SLC37A3

gene
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Also known as DKFZp761N0624SPX3

Summary

SLC37A3 (solute carrier family 37 member 3, HGNC:20651) is a protein-coding gene on chromosome 7q34, encoding Sugar phosphate exchanger 3 (Q8NCC5). Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity.

Enables xenobiotic transmembrane transporter activity. Involved in xenobiotic transmembrane transport. Located in endoplasmic reticulum membrane and lysosomal membrane.

Source: NCBI Gene 84255 — RefSeq curated summary.

At a glance

  • Gene–disease (curated): retinitis pigmentosa (Strong, GenCC)
  • Clinical variants (ClinVar): 97 total
  • MANE Select transcript: NM_207113

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:20651
Approved symbolSLC37A3
Namesolute carrier family 37 member 3
Location7q34
Locus typegene with protein product
StatusApproved
AliasesDKFZp761N0624, SPX3
Ensembl geneENSG00000157800
Ensembl biotypeprotein_coding
OMIM619137
Entrez84255

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 29 protein_coding, 7 retained_intron, 5 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined

ENST00000326232, ENST00000340308, ENST00000447932, ENST00000460560, ENST00000461089, ENST00000462881, ENST00000464834, ENST00000464865, ENST00000467233, ENST00000469193, ENST00000469636, ENST00000473060, ENST00000473707, ENST00000477006, ENST00000477571, ENST00000484416, ENST00000485139, ENST00000485538, ENST00000485734, ENST00000485861, ENST00000487319, ENST00000490760, ENST00000491357, ENST00000491505, ENST00000492027, ENST00000493423, ENST00000495257, ENST00000498469, ENST00000904341, ENST00000904342, ENST00000904343, ENST00000904344, ENST00000937910, ENST00000937911, ENST00000937912, ENST00000937913, ENST00000937914, ENST00000937915, ENST00000937916, ENST00000937917, ENST00000937918, ENST00000952704, ENST00000952705, ENST00000952706

RefSeq mRNA: 9 — MANE Select: NM_207113 NM_001287498, NM_001363373, NM_001363374, NM_001363375, NM_001363376, NM_001363377, NM_001363378, NM_032295, NM_207113

CCDS: CCDS5858, CCDS5859, CCDS75669

Canonical transcript exons

ENST00000326232 — 15 exons

ExonStartEnd
ENSE00001938760140398416140398530
ENSE00003465444140337284140337349
ENSE00003480994140355668140355764
ENSE00003487181140345869140345970
ENSE00003495331140351273140351451
ENSE00003497782140358640140358785
ENSE00003508938140369590140369682
ENSE00003571762140333752140335504
ENSE00003587166140343412140343563
ENSE00003588231140382438140382596
ENSE00003617127140380282140380390
ENSE00003648289140364408140364491
ENSE00003654242140345216140345263
ENSE00003784224140352062140352146
ENSE00003784247140348626140348767

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 96.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.2579 / max 75.7651, expressed in 1657 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
865496.25071657
865480.00723

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
body of uterusUBERON:000985396.17gold quality
deciduaUBERON:000245095.35gold quality
smooth muscle tissueUBERON:000113594.48gold quality
myometriumUBERON:000129694.31gold quality
colonic epitheliumUBERON:000039793.97gold quality
endocervixUBERON:000045893.78gold quality
cortical plateUBERON:000534393.65gold quality
uterusUBERON:000099593.62gold quality
stromal cell of endometriumCL:000225593.44gold quality
left uterine tubeUBERON:000130393.41gold quality
endometriumUBERON:000129592.64gold quality
body of pancreasUBERON:000115092.57gold quality
mucosa of stomachUBERON:000119992.43gold quality
uterine cervixUBERON:000000292.22gold quality
rectumUBERON:000105292.20gold quality
cartilage tissueUBERON:000241891.79gold quality
left ovaryUBERON:000211991.72gold quality
ectocervixUBERON:001224991.68gold quality
muscle layer of sigmoid colonUBERON:003580591.55gold quality
right ovaryUBERON:000211891.43gold quality
transverse colonUBERON:000115791.33gold quality
pancreasUBERON:000126491.33gold quality
colonUBERON:000115591.12gold quality
large intestineUBERON:000005991.09gold quality
right uterine tubeUBERON:000130291.01gold quality
ascending aortaUBERON:000149690.96gold quality
thoracic aortaUBERON:000151590.93gold quality
gall bladderUBERON:000211090.92gold quality
colonic mucosaUBERON:000031790.81gold quality
ileal mucosaUBERON:000033190.81gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3no0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

