SLC7A11-AS1

Summary

SLC7A11-AS1 (SLC7A11 antisense RNA 1, HGNC:44064) is a long non-coding RNA gene on chromosome 4q28.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44064
Approved symbol	SLC7A11-AS1
Name	SLC7A11 antisense RNA 1
Location	4q28.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	ENST00000512786
Ensembl gene	ENSG00000250033
Ensembl biotype	lncRNA
Entrez	641364
RNAcentral	URS000075F088 — lncRNA, 4671 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 lncRNA, 1 retained_intron

ENST00000510066, ENST00000510767, ENST00000512538, ENST00000512786, ENST00000514752, ENST00000732145, ENST00000732146, ENST00000732147, ENST00000732148, ENST00000732149

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000510066 — 4 exons

Exon	Start	End
ENSE00002045916	138098189	138098717
ENSE00002055176	138090834	138090980
ENSE00002062159	138062808	138062903
ENSE00002079767	138057464	138057508

Expression profiles

Bgee: expression breadth ubiquitous, 147 present calls, max score 83.14.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2350 / max 72.5607, expressed in 36 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
49694	0.1221	16
49698	0.0389	4
49696	0.0289	6
49697	0.0280	7
49695	0.0076	3
49700	0.0068	2
49699	0.0027	2

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.14	gold quality
colonic epithelium	UBERON:0000397	77.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.57	gold quality
left testis	UBERON:0004533	77.28	gold quality
right testis	UBERON:0004534	76.15	gold quality
testis	UBERON:0000473	74.93	gold quality
stromal cell of endometrium	CL:0002255	73.33	gold quality
sural nerve	UBERON:0015488	70.34	gold quality
corpus callosum	UBERON:0002336	66.49	gold quality
islet of Langerhans	UBERON:0000006	64.66	gold quality
cortical plate	UBERON:0005343	64.40	gold quality
bone marrow cell	CL:0002092	63.73	silver quality
ventricular zone	UBERON:0003053	62.20	gold quality
ganglionic eminence	UBERON:0004023	61.27	gold quality
calcaneal tendon	UBERON:0003701	60.63	gold quality
adrenal tissue	UBERON:0018303	60.59	gold quality
pancreas	UBERON:0001264	59.28	gold quality
rectum	UBERON:0001052	58.25	gold quality
monocyte	CL:0000576	58.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.92	silver quality
prefrontal cortex	UBERON:0000451	56.82	gold quality
body of pancreas	UBERON:0001150	56.80	gold quality
gall bladder	UBERON:0002110	56.53	gold quality
body of stomach	UBERON:0001161	56.12	gold quality
stomach	UBERON:0000945	55.84	gold quality
right atrium auricular region	UBERON:0006631	55.67	gold quality
cardiac atrium	UBERON:0002081	55.23	gold quality
vermiform appendix	UBERON:0001154	55.17	gold quality
left lobe of thyroid gland	UBERON:0001120	55.02	gold quality
thyroid gland	UBERON:0002046	53.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Functional role of the SLC7A11-AS1/xCT axis in the development of gastric cancer cisplatin-resistance by a GSH-dependent mechanism. (PMID:35367340)
• Downregulation of lncRNA SLC7A11-AS1 decreased the NRF2/SLC7A11 expression and inhibited the progression of colorectal cancer cells. (PMID:37077308)
• LncRNA SLC7A11-AS1 promotes the progression of hepatocellular carcinoma by mediating KLF9 ubiquitination. (PMID:37498069)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.