SLC67A1-AS
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Also known as BWR1Bp27-BWR1BSLC22A18-AS1
Summary
SLC67A1-AS (SLC67A1 antisense RNA, HGNC:10965) is a long non-coding RNA gene on chromosome 11p15.4.
At a glance
- Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:10965 |
| Approved symbol | SLC67A1-AS |
| Name | SLC67A1 antisense RNA |
| Location | 11p15.4 |
| Locus type | RNA, long non-coding |
| Status | Approved |
| Aliases | BWR1B, p27-BWR1B, SLC22A18-AS1 |
| Ensembl gene | ENSG00000254827 |
| Ensembl biotype | lncRNA |
| OMIM | 603240 |
| Entrez | 5003 |
| RNAcentral | URS0001BBE583 — lncRNA, 1535 nt, 1 organism(s) |
Gene structure
Transcript identifiers
Ensembl transcripts: 7 — 7 lncRNA
ENST00000455942, ENST00000526203, ENST00000625099, ENST00000702349, ENST00000779223, ENST00000779224, ENST00000779225
RefSeq mRNA: 0 — MANE Select: None
Canonical transcript exons
ENST00000455942 — 3 exons
| Exon | Start | End |
|---|---|---|
| ENSE00002181520 | 2887344 | 2888635 |
| ENSE00002312021 | 2902584 | 2902709 |
| ENSE00004149453 | 2903459 | 2903814 |
Expression profiles
Bgee: expression breadth ubiquitous, 124 present calls, max score 92.00.
FANTOM5 (CAGE): breadth broad, TPM avg 0.7795 / max 29.0458, expressed in 296 samples.
FANTOM5 promoters (6 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 118247 | 0.3052 | 130 |
| 118246 | 0.2612 | 126 |
| 118249 | 0.0741 | 35 |
| 118248 | 0.0695 | 31 |
| 118244 | 0.0380 | 14 |
| 118245 | 0.0315 | 11 |
Top tissues by expression
130 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| mucosa of transverse colon | UBERON:0004991 | 92.00 | gold quality |
| duodenum | UBERON:0002114 | 82.64 | gold quality |
| transverse colon | UBERON:0001157 | 81.63 | gold quality |
| right lobe of liver | UBERON:0001114 | 80.65 | gold quality |
| rectum | UBERON:0001052 | 79.22 | gold quality |
| adult mammalian kidney | UBERON:0000082 | 78.27 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 76.10 | gold quality |
| liver | UBERON:0002107 | 73.81 | gold quality |
| placenta | UBERON:0001987 | 72.83 | gold quality |
| small intestine Peyer’s patch | UBERON:0003454 | 72.12 | gold quality |
| small intestine | UBERON:0002108 | 72.05 | gold quality |
| kidney | UBERON:0002113 | 71.14 | gold quality |
| intestine | UBERON:0000160 | 69.80 | gold quality |
| colon | UBERON:0001155 | 69.48 | gold quality |
| monocyte | CL:0000576 | 69.38 | gold quality |
| leukocyte | CL:0000738 | 68.93 | gold quality |
| vermiform appendix | UBERON:0001154 | 66.50 | gold quality |
| lower esophagus mucosa | UBERON:0035834 | 66.46 | gold quality |
| granulocyte | CL:0000094 | 66.22 | gold quality |
| olfactory segment of nasal mucosa | UBERON:0005386 | 66.08 | gold quality |
| smooth muscle tissue | UBERON:0001135 | 65.28 | gold quality |
| gall bladder | UBERON:0002110 | 65.27 | gold quality |
| cortex of kidney | UBERON:0001225 | 65.24 | gold quality |
| subcutaneous adipose tissue | UBERON:0002190 | 64.67 | gold quality |
| blood | UBERON:0000178 | 64.30 | gold quality |
| adipose tissue | UBERON:0001013 | 64.17 | gold quality |
| prefrontal cortex | UBERON:0000451 | 63.83 | gold quality |
| dorsolateral prefrontal cortex | UBERON:0009834 | 63.51 | gold quality |
| omental fat pad | UBERON:0010414 | 63.24 | gold quality |
| mucosa of stomach | UBERON:0001199 | 63.00 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | yes | 5.28 |
Regulation
Is transcription factor: no
Literature-anchored findings (GeneRIF, showing 3)
- Results suggest imprinting of the paternal allele of SLC22A1LS gene in five fetal tissues: brain, liver, placenta, kidneys and lungs. (PMID:15175115)
- SLC22A18/SLC22A18AS genes are a sense-antisense pair located at human chromosome segment 11p15.5. These genes are paternally imprinted. (PMID:18721868)
- Using antibodies generated in rabbit, immunoprecipitation and Western blot analyses, translation of a 253-aa ORF at very low levels occurred. The translated protein was mainly localized in the cytoplasm. (PMID:18721868)
Cross-species orthologs
0 orthologs
Protein
Non-coding RNA — no protein product; not a drug target.
Function
No curated pathway, Gene-Ontology, or interaction data.
Disease & clinical
No curated disease, variant, or cancer-driver associations.
Drugs & pharmacology
No drug or pharmacology data — not an established drug target.