SLC38A7

Summary

SLC38A7 (solute carrier family 38 member 7, HGNC:25582) is a protein-coding gene on chromosome 16q21, encoding Sodium-coupled neutral amino acid transporter 7 (Q9NVC3). Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation.

Enables L-asparagine:sodium symporter activity and L-glutamine:sodium symporter activity. Involved in asparagine transport and glutamine transport. Located in lysosomal membrane.

Source: NCBI Gene 55238 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 60 total
• Druggable target: yes
• MANE Select transcript: NM_018231

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25582
Approved symbol	SLC38A7
Name	solute carrier family 38 member 7
Location	16q21
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10815, SNAT7
Ensembl gene	ENSG00000103042
Ensembl biotype	protein_coding
OMIM	614236
Entrez	55238

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 19 protein_coding, 4 retained_intron, 2 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined

ENST00000219320, ENST00000562149, ENST00000562397, ENST00000563196, ENST00000564010, ENST00000564100, ENST00000564391, ENST00000564720, ENST00000564964, ENST00000565785, ENST00000566598, ENST00000566953, ENST00000567930, ENST00000569209, ENST00000570101, ENST00000570214, ENST00000873636, ENST00000873637, ENST00000873638, ENST00000934505, ENST00000934506, ENST00000934507, ENST00000934508, ENST00000934509, ENST00000934510, ENST00000957363, ENST00000957364

RefSeq mRNA: 6 — MANE Select: NM_018231 NM_001308384, NM_001369608, NM_001369609, NM_001369610, NM_001369611, NM_018231

CCDS: CCDS10800, CCDS76883

Canonical transcript exons

ENST00000219320 — 12 exons

Exon	Start	End
ENSE00001201582	58683955	58684178
ENSE00001201588	58684717	58684770
ENSE00001296278	58665109	58667487
ENSE00003458608	58675940	58676054
ENSE00003463909	58677326	58677424
ENSE00003511293	58672096	58672243
ENSE00003548043	58678696	58678894
ENSE00003581857	58676289	58676346
ENSE00003620234	58671045	58671244
ENSE00003623017	58678333	58678474
ENSE00003669287	58679857	58680241
ENSE00003687026	58670113	58670167

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 92.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.2858 / max 32.5501, expressed in 1737 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157629	4.4718	1712
157628	0.7923	538
157627	0.0217	4

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	92.97	gold quality
right testis	UBERON:0004534	92.78	gold quality
left testis	UBERON:0004533	92.75	gold quality
male germ cell	CL:0000015	91.54	gold quality
apex of heart	UBERON:0002098	91.25	gold quality
stromal cell of endometrium	CL:0002255	89.92	gold quality
testis	UBERON:0000473	89.78	gold quality
oocyte	CL:0000023	88.13	gold quality
heart left ventricle	UBERON:0002084	86.38	gold quality
secondary oocyte	CL:0000655	86.25	gold quality
cardiac ventricle	UBERON:0002082	86.06	gold quality
right adrenal gland cortex	UBERON:0035827	85.97	gold quality
right adrenal gland	UBERON:0001233	85.59	gold quality
left adrenal gland	UBERON:0001234	85.23	gold quality
left adrenal gland cortex	UBERON:0035825	84.85	gold quality
adrenal cortex	UBERON:0001235	84.63	gold quality
adrenal gland	UBERON:0002369	83.93	gold quality
cortical plate	UBERON:0005343	83.16	gold quality
heart	UBERON:0000948	82.75	gold quality
right lobe of liver	UBERON:0001114	82.56	gold quality
metanephros cortex	UBERON:0010533	82.03	gold quality
right lobe of thyroid gland	UBERON:0001119	82.02	gold quality
right atrium auricular region	UBERON:0006631	81.93	gold quality
spleen	UBERON:0002106	81.76	gold quality
right frontal lobe	UBERON:0002810	81.53	gold quality
granulocyte	CL:0000094	81.45	gold quality
monocyte	CL:0000576	81.19	gold quality
mononuclear cell	CL:0000842	81.13	gold quality
prefrontal cortex	UBERON:0000451	81.05	gold quality
leukocyte	CL:0000738	80.92	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.32
E-HCAD-5	no	2.32

