SLC8A1-AS1

Summary

SLC8A1-AS1 (SLC8A1 antisense RNA 1, HGNC:44102) is a long non-coding RNA gene on chromosome 2p22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44102
Approved symbol	SLC8A1-AS1
Name	SLC8A1 antisense RNA 1
Location	2p22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227028
Ensembl biotype	lncRNA
Entrez	100128590
RNAcentral	URS0000759EA4 — lncRNA, 1002 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 43 — 43 lncRNA

ENST00000413479, ENST00000417875, ENST00000418854, ENST00000427354, ENST00000435515, ENST00000439606, ENST00000444629, ENST00000593848, ENST00000593878, ENST00000596532, ENST00000597170, ENST00000597385, ENST00000598247, ENST00000599268, ENST00000599740, ENST00000599956, ENST00000601679, ENST00000610721, ENST00000611583, ENST00000619351, ENST00000620276, ENST00000625234, ENST00000625324, ENST00000625381, ENST00000625780, ENST00000626098, ENST00000627108, ENST00000627210, ENST00000627219, ENST00000627538, ENST00000628471, ENST00000629157, ENST00000629180, ENST00000629329, ENST00000630006, ENST00000630783, ENST00000631022, ENST00000631137, ENST00000631142, ENST00000631204, ENST00000631330, ENST00000803722, ENST00000803723

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413479 — 4 exons

Exon	Start	End
ENSE00001684571	40223630	40223751
ENSE00001685605	40251684	40251774
ENSE00001711765	40254420	40254763
ENSE00001798874	40220143	40220385

Expression profiles

Bgee: expression breadth ubiquitous, 169 present calls, max score 91.65.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2350 / max 49.6042, expressed in 44 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19886	0.1902	29
19885	0.0448	18

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	91.65	gold quality
colonic epithelium	UBERON:0000397	91.33	gold quality
monocyte	CL:0000576	88.22	gold quality
leukocyte	CL:0000738	87.08	gold quality
stromal cell of endometrium	CL:0002255	86.01	gold quality
right atrium auricular region	UBERON:0006631	85.13	gold quality
secondary oocyte	CL:0000655	84.52	gold quality
cardiac atrium	UBERON:0002081	84.18	gold quality
heart left ventricle	UBERON:0002084	84.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.98	gold quality
oocyte	CL:0000023	83.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.64	gold quality
cardiac ventricle	UBERON:0002082	82.87	gold quality
heart	UBERON:0000948	82.20	gold quality
smooth muscle tissue	UBERON:0001135	81.87	gold quality
bone marrow cell	CL:0002092	80.61	gold quality
body of uterus	UBERON:0009853	77.28	gold quality
calcaneal tendon	UBERON:0003701	77.23	gold quality
sural nerve	UBERON:0015488	76.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	75.80	gold quality
ventricular zone	UBERON:0003053	75.66	gold quality
oral cavity	UBERON:0000167	75.63	gold quality
vermiform appendix	UBERON:0001154	75.56	gold quality
islet of Langerhans	UBERON:0000006	75.49	gold quality
buccal mucosa cell	CL:0002336	74.79	gold quality
cortical plate	UBERON:0005343	74.76	gold quality
apex of heart	UBERON:0002098	73.98	gold quality
ganglionic eminence	UBERON:0004023	73.76	gold quality
right coronary artery	UBERON:0001625	72.97	gold quality
popliteal artery	UBERON:0002250	72.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Association of Circulating Biomarkers of lnc-IGSF3-1:1, SCOC-AS1, and SLC8A1-AS1 with Salt Sensitivity of Blood Pressure in Chinese Population. (PMID:34855149)
• SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer malignant progression via the FUS RNA binding protein (FUS)/NUMB like endocytic adaptor protein (Numbl) axis. (PMID:35599603)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.