SLC37A3
geneOn this page
Also known as DKFZp761N0624SPX3
Summary
SLC37A3 (solute carrier family 37 member 3, HGNC:20651) is a protein-coding gene on chromosome 7q34, encoding Sugar phosphate exchanger 3 (Q8NCC5). Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity.
Enables xenobiotic transmembrane transporter activity. Involved in xenobiotic transmembrane transport. Located in endoplasmic reticulum membrane and lysosomal membrane.
Source: NCBI Gene 84255 — RefSeq curated summary.
At a glance
- Gene–disease (curated): retinitis pigmentosa (Strong, GenCC)
- Clinical variants (ClinVar): 97 total
- MANE Select transcript:
NM_207113
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:20651 |
| Approved symbol | SLC37A3 |
| Name | solute carrier family 37 member 3 |
| Location | 7q34 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | DKFZp761N0624, SPX3 |
| Ensembl gene | ENSG00000157800 |
| Ensembl biotype | protein_coding |
| OMIM | 619137 |
| Entrez | 84255 |
Gene structure
Transcript identifiers
Ensembl transcripts: 44 — 29 protein_coding, 7 retained_intron, 5 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined
ENST00000326232, ENST00000340308, ENST00000447932, ENST00000460560, ENST00000461089, ENST00000462881, ENST00000464834, ENST00000464865, ENST00000467233, ENST00000469193, ENST00000469636, ENST00000473060, ENST00000473707, ENST00000477006, ENST00000477571, ENST00000484416, ENST00000485139, ENST00000485538, ENST00000485734, ENST00000485861, ENST00000487319, ENST00000490760, ENST00000491357, ENST00000491505, ENST00000492027, ENST00000493423, ENST00000495257, ENST00000498469, ENST00000904341, ENST00000904342, ENST00000904343, ENST00000904344, ENST00000937910, ENST00000937911, ENST00000937912, ENST00000937913, ENST00000937914, ENST00000937915, ENST00000937916, ENST00000937917, ENST00000937918, ENST00000952704, ENST00000952705, ENST00000952706
RefSeq mRNA: 9 — MANE Select: NM_207113
NM_001287498, NM_001363373, NM_001363374, NM_001363375, NM_001363376, NM_001363377, NM_001363378, NM_032295, NM_207113
CCDS: CCDS5858, CCDS5859, CCDS75669
Canonical transcript exons
ENST00000326232 — 15 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001938760 | 140398416 | 140398530 |
| ENSE00003465444 | 140337284 | 140337349 |
| ENSE00003480994 | 140355668 | 140355764 |
| ENSE00003487181 | 140345869 | 140345970 |
| ENSE00003495331 | 140351273 | 140351451 |
| ENSE00003497782 | 140358640 | 140358785 |
| ENSE00003508938 | 140369590 | 140369682 |
| ENSE00003571762 | 140333752 | 140335504 |
| ENSE00003587166 | 140343412 | 140343563 |
| ENSE00003588231 | 140382438 | 140382596 |
| ENSE00003617127 | 140380282 | 140380390 |
| ENSE00003648289 | 140364408 | 140364491 |
| ENSE00003654242 | 140345216 | 140345263 |
| ENSE00003784224 | 140352062 | 140352146 |
| ENSE00003784247 | 140348626 | 140348767 |
Expression profiles
Bgee: expression breadth ubiquitous, 245 present calls, max score 96.17.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.2579 / max 75.7651, expressed in 1657 samples.
FANTOM5 promoters (2 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 86549 | 6.2507 | 1657 |
| 86548 | 0.0072 | 3 |
Top tissues by expression
252 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| body of uterus | UBERON:0009853 | 96.17 | gold quality |
| decidua | UBERON:0002450 | 95.35 | gold quality |
| smooth muscle tissue | UBERON:0001135 | 94.48 | gold quality |
| myometrium | UBERON:0001296 | 94.31 | gold quality |
| colonic epithelium | UBERON:0000397 | 93.97 | gold quality |
| endocervix | UBERON:0000458 | 93.78 | gold quality |
| cortical plate | UBERON:0005343 | 93.65 | gold quality |
| uterus | UBERON:0000995 | 93.62 | gold quality |
| stromal cell of endometrium | CL:0002255 | 93.44 | gold quality |
| left uterine tube | UBERON:0001303 | 93.41 | gold quality |
| endometrium | UBERON:0001295 | 92.64 | gold quality |
| body of pancreas | UBERON:0001150 | 92.57 | gold quality |
| mucosa of stomach | UBERON:0001199 | 92.43 | gold quality |
| uterine cervix | UBERON:0000002 | 92.22 | gold quality |
| rectum | UBERON:0001052 | 92.20 | gold quality |
| cartilage tissue | UBERON:0002418 | 91.79 | gold quality |
| left ovary | UBERON:0002119 | 91.72 | gold quality |
| ectocervix | UBERON:0012249 | 91.68 | gold quality |
| muscle layer of sigmoid colon | UBERON:0035805 | 91.55 | gold quality |
| right ovary | UBERON:0002118 | 91.43 | gold quality |
| transverse colon | UBERON:0001157 | 91.33 | gold quality |
| pancreas | UBERON:0001264 | 91.33 | gold quality |
| colon | UBERON:0001155 | 91.12 | gold quality |
| large intestine | UBERON:0000059 | 91.09 | gold quality |
| right uterine tube | UBERON:0001302 | 91.01 | gold quality |
| ascending aorta | UBERON:0001496 | 90.96 | gold quality |
| thoracic aorta | UBERON:0001515 | 90.93 | gold quality |
| gall bladder | UBERON:0002110 | 90.92 | gold quality |
| colonic mucosa | UBERON:0000317 | 90.81 | gold quality |
| ileal mucosa | UBERON:0000331 | 90.81 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | no | 0.00 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
64 targeting SLC37A3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-3163 | 100.00 | 77.23 | 8605 |
| HSA-MIR-340-5P | 100.00 | 72.50 | 4437 |
| HSA-MIR-3924 | 100.00 | 72.09 | 2394 |
| HSA-MIR-223-3P | 99.99 | 70.14 | 1140 |
| HSA-MIR-6077 | 99.99 | 68.04 | 2299 |
| HSA-MIR-545-3P | 99.95 | 70.74 | 2783 |
| HSA-MIR-1236-3P | 99.94 | 68.04 | 1695 |
| HSA-MIR-6835-3P | 99.93 | 70.49 | 2904 |
| HSA-MIR-338-5P | 99.92 | 72.34 | 2951 |
| HSA-MIR-1305 | 99.91 | 71.43 | 3443 |
| HSA-MIR-95-5P | 99.89 | 72.17 | 3973 |
| HSA-MIR-4697-3P | 99.89 | 67.09 | 1123 |
| HSA-MIR-204-5P | 99.79 | 71.62 | 2439 |
| HSA-MIR-211-5P | 99.79 | 71.65 | 2440 |
| HSA-MIR-623 | 99.76 | 68.16 | 1170 |
| HSA-MIR-4446-5P | 99.72 | 69.19 | 2544 |
| HSA-MIR-4422 | 99.72 | 72.07 | 2908 |
| HSA-MIR-4755-5P | 99.71 | 70.34 | 2716 |
| HSA-MIR-5006-3P | 99.71 | 70.26 | 2728 |
| HSA-MIR-377-5P | 99.70 | 65.28 | 712 |
| HSA-MIR-6086 | 99.70 | 65.38 | 699 |
| HSA-MIR-7154-5P | 99.69 | 70.52 | 1900 |
| HSA-MIR-142-3P | 99.62 | 71.30 | 974 |
| HSA-MIR-1260A | 99.61 | 66.67 | 1098 |
| HSA-MIR-1260B | 99.61 | 66.67 | 1098 |
| HSA-MIR-7152-5P | 99.60 | 69.33 | 2094 |
| HSA-MIR-1252-3P | 99.55 | 67.71 | 2862 |
| HSA-MIR-6832-3P | 99.52 | 70.44 | 1726 |
| HSA-MIR-330-3P | 99.41 | 69.95 | 2521 |
| HSA-MIR-5580-5P | 99.38 | 66.96 | 1139 |
Literature-anchored findings (GeneRIF, showing 1)
- SLC37A3 protein localizes in lysosomes in HeLa cells (PMID:21752829)
Cross-species orthologs
7 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| drosophila_melanogaster | dmGlut | FBGN0010497 |
| drosophila_melanogaster | Picot | FBGN0024315 |
| drosophila_melanogaster | CG9254 | FBGN0028513 |
| drosophila_melanogaster | CG6978 | FBGN0029727 |
| drosophila_melanogaster | MFS16 | FBGN0034611 |
| caenorhabditis_elegans | WBGENE00011717 | |
| caenorhabditis_elegans | WBGENE00011719 |
Paralogs (12): SLC17A6 (ENSG00000091664), SLC17A9 (ENSG00000101194), SLC17A7 (ENSG00000104888), SLC17A2 (ENSG00000112337), SLC17A5 (ENSG00000119899), SLC17A3 (ENSG00000124564), SLC17A1 (ENSG00000124568), SLC37A2 (ENSG00000134955), SLC37A4 (ENSG00000137700), SLC17A4 (ENSG00000146039), SLC37A1 (ENSG00000160190), SLC17A8 (ENSG00000179520)
Protein
Protein identifiers
Sugar phosphate exchanger 3 — Q8NCC5 (reviewed: Q8NCC5)
Alternative names: Solute carrier family 37 member 3
All UniProt accessions (16): C9J4S7, C9JZ37, Q8NCC5, F8WAR9, F8WC97, F8WF28, H7C4I4, H7C4J2, H7C4J3, H7C4J5, H7C4U0, H7C4U5, H7C4Z5, H7C594, H7C5E7, H7C5T4
UniProt curated annotations — full annotation on UniProt →
Function. Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol.
Subunit / interactions. Interacts with ATRAID; the interaction is direct and both proteins are mutually dependent for their stability.
Subcellular location. Endoplasmic reticulum membrane. Lysosome membrane.
Tissue specificity. Expressed in liver, kidney, intestine and pancreas.
Post-translational modifications. Glycosylated.
Similarity. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Isoforms (3)
| UniProt ID | Names | Canonical? |
|---|---|---|
| Q8NCC5-1 | 1 | yes |
| Q8NCC5-2 | 2 | |
| Q8NCC5-3 | 3 |
RefSeq proteins (9): NP_001274427, NP_001350302, NP_001350303, NP_001350304, NP_001350305, NP_001350306, NP_001350307, NP_115671, NP_996996* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR000849 | Sugar_P_transporter | Family |
| IPR011701 | MFS | Family |
| IPR020846 | MFS_dom | Domain |
| IPR036259 | MFS_trans_sf | Homologous_superfamily |
Pfam: PF07690
UniProt features (20 total): transmembrane region 12, splice variant 3, glycosylation site 2, sequence conflict 2, chain 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q8NCC5-F1 | 84.11 | 0.57 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Glycosylation sites (2): 58, 266
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 149 (showing top):
GOCC_VACUOLAR_MEMBRANE, GOBP_INORGANIC_ANION_TRANSPORT, GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, GOBP_PHOSPHATE_ION_TRANSPORT, ACATTCC_MIR1_MIR206, GOBP_ORGANIC_ANION_TRANSPORT, AAAGGGA_MIR204_MIR211, KUNINGER_IGF1_VS_PDGFB_TARGETS_DN, GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, MARSON_BOUND_BY_FOXP3_STIMULATED, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, ZHENG_FOXP3_TARGETS_IN_THYMUS_UP, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK
GO Biological Process (2): xenobiotic transmembrane transport (GO:0006855), transmembrane transport (GO:0055085)
GO Molecular Function (3): xenobiotic transmembrane transporter activity (GO:0042910), protein binding (GO:0005515), transmembrane transporter activity (GO:0022857)
GO Cellular Component (5): lysosomal membrane (GO:0005765), endoplasmic reticulum membrane (GO:0005789), lysosome (GO:0005764), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| xenobiotic transport | 2 |
| transmembrane transport | 2 |
| transport | 1 |
| cellular process | 1 |
| transmembrane transporter activity | 1 |
| binding | 1 |
| transporter activity | 1 |
| lysosome | 1 |
| lytic vacuole membrane | 1 |
| organelle membrane | 1 |
| nuclear outer membrane-endoplasmic reticulum membrane network | 1 |
| endoplasmic reticulum subcompartment | 1 |
| lytic vacuole | 1 |
| cytoplasm | 1 |
| endomembrane system | 1 |
| intracellular membrane-bounded organelle | 1 |
| cellular anatomical structure | 1 |
Protein interactions and networks
STRING
912 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| SLC37A3 | ATRAID | Q6UW56 | 654 |
| SLC37A3 | SLC68A1 | Q14CX5 | 498 |
| SLC37A3 | MFSD11 | O43934 | 498 |
| SLC37A3 | SLC67A2 | Q8NBP5 | 496 |
| SLC37A3 | MFSD6 | Q6ZSS7 | 466 |
| SLC37A3 | SLC71A2 | Q5SR56 | 458 |
| SLC37A3 | SLC41A2 | Q96JW4 | 445 |
| SLC37A3 | SETD4 | Q9NVD3 | 445 |
| SLC37A3 | MKLN1 | Q9UL63 | 443 |
| SLC37A3 | ST6GAL2 | Q96JF0 | 438 |
| SLC37A3 | KDM7A | Q6ZMT4 | 417 |
| SLC37A3 | SLC20A1 | Q8WUM9 | 406 |
| SLC37A3 | SLC35B1 | P78383 | 406 |
| SLC37A3 | PCDH9 | Q9HC56 | 404 |
| SLC37A3 | SLC5A7 | Q9GZV3 | 401 |
IntAct
5 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| FOXJ1 | SLC37A3 | psi-mi:“MI:0915”(physical association) | 0.370 |
| SLC37A3 | ZNF177 | psi-mi:“MI:0915”(physical association) | 0.370 |
| SLC37A3 | APOB | psi-mi:“MI:0914”(association) | 0.350 |
| SLC37A3 | PLXNB2 | psi-mi:“MI:0914”(association) | 0.350 |
BioGRID (95): SPRYD7 (Affinity Capture-MS), ATRAID (Affinity Capture-MS), CAV1 (Affinity Capture-MS), CLTCL1 (Affinity Capture-MS), APOB (Affinity Capture-MS), SLC25A46 (Affinity Capture-MS), MTX3 (Affinity Capture-MS), RNASEL (Affinity Capture-MS), TUBGCP2 (Affinity Capture-MS), ATP12A (Affinity Capture-MS), CYB5R3 (Affinity Capture-MS), DNAJC19 (Affinity Capture-MS), ARL15 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC5A3 (Affinity Capture-MS)
ESM2 similar proteins: A1L272, A2CER7, A2SWM2, A4IH46, A8WGF7, B0JZE1, B8AF63, O35440, O70451, O80605, P30638, P57057, Q08DX7, Q0IHM1, Q0VA82, Q10R54, Q2XWK0, Q2YDU8, Q3TIT8, Q3U9N9, Q5F3N0, Q5M7K3, Q5U3U7, Q5XGK0, Q63344, Q640L2, Q6DEJ6, Q6GPQ3, Q6YK44, Q6ZMD2, Q7SY29, Q7ZU13, Q8AVC3, Q8BH31, Q8K078, Q8NA29, Q8NCC5, Q8NHS3, Q8R070, Q8R0G7
Diamond homologs: O23596, P57057, Q17QZ3, Q3TIT8, Q58CV5, Q5F3N0, Q5M7K3, Q640L2, Q7SY29, Q8AVC3, Q8NCC5, Q8R070, Q8TED4, Q9C5L3, Q9SA71, Q9SB41, Q9SL56, Q9WU81, P42205, P9WG86, P9WG87
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
97 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 64 |
| Likely benign | 3 |
| Benign | 5 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
3159 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 7:140337348:TA:T | acceptor_gain | 1.0000 |
| 7:140337350:C:CC | acceptor_gain | 1.0000 |
| 7:140348623:TAC:T | donor_loss | 1.0000 |
| 7:140348624:A:T | donor_loss | 1.0000 |
| 7:140348628:ATGAT:A | donor_gain | 1.0000 |
| 7:140348715:C:CT | acceptor_gain | 1.0000 |
| 7:140348765:GTA:G | acceptor_gain | 1.0000 |
| 7:140348766:TA:T | acceptor_gain | 1.0000 |
| 7:140348767:ACTA:A | acceptor_loss | 1.0000 |
| 7:140348768:C:CA | acceptor_loss | 1.0000 |
| 7:140348768:C:CC | acceptor_gain | 1.0000 |
| 7:140351269:TTAC:T | donor_loss | 1.0000 |
| 7:140351270:TACCG:T | donor_loss | 1.0000 |
| 7:140351271:A:AC | donor_gain | 1.0000 |
| 7:140351271:ACC:A | donor_loss | 1.0000 |
| 7:140351272:C:CC | donor_gain | 1.0000 |
| 7:140351313:ATCG:A | donor_gain | 1.0000 |
| 7:140351836:T:A | donor_gain | 1.0000 |
| 7:140351865:C:CA | donor_gain | 1.0000 |
| 7:140351866:C:A | donor_gain | 1.0000 |
| 7:140352147:C:CC | acceptor_gain | 1.0000 |
| 7:140355778:C:CT | acceptor_gain | 1.0000 |
| 7:140355779:A:T | acceptor_gain | 1.0000 |
| 7:140358634:GCATA:G | donor_loss | 1.0000 |
| 7:140358635:CATA:C | donor_loss | 1.0000 |
| 7:140358636:ATAC:A | donor_loss | 1.0000 |
| 7:140358637:TA:T | donor_loss | 1.0000 |
| 7:140358639:CCCGG:C | donor_gain | 1.0000 |
| 7:140358647:T:A | donor_gain | 1.0000 |
| 7:140369583:AACTT:A | donor_loss | 1.0000 |
AlphaMissense
3214 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 7:140355742:A:G | W182R | 1.000 |
| 7:140355742:A:T | W182R | 1.000 |
| 7:140343443:C:T | G432D | 0.999 |
| 7:140343563:C:T | G392E | 0.999 |
| 7:140355720:C:A | G189V | 0.999 |
| 7:140355721:C:G | G189R | 0.999 |
| 7:140355747:C:T | G180D | 0.999 |
| 7:140358686:A:G | W159R | 0.999 |
| 7:140358686:A:T | W159R | 0.999 |
| 7:140343433:G:C | S435R | 0.998 |
| 7:140343433:G:T | S435R | 0.998 |
| 7:140343435:T:G | S435R | 0.998 |
| 7:140343437:C:T | G434E | 0.998 |
| 7:140343438:C:A | G434W | 0.998 |
| 7:140343447:C:G | D431H | 0.998 |
| 7:140343529:A:C | S403R | 0.998 |
| 7:140343529:A:T | S403R | 0.998 |
| 7:140343531:T:G | S403R | 0.998 |
| 7:140355720:C:T | G189D | 0.998 |
| 7:140355721:C:A | G189C | 0.998 |
| 7:140358684:C:A | W159C | 0.998 |
| 7:140358684:C:G | W159C | 0.998 |
| 7:140358694:G:A | S156F | 0.998 |
| 7:140364491:C:G | G98R | 0.998 |
| 7:140380390:A:C | S30R | 0.998 |
| 7:140380390:A:T | S30R | 0.998 |
| 7:140382439:T:G | S30R | 0.998 |
| 7:140343444:C:G | G432R | 0.997 |
| 7:140343455:C:T | G428E | 0.997 |
| 7:140343461:A:T | V426D | 0.997 |
dbSNP variants (sampled 300 via entrez): RS1000047037 (7:140389637 C>T), RS1000138083 (7:140390432 A>G), RS1000143169 (7:140350728 C>A,T), RS1000152851 (7:140397827 G>A), RS1000234230 (7:140370377 T>C), RS1000251328 (7:140397285 C>G,T), RS1000332899 (7:140377221 T>G), RS1000340152 (7:140338132 C>T), RS1000420178 (7:140390786 T>C), RS1000428948 (7:140384666 C>G), RS1000514242 (7:140364213 T>C), RS1000574835 (7:140372038 G>C,T), RS1000606050 (7:140371857 T>G), RS1000681725 (7:140333561 G>A,C), RS1000737436 (7:140370957 C>G)
Disease associations
OMIM: gene MIM:619137 | disease phenotypes:
GenCC curated gene-disease
| Disease | Classification | Inheritance |
|---|---|---|
| retinitis pigmentosa | Strong | Autosomal recessive |
Mondo (1): retinitis pigmentosa (MONDO:0019200)
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
0 associations (top):
MeSH disease descriptors (1)
| Descriptor | Name | Tree numbers |
|---|---|---|
| D012174 | Retinitis Pigmentosa | C11.270.684; C11.768.585.658.500; C16.320.290.684 |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
GtoPdb / IUPHAR curated pharmacology
(IUPHAR/BPS Guide to Pharmacology — expert-curated)
Target class: transporter — SLC37 family of phosphosugar/phosphate exchangers
CTD chemical–gene interactions
29 total (human), top 29 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Air Pollutants | increases abundance, increases oxidation, affects cotreatment, decreases expression | 2 |
| dicrotophos | decreases expression | 1 |
| triphenyl phosphate | affects expression | 1 |
| alpha-pinene | affects cotreatment, decreases expression, increases oxidation, increases abundance | 1 |
| beta-lapachone | increases expression | 1 |
| sodium arsenite | affects cotreatment, decreases expression, increases abundance | 1 |
| manganese chloride | increases abundance, affects cotreatment, decreases expression | 1 |
| nickel sulfate | decreases expression | 1 |
| methacrylaldehyde | affects cotreatment, decreases expression, increases oxidation, increases abundance | 1 |
| di-n-butylphosphoric acid | affects expression | 1 |
| Resveratrol | increases expression, affects cotreatment | 1 |
| Acrolein | increases abundance, affects cotreatment, decreases expression, increases oxidation | 1 |
| Arsenic | affects cotreatment, decreases expression, increases abundance | 1 |
| Benzo(a)pyrene | increases methylation | 1 |
| Doxorubicin | decreases expression | 1 |
| Drugs, Chinese Herbal | increases expression | 1 |
| Estradiol | increases expression | 1 |
| Manganese | affects cotreatment, decreases expression, increases abundance | 1 |
| Naphthoquinones | increases expression | 1 |
| Ozone | affects cotreatment, decreases expression, increases oxidation, increases abundance | 1 |
| Plant Extracts | affects cotreatment, increases expression | 1 |
| T-2 Toxin | decreases expression | 1 |
| Dronabinol | decreases expression | 1 |
| Tretinoin | decreases expression | 1 |
| Cyclosporine | increases expression | 1 |
| Antirheumatic Agents | increases expression | 1 |
| Cadmium Chloride | decreases expression | 1 |
| Particulate Matter | decreases expression, increases abundance | 1 |
| Volatile Organic Compounds | affects cotreatment, decreases expression, increases oxidation | 1 |
Cellosaurus cell lines
4 cell lines: 4 cancer cell line
First 10 cell lines (id-ordered, not curated):
| Cellosaurus | Name | Category | Sex |
|---|---|---|---|
| CVCL_D4MV | HCT116-SLC37A3-KO-c11 | Cancer cell line | Male |
| CVCL_D4MW | HCT116-SLC37A3-KO-c4 | Cancer cell line | Male |
| CVCL_D4MX | HCT116-SLC37A3-KO-c9 | Cancer cell line | Male |
| CVCL_E0NW | Ubigene HeLa SLC37A3 KO | Cancer cell line | Female |
Clinical trials (associated diseases)
234 trials via MONDO — disease-level, not drug-specific.
| Trial | Phase | Status | Title |
|---|---|---|---|
| NCT00717080 | PHASE4 | COMPLETED | The Role of Capsular Tension Ring (CTR) in Anterior Capsular Contraction |
| NCT00000114 | PHASE3 | COMPLETED | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa |
| NCT00000116 | PHASE3 | COMPLETED | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A |
| NCT00346333 | PHASE3 | COMPLETED | Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A |
| NCT01786395 | PHASE3 | TERMINATED | Phase III Efficacy and Safety Clinical Study of UF-021 for Treatment of Retinitis Pigmentosa |
| NCT04224207 | PHASE3 | COMPLETED | Management of Retinitis Pigmentosa by Mesenchymal Stem Cells by Wharton’s Jelly Derived Mesenchymal Stem Cells |
| NCT04636853 | PHASE3 | COMPLETED | CB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration |
| NCT05537220 | PHASE3 | ACTIVE_NOT_RECRUITING | Oral N-acetylcysteine for Retinitis Pigmentosa |
| NCT05800301 | PHASE3 | COMPLETED | Management of Retinitis Pigmentosa Via Combination of Wharton’s Jelly-derived Mesenchymal Stem Cells and Magnovision |
| NCT05926583 | PHASE3 | ACTIVE_NOT_RECRUITING | A Study of AAV5-hRKp.RPGR for the Treatment of Japanese Participants With X-linked Retinitis Pigmentosa |
| NCT06388200 | PHASE3 | ACTIVE_NOT_RECRUITING | A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa |
| NCT07082855 | PHASE3 | NOT_YET_RECRUITING | A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa |
| NCT07290530 | PHASE3 | NOT_YET_RECRUITING | 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome |
| NCT00100230 | PHASE2 | COMPLETED | DHA and X-Linked Retinitis Pigmentosa |
| NCT00447980 | PHASE2 | COMPLETED | A Study of Encapsulated Cell Technology (ECT) Implant for Participants With Early Stage Retinitis Pigmentosa |
| NCT00447993 | PHASE2 | COMPLETED | A Study of Encapsulated Cell Technology (ECT) Implant for Patients With Late Stage Retinitis Pigmentosa |
| NCT01233609 | PHASE2 | COMPLETED | Trial of Oral Valproic Acid for Retinitis Pigmentosa |
| NCT01399515 | PHASE2 | COMPLETED | Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa |
| NCT01530659 | PHASE2 | COMPLETED | Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa |
| NCT01560715 | PHASE2 | COMPLETED | Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa |
| NCT02609165 | PHASE2 | COMPLETED | Nerve Growth Factor Eye Drops Treatment in Patients With Retinitis Pigmentosa and Cystoid Macular Edema |
| NCT02661711 | PHASE2 | COMPLETED | Aflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study |
| NCT02804360 | PHASE2 | UNKNOWN | Intravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Macular Edema- a Retrospective Study |
| NCT02837640 | PHASE2 | UNKNOWN | Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa |
| NCT03073733 | PHASE2 | COMPLETED | Safety and Efficacy of Intravitreal Injection of Human Retinal Progenitor Cells in Adults With Retinitis Pigmentosa |
| NCT04068207 | PHASE2 | COMPLETED | Minocycline Treatment in Retinitis Pigmentosa |
| NCT04356716 | PHASE2 | COMPLETED | Sildenafil for Treatment of Choroidal Ischemia |
| NCT04604899 | PHASE2 | COMPLETED | Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects With Retinitis Pigmentosa |
| NCT04763369 | PHASE2 | UNKNOWN | Investigation of Therapeutic Efficacy and Safety of UMSCs for the Management of Retinitis Pigmentosa (RP) |
| NCT04864496 | PHASE2 | UNKNOWN | Effects of Treatment With N- Acetylcysteine on Visual Outcomes in Patients With Retinitis Pigmentosa |
| NCT04945772 | PHASE2 | COMPLETED | Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE] |
| NCT05085964 | PHASE2 | TERMINATED | An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa |
| NCT05392179 | PHASE2 | COMPLETED | A Study in Subjects With Retinitis Pigmentosa |
| NCT06627179 | PHASE2 | RECRUITING | Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene |
| NCT06628947 | PHASE2 | RECRUITING | A Phase II Study of Intravitreal KIO-301 in Patients With Late-stage Retinitis Pigmentosa |
| NCT06912633 | PHASE2 | RECRUITING | Safety of a Single, Intravitreal Injection of 6.0M jCell (Famzeretcel) in Retinitis Pigmentosa (RP) |
| NCT00063765 | PHASE1 | COMPLETED | Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye |
| NCT00065455 | PHASE1 | COMPLETED | Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa |
| NCT00458575 | PHASE1 | TERMINATED | A Study to Evaluate the Safety of CNTO 2476 in Patients With Advanced Retinitis Pigmentosa |
| NCT01068561 | PHASE1 | COMPLETED | Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa |
Related Atlas pages
- Associated diseases: retinitis pigmentosa 1
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): retinitis pigmentosa