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

121 targeting SLC38A7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-204-5P	99.79	71.62	2439

Literature-anchored findings (GeneRIF, showing 4)

• Cell fractionation confirmed the lysosomal localization of SNAT7, and flux measurements confirmed its substrate selectivity and showed a strong activation by the lysosomal pH gradient. Interestingly, gene silencing or editing experiments revealed that SNAT7 is the primary permeation pathway for glutamine across the lysosomal membrane and it is required for growth of cancer cells in a low free-glutamine environment. (PMID:28416685)
• GWAS identified a novel gene encoding an anastrozole transporter, SLC38A7, as well as epistatic interaction between SNPs in that gene and SNPs near ALPPL2 that influenced both the expression of the transporter and anastrozole plasma concentrations (PMID:30648747)
• Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma. (PMID:34171866)
• SNAT7 regulates mTORC1 via macropinocytosis. (PMID:35561222)

Cross-species orthologs

20 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc38a7	ENSDARG00000012002
mus_musculus	Slc38a7	ENSMUSG00000036534
rattus_norvegicus	Slc38a7	ENSRNOG00000012007
drosophila_melanogaster	CG16700	FBGN0030816
drosophila_melanogaster	CG4991	FBGN0030817
drosophila_melanogaster	CG13384	FBGN0032036
drosophila_melanogaster	polyph	FBGN0033572
drosophila_melanogaster	VGAT	FBGN0033911
drosophila_melanogaster	acs	FBGN0035300
drosophila_melanogaster	CG7888	FBGN0036116
drosophila_melanogaster	CG32079	FBGN0052079
drosophila_melanogaster	CG32081	FBGN0052081
drosophila_melanogaster	mah	FBGN0285912
caenorhabditis_elegans		WBGENE00006783
caenorhabditis_elegans	slc-36.4	WBGENE00010421
caenorhabditis_elegans	Y18D10A.23	WBGENE00012487
caenorhabditis_elegans		WBGENE00012629
caenorhabditis_elegans		WBGENE00012804
caenorhabditis_elegans		WBGENE00019837
caenorhabditis_elegans		WBGENE00020837

Paralogs (15): SLC38A5 (ENSG00000017483), SLC32A1 (ENSG00000101438), SLC38A1 (ENSG00000111371), SLC36A1 (ENSG00000123643), SLC38A2 (ENSG00000134294), SLC38A4 (ENSG00000139209), SLC38A6 (ENSG00000139974), SLC38A10 (ENSG00000157637), SLC38A8 (ENSG00000166558), SLC38A11 (ENSG00000169507), SLC38A9 (ENSG00000177058), SLC36A4 (ENSG00000180773), SLC36A3 (ENSG00000186334), SLC36A2 (ENSG00000186335), SLC38A3 (ENSG00000188338)

Protein

Protein identifiers

Sodium-coupled neutral amino acid transporter 7 — Q9NVC3 (reviewed: Q9NVC3)

Alternative names: Solute carrier family 38 member 7

All UniProt accessions (9): Q9NVC3, H3BMC5, H3BN87, H3BP25, H3BPK8, H3BPV9, H3BRZ0, H3BU46, H3BV81

UniProt curated annotations — full annotation on UniProt →

Function. Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.

Subunit / interactions. Interacts with the mTORC1 complex; this interaction mediates the recruitment of mTORC1 to the lysosome and its subsequent activation.

Subcellular location. Lysosome membrane. Cell projection. Axon.

