function. Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Subcellular location. Endoplasmic reticulum membrane.

Tissue specificity. Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.

Activity regulation. Inhibited by vanadate but not by chlorogenic acid.

Similarity. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.

RefSeq proteins (2): NP_001307466, NP_061837 (=MANE)

Domains & families (InterPro)

IDNameType
IPR000849Sugar_P_transporterFamily
IPR011701MFSFamily
IPR020846MFS_domDomain
IPR036259MFS_trans_sfHomologous_superfamily
IPR044740SLC37A1_2Family

Pfam: PF07690

Catalyzed reactions (Rhea), 1 shown:

  • D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in) (RHEA:71535)

UniProt features (19 total): transmembrane region 12, glycosylation site 2, sequence variant 2, sequence conflict 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-P57057-F179.590.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 81, 263

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-70263Gluconeogenesis

MSigDB gene sets: 150 (showing top): GCANCTGNY_MYOD_Q6, GOZGIT_ESR1_TARGETS_DN, GOBP_INORGANIC_ANION_TRANSPORT, BOYLAN_MULTIPLE_MYELOMA_D_DN, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_DN, GOBP_PHOSPHATE_ION_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, REACTOME_GLUCONEOGENESIS, chr21q22, GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, CREIGHTON_AKT1_SIGNALING_VIA_MTOR_UP, MYB_Q5_01, REACTOME_METABOLISM_OF_CARBOHYDRATES_AND_CARBOHYDRATE_DERIVATIVES

GO Biological Process (3): glucose-6-phosphate transport (GO:0015760), phosphate ion transmembrane transport (GO:0035435), transmembrane transport (GO:0055085)

GO Molecular Function (3): glucose 6-phosphate:phosphate antiporter activity (GO:0061513), antiporter activity (GO:0015297), transmembrane transporter activity (GO:0022857)

GO Cellular Component (4): endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020), endoplasmic reticulum (GO:0005783), organelle membrane (GO:0031090)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Glucose metabolism1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
transmembrane transport2
hexose phosphate transport1
phosphate ion transport1
transport1
cellular process1
glucose-6-phosphate transmembrane transporter activity1
hexose-phosphate:phosphate antiporter activity1
secondary active transmembrane transporter activity1
transporter activity1
organelle membrane1
nuclear outer membrane-endoplasmic reticulum membrane network1
endoplasmic reticulum subcompartment1
cellular anatomical structure1
cytoplasm1
endomembrane system1
intracellular membrane-bounded organelle1
membrane1
membrane-bounded organelle1

Protein interactions and networks

STRING

1142 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
SLC37A1HLA-FP30511464
SLC37A1SLC16A5O15375437
SLC37A1PDE9AO76083424
SLC37A1CSN1S1P47710415
SLC37A1SEL1L3Q68CR1415
SLC37A1RSPH1Q8WYR4413
SLC37A1MGST1P10620412
SLC37A1WSCD1Q658N2398
SLC37A1GPAT4Q86UL3390
SLC37A1ANKHQ9HCJ1388
SLC37A1DGAT1O75907384
SLC37A1UBASH3AP57075364
SLC37A1SLC45A3Q96JT2356
SLC37A1SLC26A2P50443354
SLC37A1SLC25A36Q96CQ1353

IntAct

7 interactions, top by confidence:

ABTypeScore
SLC37A1ADRB2psi-mi:“MI:0915”(physical association)0.370
SLC37A1GPR35psi-mi:“MI:0915”(physical association)0.370
SLC37A1GPR37psi-mi:“MI:0915”(physical association)0.370
SLC37A1HTR2Bpsi-mi:“MI:0915”(physical association)0.370
DCAF4IGLL5psi-mi:“MI:0914”(association)0.350
SLC37A1ESYT2psi-mi:“MI:0914”(association)0.350

