SLC75A1

Summary

SLC75A1 (solute carrier family 75 member 1, HGNC:16894) is a protein-coding gene on chromosome 4p16.3, encoding Solute carrier family 75 member 1 (Q14728). Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine.

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described.

Source: NCBI Gene 10227 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 90 total
• Druggable target: yes
• MANE Select transcript: NM_001146069

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16894
Approved symbol	SLC75A1
Name	solute carrier family 75 member 1
Location	4p16.3
Locus type	gene with protein product
Status	Approved
Aliases	IT10C3, TETRAN, SLC75A1
Ensembl gene	ENSG00000109736
Ensembl biotype	protein_coding
OMIM	610977
Entrez	10227

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 24 protein_coding, 4 retained_intron, 2 nonsense_mediated_decay

ENST00000329687, ENST00000355443, ENST00000503596, ENST00000507272, ENST00000507555, ENST00000508221, ENST00000508276, ENST00000509676, ENST00000512781, ENST00000514031, ENST00000514800, ENST00000866676, ENST00000866677, ENST00000866678, ENST00000866679, ENST00000866680, ENST00000866681, ENST00000866682, ENST00000866683, ENST00000866684, ENST00000866685, ENST00000866686, ENST00000932268, ENST00000932269, ENST00000967825, ENST00000967826, ENST00000967827, ENST00000967828, ENST00000967829, ENST00000967830

RefSeq mRNA: 4 — MANE Select: NM_001146069 NM_001120, NM_001146069, NM_001363679, NM_001410703

CCDS: CCDS3365, CCDS87203, CCDS93471

Canonical transcript exons

ENST00000355443 — 13 exons

Exon	Start	End
ENSE00000699262	2932600	2932758
ENSE00000699263	2933106	2933209
ENSE00002039305	2934769	2934825
ENSE00003478138	2931227	2931274
ENSE00003486031	2931825	2931936
ENSE00003491805	2931555	2931663
ENSE00003535417	2932045	2932153
ENSE00003538413	2931061	2931150
ENSE00003595948	2931375	2931465
ENSE00003604771	2930567	2930953
ENSE00003654538	2933753	2933944
ENSE00003661375	2933567	2933663
ENSE00003677523	2932351	2932512

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 98.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.3989 / max 692.2522, expressed in 1811 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
51156	26.3019	1810
51155	1.0057	419
51153	0.4470	76
51154	0.3688	77
51151	0.1791	46
51152	0.0965	29

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	98.54	gold quality
oocyte	CL:0000023	98.37	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.03	gold quality
cerebellar hemisphere	UBERON:0002245	97.73	gold quality
granulocyte	CL:0000094	97.65	gold quality
cerebellar cortex	UBERON:0002129	97.62	gold quality
metanephros cortex	UBERON:0010533	97.16	gold quality
endocervix	UBERON:0000458	97.15	gold quality
right lobe of thyroid gland	UBERON:0001119	97.14	gold quality
right ovary	UBERON:0002118	97.09	gold quality
left ovary	UBERON:0002119	96.96	gold quality
left lobe of thyroid gland	UBERON:0001120	96.94	gold quality
adenohypophysis	UBERON:0002196	96.76	gold quality
left uterine tube	UBERON:0001303	96.63	gold quality
tibial nerve	UBERON:0001323	96.52	gold quality
body of uterus	UBERON:0009853	96.51	gold quality
mucosa of transverse colon	UBERON:0004991	96.45	gold quality
upper lobe of left lung	UBERON:0008952	96.36	gold quality
cerebellum	UBERON:0002037	96.08	gold quality
ectocervix	UBERON:0012249	95.99	gold quality
right lung	UBERON:0002167	95.96	gold quality
body of stomach	UBERON:0001161	95.95	gold quality
secondary oocyte	CL:0000655	95.79	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.79	gold quality
thyroid gland	UBERON:0002046	95.78	gold quality
omental fat pad	UBERON:0010414	95.67	gold quality
right frontal lobe	UBERON:0002810	95.66	gold quality
peritoneum	UBERON:0002358	95.62	gold quality
lower esophagus mucosa	UBERON:0035834	95.58	gold quality
ventricular zone	UBERON:0003053	95.57	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9067	yes	14.98
E-ANND-3	yes	10.81
E-MTAB-7303	no	1001.99

