SLC39A3

Summary

SLC39A3 (solute carrier family 39 member 3, HGNC:17128) is a protein-coding gene on chromosome 19p13.3, encoding Zinc transporter ZIP3 (Q9BRY0). Transporter for the divalent cation Zn(2+).

Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to act upstream of or within several processes, including T cell homeostasis; chordate embryonic development; and zinc ion transport. Predicted to be located in hippocampal mossy fiber to CA3 synapse. Predicted to be active in plasma membrane.

Source: NCBI Gene 29985 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 73 total
• Druggable target: yes
• MANE Select transcript: NM_144564

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17128
Approved symbol	SLC39A3
Name	solute carrier family 39 member 3
Location	19p13.3
Locus type	gene with protein product
Status	Approved
Aliases	ZIP3
Ensembl gene	ENSG00000141873
Ensembl biotype	protein_coding
OMIM	612168
Entrez	29985

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000269740, ENST00000455372, ENST00000545664, ENST00000589166, ENST00000589363, ENST00000590875, ENST00000909979, ENST00000909980, ENST00000909981, ENST00000909982, ENST00000909983, ENST00000959861, ENST00000959862, ENST00000959863

RefSeq mRNA: 2 — MANE Select: NM_144564 NM_144564, NM_213568

CCDS: CCDS12093, CCDS45909

Canonical transcript exons

ENST00000269740 — 3 exons

Exon	Start	End
ENSE00001150023	2732524	2733485
ENSE00002257135	2739945	2740017
ENSE00003603132	2737048	2737379

Expression profiles

Bgee: expression breadth ubiquitous, 212 present calls, max score 96.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.4424 / max 275.0111, expressed in 1803 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
178203	11.6172	1775
178204	5.4066	1734
178202	0.4186	169

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	96.42	gold quality
right testis	UBERON:0004534	96.26	gold quality
testis	UBERON:0000473	93.37	gold quality
stromal cell of endometrium	CL:0002255	92.57	gold quality
prefrontal cortex	UBERON:0000451	91.28	gold quality
apex of heart	UBERON:0002098	90.02	gold quality
islet of Langerhans	UBERON:0000006	89.75	gold quality
smooth muscle tissue	UBERON:0001135	89.49	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.15	gold quality
monocyte	CL:0000576	89.10	gold quality
leukocyte	CL:0000738	88.94	gold quality
adenohypophysis	UBERON:0002196	88.65	gold quality
anterior cingulate cortex	UBERON:0009835	88.65	gold quality
right adrenal gland	UBERON:0001233	88.64	gold quality
right frontal lobe	UBERON:0002810	88.61	gold quality
left adrenal gland	UBERON:0001234	88.59	gold quality
left adrenal gland cortex	UBERON:0035825	88.37	gold quality
right adrenal gland cortex	UBERON:0035827	88.25	gold quality
pancreatic ductal cell	CL:0002079	88.13	silver quality
mucosa of transverse colon	UBERON:0004991	87.82	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.05	gold quality
granulocyte	CL:0000094	87.00	gold quality
pituitary gland	UBERON:0000007	86.96	gold quality
right lobe of liver	UBERON:0001114	86.79	gold quality
adrenal gland	UBERON:0002369	86.79	gold quality
neocortex	UBERON:0001950	86.77	gold quality
adrenal cortex	UBERON:0001235	86.73	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	86.65	gold quality
frontal cortex	UBERON:0001870	86.64	gold quality
gastrocnemius	UBERON:0001388	86.53	gold quality

Single-cell (SCXA)

Detected in 9 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-GEOD-130473	yes	531.63
E-MTAB-7407	yes	287.16
E-HCAD-6	yes	54.97
E-CURD-112	yes	35.84
E-MTAB-9067	yes	22.28
E-MTAB-10042	yes	14.32
E-ANND-3	yes	8.73
E-MTAB-6379	no	114.62
E-MTAB-9801	no	2.55

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): RREB1

miRNA regulators (miRDB)

8 targeting SLC39A3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-548U	99.65	67.78	1463
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-2467-5P	97.36	67.71	991

Literature-anchored findings (GeneRIF, showing 6)

• ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc (PMID:14525987)
• ZiP2 and Zip3 are down regulated in malignant cells (PMID:17550612)
• Gene expression regulation of ZIPs after zinc supplementation. (PMID:18279033)
• The metallothionein gene had a higher expression in the blood, when compared to zinc transporters ZnT-1, Zip-1, and Zip-3 (p=0.01 in obese patients. (PMID:21053094)
• Data show that the combination of concurrent zinc, ZIP3, and RREB-1 changes represent early events in the development of adenocarcinoma. (PMID:21613827)
• These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells (PMID:22427155)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc39a3	ENSMUSG00000046822
rattus_norvegicus	Slc39a3	ENSRNOG00000045524
drosophila_melanogaster	Zip42C.1	FBGN0033096
caenorhabditis_elegans		WBGENE00015940

Paralogs (2): SLC39A1 (ENSG00000143570), SLC39A2 (ENSG00000165794)

Protein

Protein identifiers

Zinc transporter ZIP3 — Q9BRY0 (reviewed: Q9BRY0)

Alternative names: Solute carrier family 39 member 3, Zrt- and Irt-like protein 3

All UniProt accessions (4): Q9BRY0, F5H385, K7EJZ1, K7ENJ1

UniProt curated annotations — full annotation on UniProt →

Function. Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen.

Subcellular location. Cell membrane. Apical cell membrane.

Similarity. Belongs to the ZIP transporter (TC 2.A.5) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BRY0-1	1	yes
Q9BRY0-2	2

RefSeq proteins (2): NP_653165, NP_998733 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003689	ZIP	Family

Pfam: PF02535

Catalyzed reactions (Rhea), 1 shown:

• Zn(2+)(in) = Zn(2+)(out) (RHEA:29351)

UniProt features (24 total): topological domain 9, transmembrane region 8, modified residue 2, splice variant 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BRY0-F1	81.29	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 125, 129

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-442380	Zinc influx into cells by the SLC39 gene family
R-HSA-382551	Transport of small molecules
R-HSA-425366
R-HSA-425407	SLC-mediated transmembrane transport
R-HSA-425410	Metal ion SLC transporters
R-HSA-435354	Zinc transporters

MSigDB gene sets: 204 (showing top): RNGTGGGC_UNKNOWN, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_TRANSITION_METAL_ION_TRANSPORT, GOBP_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT, CMYB_01, GOBP_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS, GOBP_T_CELL_HOMEOSTASIS, GOBP_LYMPHOCYTE_HOMEOSTASIS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_MONOATOMIC_CATION_TRANSPORT, MARTINEZ_RB1_TARGETS_UP

GO Biological Process (10): cell morphogenesis (GO:0000902), in utero embryonic development (GO:0001701), T cell homeostasis (GO:0043029), embryonic cranial skeleton morphogenesis (GO:0048701), limb development (GO:0060173), zinc ion transmembrane transport (GO:0071577), monoatomic ion transport (GO:0006811), zinc ion transport (GO:0006829), metal ion transport (GO:0030001), transmembrane transport (GO:0055085)

GO Molecular Function (3): zinc ion transmembrane transporter activity (GO:0005385), protein binding (GO:0005515), metal ion transmembrane transporter activity (GO:0046873)

GO Cellular Component (4): plasma membrane (GO:0005886), apical plasma membrane (GO:0016324), hippocampal mossy fiber to CA3 synapse (GO:0098686), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Zinc transporters	1
Transport of small molecules	1
SLC-mediated transmembrane transport	1
Metal ion SLC transporters	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
anatomical structure morphogenesis	1
chordate embryonic development	1
lymphocyte homeostasis	1
embryonic skeletal system morphogenesis	1
cranial skeletal system development	1
appendage development	1
zinc ion transport	1
monoatomic cation transmembrane transport	1
transition metal ion transport	1
monoatomic cation transport	1
cellular process	1
transition metal ion transmembrane transporter activity	1
zinc ion transmembrane transport	1
binding	1
monoatomic cation transmembrane transporter activity	1
metal ion transport	1
membrane	1
cell periphery	1
apical part of cell	1
plasma membrane region	1
thorny excrescence	1
neuron to neuron synapse	1
hippocampal mossy fiber expansion	1
cellular anatomical structure	1

Protein interactions and networks

STRING

774 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC39A3	SLC39A11	Q8N1S5	747
SLC39A3	SLC39A4	Q6P5W5	716
SLC39A3	SLC39A9	Q9NUM3	693
SLC39A3	SLC39A7	Q92504	688
SLC39A3	SLC39A5	Q6ZMH5	656
SLC39A3	SLC39A12	Q504Y0	650
SLC39A3	SLC39A13	Q96H72	649
SLC39A3	SLC39A10	Q9ULF5	621
SLC39A3	SLC39A6	Q13433	612
SLC39A3	SLC39A8	Q9C0K1	611
SLC39A3	SLC30A9	Q6PML9	607
SLC39A3	SLC39A14	Q15043	573
SLC39A3	SLC30A6	Q6NXT4	546
SLC39A3	SLC30A1	Q9Y6M5	542
SLC39A3	SLC30A7	Q8NEW0	520

IntAct

32 interactions, top by confidence:

A	B	Type	Score
TNFSF8	TOR1B	psi-mi:“MI:0914”(association)	0.640
MANSC1	KLRG2	psi-mi:“MI:0914”(association)	0.530
EVA1C	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
HLA-B	LTN1	psi-mi:“MI:0914”(association)	0.530
TNFSF8	LGALS8	psi-mi:“MI:0914”(association)	0.530
SEC22B	NBAS	psi-mi:“MI:0914”(association)	0.350
TMPRSS11B		psi-mi:“MI:0914”(association)	0.350
TNFSF8	NME4	psi-mi:“MI:0914”(association)	0.350
BSCL2	B4GAT1	psi-mi:“MI:0914”(association)	0.350
PMEL	MAN1A2	psi-mi:“MI:0914”(association)	0.350
BSCL2	TMEM223	psi-mi:“MI:0914”(association)	0.350
HIDE1	TMEM120B	psi-mi:“MI:0914”(association)	0.350
SLC39A3	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
TMPRSS11B	ADAM10	psi-mi:“MI:0914”(association)	0.350
PCDHB3	ESYT2	psi-mi:“MI:0914”(association)	0.350
CLEC2D	ESYT2	psi-mi:“MI:0914”(association)	0.350
HLA-C	TMEM131L	psi-mi:“MI:0914”(association)	0.350
KLRD1	TMEM131L	psi-mi:“MI:0914”(association)	0.350
GPR45	VWA8	psi-mi:“MI:0914”(association)	0.350
OPALIN	FAM171A2	psi-mi:“MI:0914”(association)	0.350
CLEC4A		psi-mi:“MI:0914”(association)	0.350
SPINT2		psi-mi:“MI:0914”(association)	0.350
LRRC25	SCAMP3	psi-mi:“MI:0914”(association)	0.350
RAMP3	MGST3	psi-mi:“MI:0914”(association)	0.350
HLA-B	RAB29	psi-mi:“MI:0914”(association)	0.350
P2RY8	BTAF1	psi-mi:“MI:0914”(association)	0.350
AIFM1	HSPA12A	psi-mi:“MI:0914”(association)	0.350
CA14	ORC4	psi-mi:“MI:0914”(association)	0.350
TMEM25	CRLF1	psi-mi:“MI:0914”(association)	0.350
SLC39A3	AMY1A	psi-mi:“MI:0914”(association)	0.350

BioGRID (128): SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-MS), SLC39A3 (Affinity Capture-RNA), TRAPPC13 (Negative Genetic), SLC39A3 (Negative Genetic), TRAPPC2L (Negative Genetic), VPS51 (Negative Genetic)

ESM2 similar proteins: A0A0G2KQY6, A0A3Q7ZPG5, A4IFD7, A4IIC5, A5PMX1, A8WMY3, A8X482, O04089, O45923, O64738, O82643, O94639, P40544, P59889, Q12067, Q12436, Q28J44, Q2YDD4, Q3KR82, Q52KD7, Q54LY6, Q5BJM8, Q5BL29, Q5E960, Q5MNV6, Q5RE57, Q5U1X7, Q5ZIU9, Q640S1, Q6NRI1, Q6NRM1, Q6NTL1, Q6P3N9, Q6P6S2, Q6QQT1, Q8BFU1, Q8BWY7, Q8LE59, Q8N1S5, Q8NEW0

Diamond homologs: A4IIC5, Q55EA1, Q5E960, Q5U1X7, Q99K24, Q9BRY0, G3X943, P59889, Q3SYU3, Q6QQT1, Q9NP94, Q9NY26, Q9QZ03, Q54MB9, C6KST8, A3BI11, O04089, O23039, O81123, O82643, Q0DHE3, Q38856, Q5Z653, Q6L8F7, Q6ZJ91, Q7XLD4, Q8LE59, Q8S3W4, Q8W246, Q9SLG3, Q852F6, Q94DG6, Q9LTH9, Q94EG9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

73 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	70
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

534 predictions. Top by Δscore:

Variant	Effect	Δscore
19:2733503:C:CT	acceptor_gain	1.0000
19:2733503:C:T	acceptor_gain	1.0000
19:2733504:G:T	acceptor_gain	1.0000
19:2739941:CTA:C	donor_loss	1.0000
19:2739942:TA:T	donor_loss	1.0000
19:2739943:A:C	donor_loss	1.0000
19:2739944:C:A	donor_loss	1.0000
19:2733486:C:CC	acceptor_gain	0.9900
19:2733493:C:CT	acceptor_gain	0.9900
19:2733493:C:T	acceptor_gain	0.9900
19:2733502:C:CT	acceptor_gain	0.9900
19:2739943:ACCT:A	donor_gain	0.9900
19:2739943:ACCTC:A	donor_gain	0.9900
19:2739944:CCT:C	donor_gain	0.9900
19:2739944:CCTC:C	donor_gain	0.9900
19:2739944:CCTCC:C	donor_gain	0.9900
19:2733484:AG:A	acceptor_gain	0.9800
19:2733485:GC:G	acceptor_loss	0.9800
19:2733486:CT:C	acceptor_loss	0.9800
19:2733487:T:C	acceptor_loss	0.9800
19:2733499:C:CT	acceptor_gain	0.9800
19:2737199:A:T	acceptor_gain	0.9800
19:2737380:C:CC	acceptor_gain	0.9800
19:2739943:A:AC	donor_gain	0.9800
19:2739944:C:CC	donor_gain	0.9800
19:2733483:GAG:G	acceptor_gain	0.9700
19:2733485:GCTG:G	acceptor_loss	0.9700
19:2733494:G:T	acceptor_gain	0.9700
19:2733481:TGGAG:T	acceptor_gain	0.9600
19:2733490:A:T	acceptor_gain	0.9600

AlphaMissense

2018 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:2733049:C:T	G216D	0.994
19:2733050:C:G	G216R	0.994
19:2732985:G:C	S237R	0.993
19:2732985:G:T	S237R	0.993
19:2732987:T:G	S237R	0.993
19:2733143:C:G	G185R	0.991
19:2732791:C:T	G302D	0.989
19:2732897:C:G	G267R	0.988
19:2733416:C:G	G94R	0.988
19:2733049:C:A	G216V	0.987
19:2737100:C:T	G53E	0.987
19:2732792:C:G	G302R	0.986
19:2732871:G:C	F275L	0.986
19:2732871:G:T	F275L	0.986
19:2732873:A:G	F275L	0.986
19:2732974:G:C	P241R	0.985
19:2733415:C:T	G94D	0.985
19:2732968:C:T	G243D	0.984
19:2737083:A:G	C59R	0.984
19:2737101:C:A	G53W	0.984
19:2737101:C:G	G53R	0.984
19:2737101:C:T	G53R	0.984
19:2732884:C:T	G271D	0.983
19:2733169:G:T	A176E	0.983
19:2733131:C:G	G189R	0.981
19:2732885:C:G	G271R	0.980
19:2732969:C:G	G243R	0.980
19:2733143:C:A	G185C	0.980
19:2737088:G:T	A57D	0.980
19:2737094:A:G	F55S	0.980

dbSNP variants (sampled 300 via entrez): RS1000349816 (19:2734961 G>A), RS1000602627 (19:2735692 G>A,T), RS1000777222 (19:2732114 C>G,T), RS1000806149 (19:2740411 T>A), RS1000852306 (19:2732105 A>G), RS1000906659 (19:2740753 C>G,T), RS1001387606 (19:2738296 T>C), RS1002127120 (19:2739665 G>A,T), RS1002280272 (19:2734577 C>T), RS1002341601 (19:2737326 G>A,C,T), RS1002423503 (19:2734780 C>A,T), RS1002736383 (19:2734039 T>C), RS1003262229 (19:2738495 G>A,C), RS1003393189 (19:2733154 G>A,C), RS1003692958 (19:2734015 C>T)

Disease associations

OMIM: gene MIM:612168 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066510 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC39 family of metal ion transporters

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.50	Kd	31.67	nM	CHEMBL5653589
7.48	ED50	33.26	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149425: Binding affinity to human SLC39A3 incubated for 45 mins by Kinobead based pull down assay	kd	0.0317	uM

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Zinc	increases transport, affects expression, decreases expression	4
Valproic Acid	increases expression, increases methylation	3
sodium arsenite	increases expression	2
coumarin	decreases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
14-deoxy-11,12-didehydroandrographolide	decreases expression	1
Grape Seed Proanthocyanidins	decreases expression	1
bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)	decreases expression	1
Sunitinib	increases expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	decreases phosphorylation	1
Calcitriol	decreases expression	1
Plant Extracts	decreases expression	1
Smoke	decreases expression	1
Dronabinol	increases expression	1
Tretinoin	decreases expression	1
Cadmium Chloride	increases expression	1
Okadaic Acid	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652467	Binding	Binding affinity to human SLC39A3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4NI	HCT116-SLC39A3-KO-c2	Cancer cell line	Male
CVCL_D4NJ	HCT116-SLC39A3-KO-c4	Cancer cell line	Male
CVCL_TN56	HAP1 SLC39A3 (-) 1	Cancer cell line	Male
CVCL_TN57	HAP1 SLC39A3 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.