SLC39A9

Summary

SLC39A9 (solute carrier family 39 member 9, HGNC:20182) is a protein-coding gene on chromosome 14q24.1, encoding Zinc transporter ZIP9 (Q9NUM3). Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis.

Enables G protein-coupled receptor activity; androgen binding activity; and zinc efflux transmembrane transporter activity. Involved in intracellular zinc ion homeostasis; regulation of vascular endothelial cell proliferation; and zinc ion transmembrane transport. Located in several cellular components, including mitochondrial membrane; perinuclear region of cytoplasm; and trans-Golgi network.

Source: NCBI Gene 55334 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 34 total
• MANE Select transcript: NM_018375

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20182
Approved symbol	SLC39A9
Name	solute carrier family 39 member 9
Location	14q24.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11274, ZIP9
Ensembl gene	ENSG00000029364
Ensembl biotype	protein_coding
OMIM	619116
Entrez	55334

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 5 protein_coding, 3 retained_intron, 2 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000031146, ENST00000336643, ENST00000538956, ENST00000554023, ENST00000554059, ENST00000555245, ENST00000555840, ENST00000556125, ENST00000556605, ENST00000557046, ENST00000628474, ENST00000893627

RefSeq mRNA: 6 — MANE Select: NM_018375 NM_001252148, NM_001252150, NM_001252151, NM_001252152, NM_001330185, NM_018375

CCDS: CCDS58327, CCDS58328, CCDS81816, CCDS9795

Canonical transcript exons

ENST00000336643 — 7 exons

Exon	Start	End
ENSE00002478136	69458363	69462390
ENSE00003081080	69398692	69399465
ENSE00003460102	69454812	69454897
ENSE00003612015	69453241	69453309
ENSE00003619063	69455732	69455866
ENSE00003623740	69424094	69424202
ENSE00003688718	69442069	69442266

Expression profiles

Bgee: expression breadth ubiquitous, 273 present calls, max score 96.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 64.1961 / max 759.8381, expressed in 1825 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140339	54.1696	1823
140337	4.6640	1632
140343	3.9281	1573
140338	1.0046	659
140340	0.4298	227

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	96.61	gold quality
jejunal mucosa	UBERON:0000399	95.12	gold quality
corpus epididymis	UBERON:0004359	94.80	gold quality
adrenal tissue	UBERON:0018303	94.61	gold quality
mucosa of sigmoid colon	UBERON:0004993	93.78	gold quality
colonic mucosa	UBERON:0000317	93.04	gold quality
upper leg skin	UBERON:0004262	92.95	gold quality
islet of Langerhans	UBERON:0000006	92.86	gold quality
esophagus squamous epithelium	UBERON:0006920	92.70	gold quality
caput epididymis	UBERON:0004358	92.64	gold quality
adult organism	UBERON:0007023	92.62	gold quality
stromal cell of endometrium	CL:0002255	92.20	gold quality
palpebral conjunctiva	UBERON:0001812	92.03	gold quality
skin of hip	UBERON:0001554	91.84	gold quality
tibia	UBERON:0000979	91.63	gold quality
calcaneal tendon	UBERON:0003701	91.48	gold quality
cauda epididymis	UBERON:0004360	91.39	gold quality
oral cavity	UBERON:0000167	90.71	gold quality
epithelium of nasopharynx	UBERON:0001951	90.66	gold quality
nasopharynx	UBERON:0001728	90.64	gold quality
tendon	UBERON:0000043	90.31	gold quality
renal medulla	UBERON:0000362	90.23	gold quality
eye	UBERON:0000970	90.23	gold quality
gingiva	UBERON:0001828	90.22	gold quality
right lobe of liver	UBERON:0001114	89.84	gold quality
mammalian vulva	UBERON:0000997	89.74	gold quality
bronchial epithelial cell	CL:0002328	89.62	gold quality
rectum	UBERON:0001052	89.54	gold quality
gingival epithelium	UBERON:0001949	89.48	gold quality
decidua	UBERON:0002450	89.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

162 targeting SLC39A9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-3162-3P	100.00	65.37	363
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-4753-3P	99.90	71.03	3786

Literature-anchored findings (GeneRIF, showing 13)

• SLC39A9 functions to regulate zinc homeostasis in the secretory pathway without significantly altering cytosolic zinc homeostasis. (PMID:19420709)
• ZIP9 mediates testosterone promotion of apoptosis and is widely expressed in human tissues and up-regulated in malignant breast and prostate tissues, suggesting that it is a potential therapeutic target for treating breast and prostate cancers. (PMID:25014355)
• ZIP9 expression in glioma tumors was not associated with tumor grade or IDH1 mutation status. (PMID:25921144)
• ZIP9 role glioblastoma cells migration.ZIP9 expression affects phosphorylation states of p53 and GSK-3beta. (PMID:27654922)
• The results show ZIP9 is a specific Gi coupled-mAR mediating testosterone-induced MAP kinase and zinc signaling in PC3-ZIP9 cells. (PMID:28219737)
• The study connects structural features of ZIP9 to its functions and indicates a possible relevance of ZIP9 as a pharmacological target (PMID:28943399)
• Study provides evidence that mediates testosterone-induced migratory activity of metastatic prostate cancer cells. (PMID:30262433)
• The G protein-coupled receptor family C group 6 member A (GPRC6A) and zinc transporter member 9 (ZIP9) have also been portrayed as mARs, related to the extranuclear action of androgens. (PMID:30707908)
• these data illustrate epigenetic regulation of ZIP9 and its critical role in promoting radiation-induced skin fibrosis (PMID:31254515)
• Study found that the androgen dihydrotestosterone (DHT) might function via a novel membrane androgen receptor (mAR-SLC39A9) to increase nuclear androgen receptor (nAR)-negative bladder cancer (BCa) cell migration and invasion. DHT/mAR-SLC39A9 might function by altering Galphai protein-mediated MAPK/MMP9 intracellular signaling to increase nAR-negative BCa cell migration and invasion. (PMID:31506605)
• Androgens promote vascular endothelial cell proliferation through activation of a ZIP9-dependent inhibitory G protein/PI3K-Akt/Erk/cyclin D1 pathway. (PMID:34555425)
• ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma. (PMID:34706862)
• Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection. (PMID:39173055)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc39a9	ENSDARG00000070447
mus_musculus	Slc39a9	ENSMUSG00000048833
rattus_norvegicus	Slc39a9	ENSRNOG00000005052
drosophila_melanogaster	Zip102B	FBGN0039902
caenorhabditis_elegans		WBGENE00011329

Protein

Protein identifiers

Zinc transporter ZIP9 — Q9NUM3 (reviewed: Q9NUM3)

Alternative names: Solute carrier family 39 member 9, Zrt- and Irt-like protein 9

All UniProt accessions (4): A0A0D9SFA2, C4N9M8, Q9NUM3, M0QX28

UniProt curated annotations — full annotation on UniProt →

Function. Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation. Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells. Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.

Subcellular location. Golgi apparatus. trans-Golgi network membrane. Cell membrane. Cytoplasm. Perinuclear region. Mitochondrion. Nucleus.

Tissue specificity. Highly expressed in pancreas, testis, and pituitary and moderately in the kidney, liver, uterus, heart, prostate, and brain, whereas expression is lower in the ovary and colon.

Induction. Up-regulated by testosterone in cancer cells.

Similarity. Belongs to the ZIP transporter (TC 2.A.5) family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NUM3-1	1	yes
Q9NUM3-2	2
Q9NUM3-3	3

RefSeq proteins (6): NP_001239077, NP_001239079, NP_001239080, NP_001239081, NP_001317114, NP_060845* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003689	ZIP	Family
IPR045891	ZIP9	Family

Pfam: PF02535

Catalyzed reactions (Rhea), 1 shown:

• Zn(2+)(in) = Zn(2+)(out) (RHEA:29351)

UniProt features (18 total): transmembrane region 8, splice variant 3, sequence variant 3, glycosylation site 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NUM3-F1	79.32	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 241, 29

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 205 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, MYOGENIN_Q6, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_TRANSITION_METAL_ION_TRANSPORT, GOBP_APICAL_JUNCTION_ASSEMBLY, AMIT_SERUM_RESPONSE_20_MCF10A, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, CAGCTG_AP4_Q5, GGCNKCCATNK_UNKNOWN, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_RESPONSE_TO_TESTOSTERONE, GOBP_CELL_JUNCTION_ORGANIZATION, GOCC_TRANS_GOLGI_NETWORK, CATTTCA_MIR203

GO Biological Process (10): intracellular zinc ion homeostasis (GO:0006882), bicellular tight junction assembly (GO:0070830), zinc ion transmembrane transport (GO:0071577), regulation of vascular endothelial cell proliferation (GO:1905562), regulation of cellular response to testosterone stimulus (GO:2000654), monoatomic ion transport (GO:0006811), zinc ion transport (GO:0006829), G protein-coupled receptor signaling pathway (GO:0007186), metal ion transport (GO:0030001), transmembrane transport (GO:0055085)

GO Molecular Function (6): G protein-coupled receptor activity (GO:0004930), zinc ion transmembrane transporter activity (GO:0005385), androgen binding (GO:0005497), zinc efflux transmembrane transporter activity (GO:0022883), protein binding (GO:0005515), metal ion transmembrane transporter activity (GO:0046873)

GO Cellular Component (9): nucleus (GO:0005634), mitochondrion (GO:0005739), trans-Golgi network (GO:0005802), plasma membrane (GO:0005886), mitochondrial membrane (GO:0031966), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	3
cytoplasm	3
cellular anatomical structure	3
transport	2
intracellular monoatomic cation homeostasis	1
inorganic ion homeostasis	1
apical junction assembly	1
tight junction assembly	1
zinc ion transport	1
monoatomic cation transmembrane transport	1
regulation of endothelial cell proliferation	1
vascular endothelial cell proliferation	1
regulation of response to stimulus	1
regulation of cellular process	1
cellular response to testosterone stimulus	1
transition metal ion transport	1
G protein-coupled receptor activity	1
signal transduction	1
monoatomic cation transport	1
cellular process	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
transition metal ion transmembrane transporter activity	1
zinc ion transmembrane transport	1
hormone binding	1
zinc ion transmembrane transporter activity	1
monoatomic cation efflux transmembrane transporter activity	1
binding	1
monoatomic cation transmembrane transporter activity	1
metal ion transport	1
Golgi apparatus subcompartment	1
membrane	1
cell periphery	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1
intracellular anatomical structure	1
endomembrane system	1

Protein interactions and networks

STRING

678 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC39A9	SLC39A11	Q8N1S5	861
SLC39A9	SLC39A7	Q92504	854
SLC39A9	SLC39A13	Q96H72	841
SLC39A9	SLC30A7	Q8NEW0	840
SLC39A9	SLC39A1	Q9NY26	814
SLC39A9	SLC39A6	Q13433	808
SLC39A9	SLC39A10	Q9ULF5	808
SLC39A9	SLC30A9	Q6PML9	796
SLC39A9	SLC30A5	Q8TAD4	794
SLC39A9	SLC30A6	Q6NXT4	777
SLC39A9	SLC39A14	Q15043	772
SLC39A9	SLC39A5	Q6ZMH5	767
SLC39A9	SLC39A8	Q9C0K1	751
SLC39A9	SLC30A1	Q9Y6M5	748
SLC39A9	SLC30A4	O14863	728

IntAct

129 interactions, top by confidence:

A	B	Type	Score
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
SLC39A9	SSMEM1	psi-mi:“MI:0915”(physical association)	0.560
SLC39A9	ELOVL5	psi-mi:“MI:0915”(physical association)	0.560
SLC39A9	SLC39A2	psi-mi:“MI:0915”(physical association)	0.560
SLC39A9	TRHR	psi-mi:“MI:0915”(physical association)	0.560
CREB3L3	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
HERPUD2	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
TMEM237	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
CREB3L1	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
MFSD14B	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
EVI2B	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
SSMEM1	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
CRB3	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
ANKRD46	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
TM4SF18	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
AQP6	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
CYB5B	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
SLC39A9	TMEM140	psi-mi:“MI:0915”(physical association)	0.560
NEU1	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
APH1A	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
CBARP	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
BNIP2	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
SLC66A1	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
SLC10A6	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
CD79A	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
HTR2C	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560
MFSD5	SLC39A9	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (282): SLC39A9 (Affinity Capture-RNA), SLC39A9 (Affinity Capture-RNA), CD44 (Affinity Capture-MS), TTI2 (Affinity Capture-MS), FKRP (Affinity Capture-MS), HIP1R (Affinity Capture-MS), DNAJC13 (Affinity Capture-MS), TPST2 (Affinity Capture-MS), SLC25A24 (Affinity Capture-MS), OSTC (Affinity Capture-MS), HPCAL1 (Affinity Capture-MS), CANT1 (Affinity Capture-MS), SYNGR3 (Affinity Capture-MS), METTL16 (Affinity Capture-MS), KIAA0368 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2KQY6, A0A3Q7ZPG5, A4IFD7, A4IIC5, A5PMX1, A8WMY3, A8X482, O04089, O45923, O64738, O82643, O94639, P40544, P59889, Q12067, Q12436, Q28J44, Q2YDD4, Q3KR82, Q52KD7, Q54LY6, Q5BJM8, Q5BL29, Q5E960, Q5MNV6, Q5RE57, Q5U1X7, Q5ZIU9, Q640S1, Q6NRI1, Q6NRM1, Q6NTL1, Q6P3N9, Q6P6S2, Q6QQT1, Q8BFU1, Q8BWY7, Q8LE59, Q8N1S5, Q8NEW0

Diamond homologs: A0A3Q7ZPG5, A8X482, Q1KZG0, Q3KR82, Q5BL29, Q5RE57, Q5ZIU9, Q640S1, Q6NRM1, Q6NTL1, Q8BFU1, Q95JP5, Q9NUM3, Q9V3A4, Q9XTQ7, Q9XUC4, A4IGY6, A5D7L5, A8WMY3, P0DX17, P40544, Q08E40, Q13433, Q15043, Q29175, Q2M1K6, Q31125, Q4V887, Q5FVQ0, Q5R6I6, Q5R9M9, Q5RAB7, Q5RFD5, Q5TJF6, Q5ZI20, Q6L8F3, Q6MGB4, Q6P5F6, Q6PEH9, Q78IQ7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1557 predictions. Top by Δscore:

Variant	Effect	Δscore
14:69398882:A:T	donor_gain	1.0000
14:69424169:G:GT	donor_gain	1.0000
14:69424201:GG:G	donor_gain	1.0000
14:69424202:GG:G	donor_gain	1.0000
14:69424213:G:GT	donor_gain	1.0000
14:69424213:G:T	donor_gain	1.0000
14:69442263:GACG:G	donor_gain	1.0000
14:69442267:G:GA	donor_loss	1.0000
14:69442267:G:GG	donor_gain	1.0000
14:69442268:T:TC	donor_loss	1.0000
14:69442269:GA:G	donor_loss	1.0000
14:69453239:A:AG	acceptor_gain	1.0000
14:69453240:G:GG	acceptor_gain	1.0000
14:69454797:T:TA	acceptor_gain	1.0000
14:69454804:A:AG	acceptor_gain	1.0000
14:69454805:A:G	acceptor_gain	1.0000
14:69454807:T:G	acceptor_gain	1.0000
14:69454808:A:AG	acceptor_gain	1.0000
14:69454809:T:G	acceptor_gain	1.0000
14:69454809:TAGCT:T	acceptor_loss	1.0000
14:69454810:A:AG	acceptor_gain	1.0000
14:69454810:AGCT:A	acceptor_gain	1.0000
14:69454811:G:GT	acceptor_gain	1.0000
14:69454811:GC:G	acceptor_gain	1.0000
14:69454811:GCT:G	acceptor_gain	1.0000
14:69454811:GCTG:G	acceptor_gain	1.0000
14:69454811:GCTGA:G	acceptor_gain	1.0000
14:69454898:G:C	donor_loss	1.0000
14:69455725:T:G	acceptor_gain	1.0000
14:69455727:TCCA:T	acceptor_loss	1.0000

AlphaMissense

1971 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:69399433:G:A	G22R	1.000
14:69399433:G:C	G22R	1.000
14:69399434:G:A	G22E	1.000
14:69424121:G:C	G42R	1.000
14:69424127:G:C	G44R	1.000
14:69424128:G:A	G44D	1.000
14:69424131:T:C	L45P	1.000
14:69424134:T:A	L46H	1.000
14:69424139:G:A	G48R	1.000
14:69424139:G:C	G48R	1.000
14:69424140:G:A	G48E	1.000
14:69424146:C:A	A50D	1.000
14:69424149:T:C	L51P	1.000
14:69424169:G:A	G58R	1.000
14:69424169:G:C	G58R	1.000
14:69442206:G:C	G115R	1.000
14:69442207:G:A	G115D	1.000
14:69442207:G:T	G115V	1.000
14:69442209:T:C	F116L	1.000
14:69442211:C:A	F116L	1.000
14:69442211:C:G	F116L	1.000
14:69453288:G:C	G151R	1.000
14:69453289:G:A	G151D	1.000
14:69453292:T:A	L152Q	1.000
14:69453292:T:C	L152P	1.000
14:69453298:T:A	V154D	1.000
14:69453300:C:A	H155N	1.000
14:69453300:C:G	H155D	1.000
14:69453302:T:A	H155Q	1.000
14:69453302:T:G	H155Q	1.000

dbSNP variants (sampled 300 via entrez): RS1000017124 (14:69443298 A>G), RS1000069566 (14:69443623 C>T), RS1000074215 (14:69416485 C>G,T), RS1000091488 (14:69435213 A>G,T), RS1000111538 (14:69439981 T>C), RS1000200655 (14:69397360 C>T), RS1000369282 (14:69450381 G>A), RS1000385117 (14:69403552 ATAG>A), RS1000390450 (14:69446166 A>C), RS1000420668 (14:69456632 T>C), RS1000423079 (14:69413245 A>G), RS1000469593 (14:69401464 T>C), RS1000576554 (14:69418634 T>G), RS1000614845 (14:69397586 C>T), RS1000617019 (14:69420943 T>C)

Disease associations

OMIM: gene MIM:619116 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004608_194	Granulocyte percentage of myeloid white cells	4.000000e-09
GCST90002394_483	Monocyte percentage of white cells	1.000000e-13
GCST90002398_221	Neutrophil count	2.000000e-22
GCST90002407_625	White blood cell count	2.000000e-14

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0007989	monocyte percentage of leukocytes
EFO:0004833	neutrophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC39 family of metal ion transporters

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	4
sodium arsenite	affects cotreatment, decreases expression, increases abundance, increases expression	2
Arsenic	increases abundance, affects methylation, affects cotreatment, decreases expression	2
Vehicle Emissions	decreases expression, decreases reaction, increases abundance, increases expression	2
Zinc	increases transport, decreases expression	2
Particulate Matter	decreases expression, decreases reaction, increases abundance, increases expression	2
alpha-pinene	increases abundance, affects cotreatment, increases expression	1
beta-lapachone	decreases expression, increases expression	1
ochratoxin A	decreases expression	1
vinclozolin	affects binding, decreases reaction	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
prochloraz	affects binding, decreases reaction	1
di-n-butylphosphoric acid	affects expression	1
3’,5’-dichloro-2-hydroxy-2-methylbut-3-enanilide	affects binding, decreases reaction	1
K 7174	increases expression	1
motexafin gadolinium	increases expression, affects cotreatment	1
Grape Seed Proanthocyanidins	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases reaction, decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acrolein	increases expression, increases abundance, affects cotreatment	1
Air Pollutants	increases abundance, increases expression, affects cotreatment	1
Benzo(a)pyrene	increases expression	1
Calcitriol	decreases expression	1
Doxorubicin	decreases expression	1
Hydrogen Peroxide	affects expression	1
Lead	increases expression	1
Ozone	increases abundance, affects cotreatment, increases expression	1
Plant Extracts	affects cotreatment, increases expression	1

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2G7	Abcam HeLa SLC39A9 KO	Cancer cell line	Female
CVCL_D4NT	HCT116-SLC39A9-KO-c1	Cancer cell line	Male
CVCL_D4NU	HCT116-SLC39A9-KO-c14	Cancer cell line	Male
CVCL_TN62	HAP1 SLC39A9 (-) 1	Cancer cell line	Male
CVCL_TN63	HAP1 SLC39A9 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.