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting SLC75A1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-548Q	98.71	65.35	563
HSA-MIR-4660	97.79	67.44	1328

Literature-anchored findings (GeneRIF, showing 2)

• A BLAST search identified the possible human orthologue of Tpo1p, tetracycline transporter-like protein (TETRAN), whose overexpression in cultured human cells caused resistance to some NSAIDs, suggesting that TETRAN is an efflux pump for some NSAIDs. (PMID:17362938)
• TETRAN is a novel human organic anion transporter, and that it serves as a transporter for some NSAIDs and various other organic anions at the final excretion step. (PMID:18638446)

Cross-species orthologs

23 orthologs

Organism	Symbol	Gene ID
danio_rerio	mfsd14a2	ENSDARG00000013117
danio_rerio	mfsd1l	ENSDARG00000070957
danio_rerio	mfsd8l2	ENSDARG00000076959
danio_rerio	mfsd10	ENSDARG00000086786
danio_rerio		ENSDARG00000087525
mus_musculus	Mfsd10	ENSMUSG00000001082
rattus_norvegicus	Mfsd10	ENSRNOG00000012534
drosophila_melanogaster	rtet	FBGN0028468
drosophila_melanogaster	CG11537	FBGN0035400
drosophila_melanogaster	CG18281	FBGN0037003
drosophila_melanogaster	CG17637	FBGN0037004
drosophila_melanogaster	CG5078	FBGN0037005
caenorhabditis_elegans		WBGENE00010182
caenorhabditis_elegans		WBGENE00010282
caenorhabditis_elegans		WBGENE00012222
caenorhabditis_elegans		WBGENE00016093
caenorhabditis_elegans		WBGENE00016094
caenorhabditis_elegans		WBGENE00016095
caenorhabditis_elegans		WBGENE00017339
caenorhabditis_elegans		WBGENE00017861
caenorhabditis_elegans		WBGENE00020798
caenorhabditis_elegans		WBGENE00021814
caenorhabditis_elegans		WBGENE00021870

Paralogs (6): MFSD1 (ENSG00000118855), MFSD9 (ENSG00000135953), MFSD14B (ENSG00000148110), MFSD14A (ENSG00000156875), MFSD8 (ENSG00000164073), MFSD5 (ENSG00000182544)

Protein

Protein identifiers

Solute carrier family 75 member 1 — Q14728 (reviewed: Q14728)

Alternative names: Major facilitator superfamily domain-containing protein 10, Tetracycline transporter-like protein

All UniProt accessions (6): Q14728, D6R9N3, D6RA47, D6RE79, D6RHV1, D6RIZ4

UniProt curated annotations — full annotation on UniProt →

Function. Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine.

Subcellular location. Nucleus inner membrane. Cell membrane.

Tissue specificity. Expressed in luminal membrane of renal tubules (at protein level). Detected in all tissues tested with higher expression in heart, splee, kidney, leukocytes and prostate.

Similarity. Belongs to the SLC75A transporter family.

RefSeq proteins (4): NP_001111, NP_001139541, NP_001350608, NP_001397632 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011701	MFS	Family
IPR020846	MFS_dom	Domain
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF07690

UniProt features (39 total): helix 24, transmembrane region 11, strand 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6S4M	X-RAY DIFFRACTION	2.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14728-F1	92.02	0.87

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 110 (showing top): GOBP_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT, ONKEN_UVEAL_MELANOMA_UP, WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, GOBP_ORGANIC_ANION_TRANSPORT, chr4p16, LIAO_METASTASIS, GOCC_APICAL_PLASMA_MEMBRANE, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GRUETZMANN_PANCREATIC_CANCER_UP, IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR, CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN, MILI_PSEUDOPODIA_CHEMOTAXIS_DN

GO Biological Process (4): apoptotic process (GO:0006915), sodium-independent organic anion transport (GO:0043252), tetracycline transmembrane transport (GO:0015904), transmembrane transport (GO:0055085)

GO Molecular Function (4): tetracycline transmembrane transporter activity (GO:0008493), obsolete organic anion transmembrane transporter activity (GO:0008514), protein binding (GO:0005515), transmembrane transporter activity (GO:0022857)

GO Cellular Component (7): nuclear inner membrane (GO:0005637), membrane (GO:0016020), cytoplasmic vesicle membrane (GO:0030659), brush border membrane (GO:0031526), nucleus (GO:0005634), plasma membrane (GO:0005886), organelle membrane (GO:0031090)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane transport	3
membrane	2
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
organic hydroxy compound transport	1
transport	1
cellular process	1
alcohol transmembrane transporter activity	1
tetracycline transmembrane transport	1
binding	1
transporter activity	1
organelle inner membrane	1
nuclear membrane	1
cellular anatomical structure	1
vesicle membrane	1
cytoplasmic vesicle	1
brush border	1
apical plasma membrane	1
cell projection membrane	1
intracellular membrane-bounded organelle	1
cell periphery	1
membrane-bounded organelle	1

Protein interactions and networks

STRING

1099 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC75A1	SERINC5	Q86VE9	968
SLC75A1	MFSD6	Q6ZSS7	677
SLC75A1	SVOPL	Q8N434	665
SLC75A1	SLC61A1	Q6N075	632
SLC75A1	SVOP	Q8N4V2	628
SLC75A1	MFSD11	O43934	625
SLC75A1	UNC93A	Q86WB7	614
SLC75A1	SPNS3	Q6ZMD2	587
SLC75A1	SPNS1	Q9H2V7	572
SLC75A1	SLC33A2	Q96ES6	557
SLC75A1	SLC68A1	Q14CX5	549
SLC75A1	MFSD12	Q6NUT3	537
SLC75A1	SLC67A2	Q8NBP5	518
SLC75A1	MFSD6L	Q8IWD5	513
SLC75A1	MFSD2B	A6NFX1	513

IntAct

35 interactions, top by confidence:

A	B	Type	Score
MFSD10	PECAM1	psi-mi:“MI:0915”(physical association)	0.560
KLK6	MFSD10	psi-mi:“MI:0915”(physical association)	0.560
MFSD10	TGFBR2	psi-mi:“MI:0915”(physical association)	0.560
CBX5	MFSD10	psi-mi:“MI:0915”(physical association)	0.560
TMEM63A	AP3B1	psi-mi:“MI:0914”(association)	0.530
TMEM63A	AP3D1	psi-mi:“MI:0914”(association)	0.530
CHRNA4	FZD6	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
MFSD10	PB2	psi-mi:“MI:0915”(physical association)	0.370
MFSD10	F2RL1	psi-mi:“MI:0915”(physical association)	0.370
MFSD10	NPSR1	psi-mi:“MI:0915”(physical association)	0.370
	ESYT2	psi-mi:“MI:0914”(association)	0.350
	NBAS	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
CYP2C18	PGRMC1	psi-mi:“MI:0914”(association)	0.350
CHRNA3	ENTPD6	psi-mi:“MI:0914”(association)	0.350
SAAL1	TMEM223	psi-mi:“MI:0914”(association)	0.350
MFSD10	NDUFS8	psi-mi:“MI:0914”(association)	0.350
FOS	ILVBL	psi-mi:“MI:0914”(association)	0.350
ATF2	ABLIM1	psi-mi:“MI:0914”(association)	0.350

BioGRID (271): MFSD10 (Biochemical Activity), MFSD10 (Biochemical Activity), MFSD10 (Proximity Label-MS), MFSD10 (Proximity Label-MS), MFSD10 (Affinity Capture-MS), MFSD10 (Affinity Capture-MS), MFSD10 (Affinity Capture-MS), MFSD10 (Proximity Label-MS), MFSD10 (Affinity Capture-MS), MFSD10 (Affinity Capture-MS), MFSD10 (Proximity Label-MS), MFSD10 (Proximity Label-MS), MFSD10 (Proximity Label-MS), MFSD10 (Proximity Label-MS), MFSD10 (Proximity Label-MS)

ESM2 similar proteins: A0A3Q2HW92, A6NDV4, A6NFX1, A6QLK4, B1AWJ5, F1NCD6, F1NJ67, F1PZV2, O35308, O35595, O70461, O95907, Q08DX7, Q0IHM1, Q0P5C0, Q0P5M9, Q13286, Q14728, Q29611, Q2YDU8, Q3T9M1, Q3U481, Q501I9, Q5R8G5, Q5R9A1, Q5U419, Q60HH0, Q61124, Q66H95, Q6NUT3, Q6UXD7, Q6ZMD2, Q7RTT9, Q8BFQ6, Q8CE47, Q8NA29, Q8R0G7, Q8R139, Q8TB61, Q8VCW4

Diamond homologs: A0A0C1C354, A0A0D1DYJ6, A0A0E3D8L1, A0A0F9XXG3, A0A0N7D7C9, A0A0U5GJZ5, A0A140JWS3, A0A142I724, A0A1L9WQV4, A0A1V6PBC8, A0A1W5T3J9, A0A2I1C3U4, A0A2L0P0L8, A0A2Z1U8L7, A0A348HAX9, A0A3G1DJE2, A0A3G9H2R5, A0A411KUX1, A0A443HJZ5, A0A455ZIM6, A0A4P8DK16, A0A4Q4NMP3, A0A5B8YU71, A0A6F8RNA5, A0A6J4B6H5, A0A7L8UVD5, A0A8F4NW86, A0A8K1AW52, A1JKW8, A7MHI9, A9N7L0, B4T9U3, B4TNI8, C6DBD0, D4AXV8, D7PI13, E9R876, F2SH39, J9VHZ4, K5B8L6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

90 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	65
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1919 predictions. Top by Δscore:

Variant	Effect	Δscore
4:2931272:CGG:C	acceptor_gain	1.0000
4:2931273:GGC:G	acceptor_loss	1.0000
4:2931274:GCTGG:G	acceptor_loss	1.0000
4:2931275:C:CC	acceptor_gain	1.0000
4:2931276:T:A	acceptor_loss	1.0000
4:2931370:CTCA:C	donor_loss	1.0000
4:2931371:TCA:T	donor_loss	1.0000
4:2931372:CA:C	donor_loss	1.0000
4:2931373:A:AC	donor_gain	1.0000
4:2931374:C:CC	donor_gain	1.0000
4:2931374:C:CT	donor_loss	1.0000
4:2931554:CCCG:C	donor_gain	1.0000
4:2931574:T:TA	donor_gain	1.0000
4:2931575:C:A	donor_gain	1.0000
4:2931820:CCCA:C	donor_loss	1.0000
4:2931821:CCA:C	donor_loss	1.0000
4:2931822:CACCT:C	donor_loss	1.0000
4:2931823:ACCTA:A	donor_loss	1.0000
4:2931824:CCTA:C	donor_gain	1.0000
4:2931824:CCTAC:C	donor_loss	1.0000
4:2931827:A:AC	donor_gain	1.0000
4:2931828:C:CC	donor_gain	1.0000
4:2931828:CTGAA:C	donor_gain	1.0000
4:2931832:A:C	donor_gain	1.0000
4:2932043:A:AC	donor_gain	1.0000
4:2932044:C:CC	donor_gain	1.0000
4:2932044:CTGT:C	donor_gain	1.0000
4:2932509:CCGC:C	acceptor_gain	1.0000
4:2932510:CGCC:C	acceptor_gain	1.0000
4:2932595:CTTA:C	donor_loss	1.0000