Similarity. Belongs to the amino acid/polyamine transporter 2 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NVC3-1	1	yes
Q9NVC3-2	2

RefSeq proteins (6): NP_001295313, NP_001356537, NP_001356538, NP_001356539, NP_001356540, NP_060701* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013057	AA_transpt_TM	Domain

Pfam: PF01490

Catalyzed reactions (Rhea), 2 shown:

• L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out) (RHEA:68236)
• L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out) (RHEA:71383)

UniProt features (18 total): transmembrane region 11, sequence variant 2, sequence conflict 2, chain 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NVC3-F1	84.28	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 28

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 119 (showing top): GOCC_VACUOLAR_MEMBRANE, GOBP_AMINO_ACID_TRANSMEMBRANE_TRANSPORT, GOBP_MONOATOMIC_CATION_TRANSPORT, AACWWCAANK_UNKNOWN, GOBP_ORGANIC_ACID_TRANSPORT, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, GOBP_AMINO_ACID_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, chr16q21, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, GCM_NF2, GOCC_NEURON_PROJECTION, GOBP_NEUTRAL_AMINO_ACID_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT

GO Biological Process (6): amino acid transmembrane transport (GO:0003333), sodium ion transport (GO:0006814), asparagine transport (GO:0006867), L-glutamine transport (GO:0006868), monoatomic ion transport (GO:0006811), amino acid transport (GO:0006865)

GO Molecular Function (5): L-asparagine transmembrane transporter activity (GO:0015182), L-glutamine transmembrane transporter activity (GO:0015186), L-asparagine:sodium symporter activity (GO:0140901), L-glutamine:sodium symporter activity (GO:0140902), protein binding (GO:0005515)

GO Cellular Component (6): lysosomal membrane (GO:0005765), membrane (GO:0016020), axon (GO:0030424), neuronal cell body (GO:0043025), lysosome (GO:0005764), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
neutral amino acid transport	2
transport	2
neutral L-amino acid transmembrane transporter activity	2
L-amino acid transmembrane transporter activity	2
neutral L-amino acid:sodium symporter activity	2
alanine:sodium symporter activity	2
cellular anatomical structure	2
amino acid transport	1
transmembrane transport	1
metal ion transport	1
carboxylic acid transport	1
nitrogen compound transport	1
L-amino acid transport	1
asparagine transport	1
L-glutamine transport	1
L-asparagine transmembrane transporter activity	1
L-glutamine transmembrane transporter activity	1
binding	1
lysosome	1
lytic vacuole membrane	1
neuron projection	1
somatodendritic compartment	1
cell body	1
lytic vacuole	1

Protein interactions and networks

STRING

986 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC38A7	SLC36A1	Q7Z2H8	613
SLC38A7	SLC66A1	Q6ZP29	565
SLC38A7	SLC43A2	Q8N370	532
SLC38A7	SLC7A8	Q9UHI5	522
SLC38A7	SLC7A6	Q92536	522
SLC38A7	SLC38A9	Q8NBW4	518
SLC38A7	SLC1A5	Q15758	477
SLC38A7	SLC1A4	P43007	470
SLC38A7	SLC7A7	Q9UM01	466
SLC38A7	SLC7A5	Q01650	464
SLC38A7	SLC7A4	O43246	461
SLC38A7	YIPF3	Q9GZM5	444
SLC38A7	SLC36A4	Q6YBV0	442
SLC38A7	CARHSP1	Q9Y2V2	438
SLC38A7	COPS7A	Q9UBW8	417

IntAct

192 interactions, top by confidence:

A	B	Type	Score
SLC38A7	RNF5	psi-mi:“MI:0915”(physical association)	0.720
RNF5	SLC38A7	psi-mi:“MI:0915”(physical association)	0.720
SLC38A7	TMPRSS2	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	SPINT1	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	SLC6A15	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	SAR1A	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	EBP	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	HHLA2	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	MUC1	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	EVI2B	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	TSPAN8	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	LYVE1	psi-mi:“MI:0915”(physical association)	0.560
SLC38A7	SHISAL1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (101): SLC38A7 (Two-hybrid), SLC38A7 (Affinity Capture-MS), SLC38A7 (Affinity Capture-MS), TCEA1 (Affinity Capture-MS), SLC38A7 (Affinity Capture-MS), SLC38A7 (Affinity Capture-MS), GGA1 (Affinity Capture-MS), EEF1A2 (Affinity Capture-MS), ETF1 (Affinity Capture-MS), VRK1 (Affinity Capture-MS), ACTL6B (Affinity Capture-MS), SLC38A7 (Two-hybrid), SLC38A7 (Two-hybrid), SLC38A7 (Two-hybrid), SLC38A7 (Two-hybrid)

ESM2 similar proteins: A1YG32, A2VCW5, A2VE31, A6NNN8, A7E3U5, A8KBL5, D3Z813, F4KBM7, G3UVW3, O80668, P40074, Q08AI6, Q0WQJ3, Q28HE5, Q28I47, Q3U1J0, Q3USY0, Q503G8, Q5E9S9, Q5EA97, Q5F468, Q5HZH7, Q5R443, Q5R9F5, Q5RE87, Q5SPB1, Q5XH90, Q6DEL1, Q6DFE7, Q6JWR2, Q6WWW3, Q8BWH0, Q8CFE6, Q8HXI3, Q8IZM9, Q8K2P7, Q8R1S9, Q8WUX1, Q969I6, Q96QD8

Diamond homologs: A6NNN8, A7E3U5, Q28I47, Q5HZH7, Q5R9F5, Q5RE87, Q6DEL1, Q6DFE7, Q6JWR2, Q8BWH0, Q969I6, Q9NVC3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	49
Likely benign	0
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1895 predictions. Top by Δscore:

Variant	Effect	Δscore
16:58667483:ACCAG:A	acceptor_gain	1.0000
16:58667484:CCAG:C	acceptor_gain	1.0000
16:58667484:CCAGC:C	acceptor_gain	1.0000
16:58667485:CAGC:C	acceptor_gain	1.0000
16:58667486:AG:A	acceptor_gain	1.0000
16:58667488:C:CC	acceptor_gain	1.0000
16:58670112:CCTGG:C	donor_gain	1.0000
16:58670163:CAGCC:C	acceptor_gain	1.0000
16:58670165:GCCC:G	acceptor_loss	1.0000
16:58670166:CC:C	acceptor_gain	1.0000
16:58670166:CCCTG:C	acceptor_loss	1.0000
16:58670167:CC:C	acceptor_gain	1.0000
16:58670167:CCTG:C	acceptor_loss	1.0000
16:58670168:C:A	acceptor_loss	1.0000
16:58670168:C:CC	acceptor_gain	1.0000
16:58671039:CCGCA:C	donor_loss	1.0000
16:58671040:CGCA:C	donor_loss	1.0000
16:58671041:GCAC:G	donor_loss	1.0000
16:58671042:CA:C	donor_loss	1.0000
16:58671044:C:A	donor_loss	1.0000
16:58671240:CCGCC:C	acceptor_gain	1.0000
16:58671241:CGCCC:C	acceptor_gain	1.0000
16:58671243:CC:C	acceptor_gain	1.0000
16:58671244:CC:C	acceptor_gain	1.0000
16:58672094:ACCGC:A	donor_gain	1.0000
16:58672095:CCGCC:C	donor_gain	1.0000
16:58672239:GATGC:G	acceptor_gain	1.0000
16:58672240:ATGC:A	acceptor_gain	1.0000
16:58672241:TGC:T	acceptor_gain	1.0000
16:58672242:GC:G	acceptor_gain	1.0000

AlphaMissense

3002 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:58676298:G:C	F253L	1.000
16:58676298:G:T	F253L	1.000
16:58676300:A:G	F253L	1.000
16:58678736:G:C	C143W	1.000
16:58679918:A:T	L70H	1.000
16:58679931:C:G	G66R	1.000
16:58667428:C:T	G449D	0.999
16:58667443:C:T	G444E	0.999
16:58667444:C:G	G444R	0.999
16:58667444:C:T	G444R	0.999
16:58667465:C:G	G437R	0.999
16:58667465:C:T	G437R	0.999
16:58670158:A:G	L414P	0.999
16:58670160:G:C	C413W	0.999
16:58670162:A:G	C413R	0.999
16:58671045:C:G	G411R	0.999
16:58671045:C:T	G411R	0.999
16:58671047:G:T	P410Q	0.999
16:58671080:C:T	G399E	0.999
16:58671081:C:G	G399R	0.999
16:58671081:C:T	G399R	0.999
16:58671147:A:G	W377R	0.999
16:58671147:A:T	W377R	0.999
16:58672099:C:T	G343E	0.999
16:58672100:C:A	G343W	0.999
16:58672100:C:G	G343R	0.999
16:58672100:C:T	G343R	0.999
16:58672102:C:T	C342Y	0.999
16:58672117:G:C	P337R	0.999
16:58672117:G:T	P337H	0.999

dbSNP variants (sampled 300 via entrez): RS1000099399 (16:58667152 T>A,C), RS1000168079 (16:58675416 G>A), RS1000197987 (16:58670913 G>A), RS1000206610 (16:58670599 C>T), RS1001420860 (16:58665744 G>A), RS1001532089 (16:58684138 G>A), RS1001542193 (16:58683904 G>A), RS1001545382 (16:58676713 G>A,C), RS1001813601 (16:58684558 CT>C), RS1001823767 (16:58670029 C>A,G,T), RS1002107650 (16:58670371 C>A), RS1002108567 (16:58682347 C>T), RS1002135025 (16:58673863 T>TC), RS1002229999 (16:58673666 T>A,C,G), RS1002269237 (16:58665333 T>C)

Disease associations

OMIM: gene MIM:614236 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST000363_9	QT interval	3.000000e-25
GCST002539_83	Schizophrenia	2.000000e-08
GCST006803_60	Schizophrenia	2.000000e-10
GCST007664_17	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer	4.000000e-08
GCST007664_18	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer	5.000000e-08
GCST007664_19	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer	5.000000e-08
GCST007664_20	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer	6.000000e-08
GCST007664_36	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer	2.000000e-08
GCST007664_47	Plasma anastrozole concentration in anastrozole-treated estrogen receptor positive breast cancer	7.000000e-08
GCST011743_5	HDL cholesterol levels in HIV infection	5.000000e-06
GCST012279_14	Suicide attempt severity in mood disorders	8.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004682	QT interval
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0006882	suicide behaviour measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067118 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Orphan SLC38 transporters

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.82	Kd	1506	nM	CHEMBL5653589
5.82	ED50	1506	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149422: Binding affinity to human SLC38A7 incubated for 45 mins by Kinobead based pull down assay	kd	1.5064	uM

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation, increases expression, affects cotreatment, decreases expression	3
sodium arsenite	affects cotreatment, decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, decreases methylation	2
dicrotophos	increases expression	1
beta-lapachone	decreases expression	1
aflatoxin B2	increases methylation	1
CD 437	decreases expression	1
K 7174	increases expression	1
3-(4’-hydroxy-3’-adamantylbiphenyl-4-yl)acrylic acid	decreases expression	1
bisphenol S	decreases methylation	1
jinfukang	increases expression	1
Sunitinib	increases expression	1
Acetaminophen	affects response to substance	1
Arsenic	affects cotreatment, decreases expression, increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Methyl Methanesulfonate	increases expression	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	increases expression	1
1-Methyl-3-isobutylxanthine	decreases expression, affects cotreatment	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652464	Binding	Binding affinity to human SLC38A7 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4N6	HCT116-SLC38A7-KO-c1	Cancer cell line	Male
CVCL_D4N7	HCT116-SLC38A7-KO-c22	Cancer cell line	Male
CVCL_E0NX	Ubigene HeLa SLC38A7 KO	Cancer cell line	Female
CVCL_TN47	HAP1 SLC38A7 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.