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SLC5A10

gene
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Also known as SGLT5

Summary

SLC5A10 (solute carrier family 5 member 10, HGNC:23155) is a protein-coding gene on chromosome 17p11.2, encoding Sodium/mannose cotransporter SLC5A10 (A0PJK1). Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1.

This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Source: NCBI Gene 125206 — RefSeq curated summary.

At a glance

  • GWAS associations: 1
  • Clinical variants (ClinVar): 89 total
  • MANE Select transcript: NM_001042450

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:23155
Approved symbolSLC5A10
Namesolute carrier family 5 member 10
Location17p11.2
Locus typegene with protein product
StatusApproved
AliasesSGLT5
Ensembl geneENSG00000154025
Ensembl biotypeprotein_coding
OMIM618636
Entrez125206

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 retained_intron

ENST00000317977, ENST00000395643, ENST00000395645, ENST00000395647, ENST00000417251, ENST00000584658, ENST00000884499, ENST00000961493

RefSeq mRNA: 5 — MANE Select: NM_001042450 NM_001042450, NM_001270648, NM_001270649, NM_001282417, NM_152351

CCDS: CCDS11201, CCDS42275, CCDS59277, CCDS59278, CCDS74008

Canonical transcript exons

ENST00000395645 — 15 exons

ExonStartEnd
ENSE000011561441902015519020212
ENSE000011561491901971319019928
ENSE000011561561901942319019591
ENSE000011561831897101318971218
ENSE000011561871896934218969422
ENSE000011868291897685418976989
ENSE000012381891896905218969157
ENSE000013037661895913518959239
ENSE000013214941895960418959663
ENSE000015223771901341019013517
ENSE000016614871896054818960652
ENSE000017159011901504919015199
ENSE000034739021895216518952316
ENSE000036155581895868218958753
ENSE000039034951902032519022565

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 96.47.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2759 / max 119.7524, expressed in 33 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
1598250.139826
1598270.13286
1598260.00333

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
kidney epitheliumUBERON:000481996.47gold quality
adult mammalian kidneyUBERON:000008287.78gold quality
kidneyUBERON:000211382.21gold quality
adult organismUBERON:000702381.74gold quality
cortex of kidneyUBERON:000122576.81gold quality
metanephros cortexUBERON:001053375.47gold quality
upper arm skinUBERON:000426374.90gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047372.07gold quality
ileal mucosaUBERON:000033170.72silver quality
renal medullaUBERON:000036270.06gold quality
tibialis anteriorUBERON:000138568.91silver quality
metanephrosUBERON:000008168.68gold quality
cardiac muscle of right atriumUBERON:000337968.58gold quality
left ventricle myocardiumUBERON:000656668.31gold quality
spleenUBERON:000210666.86gold quality
epithelial cell of pancreasCL:000008366.78gold quality
gingival epitheliumUBERON:000194966.63silver quality
myocardiumUBERON:000234965.65gold quality
nasal cavity epitheliumUBERON:000538465.53gold quality
bone marrowUBERON:000237165.22gold quality
bone marrow cellCL:000209264.41silver quality
deltoidUBERON:000147664.12gold quality
gingivaUBERON:000182863.81silver quality
oocyteCL:000002363.40gold quality
skeletal muscle tissue of biceps brachiiUBERON:000450263.09gold quality
bloodUBERON:000017862.96gold quality
vena cavaUBERON:000408762.70gold quality
pancreatic ductal cellCL:000207962.23silver quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099161.55gold quality
granulocyteCL:000009461.51gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no2.71

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting SLC5A10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-6127100.0066.762188
HSA-MIR-6129100.0066.462080
HSA-MIR-629-3P99.8567.991875
HSA-MIR-4713-5P99.7867.801794
HSA-MIR-674599.7465.331321
HSA-MIR-3679-3P99.6469.881599
HSA-MIR-4743-3P99.6268.122095
HSA-MIR-203A-3P99.4970.562806
HSA-MIR-4735-5P99.4368.491780
HSA-MIR-1227-5P98.6565.321549
HSA-MIR-3944-5P98.5067.55997
HSA-MIR-6747-3P97.7364.841596
HSA-MIR-191397.0766.201417
HSA-MIR-4749-3P96.4066.24798
HSA-MIR-6834-5P96.2564.88823
HSA-MIR-63596.0065.54687
HSA-MIR-6774-5P95.9465.18722

Literature-anchored findings (GeneRIF, showing 5)