AlphaMissense

2859 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:2932480:G:C	F188L	0.992
4:2932480:G:T	F188L	0.992
4:2932482:A:G	F188L	0.992
4:2933131:C:A	R116M	0.991
4:2932672:G:C	S153R	0.990
4:2932672:G:T	S153R	0.990
4:2932674:T:G	S153R	0.990
4:2932492:G:C	F184L	0.988
4:2932492:G:T	F184L	0.988
4:2932494:A:G	F184L	0.988
4:2933131:C:G	R116T	0.988
4:2933807:G:C	F39L	0.988
4:2933807:G:T	F39L	0.988
4:2933809:A:G	F39L	0.988
4:2931107:G:C	S402R	0.986
4:2931107:G:T	S402R	0.986
4:2931109:T:G	S402R	0.986
4:2933130:C:A	R116S	0.986
4:2933130:C:G	R116S	0.986
4:2931854:G:C	F295L	0.985
4:2931854:G:T	F295L	0.985
4:2931856:A:G	F295L	0.985
4:2933146:G:A	S111F	0.984
4:2933190:G:C	F96L	0.984
4:2933190:G:T	F96L	0.984
4:2933192:A:G	F96L	0.984
4:2931881:G:C	F286L	0.981
4:2931881:G:T	F286L	0.981
4:2931883:A:G	F286L	0.981
4:2932481:A:G	F188S	0.980

dbSNP variants (sampled 300 via entrez): RS1000010069 (4:2934039 G>A), RS1000166912 (4:2930575 A>C), RS1000277392 (4:2934782 G>A,C), RS1000503473 (4:2931464 G>A,C), RS1000522141 (4:2933517 C>T), RS1000586959 (4:2934300 G>A,T), RS1001759170 (4:2934065 C>A,T), RS1002406473 (4:2933355 G>A,T), RS1002898850 (4:2935665 A>G), RS1003031049 (4:2933236 G>A), RS1003248857 (4:2936694 G>A,T), RS1003639712 (4:2934653 A>C,G), RS1004126288 (4:2934883 T>C), RS1004482687 (4:2930403 G>A,T), RS1004832015 (4:2935143 C>T)

Disease associations

OMIM: gene MIM:610977 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004691_6	Huntington’s disease progression	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008336	disease progression measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067237 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.15	Kd	70.16	nM	CHEMBL5653589
7.15	ED50	70.16	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148746: Binding affinity to human MFSD10 incubated for 45 mins by Kinobead based pull down assay	kd	0.0702	uM

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	4
Air Pollutants	decreases expression, affects expression, increases abundance	2
Arsenic	affects cotreatment, decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	decreases methylation, increases expression	2
Tretinoin	increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
bisphenol A	affects expression	1
beta-lapachone	decreases expression, increases expression	1
di-n-butylphosphoric acid	affects expression	1
deguelin	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
(+)-JQ1 compound	decreases expression	1
MT19c compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Acetaminophen	increases expression	1
Vehicle Emissions	increases abundance, increases expression	1
Cisplatin	decreases expression	1
Estradiol	affects expression	1
Hydrogen Peroxide	affects cotreatment, decreases expression	1
Ozone	affects expression, increases abundance	1
Quercetin	increases expression	1
Selenium	increases expression	1
Theophylline	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	decreases expression, increases methylation	1
Cyclosporine	decreases expression	1
Aflatoxin B1	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651788	Binding	Binding affinity to human MFSD10 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4DB	HEK-MFSD10-KO-c2	Transformed cell line	Female
CVCL_D4G7	HCT116-MFSD10-KO-c18	Cancer cell line	Male
CVCL_D4G8	HCT116-MFSD10-KO-c24	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.