SLC43A3

Summary

SLC43A3 (solute carrier family 43 member 3, HGNC:17466) is a protein-coding gene on chromosome 11q12.1, encoding Equilibrative nucleobase transporter 1 (Q8NBI5). Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine.

Enables adenine transmembrane transporter activity; guanine transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in hypoxanthine transport. Located in basolateral plasma membrane.

Source: NCBI Gene 29015 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 74 total
• Druggable target: yes
• MANE Select transcript: NM_199329

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17466
Approved symbol	SLC43A3
Name	solute carrier family 43 member 3
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	SEEEG-1, Eeg1, DKFZp762A227, FOAP-13, PRO1659
Ensembl gene	ENSG00000134802
Ensembl biotype	protein_coding
OMIM	618034
Entrez	29015

Gene structure

Transcript identifiers

Ensembl transcripts: 62 — 57 protein_coding, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 TEC

ENST00000352187, ENST00000395123, ENST00000395124, ENST00000524863, ENST00000525205, ENST00000525474, ENST00000526125, ENST00000526621, ENST00000528098, ENST00000528187, ENST00000529112, ENST00000529113, ENST00000529494, ENST00000529554, ENST00000529748, ENST00000529896, ENST00000530005, ENST00000530232, ENST00000530316, ENST00000532278, ENST00000532795, ENST00000533051, ENST00000533235, ENST00000533245, ENST00000533524, ENST00000625097, ENST00000865320, ENST00000865321, ENST00000865322, ENST00000865323, ENST00000865324, ENST00000865325, ENST00000865326, ENST00000865327, ENST00000865328, ENST00000865329, ENST00000865330, ENST00000865331, ENST00000865332, ENST00000865333, ENST00000865334, ENST00000865335, ENST00000865336, ENST00000865337, ENST00000865338, ENST00000865339, ENST00000865340, ENST00000865341, ENST00000865342, ENST00000865343, ENST00000865344, ENST00000865345, ENST00000865346, ENST00000920080, ENST00000920081, ENST00000955576, ENST00000955577, ENST00000955578, ENST00000955579, ENST00000955580, ENST00000955581, ENST00000955582

RefSeq mRNA: 5 — MANE Select: NM_199329 NM_001278201, NM_001278206, NM_014096, NM_017611, NM_199329

CCDS: CCDS60784, CCDS7956

Canonical transcript exons

ENST00000395124 — 14 exons

Exon	Start	End
ENSE00001027262	57409935	57410121
ENSE00001358103	57426588	57426652
ENSE00001520661	57427062	57427121
ENSE00002159268	57406954	57407896
ENSE00003471984	57425541	57425670
ENSE00003515103	57414933	57415106
ENSE00003515737	57414615	57414731
ENSE00003523085	57420972	57421064
ENSE00003531659	57409175	57409298
ENSE00003561334	57425989	57426352
ENSE00003587529	57421297	57421373
ENSE00003611380	57416573	57416670
ENSE00003651684	57417748	57417887
ENSE00003783955	57423982	57424028

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 98.08.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 34.2904 / max 354.7113, expressed in 1566 samples.

FANTOM5 promoters (20 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119776	29.3600	1560
119773	0.9403	192
119777	0.7923	501
119779	0.7504	292
119774	0.6208	321
119762	0.3384	163
119775	0.2006	104
206287	0.1919	104
119780	0.1808	72
119767	0.1758	75

Top tissues by expression

272 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	98.08	gold quality
right lobe of thyroid gland	UBERON:0001119	96.89	gold quality
left lobe of thyroid gland	UBERON:0001120	96.83	gold quality
thyroid gland	UBERON:0002046	96.33	gold quality
cartilage tissue	UBERON:0002418	96.15	gold quality
calcaneal tendon	UBERON:0003701	96.03	gold quality
liver	UBERON:0002107	95.89	gold quality
omental fat pad	UBERON:0010414	95.22	gold quality
peritoneum	UBERON:0002358	95.15	gold quality
monocyte	CL:0000576	94.96	gold quality
mononuclear cell	CL:0000842	94.90	gold quality
upper lobe of left lung	UBERON:0008952	94.72	gold quality
leukocyte	CL:0000738	94.68	gold quality
upper lobe of lung	UBERON:0008948	94.51	gold quality
adipose tissue of abdominal region	UBERON:0007808	94.32	gold quality
ectocervix	UBERON:0012249	94.09	gold quality
right lung	UBERON:0002167	94.06	gold quality
tibial nerve	UBERON:0001323	93.96	gold quality
subcutaneous adipose tissue	UBERON:0002190	93.72	gold quality
right coronary artery	UBERON:0001625	93.70	gold quality
apex of heart	UBERON:0002098	93.62	gold quality
mucosa of stomach	UBERON:0001199	93.39	gold quality
oocyte	CL:0000023	93.14	gold quality
ascending aorta	UBERON:0001496	93.05	gold quality
thoracic aorta	UBERON:0001515	93.01	gold quality
left coronary artery	UBERON:0001626	92.97	gold quality
minor salivary gland	UBERON:0001830	92.95	gold quality
left uterine tube	UBERON:0001303	92.94	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	92.82	gold quality
descending thoracic aorta	UBERON:0002345	92.78	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-114	yes	58.50
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting SLC43A3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4650-5P	99.98	64.69	999
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-3913-5P	99.78	67.26	968
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-3122	99.50	66.33	821
HSA-MIR-365A-3P	99.43	70.02	836
HSA-MIR-365B-3P	99.43	70.02	836
HSA-MIR-3182	99.40	68.15	2454
HSA-MIR-19A-5P	99.36	66.93	1675
HSA-MIR-19B-1-5P	99.36	67.07	1669
HSA-MIR-19B-2-5P	99.36	67.07	1669
HSA-MIR-4711-3P	98.97	66.87	1020
HSA-MIR-4656	98.79	66.22	1306
HSA-MIR-147A	98.33	66.40	795
HSA-MIR-5088-3P	98.29	66.63	1310
HSA-MIR-6773-3P	98.17	65.51	1213
HSA-MIR-1302	97.92	67.27	844
HSA-MIR-188-5P	97.89	67.01	756
HSA-MIR-6818-5P	97.50	67.10	1167
HSA-MIR-6866-3P	97.38	66.94	748
HSA-MIR-4298	97.26	66.59	765
HSA-MIR-10398-5P	97.12	64.94	1051
HSA-MIR-3622A-3P	97.06	66.43	1000
HSA-MIR-6729-3P	96.91	66.79	703
HSA-MIR-3622B-3P	96.82	66.36	988
HSA-MIR-8081	96.42	67.75	738
HSA-MIR-1251-5P	95.78	64.10	374
HSA-MIR-6851-3P	95.73	65.11	688

Literature-anchored findings (GeneRIF, showing 6)

• SLC43A3 is an equilibrative nucleobase transporter involved in purine salvage in mammals. (PMID:26455426)
• transcriptome sequencing of patient-derived angiosarcoma cells, identified a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. (PMID:26527604)
• Slc43a3 is a regulator of free fatty acid flux. (PMID:32217606)
• Functional Analysis of the Role of Equilibrative Nucleobase Transporter 1 (ENBT1/SLC43A3) in Adenine Transport in HepG2 Cells. (PMID:32339528)
• Impact of SLC43A3/ENBT1 Expression and Function on 6-Mercaptopurine Transport and Cytotoxicity in Human Acute Lymphoblastic Leukemia Cells. (PMID:35798387)
• Functional comparison of human and murine equilibrative nucleobase transporter 1. (PMID:39361655)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc43a3b	ENSDARG00000057949
danio_rerio	slc43a3a	ENSDARG00000059682
mus_musculus	Slc43a3	ENSMUSG00000027074
rattus_norvegicus	Slc43a3	ENSRNOG00000061768

Protein

Protein identifiers

Equilibrative nucleobase transporter 1 — Q8NBI5 (reviewed: Q8NBI5)

Alternative names: Protein FOAP-13, Solute carrier family 43 member 3

All UniProt accessions (17): E9PJL1, E9PJL3, E9PJT6, Q8NBI5, E9PKW3, E9PL23, E9PLF2, E9PLP1, E9PLW1, E9PMZ1, E9PNM4, E9PPE4, E9PR64, E9PR94, E9PS74, E9PSH9, H0YD64

UniProt curated annotations — full annotation on UniProt →

Function. Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine. May regulate fatty acid (FA) transport in adipocytes, acting as a positive regulator of FA efflux and as a negative regulator of FA uptake. Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobase adenine. Mediates the influx and efflux of the purine nucleobase analog drug 6-mercaptopurine across the membrane. Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobase adenine. Mediates the influx and efflux of the purine nucleobase analog drug 6-mercaptopurine across the membrane.

Subcellular location. Basolateral cell membrane.

Tissue specificity. Widely expressed with highest levels in the liver and lung, followed by the pancreas. Highly expressed in macrophages (Ref.1).

Activity regulation. Adenine transport is strongly inhibited by decynium-22. 6-mercaptopurine-transport is inhibited by 6-thioguanine, 6-methylmercaptopurine and decynium-22. 6-mercaptopurine-transport is inhibited by 6-thioguanine, 6-methylmercaptopurine and decynium-22.

Similarity. Belongs to the SLC43A transporter (TC 2.A.1.44) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8NBI5-1	1	yes
Q8NBI5-2	2

RefSeq proteins (5): NP_001265130, NP_001265135, NP_054815, NP_060081, NP_955361* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027197	SLC43A3	Family
IPR036259	MFS_trans_sf	Homologous_superfamily

Catalyzed reactions (Rhea), 3 shown:

• hypoxanthine(out) = hypoxanthine(in) (RHEA:71515)
• adenine(out) = adenine(in) (RHEA:71523)
• guanine(out) = guanine(in) (RHEA:71531)

UniProt features (22 total): transmembrane region 12, glycosylation site 3, modified residue 2, sequence conflict 2, chain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NBI5-F1	83.24	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 253, 258

Glycosylation sites (3): 56, 220, 229

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 283 (showing top): BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GCANCTGNY_MYOD_Q6, GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN, CAGCTG_AP4_Q5, GOBP_ORGANIC_ACID_TRANSPORT, MODULE_331, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_UP, CAIRO_HEPATOBLASTOMA_DN, GOBP_ORGANIC_ANION_TRANSPORT, BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, GOBP_MONOCARBOXYLIC_ACID_TRANSPORT, SENESE_HDAC1_TARGETS_UP, VANTVEER_BREAST_CANCER_ESR1_DN

GO Biological Process (6): hypoxanthine transport (GO:0035344), lipid transport (GO:0006869), adenine transport (GO:0015853), fatty acid transport (GO:0015908), xenobiotic transport (GO:0042908), guanine transmembrane transport (GO:1903716)

GO Molecular Function (5): adenine transmembrane transporter activity (GO:0015207), guanine transmembrane transporter activity (GO:0015208), fatty acid transmembrane transporter activity (GO:0015245), xenobiotic transmembrane transporter activity (GO:0042910), protein binding (GO:0005515)

GO Cellular Component (3): basolateral plasma membrane (GO:0016323), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
purine nucleobase transport	2
transport	2
purine nucleobase transmembrane transporter activity	2
lipid localization	1
lipid transport	1
monocarboxylic acid transport	1
guanine transport	1
purine nucleobase transmembrane transport	1
adenine transport	1
guanine transmembrane transport	1
monocarboxylic acid transmembrane transporter activity	1
fatty acid transport	1
lipid transmembrane transporter activity	1
transmembrane transporter activity	1
xenobiotic transport	1
binding	1
basal plasma membrane	1
plasma membrane region	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

906 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC43A3	TXNL1	O43396	501
SLC43A3	SLC29A1	Q99808	447
SLC43A3	M0QY95	M0QY95	434
SLC43A3	NUP160	Q12769	423
SLC43A3	FBLIM1	Q8WUP2	417
SLC43A3	UTP18	Q9Y5J1	413
SLC43A3	FAM234A	Q9H0X4	410
SLC43A3	TIMM10	P62072	406
SLC43A3	SLC29A2	Q14542	404
SLC43A3	SLC6A15	Q9H2J7	377
SLC43A3	SLC35F5	Q8WV83	370
SLC43A3	SLC38A7	Q9NVC3	370
SLC43A3	SLC7A6	Q92536	344
SLC43A3	SLC35B3	Q9H1N7	332
SLC43A3	SLC46A2	Q9BY10	328

IntAct

28 interactions, top by confidence:

A	B	Type	Score
IFT70A	IFT56	psi-mi:“MI:0914”(association)	0.790
IFT70B	IFT56	psi-mi:“MI:0914”(association)	0.790
SLC43A3	VCP	psi-mi:“MI:0915”(physical association)	0.560
WNK2	SLC43A3	psi-mi:“MI:0915”(physical association)	0.400
LAMC3	SLC43A3	psi-mi:“MI:0915”(physical association)	0.370
Mad2l1bp	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
Kcnk1	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
KRBOX4	ASXL2	psi-mi:“MI:0914”(association)	0.350
Ercc6l	RPL17	psi-mi:“MI:0914”(association)	0.350
Ndel1	VEZF1	psi-mi:“MI:0914”(association)	0.350
Atp2a2	ESYT2	psi-mi:“MI:0914”(association)	0.350
STRN	STK24	psi-mi:“MI:0914”(association)	0.350
SH2D3C	TMEM14DP	psi-mi:“MI:0914”(association)	0.350
	NPC1	psi-mi:“MI:0914”(association)	0.350
SLC43A3	TTR	psi-mi:“MI:0914”(association)	0.350
ARL6IP6	ESYT2	psi-mi:“MI:0914”(association)	0.350
TSPAN15	TMEM223	psi-mi:“MI:0914”(association)	0.350
ATP5PF	TMEM120B	psi-mi:“MI:0914”(association)	0.350
SPPL2B	HAS3	psi-mi:“MI:0914”(association)	0.350
SYNGR1	TNPO2	psi-mi:“MI:0914”(association)	0.350
HTR1B	SCAMP2	psi-mi:“MI:0914”(association)	0.350
SLC43A3	SURF4	psi-mi:“MI:0914”(association)	0.350
SPPL2B	POC1B-GALNT4	psi-mi:“MI:0914”(association)	0.350
SLC43A3	PLPP3	psi-mi:“MI:0914”(association)	0.350
	SLC43A3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (95): SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-MS), SLC43A3 (Affinity Capture-RNA), SLC43A3 (Two-hybrid)

ESM2 similar proteins: A1L272, A6QL92, B8AF63, E2RFJ3, E7EXX2, O35458, O35633, O54902, O80605, P49281, P49282, P51027, P57057, P58355, Q0VA82, Q28CV2, Q569T7, Q5F383, Q5R6J3, Q5RD30, Q5U3U7, Q62052, Q640L2, Q6DEJ6, Q6DIV6, Q6GPQ3, Q6GQE1, Q6P499, Q6PF45, Q6YK44, Q7RTT9, Q8BGN5, Q8BH31, Q8CBH5, Q8MIQ9, Q8NA29, Q8NBI5, Q8NHS3, Q8R070, Q8R139

Diamond homologs: A2AVZ9, Q1JPD8, Q8NBI5, A4IHK6, O75387, Q0VCM6, Q5RF58, Q8BSM7, Q8CGA3, Q8N370, Q04991

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	54
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2609 predictions. Top by Δscore:

Variant	Effect	Δscore
11:57409166:AGTAC:A	donor_loss	1.0000
11:57409167:GTAC:G	donor_loss	1.0000
11:57409168:TAC:T	donor_loss	1.0000
11:57409169:ACT:A	donor_loss	1.0000
11:57409170:CTCAC:C	donor_loss	1.0000
11:57409171:T:TA	donor_loss	1.0000
11:57409172:C:CC	donor_loss	1.0000
11:57409173:A:AC	donor_gain	1.0000
11:57409173:AC:A	donor_loss	1.0000
11:57409174:C:A	donor_loss	1.0000
11:57409174:C:CA	donor_gain	1.0000
11:57409174:C:CC	donor_gain	1.0000
11:57409174:CGTAA:C	donor_gain	1.0000
11:57409294:GGAAA:G	acceptor_gain	1.0000
11:57409295:GAAA:G	acceptor_gain	1.0000
11:57409296:AAA:A	acceptor_gain	1.0000
11:57409297:AA:A	acceptor_gain	1.0000
11:57409299:C:CC	acceptor_gain	1.0000
11:57409300:T:C	acceptor_loss	1.0000
11:57409928:CACTT:C	donor_loss	1.0000
11:57409929:ACTTA:A	donor_loss	1.0000
11:57409930:CTT:C	donor_loss	1.0000
11:57409931:TTA:T	donor_loss	1.0000
11:57409932:TA:T	donor_loss	1.0000
11:57409933:A:AC	donor_gain	1.0000
11:57409934:C:CC	donor_gain	1.0000
11:57409934:CG:C	donor_gain	1.0000
11:57409934:CGCAA:C	donor_gain	1.0000
11:57414612:CAC:C	donor_loss	1.0000
11:57414613:A:AC	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000130726 (11:57412910 T>C), RS1000196079 (11:57428092 A>C,G), RS1000403715 (11:57422777 G>C), RS1000732768 (11:57411382 C>T), RS1000848484 (11:57429448 G>A), RS1001171005 (11:57422419 A>G), RS1001292577 (11:57412106 C>A), RS1001409434 (11:57428934 C>T), RS1001570799 (11:57408163 C>T), RS1001685324 (11:57408399 T>C), RS1001724806 (11:57427717 C>T), RS1001734696 (11:57428637 C>T), RS1002036860 (11:57410210 G>A), RS1002090961 (11:57410561 T>G), RS1002423467 (11:57416706 A>C)

Disease associations

OMIM: gene MIM:618034 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST001438_11	Crohn’s disease	8.000000e-09
GCST004616_86	Platelet distribution width	1.000000e-11
GCST005024_10	Pursuit maintenance gain	1.000000e-06
GCST005024_93	Pursuit maintenance gain	3.000000e-06
GCST90002381_299	Eosinophil count	1.000000e-15
GCST90002382_383	Eosinophil percentage of white cells	2.000000e-11
GCST90002401_181	Platelet distribution width	8.000000e-26
GCST90002402_347	Platelet count	1.000000e-11

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0007984	platelet component distribution width
EFO:0008433	pursuit maintenance gain measurement
EFO:0004842	eosinophil count
EFO:0007991	eosinophil percentage of leukocytes
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067117 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC43 family of large neutral amino acid transporters

CTD chemical–gene interactions

59 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression, affects expression, affects splicing	4
Valproic Acid	affects expression, increases expression	4
Ozone	affects cotreatment, increases oxidation, increases abundance, affects expression	3
Cadmium Chloride	decreases expression, increases abundance	3
Particulate Matter	affects cotreatment, decreases expression, increases abundance, increases expression	3
bisphenol A	decreases expression, increases expression	2
nickel sulfate	decreases expression, increases expression	2
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	2
Acrolein	affects cotreatment, increases oxidation, increases abundance	2
Air Pollutants	affects expression, affects cotreatment, increases abundance, increases oxidation	2
Nickel	increases expression	2
Tobacco Smoke Pollution	decreases expression	2
GSK-J4	increases expression	1
methylmercuric chloride	increases expression	1
alpha-pinene	increases oxidation, increases abundance, affects cotreatment	1
sodium arsenate	increases abundance, increases expression	1
beta-lapachone	increases expression	1
arsenite	increases methylation	1
butyraldehyde	increases expression	1
perfluorooctanoic acid	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
pentanal	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
entinostat	increases expression	1
3-iodothyronamine	affects uptake	1
abrine	increases expression	1
incobotulinumtoxinA	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652470	Binding	Binding affinity to human SLC43A3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2G9	Abcam HeLa SLC43A3 KO	Cancer cell line	Female
CVCL_D4FA	1321N1-SLC43A3-KO-c3	Cancer cell line	Male
CVCL_D4FB	1321N1-SLC43A3-KO-c6	Cancer cell line	Male
CVCL_TN73	HAP1 SLC43A3 (-) 1	Cancer cell line	Male
CVCL_TN74	HAP1 SLC43A3 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.