SLC45A4

Summary

SLC45A4 (solute carrier family 45 member 4, HGNC:29196) is a protein-coding gene on chromosome 8q24.3, encoding Polyamine-transporter SLC45A4 (Q5BKX6). Neuronal polyamine-transporter involved in pain perception.

Predicted to enable sucrose:proton symporter activity. Predicted to be involved in sucrose transport. Predicted to be active in membrane.

Source: NCBI Gene 57210 — RefSeq curated summary.

At a glance

• GWAS associations: 24
• Clinical variants (ClinVar): 205 total
• MANE Select transcript: NM_001286646

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29196
Approved symbol	SLC45A4
Name	solute carrier family 45 member 4
Location	8q24.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1126
Ensembl gene	ENSG00000022567
Ensembl biotype	protein_coding
OMIM	619581
Entrez	57210

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000024061, ENST00000517878, ENST00000519067, ENST00000519986, ENST00000520137, ENST00000521804, ENST00000851763, ENST00000937919, ENST00000937920, ENST00000937921

RefSeq mRNA: 3 — MANE Select: NM_001286646 NM_001080431, NM_001286646, NM_001286648

CCDS: CCDS34948, CCDS69550, CCDS75795

Canonical transcript exons

ENST00000517878 — 9 exons

Exon	Start	End
ENSE00000664773	141215759	141215970
ENSE00000664774	141217090	141217189
ENSE00001115284	141218011	141219029
ENSE00001647269	141253989	141254629
ENSE00001801117	141212197	141212556
ENSE00002092254	141207174	141211697
ENSE00003515680	141221577	141221765
ENSE00003550226	141219650	141219829
ENSE00003899781	141308096	141308288

Expression profiles

Bgee: expression breadth ubiquitous, 230 present calls, max score 95.69.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.8768 / max 1770.1519, expressed in 1751 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95384	13.5747	1249
95385	6.8628	1615
95386	1.0009	595
95387	0.4219	220
95383	0.0166	5

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	95.69	gold quality
endothelial cell	CL:0000115	94.89	gold quality
blood	UBERON:0000178	90.00	gold quality
kidney epithelium	UBERON:0004819	87.73	silver quality
pigmented layer of retina	UBERON:0001782	87.43	gold quality
retina	UBERON:0000966	87.40	gold quality
epithelial cell of pancreas	CL:0000083	86.75	silver quality
postcentral gyrus	UBERON:0002581	85.12	gold quality
Brodmann (1909) area 23	UBERON:0013554	85.04	gold quality
middle temporal gyrus	UBERON:0002771	84.98	gold quality
primary visual cortex	UBERON:0002436	84.65	gold quality
calcaneal tendon	UBERON:0003701	84.53	gold quality
parietal lobe	UBERON:0001872	84.29	gold quality
occipital lobe	UBERON:0002021	83.32	gold quality
bronchial epithelial cell	CL:0002328	83.11	gold quality
ileal mucosa	UBERON:0000331	82.72	gold quality
superior frontal gyrus	UBERON:0002661	82.68	gold quality
eye	UBERON:0000970	82.63	gold quality
bronchus	UBERON:0002185	82.47	gold quality
placenta	UBERON:0001987	82.09	gold quality
renal medulla	UBERON:0000362	82.07	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.05	gold quality
nasal cavity epithelium	UBERON:0005384	81.86	silver quality
adenohypophysis	UBERON:0002196	81.42	gold quality
pituitary gland	UBERON:0000007	81.30	gold quality
palpebral conjunctiva	UBERON:0001812	81.06	gold quality
bone marrow cell	CL:0002092	80.76	gold quality
right frontal lobe	UBERON:0002810	80.46	gold quality
prefrontal cortex	UBERON:0000451	80.44	gold quality
frontal cortex	UBERON:0001870	80.42	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	25.54
E-ANND-3	yes	3.52
E-MTAB-6142	no	34.46

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

183 targeting SLC45A4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-4715-3P	99.98	66.03	670

Literature-anchored findings (GeneRIF, showing 2)

• SLC45A4 promotes glycolysis and prevents AMPK/ULK1-induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma. (PMID:34010493)
• The Slc45a4 Gene Regulates Pigmentation in a Manner Distinct from that of the OCA4 Gene Slc45a2. (PMID:37775036)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc45a4b	ENSDARG00000077326
danio_rerio	SLC45A4	ENSDARG00000104981
mus_musculus	Slc45a4	ENSMUSG00000079020
rattus_norvegicus	Slc45a4	ENSRNOG00000007818
drosophila_melanogaster	Slc45-1	FBGN0035968
drosophila_melanogaster	lovit	FBGN0267429

Paralogs (3): SLC45A3 (ENSG00000158715), SLC45A1 (ENSG00000162426), SLC45A2 (ENSG00000164175)

Protein

Protein identifiers

Polyamine-transporter SLC45A4 — Q5BKX6 (reviewed: Q5BKX6)

Alternative names: Solute carrier family 45 member 4

All UniProt accessions (4): E5RGN5, E5RJM7, E7EV90, Q5BKX6

UniProt curated annotations — full annotation on UniProt →

Function. Neuronal polyamine-transporter involved in pain perception. Transports polyamines such as putrescine, cadaverine, spermine and spermidine. Expressed in sensory neuron subtypes within the dorsal root ganglion, where it regulates the excitability of C-polymodal nociceptors by mediating polyamine transport.

Subcellular location. Cell membrane.

Similarity. Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q5BKX6-1	1	yes
Q5BKX6-2	2
Q5BKX6-3	3

RefSeq proteins (3): NP_001073900, NP_001273575, NP_001273577 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011701	MFS	Family
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF07690

Catalyzed reactions (Rhea), 2 shown:

• spermidine(in) = spermidine(out) (RHEA:35039)
• putrescine(out) = putrescine(in) (RHEA:72135)

UniProt features (52 total): topological domain 13, transmembrane region 12, mutagenesis site 10, region of interest 5, modified residue 4, splice variant 3, sequence variant 2, chain 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
9GIU	ELECTRON MICROSCOPY	2.8
9GHZ	ELECTRON MICROSCOPY	3.25

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5BKX6-F1	65.66	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 424, 454, 485, 732

Mutagenesis-validated functional residues (10):

Position	Phenotype
63	abolished polyamine-transporter activity.
66	abolished polyamine-transporter activity.
66	does not affect the polyamine-transporter activity.
169	abolished polyamine-transporter activity.
173	abolished polyamine-transporter activity.
176	abolished polyamine-transporter activity.
450–453	does not affect the polyamine-transporter activity.
519	decreased polyamine-transporter activity.
672	decreased polyamine-transporter activity.
672	slightly decreased polyamine-transporter activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 147 (showing top): GOBP_CARBOHYDRATE_TRANSPORT, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_SENSORY_PERCEPTION_OF_PAIN, MODULE_205, LIAO_METASTASIS, GOMF_PROTON_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOBP_SENSORY_PERCEPTION, GOBP_ORGANIC_CATION_TRANSPORT, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOBP_TRANSMEMBRANE_TRANSPORT, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON, GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_SOLUTE_MONOATOMIC_CATION_SYMPORTER_ACTIVITY

GO Biological Process (5): sucrose transport (GO:0015770), sensory perception of pain (GO:0019233), carbohydrate transmembrane transport (GO:0034219), transmembrane transport (GO:0055085), proton transmembrane transport (GO:1902600)

GO Molecular Function (8): spermine transmembrane transporter activity (GO:0000297), sucrose:proton symporter activity (GO:0008506), polyamine transmembrane transporter activity (GO:0015203), putrescine transmembrane transporter activity (GO:0015489), spermidine transmembrane transporter activity (GO:0015606), carbohydrate:proton symporter activity (GO:0005351), symporter activity (GO:0015293), transmembrane transporter activity (GO:0022857)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
polyamine transmembrane transporter activity	3
transmembrane transport	2
disaccharide transport	1
sensory perception	1
carbohydrate transport	1
transport	1
cellular process	1
monoatomic cation transmembrane transport	1
spermine transmembrane transport	1
carbohydrate:proton symporter activity	1
sucrose:monoatomic cation symporter activity	1
transmembrane transporter activity	1
polyamine transmembrane transport	1
putrescine transport	1
spermidine transmembrane transport	1
carbohydrate:monoatomic cation symporter activity	1
solute:proton symporter activity	1
secondary active transmembrane transporter activity	1
transporter activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

870 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC45A4	DENND3	A2RUS2	542
SLC45A4	CHRAC1	Q9NRG0	491
SLC45A4	ATP7A	Q04656	448
SLC45A4	TRAPPC9	Q96Q05	445
SLC45A4	EPS8L3	Q8TE67	435
SLC45A4	CCDC82	Q8N4S0	426
SLC45A4	SLC66A1LP	A1A4F0	392
SLC45A4	SLC35B3	Q9H1N7	367
SLC45A4	DCDC2B	A2VCK2	367
SLC45A4	SLC31A1	O15431	366
SLC45A4	SDK1	Q7Z5N4	364
SLC45A4	PTK2	Q05397	362
SLC45A4	OR8K5	Q8NH50	356
SLC45A4	NAT14	Q8WUY8	348
SLC45A4	GARIN1B	Q96KD3	334
SLC45A4	SLC15A5	A6NIM6	334

IntAct

108 interactions, top by confidence:

A	B	Type	Score
SLC45A4	SNX27	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	PDZD2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	IL16	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	SNTB1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	SNTA1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	SNTG1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	MAST2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	DLG1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	PTPN3	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	DLG4	psi-mi:“MI:0407”(direct interaction)	0.440
PDZD7	SLC45A4	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	HTRA1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	MAGI2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	SYNJ2BP	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	DLG3	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	MAGI3	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	RHPN1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	DLG2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	GIPC2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	MAST1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	SNTG2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	LNX2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	FRMPD2	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	ARHGAP21	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	RADIL	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	PDZK1	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	ARHGEF11	psi-mi:“MI:0407”(direct interaction)	0.440
SLC45A4	HTRA4	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (40): SLC45A4 (Affinity Capture-MS), SLC45A4 (Affinity Capture-RNA), SLC45A4 (Two-hybrid), ANKLE2 (Affinity Capture-MS), VPS25 (Affinity Capture-MS), UBQLN1 (Affinity Capture-MS), SLC45A4 (Affinity Capture-MS), SNF8 (Affinity Capture-MS), UBQLN4 (Affinity Capture-MS), SLC45A4 (Affinity Capture-RNA), SLC45A4 (Protein-peptide), SLC45A4 (Affinity Capture-RNA), CNNM1 (Affinity Capture-MS), CSNK1A1 (Affinity Capture-MS), EIF3CL (Affinity Capture-MS)

ESM2 similar proteins: A0A125YQS6, A0A125YY03, A0A7J6K338, A1Z7R6, A4IHK6, A5K9W3, G4SDH4, J9UD11, O43306, O60266, O75387, O76269, O76343, P14773, P30804, P48768, Q01341, Q03343, Q04400, Q0C8L9, Q0VCM6, Q41706, Q4D3E8, Q4X251, Q57VW6, Q5B0V6, Q5BKX6, Q5RF58, Q5ZMT9, Q6C520, Q6CGU8, Q7Z8U2, Q8BIV7, Q8BSM7, Q8CGA3, Q8K4S3, Q8K596, Q8N370, Q93380, Q93Z75

Diamond homologs: A2X6E6, A2ZN77, B8AF63, O80605, Q03411, Q0ILJ3, Q10R54, Q39231, Q39232, Q5BKX6, Q67YF8, Q69JW3, Q6A329, Q6YK44, Q944W2, Q948L0, Q9C8X2, Q9FE59, Q9FG00, Q9LKH3, Q9ZVK6, O14091, Q8BIV7, P58355, Q0P5V9, Q4LE88, Q8K4S3, Q9UMX9, Q9Y2W3, Q8K0H7, Q95KI5, Q96JT2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 77 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Dopamine Neurotransmitter Release Cycle	5	50.7×	2e-06
Assembly and cell surface presentation of NMDA receptors	9	46.6×	2e-11
Neurexins and neuroligins	11	44.2×	1e-13
Protein-protein interactions at synapses	7	37.9×	3e-08
RHOA GTPase cycle	5	7.6×	4e-03
Neuronal System	7	6.3×	1e-03
RHO GTPase cycle	5	6.1×	9e-03
Signaling by Rho GTPases	8	5.6×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
protein localization to synapse	6	61.3×	1e-07
establishment or maintenance of epithelial cell apical/basal polarity	7	54.2×	2e-08
receptor clustering	5	41.6×	1e-05
regulation of postsynaptic membrane neurotransmitter receptor levels	6	39.6×	1e-06
protein-containing complex assembly	7	10.6×	3e-04
regulation of small GTPase mediated signal transduction	5	9.6×	4e-03
cell-cell adhesion	7	9.5×	4e-04
chemical synaptic transmission	7	7.2×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

205 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	165
Likely benign	17
Benign	13

Top pathogenic / likely-pathogenic (0)

SpliceAI

1535 predictions. Top by Δscore:

Variant	Effect	Δscore
8:141212203:CT:C	donor_gain	1.0000
8:141212219:C:A	donor_gain	1.0000
8:141212231:T:TA	donor_gain	1.0000
8:141212552:ATGTA:A	acceptor_gain	1.0000
8:141212553:TGTA:T	acceptor_gain	1.0000
8:141212554:GTA:G	acceptor_gain	1.0000
8:141212554:GTACT:G	acceptor_loss	1.0000
8:141212555:TA:T	acceptor_gain	1.0000
8:141212557:C:CC	acceptor_gain	1.0000
8:141212557:CTGCA:C	acceptor_loss	1.0000
8:141212558:T:A	acceptor_loss	1.0000
8:141215758:C:CG	donor_loss	1.0000
8:141215758:CCTG:C	donor_gain	1.0000
8:141215966:CAGGG:C	acceptor_gain	1.0000
8:141215967:AGGG:A	acceptor_gain	1.0000
8:141215968:GGG:G	acceptor_gain	1.0000
8:141215971:C:CC	acceptor_gain	1.0000
8:141219026:AGGCC:A	acceptor_loss	1.0000
8:141219027:GGCCT:G	acceptor_loss	1.0000
8:141219030:C:CC	acceptor_gain	1.0000
8:141219644:CGTTA:C	donor_loss	1.0000
8:141219645:GTTAC:G	donor_loss	1.0000
8:141219646:TTA:T	donor_loss	1.0000
8:141219647:TAC:T	donor_loss	1.0000
8:141219648:ACC:A	donor_loss	1.0000
8:141219649:C:CA	donor_loss	1.0000
8:141219649:CCGG:C	donor_gain	1.0000
8:141219682:T:TA	donor_gain	1.0000
8:141219829:CCT:C	acceptor_loss	1.0000
8:141219830:C:CG	acceptor_loss	1.0000

AlphaMissense

5275 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000015547 (8:141273689 T>C,G), RS1000038814 (8:141288821 C>A,T), RS1000053235 (8:141209196 C>T), RS1000104119 (8:141214522 A>G), RS1000107027 (8:141244792 G>A), RS1000122640 (8:141291336 C>T), RS1000125195 (8:141272546 A>C), RS1000141306 (8:141244504 G>C), RS1000148172 (8:141279184 C>A), RS1000196256 (8:141226590 T>C), RS1000248750 (8:141251650 C>T), RS1000265248 (8:141286787 C>T), RS1000284652 (8:141265303 C>T), RS1000293483 (8:141296363 G>A), RS1000308503 (8:141296716 G>A,T)

Disease associations

OMIM: gene MIM:619581 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

24 associations (top):

Study	Trait	p-value
GCST004607_170	Plateletcrit	3.000000e-11
GCST004611_39	High light scatter reticulocyte count	5.000000e-10
GCST004612_48	High light scatter reticulocyte percentage of red cells	1.000000e-10
GCST004619_31	Reticulocyte fraction of red cells	3.000000e-09
GCST004628_101	Immature fraction of reticulocytes	8.000000e-10
GCST005146_32	Birth weight	2.000000e-09
GCST008362_183	Birth weight	2.000000e-11
GCST010002_313	Refractive error	5.000000e-10
GCST011494_42	Daytime nap	2.000000e-09
GCST012020_16	Serum metabolite levels	1.000000e-16
GCST90002382_262	Eosinophil percentage of white cells	1.000000e-10
GCST90002385_373	High light scatter reticulocyte count	3.000000e-22
GCST90002385_374	High light scatter reticulocyte count	2.000000e-13
GCST90002386_418	High light scatter reticulocyte percentage of red cells	1.000000e-22
GCST90002386_419	High light scatter reticulocyte percentage of red cells	4.000000e-13
GCST90002387_330	Immature fraction of reticulocytes	5.000000e-27
GCST90002387_331	Immature fraction of reticulocytes	4.000000e-18
GCST90002388_213	Lymphocyte count	4.000000e-24
GCST90002398_243	Neutrophil count	1.000000e-11
GCST90002400_454	Plateletcrit	6.000000e-28
GCST90002405_526	Reticulocyte count	1.000000e-11
GCST90002406_316	Reticulocyte fraction of red cells	4.000000e-12
GCST90002407_524	White blood cell count	6.000000e-15
GCST90011899_185	Aspartate aminotransferase levels	5.000000e-26

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0007985	platelet crit
EFO:0007986	reticulocyte count
EFO:0004344	birth weight
EFO:0007828	daytime rest measurement
EFO:0007991	eosinophil percentage of leukocytes
EFO:0004587	lymphocyte count
EFO:0004833	neutrophil count
EFO:0004736	aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC45 family of putative sugar transporters

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects splicing, increases expression	3
Arsenic Trioxide	decreases expression, affects binding, decreases reaction	2
Air Pollutants	increases abundance, increases expression, affects expression	2
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	2
Aflatoxin B1	decreases methylation, increases methylation	2
Cadmium Chloride	decreases expression, increases expression	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
trichostatin A	affects expression	1
butyraldehyde	decreases expression	1
ferrous chloride	decreases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
nutlin 3	affects cotreatment, increases expression	1
3-iodothyronamine	affects uptake	1
abrine	decreases expression	1
bisphenol S	decreases methylation	1
jinfukang	affects cotreatment, increases expression	1
Acetaminophen	affects expression	1
Arsenic	affects methylation	1
Vehicle Emissions	increases abundance, increases expression	1
Camptothecin	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Folic Acid	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4PE	HCT116-SLC45A4-KO-c10	Cancer cell line	Male
CVCL_D4PF	HCT116-SLC45A4-KO-c7	Cancer cell line	Male
CVCL_D4PG	HCT116-SLC45A4-KO-c8	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.