  • SGLT-5 as a kidney mannose transporter (PMID:22212718)
  • hSGLT5 is a sodium/mannose transporter that is blocked by phlorizin. Li(+) and H(+) ions were also able to drive mannose transport, and transport was electrogenic. (PMID:24573086)
  • Results show that rs2257609 C>T is located in the intron region of SLC5A10 and is significantly associated with worse overall and disease-free survival of non-small-cell lung cancer (NSCLC) patients. The rs2257609 C>T variant does not affect the expression of SLC5A10 mRNA, but alters the mRNA expression and promoter activity of DRG2. (PMID:30281872)
  • Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study. (PMID:30976018)
  • SGLT5 is the renal transporter for 1,5-anhydroglucitol, a major player in two rare forms of neutropenia. (PMID:37594549)

Cross-species orthologs

15 orthologs

OrganismSymbolGene ID
danio_rerioslc5a10ENSDARG00000074212
mus_musculusSlc5a10ENSMUSG00000042371
rattus_norvegicusSlc5a10ENSRNOG00000002616
drosophila_melanogasterCG2187FBGN0017448
drosophila_melanogasterrumpelFBGN0029950
drosophila_melanogasterSLC5A11FBGN0031998
drosophila_melanogasterbumpelFBGN0037895
drosophila_melanogasterChTFBGN0038641
drosophila_melanogastersaltFBGN0039872
drosophila_melanogasterSmvtFBGN0039873
drosophila_melanogasterCG31262FBGN0051262
drosophila_melanogasterCG31668FBGN0051668
drosophila_melanogasterCG33124FBGN0053124
drosophila_melanogasterkumpelFBGN0250757
caenorhabditis_elegansWBGENE00000501

Paralogs (12): SLC5A1 (ENSG00000100170), SLC5A4 (ENSG00000100191), SLC5A5 (ENSG00000105641), SLC5A7 (ENSG00000115665), SLC5A9 (ENSG00000117834), SLC5A6 (ENSG00000138074), SLC5A2 (ENSG00000140675), SLC5A12 (ENSG00000148942), SLC5A11 (ENSG00000158865), SLC5A3 (ENSG00000198743), SLC5A8 (ENSG00000256870), (ENSG00000293606)

Protein

Protein identifiers

Sodium/mannose cotransporter SLC5A10 — A0PJK1 (reviewed: A0PJK1)

Alternative names: Sodium/glucose cotransporter 5, Solute carrier family 5 member 10

All UniProt accessions (1): A0PJK1

UniProt curated annotations — full annotation on UniProt →

Function. Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2. Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney. Appears to have no transporter activity.

Subcellular location. Apical cell membrane.

Tissue specificity. Predominantly expressed at high levels in kidney. Very low expression is detected in testes. Expressed in kidney. The most abundant isoform expressed in kidney. Expressed in kidney. Expressed in kidney.

Activity regulation. Inhibited by phlorizin.

Similarity. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Isoforms (5)

UniProt IDNamesCanonical?
A0PJK1-11, IF2yes
A0PJK1-22, IF3
A0PJK1-33
A0PJK1-44, IF1
A0PJK1-55, IF4

RefSeq proteins (5): NP_001035915, NP_001257577, NP_001257578, NP_001269346, NP_689564 (=MANE)

Domains & families (InterPro)

IDNameType
IPR001734Na/solute_symporterFamily
IPR018212Na/solute_symporter_CSConserved_site
IPR038377Na/Glc_symporter_sfHomologous_superfamily

Pfam: PF00474

Catalyzed reactions (Rhea), 2 shown:

  • D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in) (RHEA:72907)
  • D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in) (RHEA:72915)

UniProt features (40 total): topological domain 14, transmembrane region 14, splice variant 5, modified residue 3, glycosylation site 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-A0PJK1-F188.170.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 141, 145, 148

Glycosylation sites (2): 4, 96

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

IDPathway
R-HSA-189200Cellular hexose transport
R-HSA-382551Transport of small molecules
R-HSA-425407SLC-mediated transmembrane transport

MSigDB gene sets: 55 (showing top): GOBP_CARBOHYDRATE_TRANSPORT, GOBP_SODIUM_ION_TRANSMEMBRANE_TRANSPORT, CAGCTG_AP4_Q5, GOBP_MONOATOMIC_CATION_TRANSPORT, HEN1_01, GOCC_APICAL_PLASMA_MEMBRANE, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_SODIUM_ION_TRANSPORT, GOCC_APICAL_PART_OF_CELL, GOCC_PLASMA_MEMBRANE_REGION, GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_SOLUTE_MONOATOMIC_CATION_SYMPORTER_ACTIVITY