BioGRID (93): SLC37A1 (Affinity Capture-RNA), SLC37A1 (Affinity Capture-MS), SLC37A1 (Two-hybrid), SLC37A1 (Two-hybrid), SLC37A1 (Two-hybrid), SLC37A1 (Two-hybrid), ABCA3 (Affinity Capture-MS), ACBD3 (Affinity Capture-MS), ACVR1B (Affinity Capture-MS), ADCY3 (Affinity Capture-MS), ADCY9 (Affinity Capture-MS), ATP6V0A2 (Affinity Capture-MS), AUP1 (Affinity Capture-MS), BIRC2 (Affinity Capture-MS), BMPR1A (Affinity Capture-MS)

ESM2 similar proteins: A0A2K2AIF4, A0A2K2BF92, A0A6P3HVI0, A1L272, A2SWM2, B8AF63, B9H7I1, B9N9Y7, E2RFJ3, E7EXX2, O02228, O54902, O77741, O80605, P41251, P49279, P49280, P49281, P49282, P51027, P56436, P57057, P70553, Q0D7E4, Q27946, Q27981, Q5M7K3, Q5R6B8, Q5R839, Q653V6, Q6DIV6, Q6PF45, Q6YK44, Q86UD5, Q8AVC3, Q8BJA2, Q8CH36, Q8H4H5, Q8IVJ1, Q8L4X4

Diamond homologs: O23596, P57057, Q17QZ3, Q3TIT8, Q58CV5, Q5F3N0, Q5M7K3, Q640L2, Q7SY29, Q8AVC3, Q8NCC5, Q8R070, Q8TED4, Q9C5L3, Q9SA71, Q9SB41, Q9SL56, Q9WU81, P42205, P9WG86, P9WG87

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

137 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance85
Likely benign15
Benign10

Top pathogenic / likely-pathogenic (0)

SpliceAI

4321 predictions. Top by Δscore:

VariantEffectΔscore
21:42539510:A:AGacceptor_gain1.0000
21:42539511:G:GCacceptor_gain1.0000
21:42539511:GTGGC:Gacceptor_gain1.0000
21:42539644:TCAGG:Tdonor_loss1.0000
21:42539647:GGT:Gdonor_loss1.0000
21:42539648:G:GCdonor_loss1.0000
21:42539649:T:Gdonor_loss1.0000
21:42542476:GGAAG:Gdonor_gain1.0000
21:42542477:GAAGG:Gdonor_gain1.0000
21:42542478:A:Tdonor_gain1.0000
21:42542478:AAGGT:Adonor_loss1.0000
21:42542479:AGGTG:Adonor_loss1.0000
21:42542482:T:Gdonor_loss1.0000
21:42554058:CCA:Cacceptor_loss1.0000
21:42554059:CAGC:Cacceptor_loss1.0000
21:42554060:A:AGacceptor_gain1.0000
21:42554060:AG:Aacceptor_loss1.0000
21:42554061:G:GAacceptor_gain1.0000
21:42554061:GC:Gacceptor_gain1.0000
21:42554061:GCA:Gacceptor_gain1.0000
21:42554141:TGGTA:Tdonor_loss1.0000
21:42554142:GGTA:Gdonor_loss1.0000
21:42554143:GTAA:Gdonor_loss1.0000
21:42554144:T:Gdonor_loss1.0000
21:42558941:A:AGacceptor_gain1.0000
21:42558941:AAT:Aacceptor_gain1.0000
21:42558941:AATG:Aacceptor_gain1.0000
21:42558942:A:Gacceptor_gain1.0000
21:42558942:AT:Aacceptor_gain1.0000
21:42558942:ATG:Aacceptor_gain1.0000

AlphaMissense

3461 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
21:42543458:T:AW196R0.999
21:42543458:T:CW196R0.999
21:42562103:T:CL336P0.999
21:42525835:G:CR39P0.998
21:42562090:T:CF332L0.998
21:42562092:C:AF332L0.998
21:42562092:C:GF332L0.998
21:42568430:G:AG472D0.998
21:42568438:G:AG475R0.998
21:42568438:G:CG475R0.998
21:42574818:G:AG475E0.998
21:42535516:T:CF106L0.997
21:42535518:C:AF106L0.997
21:42535518:C:GF106L0.997
21:42542434:T:AW173R0.997
21:42542434:T:CW173R0.997
21:42562118:T:CL341P0.997
21:42562145:T:CL350P0.997
21:42567045:T:AV444D0.997
21:42568411:G:CA466P0.997
21:42568415:T:AI467N0.997
21:42568423:G:TG470W0.997
21:42568424:G:AG470E0.997
21:42568429:G:CG472R0.997
21:42574824:C:AA477D0.997
21:42574829:G:CG479R0.997
21:42525846:A:CS43R0.996
21:42525848:C:AS43R0.996
21:42525848:C:GS43R0.996
21:42525853:T:AV45D0.996

dbSNP variants (sampled 300 via entrez): RS1000018467 (21:42529975 C>G), RS1000023546 (21:42570332 G>A), RS1000074876 (21:42543943 G>C), RS1000098294 (21:42513134 C>A), RS1000164827 (21:42506639 C>T), RS1000221949 (21:42540902 C>G), RS1000226812 (21:42575356 C>T), RS1000230730 (21:42540640 G>C), RS1000240230 (21:42524565 G>T), RS1000271360 (21:42551182 A>G,T), RS1000339320 (21:42580947 T>C,G), RS1000367473 (21:42500762 T>G), RS1000371793 (21:42580685 G>A,C,T), RS1000376629 (21:42546523 C>T), RS1000393520 (21:42509579 G>A)

Disease associations

OMIM: gene MIM:608094 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

VariantGenesLevelScore#Clin annotsDrugs
rs35112095SLC37A10.000

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC37 family of phosphosugar/phosphate exchangers

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Aciddecreases expression, increases expression2
aristolochic acid Iincreases expression1
triphenyl phosphateaffects expression1
perfluorooctanoic aciddecreases expression1
manganese chlorideincreases expression, increases abundance1
benzo(e)pyreneincreases methylation1
nickel sulfateincreases expression1
perfluorooctane sulfonic aciddecreases expression1
CGP 52608affects binding, increases reaction1
perfluoro-n-nonanoic aciddecreases expression1
3-nitrobenzanthronedecreases expression1
perfluorohexanesulfonic aciddecreases expression1
2,2’,4,4’,5-brominated diphenyl etherincreases expression1
3-iodothyronamineaffects uptake1
abrineincreases expression1
jinfukangaffects cotreatment, increases expression1
(+)-JQ1 compounddecreases expression1
Zoledronic Acidincreases expression1
Benzo(a)pyrenedecreases methylation, increases methylation1
Cisplatinaffects cotreatment, increases expression1
Manganeseincreases abundance, increases expression1
Methapyrileneincreases methylation1
Tretinoinincreases expression1
Vanadatesdecreases expression1
Zidovudineincreases expression1
Antirheumatic Agentsdecreases expression1
Cadmium Chlorideincreases expression1
Okadaic Acidincreases expression1

Cellosaurus cell lines

7 cell lines: 7 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_1252HCC1428Cancer cell lineFemale
CVCL_C9DBHCC1428/Cas9-hygCancer cell lineFemale
CVCL_D4VXLS180-SLC37A1-KO-c2Cancer cell lineFemale
CVCL_D4VYLS180-SLC37A1-KO-c3Cancer cell lineFemale
CVCL_TN36HAP1 SLC37A1 (-) 1Cancer cell lineMale
CVCL_XT29HAP1 SLC37A1 (-) 2Cancer cell lineMale
CVCL_YX83HCC1428-LTEDCancer cell lineFemale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 76

This page pulls from 76 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgtopdb_interactiongwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot