SLC43A1

Summary

SLC43A1 (solute carrier family 43 member 1, HGNC:9225) is a protein-coding gene on chromosome 11q12.1, encoding Large neutral amino acids transporter small subunit 3 (O75387). Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine.

SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).

Source: NCBI Gene 8501 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 107 total
• Druggable target: yes
• MANE Select transcript: NM_003627

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9225
Approved symbol	SLC43A1
Name	solute carrier family 43 member 1
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	R00504, PB39
Ensembl gene	ENSG00000149150
Ensembl biotype	protein_coding
OMIM	603733
Entrez	8501

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 33 protein_coding, 3 nonsense_mediated_decay, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000278426, ENST00000524995, ENST00000525764, ENST00000528450, ENST00000529452, ENST00000530159, ENST00000533066, ENST00000533263, ENST00000533515, ENST00000534105, ENST00000901378, ENST00000901379, ENST00000901380, ENST00000901381, ENST00000901382, ENST00000901383, ENST00000901384, ENST00000901385, ENST00000901386, ENST00000901387, ENST00000901388, ENST00000901389, ENST00000930667, ENST00000930668, ENST00000930669, ENST00000930670, ENST00000930671, ENST00000930672, ENST00000930673, ENST00000930674, ENST00000930675, ENST00000930676, ENST00000930677, ENST00000967927, ENST00000967928, ENST00000967929, ENST00000967930, ENST00000967931

RefSeq mRNA: 2 — MANE Select: NM_003627 NM_001198810, NM_003627

CCDS: CCDS7958

Canonical transcript exons

ENST00000278426 — 15 exons

Exon	Start	End
ENSE00001027282	57513958	57514124
ENSE00001027283	57487095	57487218
ENSE00002146364	57484534	57485242
ENSE00002167073	57515444	57515702
ENSE00003490019	57496031	57496164
ENSE00003500220	57497753	57497845
ENSE00003554107	57500779	57500855
ENSE00003605508	57491716	57491862
ENSE00003613926	57500988	57501043
ENSE00003656019	57489251	57489392
ENSE00003661739	57491591	57491626
ENSE00003662775	57488916	57488989
ENSE00003685436	57491224	57491362
ENSE00003789082	57501152	57501329
ENSE00003789453	57493993	57494171

Expression profiles

Bgee: expression breadth ubiquitous, 198 present calls, max score 98.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.2562 / max 289.7168, expressed in 1543 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119792	8.7415	1476
119789	0.9927	391
119787	0.8917	363
119788	0.3360	154
119791	0.1752	58
119790	0.1191	46

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	98.75	gold quality
right lobe of liver	UBERON:0001114	96.81	gold quality
liver	UBERON:0002107	92.98	gold quality
pancreas	UBERON:0001264	91.71	gold quality
mucosa of stomach	UBERON:0001199	91.29	gold quality
body of stomach	UBERON:0001161	90.66	gold quality
right ovary	UBERON:0002118	89.84	gold quality
left ovary	UBERON:0002119	88.86	gold quality
gall bladder	UBERON:0002110	88.79	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.16	gold quality
stomach	UBERON:0000945	87.96	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.46	gold quality
stromal cell of endometrium	CL:0002255	86.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	86.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	86.08	gold quality
body of uterus	UBERON:0009853	86.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	85.99	gold quality
lower esophagus	UBERON:0013473	85.94	gold quality
apex of heart	UBERON:0002098	85.91	gold quality
gastrocnemius	UBERON:0001388	85.57	gold quality
muscle of leg	UBERON:0001383	85.47	gold quality
fundus of stomach	UBERON:0001160	85.21	gold quality
ovary	UBERON:0000992	84.67	gold quality
endocervix	UBERON:0000458	84.38	gold quality
trabecular bone tissue	UBERON:0002483	84.38	gold quality
right lobe of thyroid gland	UBERON:0001119	84.35	gold quality
skin of leg	UBERON:0001511	84.15	gold quality
right lung	UBERON:0002167	84.12	gold quality
omental fat pad	UBERON:0010414	84.07	gold quality
peritoneum	UBERON:0002358	84.02	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-81547	yes	21.36
E-ANND-3	yes	19.93

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NR1I2

miRNA regulators (miRDB)

32 targeting SLC43A1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4650-5P	99.98	64.69	999
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-623	99.76	68.16	1170
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-6832-3P	99.52	70.44	1726
HSA-MIR-8064	99.45	66.92	875
HSA-MIR-670-3P	99.03	68.88	2404
HSA-MIR-4650-3P	99.01	68.39	1062
HSA-MIR-320A-5P	98.88	66.75	1248
HSA-MIR-6895-3P	98.79	65.69	996
HSA-MIR-6868-3P	98.63	69.64	2259
HSA-MIR-12125	98.59	67.54	1044
HSA-MIR-1237-3P	98.55	67.65	1423
HSA-MIR-1248	98.47	67.54	1314
HSA-MIR-6516-5P	98.42	70.19	1551
HSA-MIR-6831-5P	98.26	67.20	990
HSA-MIR-8057	97.64	66.54	897
HSA-MIR-6514-3P	97.52	66.50	808
HSA-MIR-214-5P	97.34	66.50	617
HSA-MIR-3649	96.85	64.10	340
HSA-MIR-6822-3P	96.60	66.06	680
HSA-MIR-6888-5P	95.89	63.78	831
HSA-MIR-6805-5P	95.79	64.86	670
HSA-MIR-1237-5P	95.38	62.21	451

Literature-anchored findings (GeneRIF, showing 1)

• LAT3 is a transporter subserving system L2 and should denote a new family of organic solute transporters (PMID:12930836)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc43a1a	ENSDARG00000037393
danio_rerio	slc43a1b	ENSDARG00000037748
mus_musculus	Slc43a1	ENSMUSG00000027075
rattus_norvegicus	Slc43a1	ENSRNOG00000008243

Paralogs (1): SLC43A2 (ENSG00000167703)

Protein

Protein identifiers

Large neutral amino acids transporter small subunit 3 — O75387 (reviewed: O75387)

Alternative names: L-type amino acid transporter 3, Prostate cancer overexpressed gene 1 protein, Solute carrier family 43 member 1

All UniProt accessions (6): O75387, E9PJ68, E9PJT8, E9PR87, E9PRF0, H0YEH0

UniProt curated annotations — full annotation on UniProt →

Function. Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine. The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion.

Subcellular location. Cell membrane. Apical cell membrane. Endoplasmic reticulum membrane.

Tissue specificity. Ubiquitously expressed in fetus and adult. Highest expression in adult pancreas, liver, skeletal muscle. In fetus, highest expression in liver and lower levels in kidney, and lung. Exclusively expressed in the glomeruli along the glomerular capillary walls.

Similarity. Belongs to the SLC43A transporter (TC 2.A.1.44) family.

Isoforms (2)

UniProt ID	Names	Canonical?
O75387-1	1, 2.3kb	yes
O75387-2	2, 5kb

RefSeq proteins (2): NP_001185739, NP_003618* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011701	MFS	Family
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF07690

Catalyzed reactions (Rhea), 6 shown:

• L-phenylalanine(in) = L-phenylalanine(out) (RHEA:27950)
• L-valine(in) = L-valine(out) (RHEA:29703)
• L-methionine(in) = L-methionine(out) (RHEA:70939)
• L-isoleucine(in) = L-isoleucine(out) (RHEA:70943)
• L-leucine(in) = L-leucine(out) (RHEA:73011)
• D-leucine(in) = D-leucine(out) (RHEA:73015)

UniProt features (22 total): transmembrane region 12, modified residue 3, glycosylation site 3, sequence variant 2, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75387-F1	79.71	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 237, 262, 267

Glycosylation sites (3): 57, 212, 229

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-352230	Amino acid transport across the plasma membrane
R-HSA-382551	Transport of small molecules
R-HSA-425393
R-HSA-425407	SLC-mediated transmembrane transport

MSigDB gene sets: 214 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, GOBP_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT, GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT, MODULE_255, XU_GH1_AUTOCRINE_TARGETS_UP, MODULE_45, MODULE_317, MODULE_16, GOBP_AMINO_ACID_TRANSMEMBRANE_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, KANG_FLUOROURACIL_RESISTANCE_DN, NFKB_C, GOBP_NEGATIVE_REGULATION_OF_TRANSPORT, GOBP_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT, MYCMAX_01

GO Biological Process (9): amino acid transport (GO:0006865), neutral amino acid transport (GO:0015804), isoleucine transport (GO:0015818), L-leucine transport (GO:0015820), negative regulation of amino acid transport (GO:0051956), L-valine transmembrane transport (GO:1903785), negative regulation of L-leucine import across plasma membrane (GO:1905533), L-amino acid transport (GO:0015807), transmembrane transport (GO:0055085)

GO Molecular Function (8): L-valine transmembrane transporter activity (GO:0005304), amino acid transmembrane transporter activity (GO:0015171), neutral L-amino acid transmembrane transporter activity (GO:0015175), L-amino acid transmembrane transporter activity (GO:0015179), L-isoleucine transmembrane transporter activity (GO:0015188), L-leucine transmembrane transporter activity (GO:0015190), protein binding (GO:0005515), transmembrane transporter activity (GO:0022857)

GO Cellular Component (6): endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), apical plasma membrane (GO:0016324), podocyte foot (GO:0098846), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
SLC-mediated transport of amino acids	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
amino acid transport	3
neutral amino acid transport	3
neutral L-amino acid transmembrane transporter activity	3
L-amino acid transmembrane transporter activity	3
branched-chain amino acid transmembrane transporter activity	3
transport	2
branched-chain amino acid transport	2
L-alpha-amino acid transmembrane transport	2
amino acid transmembrane transporter activity	2
L-amino acid transport	1
negative regulation of amine transport	1
regulation of amino acid transport	1
valine transport	1
negative regulation of organic acid transport	1
negative regulation of transmembrane transport	1
negative regulation of amino acid transport	1
L-leucine import across plasma membrane	1
regulation of L-leucine import across plasma membrane	1
carboxylic acid transport	1
nitrogen compound transport	1
cellular process	1
L-valine transmembrane transport	1
amino acid transmembrane transport	1
transmembrane transporter activity	1
carboxylic acid transmembrane transporter activity	1
binding	1
transporter activity	1
transmembrane transport	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
apical part of cell	1
plasma membrane region	1
plasma membrane bounded cell projection	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

710 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC43A1	SLC7A8	Q9UHI5	943
SLC43A1	SLC3A2	P08195	937
SLC43A1	SLC7A5	Q01650	913
SLC43A1	SLC7A6	Q92536	647
SLC43A1	SLC1A5	Q15758	548
SLC43A1	SLC38A2	Q96QD8	543
SLC43A1	SLC38A1	Q9H2H9	506
SLC43A1	SLC16A10	Q8TF71	490
SLC43A1	SLC6A15	Q9H2J7	489
SLC43A1	SLC7A9	P82251	455
SLC43A1	SLC7A7	Q9UM01	455
SLC43A1	SLC2A4RG	Q9NR83	418
SLC43A1	SLC7A2	P52569	416
SLC43A1	SLC1A4	P43007	412
SLC43A1	SLC36A1	Q7Z2H8	410

IntAct

14 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SLC43A1	BACH2	psi-mi:“MI:0915”(physical association)	0.560
YIPF3	TMEM120B	psi-mi:“MI:0914”(association)	0.530
CD81	STX3	psi-mi:“MI:0914”(association)	0.350
ZACN	FAM234B	psi-mi:“MI:0914”(association)	0.350
SLC22A4	RTL8C	psi-mi:“MI:0914”(association)	0.350
KCNE3	PIK3R2	psi-mi:“MI:0914”(association)	0.350
SLC17A2	ABCD4	psi-mi:“MI:0914”(association)	0.350
OR10H2	ABCD4	psi-mi:“MI:0914”(association)	0.350
SLC43A1	PLPP1	psi-mi:“MI:0914”(association)	0.350
KCNK3	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
SLC43A1	BACH2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (53): SLC43A1 (Affinity Capture-MS), SLC43A1 (Affinity Capture-MS), SLC43A1 (Affinity Capture-MS), SLC43A1 (Affinity Capture-MS), SLC43A1 (Proximity Label-MS), SLC43A1 (Affinity Capture-MS), SLC43A1 (Two-hybrid), SLC43A1 (Proximity Label-MS), SLC43A1 (Proximity Label-MS), SLC43A1 (Proximity Label-MS), SLC43A1 (Affinity Capture-MS), SLC43A1 (Affinity Capture-MS), SLC43A1 (Affinity Capture-MS), SLC43A1 (Affinity Capture-MS), SLC43A1 (Affinity Capture-MS)

ESM2 similar proteins: A0A125YQS6, A0A125YY03, A0A7J6K338, A1Z7R6, A4IHK6, A5K9W3, G4SDH4, J9UD11, O43306, O60266, O75387, O76269, O76343, P14773, P30804, P48768, Q01341, Q03343, Q04400, Q0C8L9, Q0VCM6, Q41706, Q4D3E8, Q4X251, Q57VW6, Q5B0V6, Q5BKX6, Q5RF58, Q5ZMT9, Q6C520, Q6CGU8, Q7Z8U2, Q8BIV7, Q8BSM7, Q8CGA3, Q8K4S3, Q8K596, Q8N370, Q93380, Q93Z75

Diamond homologs: A4IHK6, O75387, Q0VCM6, Q5RF58, Q8BSM7, Q8CGA3, Q8N370, Q8NBI5, Q1JPD8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

107 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	79
Likely benign	7
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

2833 predictions. Top by Δscore:

Variant	Effect	Δscore
11:57487107:T:A	donor_gain	1.0000
11:57488915:CA:C	donor_gain	1.0000
11:57491358:CCCAA:C	acceptor_gain	1.0000
11:57491359:CCAAC:C	acceptor_gain	1.0000
11:57491712:TCA:T	donor_loss	1.0000
11:57491713:CAC:C	donor_loss	1.0000
11:57491714:A:AC	donor_gain	1.0000
11:57491714:ACCAT:A	donor_loss	1.0000
11:57491715:C:A	donor_loss	1.0000
11:57491715:C:CC	donor_gain	1.0000
11:57491715:CCATG:C	donor_gain	1.0000
11:57491859:GACC:G	acceptor_gain	1.0000
11:57491861:CC:C	acceptor_gain	1.0000
11:57491862:CC:C	acceptor_gain	1.0000
11:57491863:C:CC	acceptor_gain	1.0000
11:57491863:C:T	acceptor_gain	1.0000
11:57493987:ACTC:A	donor_loss	1.0000
11:57493988:CTCAC:C	donor_loss	1.0000
11:57493989:T:TC	donor_loss	1.0000
11:57493990:C:CG	donor_loss	1.0000
11:57493991:A:AC	donor_gain	1.0000
11:57493991:AC:A	donor_loss	1.0000
11:57493991:ACT:A	donor_gain	1.0000
11:57493991:ACTCT:A	donor_gain	1.0000
11:57493992:C:CA	donor_gain	1.0000
11:57493992:CT:C	donor_gain	1.0000
11:57493992:CTC:C	donor_gain	1.0000
11:57493992:CTCT:C	donor_gain	1.0000
11:57493992:CTCTC:C	donor_gain	1.0000
11:57494025:T:TA	donor_gain	1.0000

AlphaMissense

3634 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:57487167:A:C	S487R	0.996
11:57487167:A:T	S487R	0.996
11:57487169:T:G	S487R	0.996
11:57491813:G:C	S307R	0.995
11:57491813:G:T	S307R	0.995
11:57491815:T:G	S307R	0.995
11:57497793:C:T	G173D	0.995
11:57497794:C:G	G173R	0.994
11:57501043:A:C	S111R	0.993
11:57501043:A:T	S111R	0.993
11:57501153:T:G	S111R	0.993
11:57501220:G:C	S88R	0.992
11:57501220:G:T	S88R	0.992
11:57501222:T:G	S88R	0.992
11:57514015:A:G	W33R	0.992
11:57514015:A:T	W33R	0.992
11:57501236:C:T	G83D	0.990
11:57501244:G:C	F80L	0.990
11:57501244:G:T	F80L	0.990
11:57501246:A:G	F80L	0.990
11:57487215:G:C	F471L	0.989
11:57487215:G:T	F471L	0.989
11:57487217:A:G	F471L	0.989
11:57488958:C:G	R456P	0.989
11:57491321:A:G	C366R	0.989
11:57514013:C:A	W33C	0.989
11:57514013:C:G	W33C	0.989
11:57514018:C:G	G32R	0.989
11:57487192:A:G	L479P	0.988
11:57491296:C:T	G374D	0.988

dbSNP variants (sampled 300 via entrez): RS1000013983 (11:57496429 T>A), RS1000068436 (11:57499842 C>A), RS1000200734 (11:57489920 G>A), RS1000332266 (11:57497233 G>A), RS1000343231 (11:57504057 C>T), RS1000473018 (11:57510308 A>C), RS1000493497 (11:57490263 C>T), RS1000534054 (11:57492060 C>T), RS1000672534 (11:57498443 C>A,T), RS1000780207 (11:57507681 C>G), RS1000911718 (11:57515910 T>G), RS1000969891 (11:57516543 T>A,C), RS1001025330 (11:57494897 G>C), RS1001030607 (11:57485344 A>T), RS1001046251 (11:57485035 C>G,T)

Disease associations

OMIM: gene MIM:603733 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004748_22	Lung cancer	5.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4148 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC43 family of large neutral amino acid transporters

CTD chemical–gene interactions

53 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression	4
bisphenol A	increases expression	2
sodium arsenite	decreases expression, increases expression	2
entinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Benzo(a)pyrene	decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Tunicamycin	increases expression	2
Cyclosporine	affects expression, increases expression	2
Aflatoxin B1	decreases expression, affects expression	2
allyl 2,4,6-tribromophenyl ether	increases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
trichostatin A	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
tri-o-cresyl phosphate	increases expression	1
ochratoxin A	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
perfluoro-n-nonanoic acid	increases expression	1
motexafin gadolinium	increases expression, affects cotreatment	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
belinostat	increases expression	1
abrine	decreases expression	1
quinocetone	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
2,3-dibromopropyl-2,4,6-tribromophenyl ether	increases expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	increases expression	1

ChEMBL screening assays

3 unique, capped per target: 3 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3854167	Binding	Inhibition of LAT3 in human LNCAP cells assessed as inhibition of [3H]L-leucine uptake at 10 uM after 15 mins by liquid scintillation counting method relative to control	Bioactive Dihydro-β-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis. — J Nat Prod

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4TR	HuH7-SLC43A1-KO-c1	Cancer cell line	Male
CVCL_D4TS	HuH7-SLC43A1-KO-c12	Cancer cell line	Male
CVCL_TN70	HAP1 SLC43A1 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.