64 targeting SLC37A3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-3163100.0077.238605
HSA-MIR-340-5P100.0072.504437
HSA-MIR-3924100.0072.092394
HSA-MIR-223-3P99.9970.141140
HSA-MIR-607799.9968.042299
HSA-MIR-545-3P99.9570.742783
HSA-MIR-1236-3P99.9468.041695
HSA-MIR-6835-3P99.9370.492904
HSA-MIR-338-5P99.9272.342951
HSA-MIR-130599.9171.433443
HSA-MIR-95-5P99.8972.173973
HSA-MIR-4697-3P99.8967.091123
HSA-MIR-204-5P99.7971.622439
HSA-MIR-211-5P99.7971.652440
HSA-MIR-62399.7668.161170
HSA-MIR-4446-5P99.7269.192544
HSA-MIR-442299.7272.072908
HSA-MIR-4755-5P99.7170.342716
HSA-MIR-5006-3P99.7170.262728
HSA-MIR-377-5P99.7065.28712
HSA-MIR-608699.7065.38699
HSA-MIR-7154-5P99.6970.521900
HSA-MIR-142-3P99.6271.30974
HSA-MIR-1260A99.6166.671098
HSA-MIR-1260B99.6166.671098
HSA-MIR-7152-5P99.6069.332094
HSA-MIR-1252-3P99.5567.712862
HSA-MIR-6832-3P99.5270.441726
HSA-MIR-330-3P99.4169.952521
HSA-MIR-5580-5P99.3866.961139

Literature-anchored findings (GeneRIF, showing 1)

  • SLC37A3 protein localizes in lysosomes in HeLa cells (PMID:21752829)

Cross-species orthologs

7 orthologs

OrganismSymbolGene ID
drosophila_melanogasterdmGlutFBGN0010497
drosophila_melanogasterPicotFBGN0024315
drosophila_melanogasterCG9254FBGN0028513
drosophila_melanogasterCG6978FBGN0029727
drosophila_melanogasterMFS16FBGN0034611
caenorhabditis_elegansWBGENE00011717
caenorhabditis_elegansWBGENE00011719

Paralogs (12): SLC17A6 (ENSG00000091664), SLC17A9 (ENSG00000101194), SLC17A7 (ENSG00000104888), SLC17A2 (ENSG00000112337), SLC17A5 (ENSG00000119899), SLC17A3 (ENSG00000124564), SLC17A1 (ENSG00000124568), SLC37A2 (ENSG00000134955), SLC37A4 (ENSG00000137700), SLC17A4 (ENSG00000146039), SLC37A1 (ENSG00000160190), SLC17A8 (ENSG00000179520)

Protein

Protein identifiers

Sugar phosphate exchanger 3Q8NCC5 (reviewed: Q8NCC5)

Alternative names: Solute carrier family 37 member 3

All UniProt accessions (16): C9J4S7, C9JZ37, Q8NCC5, F8WAR9, F8WC97, F8WF28, H7C4I4, H7C4J2, H7C4J3, H7C4J5, H7C4U0, H7C4U5, H7C4Z5, H7C594, H7C5E7, H7C5T4

UniProt curated annotations — full annotation on UniProt →

Function. Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol.

Subunit / interactions. Interacts with ATRAID; the interaction is direct and both proteins are mutually dependent for their stability.

Subcellular location. Endoplasmic reticulum membrane. Lysosome membrane.

Tissue specificity. Expressed in liver, kidney, intestine and pancreas.

Post-translational modifications. Glycosylated.

Similarity. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.

Isoforms (3)

UniProt IDNamesCanonical?
Q8NCC5-11yes
Q8NCC5-22
Q8NCC5-33

RefSeq proteins (9): NP_001274427, NP_001350302, NP_001350303, NP_001350304, NP_001350305, NP_001350306, NP_001350307, NP_115671, NP_996996* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000849Sugar_P_transporterFamily
IPR011701MFSFamily
IPR020846MFS_domDomain
IPR036259MFS_trans_sfHomologous_superfamily

Pfam: PF07690

UniProt features (20 total): transmembrane region 12, splice variant 3, glycosylation site 2, sequence conflict 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8NCC5-F184.110.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 58, 266

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 149 (showing top): GOCC_VACUOLAR_MEMBRANE, GOBP_INORGANIC_ANION_TRANSPORT, GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, GOBP_PHOSPHATE_ION_TRANSPORT, ACATTCC_MIR1_MIR206, GOBP_ORGANIC_ANION_TRANSPORT, AAAGGGA_MIR204_MIR211, KUNINGER_IGF1_VS_PDGFB_TARGETS_DN, GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, MARSON_BOUND_BY_FOXP3_STIMULATED, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, ZHENG_FOXP3_TARGETS_IN_THYMUS_UP, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK

GO Biological Process (2): xenobiotic transmembrane transport (GO:0006855), transmembrane transport (GO:0055085)

GO Molecular Function (3): xenobiotic transmembrane transporter activity (GO:0042910), protein binding (GO:0005515), transmembrane transporter activity (GO:0022857)

GO Cellular Component (5): lysosomal membrane (GO:0005765), endoplasmic reticulum membrane (GO:0005789), lysosome (GO:0005764), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
xenobiotic transport2
transmembrane transport2
transport1
cellular process1
transmembrane transporter activity1
binding1
transporter activity1
lysosome1
lytic vacuole membrane1
organelle membrane1
nuclear outer membrane-endoplasmic reticulum membrane network1
endoplasmic reticulum subcompartment1
lytic vacuole1
cytoplasm1
endomembrane system1
intracellular membrane-bounded organelle1
cellular anatomical structure1

Protein interactions and networks

STRING

912 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
SLC37A3ATRAIDQ6UW56654
SLC37A3SLC68A1Q14CX5498
SLC37A3MFSD11O43934498
SLC37A3SLC67A2Q8NBP5496
SLC37A3MFSD6Q6ZSS7466
SLC37A3SLC71A2Q5SR56458
SLC37A3SLC41A2Q96JW4445
SLC37A3SETD4Q9NVD3445
SLC37A3MKLN1Q9UL63443
SLC37A3ST6GAL2Q96JF0438
SLC37A3KDM7AQ6ZMT4417
SLC37A3SLC20A1Q8WUM9406
SLC37A3SLC35B1P78383406
SLC37A3PCDH9Q9HC56404
SLC37A3SLC5A7Q9GZV3401

IntAct

5 interactions, top by confidence:

ABTypeScore
FOXJ1SLC37A3psi-mi:“MI:0915”(physical association)0.370
SLC37A3ZNF177psi-mi:“MI:0915”(physical association)0.370
SLC37A3APOBpsi-mi:“MI:0914”(association)0.350
SLC37A3PLXNB2psi-mi:“MI:0914”(association)0.350

BioGRID (95): SPRYD7 (Affinity Capture-MS), ATRAID (Affinity Capture-MS), CAV1 (Affinity Capture-MS), CLTCL1 (Affinity Capture-MS), APOB (Affinity Capture-MS), SLC25A46 (Affinity Capture-MS), MTX3 (Affinity Capture-MS), RNASEL (Affinity Capture-MS), TUBGCP2 (Affinity Capture-MS), ATP12A (Affinity Capture-MS), CYB5R3 (Affinity Capture-MS), DNAJC19 (Affinity Capture-MS), ARL15 (Affinity Capture-MS), SLC25A30 (Affinity Capture-MS), SLC5A3 (Affinity Capture-MS)

ESM2 similar proteins: A1L272, A2CER7, A2SWM2, A4IH46, A8WGF7, B0JZE1, B8AF63, O35440, O70451, O80605, P30638, P57057, Q08DX7, Q0IHM1, Q0VA82, Q10R54, Q2XWK0, Q2YDU8, Q3TIT8, Q3U9N9, Q5F3N0, Q5M7K3, Q5U3U7, Q5XGK0, Q63344, Q640L2, Q6DEJ6, Q6GPQ3, Q6YK44, Q6ZMD2, Q7SY29, Q7ZU13, Q8AVC3, Q8BH31, Q8K078, Q8NA29, Q8NCC5, Q8NHS3, Q8R070, Q8R0G7

Diamond homologs: O23596, P57057, Q17QZ3, Q3TIT8, Q58CV5, Q5F3N0, Q5M7K3, Q640L2, Q7SY29, Q8AVC3, Q8NCC5, Q8R070, Q8TED4, Q9C5L3, Q9SA71, Q9SB41, Q9SL56, Q9WU81, P42205, P9WG86, P9WG87

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

97 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance64
Likely benign3
Benign5

Top pathogenic / likely-pathogenic (0)

SpliceAI

3159 predictions. Top by Δscore:

VariantEffectΔscore
7:140337348:TA:Tacceptor_gain1.0000
7:140337350:C:CCacceptor_gain1.0000
7:140348623:TAC:Tdonor_loss1.0000
7:140348624:A:Tdonor_loss1.0000
7:140348628:ATGAT:Adonor_gain1.0000
7:140348715:C:CTacceptor_gain1.0000
7:140348765:GTA:Gacceptor_gain1.0000
7:140348766:TA:Tacceptor_gain1.0000
7:140348767:ACTA:Aacceptor_loss1.0000
7:140348768:C:CAacceptor_loss1.0000
7:140348768:C:CCacceptor_gain1.0000
7:140351269:TTAC:Tdonor_loss1.0000
7:140351270:TACCG:Tdonor_loss1.0000
7:140351271:A:ACdonor_gain1.0000
7:140351271:ACC:Adonor_loss1.0000
7:140351272:C:CCdonor_gain1.0000
7:140351313:ATCG:Adonor_gain1.0000
7:140351836:T:Adonor_gain1.0000
7:140351865:C:CAdonor_gain1.0000
7:140351866:C:Adonor_gain1.0000
7:140352147:C:CCacceptor_gain1.0000
7:140355778:C:CTacceptor_gain1.0000
7:140355779:A:Tacceptor_gain1.0000
7:140358634:GCATA:Gdonor_loss1.0000
7:140358635:CATA:Cdonor_loss1.0000
7:140358636:ATAC:Adonor_loss1.0000
7:140358637:TA:Tdonor_loss1.0000
7:140358639:CCCGG:Cdonor_gain1.0000
7:140358647:T:Adonor_gain1.0000
7:140369583:AACTT:Adonor_loss1.0000

AlphaMissense

3214 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
7:140355742:A:GW182R1.000
7:140355742:A:TW182R1.000
7:140343443:C:TG432D0.999
7:140343563:C:TG392E0.999
7:140355720:C:AG189V0.999
7:140355721:C:GG189R0.999
7:140355747:C:TG180D0.999
7:140358686:A:GW159R0.999
7:140358686:A:TW159R0.999
7:140343433:G:CS435R0.998
7:140343433:G:TS435R0.998
7:140343435:T:GS435R0.998
7:140343437:C:TG434E0.998
7:140343438:C:AG434W0.998
7:140343447:C:GD431H0.998
7:140343529:A:CS403R0.998
7:140343529:A:TS403R0.998
7:140343531:T:GS403R0.998
7:140355720:C:TG189D0.998
7:140355721:C:AG189C0.998
7:140358684:C:AW159C0.998
7:140358684:C:GW159C0.998
7:140358694:G:AS156F0.998
7:140364491:C:GG98R0.998
7:140380390:A:CS30R0.998
7:140380390:A:TS30R0.998
7:140382439:T:GS30R0.998
7:140343444:C:GG432R0.997
7:140343455:C:TG428E0.997
7:140343461:A:TV426D0.997

dbSNP variants (sampled 300 via entrez): RS1000047037 (7:140389637 C>T), RS1000138083 (7:140390432 A>G), RS1000143169 (7:140350728 C>A,T), RS1000152851 (7:140397827 G>A), RS1000234230 (7:140370377 T>C), RS1000251328 (7:140397285 C>G,T), RS1000332899 (7:140377221 T>G), RS1000340152 (7:140338132 C>T), RS1000420178 (7:140390786 T>C), RS1000428948 (7:140384666 C>G), RS1000514242 (7:140364213 T>C), RS1000574835 (7:140372038 G>C,T), RS1000606050 (7:140371857 T>G), RS1000681725 (7:140333561 G>A,C), RS1000737436 (7:140370957 C>G)

Disease associations

OMIM: gene MIM:619137 | disease phenotypes:

GenCC curated gene-disease

DiseaseClassificationInheritance
retinitis pigmentosaStrongAutosomal recessive

Mondo (1): retinitis pigmentosa (MONDO:0019200)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

DescriptorNameTree numbers
D012174Retinitis PigmentosaC11.270.684; C11.768.585.658.500; C16.320.290.684

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC37 family of phosphosugar/phosphate exchangers

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

ChemicalActions (top 5)PubMed papers
Air Pollutantsincreases abundance, increases oxidation, affects cotreatment, decreases expression2
dicrotophosdecreases expression1
triphenyl phosphateaffects expression1
alpha-pineneaffects cotreatment, decreases expression, increases oxidation, increases abundance1
beta-lapachoneincreases expression1
sodium arseniteaffects cotreatment, decreases expression, increases abundance1
manganese chlorideincreases abundance, affects cotreatment, decreases expression1
nickel sulfatedecreases expression1
methacrylaldehydeaffects cotreatment, decreases expression, increases oxidation, increases abundance1
di-n-butylphosphoric acidaffects expression1
Resveratrolincreases expression, affects cotreatment1
Acroleinincreases abundance, affects cotreatment, decreases expression, increases oxidation1
Arsenicaffects cotreatment, decreases expression, increases abundance1
Benzo(a)pyreneincreases methylation1
Doxorubicindecreases expression1
Drugs, Chinese Herbalincreases expression1
Estradiolincreases expression1
Manganeseaffects cotreatment, decreases expression, increases abundance1
Naphthoquinonesincreases expression1
Ozoneaffects cotreatment, decreases expression, increases oxidation, increases abundance1
Plant Extractsaffects cotreatment, increases expression1
T-2 Toxindecreases expression1
Dronabinoldecreases expression1
Tretinoindecreases expression1
Cyclosporineincreases expression1
Antirheumatic Agentsincreases expression1
Cadmium Chloridedecreases expression1
Particulate Matterdecreases expression, increases abundance1
Volatile Organic Compoundsaffects cotreatment, decreases expression, increases oxidation1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_D4MVHCT116-SLC37A3-KO-c11Cancer cell lineMale
CVCL_D4MWHCT116-SLC37A3-KO-c4Cancer cell lineMale
CVCL_D4MXHCT116-SLC37A3-KO-c9Cancer cell lineMale
CVCL_E0NWUbigene HeLa SLC37A3 KOCancer cell lineFemale

Clinical trials (associated diseases)

234 trials via MONDO — disease-level, not drug-specific.

TrialPhaseStatusTitle
NCT00717080PHASE4COMPLETEDThe Role of Capsular Tension Ring (CTR) in Anterior Capsular Contraction
NCT00000114PHASE3COMPLETEDRandomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa
NCT00000116PHASE3COMPLETEDRandomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A
NCT00346333PHASE3COMPLETEDClinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A
NCT01786395PHASE3TERMINATEDPhase III Efficacy and Safety Clinical Study of UF-021 for Treatment of Retinitis Pigmentosa
NCT04224207PHASE3COMPLETEDManagement of Retinitis Pigmentosa by Mesenchymal Stem Cells by Wharton’s Jelly Derived Mesenchymal Stem Cells
NCT04636853PHASE3COMPLETEDCB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration
NCT05537220PHASE3ACTIVE_NOT_RECRUITINGOral N-acetylcysteine for Retinitis Pigmentosa
NCT05800301PHASE3COMPLETEDManagement of Retinitis Pigmentosa Via Combination of Wharton’s Jelly-derived Mesenchymal Stem Cells and Magnovision
NCT05926583PHASE3ACTIVE_NOT_RECRUITINGA Study of AAV5-hRKp.RPGR for the Treatment of Japanese Participants With X-linked Retinitis Pigmentosa
NCT06388200PHASE3ACTIVE_NOT_RECRUITINGA Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa
NCT07082855PHASE3NOT_YET_RECRUITINGA Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa
NCT07290530PHASE3NOT_YET_RECRUITING24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome
NCT00100230PHASE2COMPLETEDDHA and X-Linked Retinitis Pigmentosa
NCT00447980PHASE2COMPLETEDA Study of Encapsulated Cell Technology (ECT) Implant for Participants With Early Stage Retinitis Pigmentosa
NCT00447993PHASE2COMPLETEDA Study of Encapsulated Cell Technology (ECT) Implant for Patients With Late Stage Retinitis Pigmentosa
NCT01233609PHASE2COMPLETEDTrial of Oral Valproic Acid for Retinitis Pigmentosa
NCT01399515PHASE2COMPLETEDEfficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa
NCT01530659PHASE2COMPLETEDRetinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa
NCT01560715PHASE2COMPLETEDAutologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa
NCT02609165PHASE2COMPLETEDNerve Growth Factor Eye Drops Treatment in Patients With Retinitis Pigmentosa and Cystoid Macular Edema
NCT02661711PHASE2COMPLETEDAflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study
NCT02804360PHASE2UNKNOWNIntravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Macular Edema- a Retrospective Study
NCT02837640PHASE2UNKNOWNStudying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa
NCT03073733PHASE2COMPLETEDSafety and Efficacy of Intravitreal Injection of Human Retinal Progenitor Cells in Adults With Retinitis Pigmentosa
NCT04068207PHASE2COMPLETEDMinocycline Treatment in Retinitis Pigmentosa
NCT04356716PHASE2COMPLETEDSildenafil for Treatment of Choroidal Ischemia
NCT04604899PHASE2COMPLETEDSafety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects With Retinitis Pigmentosa
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  • Associated diseases: retinitis pigmentosa 1
  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): retinitis pigmentosa