GO Biological Process (7): hexose transmembrane transport (GO:0008645), monoatomic ion transport (GO:0006811), sodium ion transport (GO:0006814), fructose transmembrane transport (GO:0015755), mannose transmembrane transport (GO:0015761), sodium ion transmembrane transport (GO:0035725), transmembrane transport (GO:0055085)

GO Molecular Function (5): D-glucose:sodium symporter activity (GO:0005412), solute:sodium symporter activity (GO:0015370), mannose:sodium symporter activity (GO:0140929), fructose:sodium symporter activity (GO:0140930), transmembrane transporter activity (GO:0022857)

GO Cellular Component (4): plasma membrane (GO:0005886), apical plasma membrane (GO:0016324), extracellular exosome (GO:0070062), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
SLC-mediated transmembrane transport1
Transport of small molecules1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
carbohydrate:monoatomic cation symporter activity3
solute:sodium symporter activity3
transport2
hexose transmembrane transport2
monosaccharide transmembrane transport1
metal ion transport1
sodium ion transport1
monoatomic cation transmembrane transport1
cellular process1
D-glucose transmembrane transporter activity1
sodium ion transmembrane transporter activity1
solute:monoatomic cation symporter activity1
mannose transmembrane transporter activity1
fructose transmembrane transporter activity1
transporter activity1
transmembrane transport1
membrane1
cell periphery1
apical part of cell1
plasma membrane region1
extracellular vesicle1
cellular anatomical structure1

Protein interactions and networks

STRING

803 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
SLC5A10SLC2A2P11168635
SLC5A10SLC2A5P22732552
SLC5A10GOLT1AQ6ZVE7454
SLC5A10SLC60A2Q5TF39425
SLC5A10SLC1A1P43005423
SLC5A10SACK1GA6ND36418
SLC5A10PPTC7Q8NI37408
SLC5A10CFAP20DCQ6ZVT6406
SLC5A10CCAR1Q8IX12403
SLC5A10SLC15A1P46059390
SLC5A10CNOT12Q9C0C2383
SLC5A10SEC24AO95486382
SLC5A10SLC50A1Q9BRV3373
SLC5A10RD3LP0DJH9364
SLC5A10MPRIPQ6WCQ1363

IntAct

3 interactions, top by confidence:

ABTypeScore
SLC5A10UBQLN4psi-mi:“MI:0914”(association)0.350
SLC5A1SLC5A10psi-mi:“MI:0914”(association)0.350

BioGRID (4): UBQLN4 (Affinity Capture-MS), UBQLN1 (Affinity Capture-MS), SLC5A10 (Proximity Label-MS), SLC5A10 (Affinity Capture-MS)

ESM2 similar proteins: A0PJK1, A8I1B9, A8WHP3, B9NAE4, D3ZIS0, O02228, O77741, P11170, P13866, P26429, P26430, P31636, P31637, P31639, P41251, P49279, P49280, P53790, P53791, P53792, P53793, P53794, P56436, P70553, P83740, Q27946, Q27981, Q28610, Q28728, Q2M3M2, Q3ZC26, Q5FY69, Q5SWY8, Q6R4Q5, Q7T384, Q8BGY9, Q8C3K6, Q8K0E3, Q8UWF0, Q8VDT1

Diamond homologs: A0PJK1, A8I1B9, A8WHP3, D3ZIS0, P11170, P13866, P26429, P26430, P31636, P31637, P31639, P53790, P53791, P53792, P53793, P53794, P96169, Q28610, Q28728, Q2M3M2, Q3ZC26, Q5FY69, Q5SWY8, Q6R4Q5, Q8C3K6, Q8K0E3, Q8VDT1, Q8WWX8, Q91ZP4, Q923I7, Q9ET37, Q9JKZ2, Q9NY91, Q9Z1F2, P31448

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

89 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance78
Likely benign4
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4261 predictions. Top by Δscore:

VariantEffectΔscore
17:18958680:A:AGacceptor_gain1.0000
17:18958681:G:GGacceptor_gain1.0000
17:18958681:GTCC:Gacceptor_gain1.0000
17:18958681:GTCCT:Gacceptor_gain1.0000
17:18958751:CCGGT:Cdonor_loss1.0000
17:18958752:CGGTG:Cdonor_loss1.0000
17:18958753:GGT:Gdonor_loss1.0000
17:18958754:G:Cdonor_loss1.0000
17:18958754:G:GGdonor_gain1.0000
17:18958755:T:Adonor_loss1.0000
17:18959130:TCCA:Tacceptor_loss1.0000
17:18959131:CCA:Cacceptor_loss1.0000
17:18959133:A:AGacceptor_gain1.0000
17:18959133:AGATT:Aacceptor_gain1.0000
17:18959134:G:GAacceptor_gain1.0000
17:18959134:GA:Gacceptor_gain1.0000
17:18959134:GAT:Gacceptor_gain1.0000
17:18959134:GATT:Gacceptor_gain1.0000
17:18959134:GATTG:Gacceptor_gain1.0000
17:18959235:GGAAT:Gdonor_gain1.0000
17:18959236:GAAT:Gdonor_gain1.0000
17:18959236:GAATG:Gdonor_gain1.0000
17:18959238:AT:Adonor_gain1.0000
17:18959238:ATGTG:Adonor_loss1.0000
17:18959240:G:GGdonor_gain1.0000
17:18959240:G:Tdonor_loss1.0000
17:18959241:T:Adonor_loss1.0000
17:18959602:A:AGacceptor_gain1.0000
17:18959603:G:GGacceptor_gain1.0000
17:18959660:AGAGG:Adonor_loss1.0000

AlphaMissense

3825 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
17:18976920:A:CS305R0.997
17:18976922:C:AS305R0.997
17:18976922:C:GS305R0.997
17:18976971:A:CS322R0.997
17:18976973:C:AS322R0.997
17:18976973:C:GS322R0.997
17:19019451:A:CS424R0.997
17:19019453:T:AS424R0.997
17:19019453:T:GS424R0.997
17:18959156:A:CS69R0.995
17:18959158:C:AS69R0.995
17:18959158:C:GS69R0.995
17:18976975:G:CR323P0.995
17:19013494:T:CL356P0.995
17:19015117:A:CS387R0.995
17:19015119:C:AS387R0.995
17:19015119:C:GS387R0.995
17:18959228:T:CF93L0.994
17:18959230:C:AF93L0.994
17:18959230:C:GF93L0.994
17:18971159:T:AW263R0.994
17:18971159:T:CW263R0.994
17:18976865:G:CQ286H0.994
17:18976865:G:TQ286H0.994
17:19015123:A:CS389R0.994
17:19015125:C:AS389R0.994
17:19015125:C:GS389R0.994
17:18969398:G:AG206R0.993
17:18969398:G:CG206R0.993
17:18976879:C:AA291D0.993

dbSNP variants (sampled 300 via entrez): RS1000017554 (17:18979405 CG>C), RS1000040617 (17:19013460 G>A), RS1000108166 (17:19005577 G>C), RS1000119288 (17:18982264 C>G), RS1000156355 (17:18968490 G>A), RS1000190467 (17:18982965 G>A), RS1000198665 (17:18967288 C>A,G,T), RS1000230446 (17:19017992 T>C), RS1000235019 (17:19020856 G>C), RS1000254136 (17:18967113 C>T), RS1000305407 (17:19006343 C>G,T), RS1000423531 (17:18968662 C>G), RS1000459233 (17:18972523 G>A), RS1000612309 (17:19015852 T>C), RS1000636305 (17:19006672 A>C)

Disease associations

OMIM: gene MIM:618636 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

StudyTraitp-value
GCST004643_21,5-anhydroglucitol levels2.000000e-17

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:00080091,5 anhydroglucitol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — Hexose transporter family

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arsenitedecreases expression, increases expression2
Resveratrolaffects cotreatment, decreases expression2
propionaldehydeincreases expression1
mono-(2-ethylhexyl)phthalatedecreases expression1
benzo(e)pyreneincreases methylation1
CGP 52608affects binding, increases reaction1
abrineincreases expression1
bisphenol Saffects cotreatment, increases methylation1
PCI 5002affects cotreatment, increases expression1
Fulvestrantincreases methylation, affects cotreatment1
Benzo(a)pyreneaffects methylation1
Copperaffects cotreatment, decreases expression1
Endosulfanincreases expression1
Methapyrileneincreases methylation1
Plant Extractsaffects cotreatment, decreases expression1
Silicon Dioxidedecreases expression1
Tobacco Smoke Pollutionincreases expression1
Tretinoinincreases expression1
Valproic Acidincreases methylation1
Zincaffects cotreatment, increases expression1
Aflatoxin B1increases methylation1
Cadmium Chlorideincreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 76

This page pulls from 76 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgtopdb_interactiongwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot