SLC52A1

Summary

SLC52A1 (solute carrier family 52 member 1, HGNC:30225) is a protein-coding gene on chromosome 17p13.2, encoding Solute carrier family 52, riboflavin transporter, member 1 (Q9NWF4). Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Source: NCBI Gene 55065 — RefSeq curated summary.

At a glance

• Gene–disease (curated): maternal riboflavin deficiency (Moderate, ClinGen) — +1 more curated relationship
• GWAS associations: 3
• Clinical variants (ClinVar): 290 total — 3 pathogenic
• Phenotypes (HPO): 11
• MANE Select transcript: NM_017986

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30225
Approved symbol	SLC52A1
Name	solute carrier family 52 member 1
Location	17p13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10060, GPCR42, PAR2, hRFT1, RFVT1
Ensembl gene	ENSG00000132517
Ensembl biotype	protein_coding
OMIM	607883
Entrez	55065

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 2 retained_intron

ENST00000254853, ENST00000424747, ENST00000512825, ENST00000573674, ENST00000575919, ENST00000894338, ENST00000923984, ENST00000961589, ENST00000961590, ENST00000961591

RefSeq mRNA: 2 — MANE Select: NM_017986 NM_001104577, NM_017986

CCDS: CCDS11066

Canonical transcript exons

ENST00000254853 — 5 exons

Exon	Start	End
ENSE00000675324	5033479	5034358
ENSE00001309445	5034477	5034713
ENSE00001853979	5034861	5035426
ENSE00003502467	5032602	5033169
ENSE00003637764	5033261	5033384

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 84.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1868 / max 32.0358, expressed in 62 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
164014	0.1700	51
164015	0.0168	6

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	84.19	gold quality
placenta	UBERON:0001987	82.47	gold quality
jejunal mucosa	UBERON:0000399	78.65	gold quality
small intestine	UBERON:0002108	75.43	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.95	gold quality
ileal mucosa	UBERON:0000331	74.49	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.45	silver quality
skin of leg	UBERON:0001511	72.74	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.68	gold quality
mucosa of transverse colon	UBERON:0004991	69.51	gold quality
zone of skin	UBERON:0000014	69.40	gold quality
buccal mucosa cell	CL:0002336	69.26	gold quality
skin of abdomen	UBERON:0001416	69.15	gold quality
epithelium of bronchus	UBERON:0002031	68.26	gold quality
right uterine tube	UBERON:0001302	68.15	gold quality
bronchial epithelial cell	CL:0002328	67.64	gold quality
bronchus	UBERON:0002185	67.27	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	66.89	gold quality
jejunum	UBERON:0002115	64.78	gold quality
nasal cavity mucosa	UBERON:0001826	63.44	gold quality
cartilage tissue	UBERON:0002418	63.18	gold quality
nasal cavity epithelium	UBERON:0005384	62.75	gold quality
mucosa of paranasal sinus	UBERON:0005030	61.85	gold quality
vena cava	UBERON:0004087	61.78	gold quality
upper leg skin	UBERON:0004262	61.74	gold quality
lower esophagus mucosa	UBERON:0035834	61.09	gold quality
decidua	UBERON:0002450	60.65	silver quality
esophagus mucosa	UBERON:0002469	60.14	gold quality
trabecular bone tissue	UBERON:0002483	59.52	gold quality
mucosa of sigmoid colon	UBERON:0004993	59.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.50

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting SLC52A1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-29B-2-5P	99.67	68.98	1726
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-3182	99.40	68.15	2454
HSA-MIR-4528	99.18	69.77	1936
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-7114-5P	98.51	67.87	1349
HSA-MIR-12116	97.94	68.91	595
HSA-MIR-122-5P	97.23	64.92	1024

Literature-anchored findings (GeneRIF, showing 12)

• Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter. (PMID:18632736)
• We demonstrated that TFAP-2gamma is one of the transcription factors involved in the PAR-2 expression in human villous trophoblast cells. (PMID:22702469)
• Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3. (PMID:23413253)
• summary of recent findings on the cloning, nomenclature, functional characterization and genetic diseases of RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3 [review] (PMID:23506902)
• data suggest that MMND is a distinct clinical subgroup of childhood onset MND patients where the known genetic defects are so far negative. (PMID:24139842)
• results are the first to reveal the identity of the minimal SLC52A1 promoter and to establish an important role for Sp-1 in its activity (PMID:25284511)
• We here report a case of transient MADD, caused by a heterozygous intronic variation, c.1134+11G>A, in the SLC52A1 gene encoding RFVT1. This variation creates a binding site for the splice inhibitory hnRNP A1 protein and causes exon 4 skipping. Riboflavin deficiency and maternal malnutrition during pregnancy might have been the determining factor in the outcome of this case. (PMID:29122468)
• In HT-29 cells, the RFVT1 protein level was drastically lower. In tumor tissues of patients with CRC, RFVT1 content was reduced at both protein and mRNA levels compared to normal mucosa. (PMID:29715086)
• In the in vitro model, exposing Caco-2 cells to tumor necrosis factor-alpha (TNF-alpha) led to a significant inhibition in RF uptake, an effect that was abrogated upon knocking down TNF receptor 1 (TNFR1). The inhibition in RF uptake was associated with a significant reduction in the expression of hRFVT-3 and -1 protein and mRNA levels, as well as in the activity of the SLC52A3 and SLC52A1 promoters (PMID:30156861)
• Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis. (PMID:33427755)
• Riboflavin transporter SLC52A1, a target of p53, suppresses cellular senescence by activating mitochondrial complex II. (PMID:34524871)
• Riboflavin 1 Transporter Deficiency: Novel SLC52A1 Variants and Expansion of the Phenotypic Spectrum. (PMID:37510312)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc52a2	ENSDARG00000102035
mus_musculus	Slc52a2	ENSMUSG00000022560
rattus_norvegicus	Slc52a2	ENSRNOG00000032561
drosophila_melanogaster	Rift	FBGN0039882
caenorhabditis_elegans		WBGENE00021626
caenorhabditis_elegans		WBGENE00044637

Paralogs (2): SLC52A3 (ENSG00000101276), SLC52A2 (ENSG00000185803)

Protein

Protein identifiers

Solute carrier family 52, riboflavin transporter, member 1 — Q9NWF4 (reviewed: Q9NWF4)

Alternative names: Porcine endogenous retrovirus A receptor 2, Protein GPR172B, Riboflavin transporter 1

All UniProt accessions (2): Q9NWF4, F5H5Y1

UniProt curated annotations — full annotation on UniProt →

Function. Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. (Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).

Subcellular location. Cell membrane.

Tissue specificity. Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues.

Disease relevance. Riboflavin deficiency (RBFVD) [MIM:615026] A disorder caused by a primary defect in riboflavin metabolism, or by dietary riboflavin deficiency. Riboflavin deficiency during pregnancy results in hypoglycemia, metabolic acidosis, dicarboxylic aciduria and elevated plasma acylcarnitine levels in the newborn. Treatment with oral riboflavin results in complete resolution of the clinical and biochemical findings. The disease is caused by variants affecting the gene represented in this entry.

Activity regulation. The activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD).

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the riboflavin transporter family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NWF4-1	1	yes
Q9NWF4-2	2, RFT1sv

RefSeq proteins (2): NP_001098047, NP_060456* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009357	Riboflavin_transptr	Family

Pfam: PF06237

Catalyzed reactions (Rhea), 1 shown:

• riboflavin(in) = riboflavin(out) (RHEA:35015)

UniProt features (21 total): transmembrane region 11, sequence variant 4, splice variant 2, chain 1, region of interest 1, compositionally biased region 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NWF4-F1	84.13	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 178

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-196843	Vitamin B2 (riboflavin) metabolism
R-HSA-1430728	Metabolism
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors
R-HSA-196854	Metabolism of vitamins and cofactors

MSigDB gene sets: 90 (showing top): GOBP_ORGANIC_ANION_TRANSPORT, GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERACTION_WITH_HOST, GOBP_VIRAL_LIFE_CYCLE, GOBP_VITAMIN_TRANSPORT, MODULE_48, MODULE_95, ACACTCC_MIR122A, REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS, GOMF_TRANSPORTER_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_UP, MODULE_163, GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_EXOGENOUS_PROTEIN_BINDING, REACTOME_VITAMIN_B2_RIBOFLAVIN_METABOLISM, REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS

GO Biological Process (3): riboflavin metabolic process (GO:0006771), riboflavin transport (GO:0032218), symbiont entry into host cell (GO:0046718)

GO Molecular Function (3): virus receptor activity (GO:0001618), riboflavin transmembrane transporter activity (GO:0032217), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Metabolism of water-soluble vitamins and cofactors	1
Metabolism of vitamins and cofactors	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
flavin-containing compound metabolic process	1
vitamin transport	1
nitrogen compound transport	1
viral life cycle	1
symbiont entry into host	1
symbiont entry into host cell	1
exogenous protein binding	1
riboflavin transport	1
vitamin transmembrane transporter activity	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

704 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC52A1	FLAD1	Q8NFF5	755
SLC52A1	SLC25A32	Q9H2D1	637
SLC52A1	ETFDH	Q16134	622
SLC52A1	RFK	Q969G6	557
SLC52A1	ETFB	P38117	516
SLC52A1	ETFA	P13804	474
SLC52A1	SLC23A1	Q9UHI7	460
SLC52A1	SLC20A2	Q08357	433
SLC52A1	SLC6A20	Q9NP91	417
SLC52A1	SLC44A4	Q53GD3	407
SLC52A1	TRIM49B	A6NDI0	358
SLC52A1	SLC19A2	O60779	339
SLC52A1	RTBDN	Q9BSG5	336
SLC52A1	SLC35H1	Q9NQQ7	327
SLC52A1	ACE	P12821	322

IntAct

29 interactions, top by confidence:

A	B	Type	Score
SLC52A1	SHISAL1	psi-mi:“MI:0915”(physical association)	0.560
SGCB	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
TMEM237	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
GJA8	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
CREB3L1	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
AQP6	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
IFNGR2	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
SLC7A1	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
TMEM179B	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
SHISAL1	SLC52A1	psi-mi:“MI:0915”(physical association)	0.560
SLC52A1	CLGN	psi-mi:“MI:0914”(association)	0.350
SLC52A1	SGCB	psi-mi:“MI:0915”(physical association)	0.000
SLC52A1	TMEM237	psi-mi:“MI:0915”(physical association)	0.000
SLC52A1	CREB3L1	psi-mi:“MI:0915”(physical association)	0.000
SLC52A1	AQP6	psi-mi:“MI:0915”(physical association)	0.000
SLC52A1	IFNGR2	psi-mi:“MI:0915”(physical association)	0.000
SLC52A1	GJA8	psi-mi:“MI:0915”(physical association)	0.000
SLC52A1	SLC7A1	psi-mi:“MI:0915”(physical association)	0.000
SLC52A1	TMEM179B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (18): SLC52A1 (Two-hybrid), SLC52A1 (Two-hybrid), KIAA1644 (Two-hybrid), SLC7A1 (Two-hybrid), TMEM237 (Two-hybrid), CREB3L1 (Two-hybrid), IFNGR2 (Two-hybrid), SGCB (Two-hybrid), TMEM179B (Two-hybrid), CANX (Affinity Capture-MS), CLGN (Affinity Capture-MS), COL14A1 (Affinity Capture-MS), FRMD5 (Affinity Capture-MS), HADHB (Affinity Capture-MS), NME2P1 (Affinity Capture-MS)

ESM2 similar proteins: A6NGC4, A6NKX4, A6NM10, F1NZP5, O96011, P0C242, P27544, P27545, Q0VCY6, Q2TBI8, Q3SYU3, Q4V8E5, Q5F2F2, Q5JZQ7, Q5RFI0, Q5U2T1, Q5U419, Q6AYM9, Q6GQT6, Q6PIS1, Q6TCG5, Q6UXD7, Q6UXT9, Q71RH2, Q7TNV1, Q7Z403, Q80ZE4, Q863Y8, Q86WI3, Q8BMT9, Q8CHK3, Q8IU68, Q8IXF9, Q8N9H8, Q8TBR7, Q8VC26, Q8WUG5, Q96N66, Q99640, Q99JT6

Diamond homologs: B0S5Y3, B5MEV3, B5X4H8, C1BKZ7, D2HSA6, G4SDH4, Q3LFN0, Q4FZU9, Q5E9R1, Q6GMG6, Q863Y7, Q863Y8, Q9D6X5, Q9D8F3, Q9HAB3, Q9NQ40, Q9NWF4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

290 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	3
Likely pathogenic	0
Uncertain significance	176
Likely benign	81
Benign	17

Top pathogenic / likely-pathogenic (3)

Variant ID	HGVS	Classification
1319723	NM_017986.4(SLC52A1):c.3G>A (p.Met1Ile)	Pathogenic
210044	Single allele	Pathogenic
39608	NG_033117.2:g.(12554_12700)_(13936_14029)del	Pathogenic

SpliceAI

984 predictions. Top by Δscore:

Variant	Effect	Δscore
17:5034221:C:CT	donor_gain	0.9900
17:5034222:T:TT	donor_gain	0.9900
17:5034475:AC:A	donor_gain	0.9900
17:5034476:CC:C	donor_gain	0.9900
17:5034476:CCCT:C	donor_gain	0.9900
17:5034495:C:CT	donor_gain	0.9900
17:5034660:C:A	donor_gain	0.9900
17:5033269:C:CT	donor_gain	0.9800
17:5034230:G:C	donor_gain	0.9800
17:5034267:G:A	donor_gain	0.9800
17:5034296:C:CT	donor_gain	0.9800
17:5034356:AACCT:A	acceptor_loss	0.9800
17:5034357:ACC:A	acceptor_loss	0.9800
17:5034358:CCT:C	acceptor_loss	0.9800
17:5034359:CT:C	acceptor_loss	0.9800
17:5034360:T:C	acceptor_loss	0.9800
17:5034496:C:CT	donor_gain	0.9800
17:5034659:T:TA	donor_gain	0.9800
17:5034464:C:A	donor_gain	0.9700
17:5033474:TGCA:T	donor_loss	0.9600
17:5033475:GCACC:G	donor_loss	0.9600
17:5033476:CA:C	donor_loss	0.9600
17:5033478:C:CT	donor_loss	0.9600
17:5034297:C:CT	donor_gain	0.9600
17:5034470:CACTC:C	donor_loss	0.9600
17:5034472:CTCAC:C	donor_loss	0.9600
17:5034473:T:TC	donor_loss	0.9600
17:5034474:C:CC	donor_loss	0.9600
17:5033166:GCACC:G	acceptor_loss	0.9400
17:5033167:CACCT:C	acceptor_loss	0.9400

AlphaMissense

2799 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:5033580:A:C	F303L	0.965
17:5033580:A:T	F303L	0.965
17:5033582:A:G	F303L	0.965
17:5034027:A:C	S154R	0.965
17:5034027:A:T	S154R	0.965
17:5034029:T:G	S154R	0.965
17:5033306:G:C	S363R	0.964
17:5033306:G:T	S363R	0.964
17:5033308:T:G	S363R	0.964
17:5033856:G:C	F211L	0.964
17:5033856:G:T	F211L	0.964
17:5033858:A:G	F211L	0.964
17:5033583:G:C	S302R	0.963
17:5033583:G:T	S302R	0.963
17:5033585:T:G	S302R	0.963
17:5033901:G:C	F196L	0.959
17:5033901:G:T	F196L	0.959
17:5033903:A:G	F196L	0.959
17:5034093:G:C	F132L	0.958
17:5034093:G:T	F132L	0.958
17:5034095:A:G	F132L	0.958
17:5032996:A:C	F436L	0.951
17:5032996:A:T	F436L	0.951
17:5032998:A:G	F436L	0.951
17:5034084:G:C	F135L	0.950
17:5034084:G:T	F135L	0.950
17:5034086:A:G	F135L	0.950
17:5034354:C:A	W45C	0.948
17:5034354:C:G	W45C	0.948
17:5034508:C:A	E33D	0.941

dbSNP variants (sampled 300 via entrez): RS1000102935 (17:5037524 C>A,G,T), RS1000118008 (17:5040772 A>G), RS1000172211 (17:5040509 C>CAAAT), RS1000302751 (17:5032880 G>A,C,T), RS1000518613 (17:5038519 A>G), RS1000690866 (17:5032559 G>A), RS1001330085 (17:5034227 T>A), RS1001490164 (17:5037931 T>G), RS1001760228 (17:5039691 C>G,T), RS1002265136 (17:5035429 C>G), RS1002333843 (17:5043752 T>A,C), RS1002669297 (17:5042558 A>C), RS1003167866 (17:5040825 T>G), RS1003266819 (17:5037020 A>G,T), RS1003699106 (17:5036655 G>A)

Disease associations

OMIM: gene MIM:607883 | disease phenotypes: MIM:615026

GenCC curated gene-disease

Disease	Classification	Inheritance
ariboflavinosis	Moderate	Autosomal dominant
maternal riboflavin deficiency	Supportive	Autosomal dominant

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
maternal riboflavin deficiency	Moderate	AD

Mondo (2): ariboflavinosis (MONDO:0004573), maternal riboflavin deficiency (MONDO:0014013)

Orphanet (1): Maternal riboflavin deficiency (Orphanet:411712)

HPO phenotypes

11 total (11 of 11 shown, HPO-id order):

HPO	Term
HP:0000006	Autosomal dominant inheritance
HP:0001252	Hypotonia
HP:0001254	Lethargy
HP:0001942	Metabolic acidosis
HP:0001943	Hypoglycemia
HP:0002033	Poor suck
HP:0002045	Hypothermia
HP:0003128	Lactic acidosis
HP:0003215	Dicarboxylic aciduria
HP:0045045	Elevated circulating acylcarnitine concentration
HP:0100504	Decreased circulating vitamin B2 concentration

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004744_24	Lung adenocarcinoma	5.000000e-06
GCST90000047_220	Age at first sexual intercourse	5.000000e-08
GCST90013442_27	Keratoconus	2.000000e-14

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC52 family of riboflavin transporters

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, affects cotreatment, decreases expression, increases abundance	2
Arsenic	increases abundance, affects methylation, affects cotreatment, decreases expression	2
Benzo(a)pyrene	decreases methylation, increases expression	2
Tobacco Smoke Pollution	decreases expression	2
Aflatoxin B1	increases expression	2
propionaldehyde	increases expression	1
butyraldehyde	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
nutlin 3	affects cotreatment, increases expression	1
jinfukang	increases expression, affects cotreatment	1
Resveratrol	decreases expression, affects cotreatment	1
Fulvestrant	increases methylation	1
Camptothecin	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Formaldehyde	decreases expression	1
Manganese	increases abundance, affects cotreatment, decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	increases methylation	1
Zinc	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4W1	LS180-SLC52A1-KO-c6	Cancer cell line	Female
CVCL_D4W2	LS180-SLC52A1-KO-c8	Cancer cell line	Female

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT05687474	Not specified	COMPLETED	Baby Detect : Genomic Newborn Screening